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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb5

Z-value: 1.65

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Transcription factors associated with Hoxb5

Gene Symbol Gene ID Gene Info
Hoxb5
ENSMUSG00000038700.3 homeobox B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb5mm10_v2_chr11_+_96302595_963025950.554.8e-04Click!

Activity profile of Hoxb5 motif

Sorted Z-values of Hoxb5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_121636173 14.65 ENSMUST00000032203.7
A2m
alpha-2-macroglobulin
chr11_+_74619594 9.62 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr7_+_143005046 7.63 ENSMUST00000009396.6
Tspan32
tetraspanin 32
chr7_+_143005770 7.10 ENSMUST00000143512.1
Tspan32
tetraspanin 32
chr19_-_45816007 7.10 ENSMUST00000079431.3
ENSMUST00000026247.6
ENSMUST00000162528.2
Kcnip2
Kv channel-interacting protein 2
chr7_+_143005677 6.97 ENSMUST00000082008.5
ENSMUST00000105925.1
ENSMUST00000105924.1
Tspan32
tetraspanin 32
chr7_+_143005638 6.77 ENSMUST00000075172.5
ENSMUST00000105923.1
Tspan32
tetraspanin 32
chr6_+_145121727 4.82 ENSMUST00000032396.6
Lrmp
lymphoid-restricted membrane protein
chrX_+_8271642 4.81 ENSMUST00000115590.1
Slc38a5
solute carrier family 38, member 5
chr2_-_164743182 4.23 ENSMUST00000103096.3
Wfdc3
WAP four-disulfide core domain 3
chr12_-_36042476 4.21 ENSMUST00000020896.8
Tspan13
tetraspanin 13
chr17_+_47593516 4.12 ENSMUST00000182874.1
Ccnd3
cyclin D3
chr18_+_36528145 4.08 ENSMUST00000074298.6
ENSMUST00000115694.2
Slc4a9
solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr3_+_67374091 3.87 ENSMUST00000077916.5
Mlf1
myeloid leukemia factor 1
chr17_+_47593444 3.87 ENSMUST00000182209.1
Ccnd3
cyclin D3
chr3_+_67374116 3.74 ENSMUST00000061322.8
Mlf1
myeloid leukemia factor 1
chr4_-_149137536 3.40 ENSMUST00000176124.1
ENSMUST00000177408.1
ENSMUST00000105695.1
ENSMUST00000030813.3
Apitd1
apoptosis-inducing, TAF9-like domain 1
chr2_+_125247190 3.38 ENSMUST00000082122.7
Dut
deoxyuridine triphosphatase
chr7_-_44532064 3.27 ENSMUST00000098483.2
ENSMUST00000035323.4
Spib
Spi-B transcription factor (Spi-1/PU.1 related)
chr5_+_143933059 3.14 ENSMUST00000166847.1
Rsph10b
radial spoke head 10 homolog B (Chlamydomonas)
chr8_+_123332676 3.13 ENSMUST00000010298.6
Spire2
spire homolog 2 (Drosophila)
chr2_+_85136355 3.05 ENSMUST00000057019.7
Aplnr
apelin receptor
chr6_+_72549430 2.99 ENSMUST00000155705.1
Capg
capping protein (actin filament), gelsolin-like
chr6_+_72549252 2.96 ENSMUST00000114071.1
Capg
capping protein (actin filament), gelsolin-like
chr7_+_25627604 2.83 ENSMUST00000076034.6
B3gnt8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chrX_-_48454152 2.80 ENSMUST00000114958.1
Elf4
E74-like factor 4 (ets domain transcription factor)
chr1_-_193370260 2.80 ENSMUST00000016323.4
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr9_-_35558522 2.76 ENSMUST00000034612.5
Ddx25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chrX_+_151046131 2.67 ENSMUST00000112685.1
Fgd1
FYVE, RhoGEF and PH domain containing 1
chr17_+_47630690 2.65 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr10_+_128909866 2.59 ENSMUST00000026407.7
Cd63
CD63 antigen
chr19_-_11623643 2.52 ENSMUST00000164792.1
ENSMUST00000025583.5
Ms4a2
membrane-spanning 4-domains, subfamily A, member 2
chr6_-_18514802 2.43 ENSMUST00000090601.5
Cttnbp2
cortactin binding protein 2
chrX_+_7822289 2.32 ENSMUST00000009875.4
Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr14_+_32159865 2.17 ENSMUST00000163336.1
ENSMUST00000169722.1
ENSMUST00000168385.1
Ncoa4
nuclear receptor coactivator 4
chr1_-_193370225 2.16 ENSMUST00000169907.1
Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr12_-_78983476 2.04 ENSMUST00000070174.7
Tmem229b
transmembrane protein 229B
chr7_-_133709051 1.96 ENSMUST00000124759.1
ENSMUST00000106144.1
Uros
uroporphyrinogen III synthase
chr10_-_88683021 1.92 ENSMUST00000004473.8
Spic
Spi-C transcription factor (Spi-1/PU.1 related)
chr12_-_78980758 1.91 ENSMUST00000174072.1
Tmem229b
transmembrane protein 229B
chr8_+_13339656 1.90 ENSMUST00000170909.1
Tfdp1
transcription factor Dp 1
chr8_+_95081187 1.89 ENSMUST00000034239.7
Katnb1
katanin p80 (WD40-containing) subunit B 1
chr11_+_119229092 1.78 ENSMUST00000053440.7
Ccdc40
coiled-coil domain containing 40
chr6_-_128362812 1.69 ENSMUST00000112152.1
ENSMUST00000057421.8
ENSMUST00000112151.1
Rhno1
RAD9-HUS1-RAD1 interacting nuclear orphan 1
chr18_+_53472981 1.68 ENSMUST00000115399.1
Prdm6
PR domain containing 6
chr2_-_153225396 1.64 ENSMUST00000099194.2
Tspyl3
TSPY-like 3
chr6_+_141249161 1.52 ENSMUST00000043259.7
Pde3a
phosphodiesterase 3A, cGMP inhibited
chr4_+_109415631 1.51 ENSMUST00000106618.1
Ttc39a
tetratricopeptide repeat domain 39A
chr7_-_133708958 1.45 ENSMUST00000106146.1
Uros
uroporphyrinogen III synthase
chr12_+_17924294 1.43 ENSMUST00000169657.1
B430203G13Rik
RIKEN cDNA B430203G13 gene
chr17_+_57105385 1.37 ENSMUST00000039490.7
Tnfsf9
tumor necrosis factor (ligand) superfamily, member 9
chr4_-_131821516 1.37 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr3_+_89215170 1.36 ENSMUST00000029682.4
Thbs3
thrombospondin 3
chr8_+_70594466 1.36 ENSMUST00000019283.9
Isyna1
myo-inositol 1-phosphate synthase A1
chr7_-_133709069 1.34 ENSMUST00000106145.3
Uros
uroporphyrinogen III synthase
chr11_-_59136375 1.34 ENSMUST00000047441.7
ENSMUST00000081658.5
ENSMUST00000052872.7
ENSMUST00000020732.4
Obscn
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr7_-_127208423 1.29 ENSMUST00000120705.1
Tbc1d10b
TBC1 domain family, member 10b
chrX_+_20687954 1.25 ENSMUST00000115364.1
Cdk16
cyclin-dependent kinase 16
chr7_-_31150981 1.24 ENSMUST00000085636.6
ENSMUST00000001280.7
Gramd1a
GRAM domain containing 1A
chr18_-_61707583 1.17 ENSMUST00000025472.1
Pcyox1l
prenylcysteine oxidase 1 like
chr7_-_45466894 1.16 ENSMUST00000033093.8
Bax
BCL2-associated X protein
chr7_-_28547109 1.12 ENSMUST00000057974.3
Nccrp1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr7_-_100964371 1.07 ENSMUST00000060174.4
P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr16_-_19515634 1.06 ENSMUST00000054606.1
Olfr167
olfactory receptor 167
chr10_-_81014902 1.05 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
Gng7
guanine nucleotide binding protein (G protein), gamma 7
chr5_-_141000590 1.00 ENSMUST00000085786.5
Card11
caspase recruitment domain family, member 11
chr10_-_127211528 0.97 ENSMUST00000013970.7
Pip4k2c
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr2_-_5862923 0.90 ENSMUST00000071016.2
Gm13199
predicted gene 13199
chr1_+_74771886 0.79 ENSMUST00000006716.6
Wnt6
wingless-related MMTV integration site 6
chr1_-_74544275 0.76 ENSMUST00000044260.4
Usp37
ubiquitin specific peptidase 37
chr2_+_26973416 0.72 ENSMUST00000014996.7
ENSMUST00000102891.3
Adamts13
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
chrX_-_10117597 0.69 ENSMUST00000115543.2
ENSMUST00000044789.3
ENSMUST00000115544.2
Srpx
sushi-repeat-containing protein
chr15_+_12205009 0.61 ENSMUST00000038172.8
Mtmr12
myotubularin related protein 12
chr1_+_172481788 0.58 ENSMUST00000127052.1
Igsf9
immunoglobulin superfamily, member 9
chr7_+_16875302 0.50 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr4_+_14864076 0.49 ENSMUST00000029875.3
Tmem55a
transmembrane protein 55A
chr11_-_99155067 0.43 ENSMUST00000103134.3
Ccr7
chemokine (C-C motif) receptor 7
chr16_+_17070220 0.42 ENSMUST00000141959.1
Ypel1
yippee-like 1 (Drosophila)
chr4_-_108848619 0.41 ENSMUST00000164855.1
A730015C16Rik
RIKEN cDNA A730015C16 gene
chrX_-_134111852 0.41 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr6_-_113501818 0.34 ENSMUST00000101059.1
Prrt3
proline-rich transmembrane protein 3
chrX_-_134111708 0.34 ENSMUST00000159259.1
ENSMUST00000113275.3
Nox1
NADPH oxidase 1
chr18_+_74268251 0.33 ENSMUST00000097530.3
Mbd1
methyl-CpG binding domain protein 1
chr2_+_152962485 0.30 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9
tubulin tyrosine ligase-like family, member 9
chr2_-_130629994 0.28 ENSMUST00000110262.1
ENSMUST00000028761.4
Fastkd5
Ubox5
FAST kinase domains 5
U box domain containing 5
chr7_-_123500449 0.28 ENSMUST00000042470.7
ENSMUST00000128217.1
Zkscan2
zinc finger with KRAB and SCAN domains 2
chr15_-_28025834 0.25 ENSMUST00000090247.5
Trio
triple functional domain (PTPRF interacting)
chr7_+_127296369 0.21 ENSMUST00000170971.1
Itgal
integrin alpha L
chr13_-_14063395 0.20 ENSMUST00000170957.1
Ggps1
geranylgeranyl diphosphate synthase 1
chr8_-_25597459 0.20 ENSMUST00000079160.6
Letm2
leucine zipper-EF-hand containing transmembrane protein 2
chr6_+_24795824 0.19 ENSMUST00000031693.2
Spam1
sperm adhesion molecule 1
chr3_-_103737995 0.18 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr5_-_137786651 0.18 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr4_-_141874879 0.18 ENSMUST00000036854.3
Efhd2
EF hand domain containing 2
chr5_-_137786681 0.16 ENSMUST00000132726.1
Mepce
methylphosphate capping enzyme
chr2_-_167062607 0.16 ENSMUST00000128676.1
Znfx1
zinc finger, NFX1-type containing 1
chr5_-_103211251 0.15 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
Mapk10
mitogen-activated protein kinase 10
chr5_+_117133567 0.14 ENSMUST00000179276.1
ENSMUST00000092889.5
ENSMUST00000145640.1
Taok3
TAO kinase 3
chr17_+_34240015 0.13 ENSMUST00000173764.1
H2-Ob
histocompatibility 2, O region beta locus
chr17_+_28692568 0.11 ENSMUST00000114752.1
Mapk14
mitogen-activated protein kinase 14
chrM_+_11734 0.11 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr7_+_19004047 0.10 ENSMUST00000053713.3
Irf2bp1
interferon regulatory factor 2 binding protein 1
chr7_+_127296291 0.05 ENSMUST00000106306.2
ENSMUST00000120857.1
Itgal
integrin alpha L
chr17_+_35077080 0.03 ENSMUST00000172959.1
Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr1_-_135958975 0.01 ENSMUST00000129302.1
Igfn1
immunoglobulin-like and fibronectin type III domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
2.8 28.5 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
1.4 7.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
1.2 4.8 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
1.1 3.4 GO:0006226 dUMP biosynthetic process(GO:0006226)
1.0 3.1 GO:0070649 formin-nucleated actin cable assembly(GO:0070649)
0.8 3.0 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.7 2.8 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.7 7.6 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.6 2.5 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.5 2.7 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 2.6 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.5 1.9 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.4 2.8 GO:0001866 NK T cell proliferation(GO:0001866)
0.4 1.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.4 1.2 GO:0002352 B cell negative selection(GO:0002352) B cell homeostatic proliferation(GO:0002358) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.4 1.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 8.0 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 1.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.3 4.8 GO:0015816 glycine transport(GO:0015816)
0.2 1.4 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.2 5.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 1.9 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 0.7 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.2 0.8 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.4 GO:2000520 lymphocyte migration into lymphoid organs(GO:0097021) positive regulation of thymocyte migration(GO:2000412) regulation of immunological synapse formation(GO:2000520) regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 1.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 1.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 1.7 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 2.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 1.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.0 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 1.4 GO:0060346 bone trabecula formation(GO:0060346)
0.1 3.3 GO:0030225 macrophage differentiation(GO:0030225)
0.1 1.0 GO:0070970 interleukin-2 secretion(GO:0070970)
0.1 0.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0 2.8 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.3 GO:0040031 snRNA modification(GO:0040031)
0.0 4.1 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.2 GO:0030252 growth hormone secretion(GO:0030252)
0.0 2.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.1 GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002587)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 5.0 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 4.7 GO:0007338 single fertilization(GO:0007338)
0.0 0.3 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 1.7 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 4.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.9 GO:0001824 blastocyst development(GO:0001824)
0.0 0.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.3 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.5 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.6 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 2.1 GO:1903169 regulation of calcium ion transmembrane transport(GO:1903169)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 28.5 GO:0070442 integrin alphaIIb-beta3 complex(GO:0070442)
0.6 2.6 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.4 5.9 GO:0090543 Flemming body(GO:0090543)
0.2 1.3 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.2 7.6 GO:0097546 ciliary base(GO:0097546)
0.2 2.2 GO:0044754 autolysosome(GO:0044754)
0.2 2.8 GO:0033391 chromatoid body(GO:0033391)
0.1 7.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.1 9.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 10.7 GO:0072562 blood microparticle(GO:0072562)
0.1 0.3 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.1 3.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0042101 T cell receptor complex(GO:0042101)
0.0 2.8 GO:0016605 PML body(GO:0016605)
0.0 1.7 GO:0005776 autophagosome(GO:0005776)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.8 GO:0005930 axoneme(GO:0005930)
0.0 1.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.7 GO:0001726 ruffle(GO:0001726)
0.0 0.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.5 GO:0031902 late endosome membrane(GO:0031902)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0043120 interleukin-8 binding(GO:0019959) tumor necrosis factor binding(GO:0043120)
1.9 9.4 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.9 2.8 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.8 4.8 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.6 2.5 GO:0019767 IgE receptor activity(GO:0019767)
0.4 1.1 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.3 4.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 3.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 1.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.3 2.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 1.9 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 4.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 9.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 0.7 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 1.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 1.2 GO:0051434 BH3 domain binding(GO:0051434)
0.1 1.3 GO:0031432 titin binding(GO:0031432)
0.1 1.0 GO:0050700 CARD domain binding(GO:0050700)
0.1 4.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 4.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 3.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.5 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.0 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 3.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 2.8 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 1.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 4.5 GO:0051015 actin filament binding(GO:0051015)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 14.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 8.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.2 1.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 2.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 2.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID E2F PATHWAY E2F transcription factor network
0.0 1.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.0 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.7 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 14.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 4.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 9.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 3.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 4.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 4.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.8 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 3.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 2.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.5 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF