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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxb6

Z-value: 0.92

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Transcription factors associated with Hoxb6

Gene Symbol Gene ID Gene Info
Hoxb6
ENSMUSG00000000690.4 homeobox B6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb6mm10_v2_chr11_+_96292453_96292508-0.124.7e-01Click!

Activity profile of Hoxb6 motif

Sorted Z-values of Hoxb6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_87092546 4.59 ENSMUST00000132667.1
ENSMUST00000145617.1
ENSMUST00000094649.4
Ugt2b36
UDP glucuronosyltransferase 2 family, polypeptide B36
chr3_+_60081861 4.00 ENSMUST00000029326.5
Sucnr1
succinate receptor 1
chr1_-_162898484 2.79 ENSMUST00000143123.1
Fmo2
flavin containing monooxygenase 2
chr2_-_164638789 2.76 ENSMUST00000109336.1
Wfdc16
WAP four-disulfide core domain 16
chr9_-_70141484 2.54 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr7_+_51880312 2.16 ENSMUST00000145049.1
Gas2
growth arrest specific 2
chrX_-_143933089 1.97 ENSMUST00000087313.3
Dcx
doublecortin
chr19_+_26748268 1.87 ENSMUST00000175791.1
ENSMUST00000176698.1
ENSMUST00000177252.1
ENSMUST00000176475.1
ENSMUST00000112637.2
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_+_45999297 1.56 ENSMUST00000110380.1
ENSMUST00000066451.3
Lrp2bp
Lrp2 binding protein
chr13_-_85127514 1.42 ENSMUST00000179230.1
Gm4076
predicted gene 4076
chr19_+_25406661 1.42 ENSMUST00000146647.1
Kank1
KN motif and ankyrin repeat domains 1
chr14_+_118137101 1.37 ENSMUST00000022728.2
Gpr180
G protein-coupled receptor 180
chr8_-_77610597 1.34 ENSMUST00000034030.8
Tmem184c
transmembrane protein 184C
chr14_-_68582078 1.24 ENSMUST00000022641.7
Adamdec1
ADAM-like, decysin 1
chr8_-_77610668 1.22 ENSMUST00000141202.1
ENSMUST00000152168.1
Tmem184c
transmembrane protein 184C
chr2_+_125859134 1.20 ENSMUST00000028636.6
ENSMUST00000125084.1
Galk2
galactokinase 2
chr4_-_138326234 0.97 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1
PTEN induced putative kinase 1
chr9_+_54538984 0.91 ENSMUST00000060242.5
ENSMUST00000118413.1
Sh2d7
SH2 domain containing 7
chr7_+_113207465 0.89 ENSMUST00000047321.7
Arntl
aryl hydrocarbon receptor nuclear translocator-like
chr19_+_24875679 0.83 ENSMUST00000073080.5
Gm10053
predicted gene 10053
chr8_+_13435459 0.81 ENSMUST00000167071.1
ENSMUST00000167505.1
Tmem255b
transmembrane protein 255B
chrX_-_143933204 0.78 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx
doublecortin
chr2_-_125859139 0.78 ENSMUST00000110463.1
ENSMUST00000028635.5
Cops2
COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)
chr9_+_21955747 0.78 ENSMUST00000053583.5
Swsap1
SWIM type zinc finger 7 associated protein 1
chr3_-_116712644 0.77 ENSMUST00000029569.2
Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr5_+_88583527 0.75 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr4_-_134853294 0.68 ENSMUST00000030628.8
Tmem57
transmembrane protein 57
chr8_+_111033890 0.66 ENSMUST00000034441.7
Aars
alanyl-tRNA synthetase
chr6_-_119388671 0.66 ENSMUST00000169744.1
Adipor2
adiponectin receptor 2
chr3_+_66985647 0.65 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_-_79145875 0.48 ENSMUST00000118340.1
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
chr13_-_92030897 0.46 ENSMUST00000149630.1
Rasgrf2
RAS protein-specific guanine nucleotide-releasing factor 2
chrX_+_57212110 0.39 ENSMUST00000033466.1
Cd40lg
CD40 ligand
chr8_+_110618577 0.35 ENSMUST00000034190.9
Vac14
Vac14 homolog (S. cerevisiae)
chr12_-_119238794 0.35 ENSMUST00000026360.8
Itgb8
integrin beta 8
chr11_-_99244058 0.34 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr2_+_86041317 0.31 ENSMUST00000111589.1
Olfr1033
olfactory receptor 1033
chrX_+_38600626 0.31 ENSMUST00000000365.2
Mcts1
malignant T cell amplified sequence 1
chr5_+_31526989 0.30 ENSMUST00000114533.2
ENSMUST00000117262.1
ENSMUST00000117319.1
Slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr13_+_93304066 0.29 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr4_+_150997081 0.23 ENSMUST00000030803.1
Uts2
urotensin 2
chr10_-_58675631 0.23 ENSMUST00000003312.4
Edar
ectodysplasin-A receptor
chr1_-_22805994 0.21 ENSMUST00000097808.4
Rims1
regulating synaptic membrane exocytosis 1
chr3_+_66985680 0.21 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_39122277 0.20 ENSMUST00000136546.1
Fam229b
family with sequence similarity 229, member B
chr4_+_15881255 0.18 ENSMUST00000029876.1
Calb1
calbindin 1
chr10_-_64090265 0.17 ENSMUST00000105439.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr13_+_93304799 0.15 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr12_-_72917872 0.15 ENSMUST00000044000.5
4930447C04Rik
RIKEN cDNA 4930447C04 gene
chr11_-_69795930 0.12 ENSMUST00000045971.8
Chrnb1
cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)
chrX_+_107088452 0.11 ENSMUST00000150494.1
P2ry10
purinergic receptor P2Y, G-protein coupled 10
chr7_-_38528193 0.07 ENSMUST00000079759.5
Gm5591
predicted gene 5591
chr11_-_72215592 0.07 ENSMUST00000021157.8
Med31
mediator of RNA polymerase II transcription, subunit 31 homolog (yeast)
chr6_+_49319274 0.06 ENSMUST00000055559.7
ENSMUST00000114491.1
Ccdc126
coiled-coil domain containing 126
chr6_-_12109583 0.05 ENSMUST00000080891.5
Gm6578
predicted gene 6578
chrX_+_164162167 0.05 ENSMUST00000131543.1
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr3_-_94412883 0.01 ENSMUST00000181305.1
1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr15_+_102990576 0.01 ENSMUST00000001703.6
Hoxc8
homeobox C8
chr15_+_37425554 0.00 ENSMUST00000022897.1
4930447A16Rik
RIKEN cDNA 4930447A16 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 2.8 GO:0072592 oxygen metabolic process(GO:0072592)
0.2 1.0 GO:1903384 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.2 0.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.9 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 0.5 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.2 0.8 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 2.7 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:2001200 positive regulation of dendritic cell differentiation(GO:2001200)
0.1 1.2 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.3 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.2 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.1 0.7 GO:0061042 vascular wound healing(GO:0061042)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.1 GO:0010705 meiotic DNA double-strand break processing involved in reciprocal meiotic recombination(GO:0010705)
0.0 0.8 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.2 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.0 1.4 GO:0019236 response to pheromone(GO:0019236)
0.0 0.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.4 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.2 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.5 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.4 GO:0001573 ganglioside metabolic process(GO:0001573)
0.0 0.1 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.0 2.2 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.2 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.4 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.9 GO:0033391 chromatoid body(GO:0033391)
0.0 0.8 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.8 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004335 galactokinase activity(GO:0004335)
0.3 2.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.7 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.1 1.0 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 4.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.4 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 4.6 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 1.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 2.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules