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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc10

Z-value: 1.20

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Transcription factors associated with Hoxc10

Gene Symbol Gene ID Gene Info
Hoxc10
ENSMUSG00000022484.7 homeobox C10

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc10mm10_v2_chr15_+_102966794_102966812-0.038.6e-01Click!

Activity profile of Hoxc10 motif

Sorted Z-values of Hoxc10 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_30924169 10.97 ENSMUST00000074671.6
Hamp2
hepcidin antimicrobial peptide 2
chr5_+_146079254 7.59 ENSMUST00000035571.8
Cyp3a59
cytochrome P450, family 3, subfamily a, polypeptide 59
chr17_+_31433054 4.17 ENSMUST00000136384.1
Pde9a
phosphodiesterase 9A
chr17_-_31144271 3.87 ENSMUST00000024826.7
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr8_+_45069137 3.86 ENSMUST00000067984.7
Mtnr1a
melatonin receptor 1A
chr18_+_20247340 3.44 ENSMUST00000054128.6
Dsg1c
desmoglein 1 gamma
chr14_-_47189406 3.13 ENSMUST00000089959.6
Gch1
GTP cyclohydrolase 1
chr11_+_94211431 2.82 ENSMUST00000041589.5
Tob1
transducer of ErbB-2.1
chr7_-_73537621 2.68 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr1_+_127729405 2.64 ENSMUST00000038006.6
Acmsd
amino carboxymuconate semialdehyde decarboxylase
chr7_-_139582790 2.55 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr16_-_23988852 2.42 ENSMUST00000023151.5
Bcl6
B cell leukemia/lymphoma 6
chr2_-_25469742 2.22 ENSMUST00000114259.2
ENSMUST00000015234.6
Ptgds
prostaglandin D2 synthase (brain)
chr6_+_71199827 2.06 ENSMUST00000067492.7
Fabp1
fatty acid binding protein 1, liver
chr2_-_25470031 2.00 ENSMUST00000114251.1
Ptgds
prostaglandin D2 synthase (brain)
chr17_-_91092715 1.63 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1
neurexin I
chr11_-_73324616 1.63 ENSMUST00000021119.2
Aspa
aspartoacylase
chr8_-_5105232 1.61 ENSMUST00000023835.1
Slc10a2
solute carrier family 10, member 2
chr7_-_141434532 1.59 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr13_+_24943144 1.59 ENSMUST00000021773.5
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr6_-_136875794 1.56 ENSMUST00000032342.1
Mgp
matrix Gla protein
chr4_+_144893127 1.54 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr15_-_58214882 1.53 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr9_-_44799179 1.53 ENSMUST00000114705.1
ENSMUST00000002100.7
Tmem25
transmembrane protein 25
chrM_+_3906 1.52 ENSMUST00000082396.1
mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr2_-_32451396 1.51 ENSMUST00000028160.8
ENSMUST00000113310.2
Slc25a25
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
chr1_-_69108039 1.48 ENSMUST00000121473.1
Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr1_-_36244245 1.44 ENSMUST00000046875.7
Uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chrX_+_139563316 1.39 ENSMUST00000113027.1
Rnf128
ring finger protein 128
chr7_-_141435327 1.34 ENSMUST00000138865.1
Slc25a22
solute carrier family 25 (mitochondrial carrier, glutamate), member 22
chr7_-_19023538 1.27 ENSMUST00000036018.5
Foxa3
forkhead box A3
chr2_+_32395896 1.12 ENSMUST00000028162.3
Ptges2
prostaglandin E synthase 2
chr10_+_52391606 1.09 ENSMUST00000067085.4
Nepn
nephrocan
chr17_-_90088343 1.09 ENSMUST00000173917.1
Nrxn1
neurexin I
chr16_-_89508313 1.07 ENSMUST00000056118.2
Krtap7-1
keratin associated protein 7-1
chr8_+_45069374 1.02 ENSMUST00000130141.1
Mtnr1a
melatonin receptor 1A
chr2_-_69712461 1.01 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1
FAST kinase domains 1
chr18_+_20310738 1.01 ENSMUST00000077146.3
Dsg1a
desmoglein 1 alpha
chr11_-_84067063 0.98 ENSMUST00000108101.1
Dusp14
dual specificity phosphatase 14
chr9_+_50575273 0.91 ENSMUST00000059081.6
ENSMUST00000180021.1
Il18
interleukin 18
chr18_+_20376723 0.88 ENSMUST00000076737.6
Dsg1b
desmoglein 1 beta
chr17_+_33824591 0.87 ENSMUST00000048249.6
Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chrX_-_134541847 0.87 ENSMUST00000054213.4
Timm8a1
translocase of inner mitochondrial membrane 8A1
chr13_-_91388079 0.87 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr4_-_42661893 0.83 ENSMUST00000108006.3
Il11ra2
interleukin 11 receptor, alpha chain 2
chr12_+_59095653 0.80 ENSMUST00000021384.4
Mia2
melanoma inhibitory activity 2
chr7_-_30729505 0.72 ENSMUST00000006478.8
Tmem147
transmembrane protein 147
chr6_-_124965403 0.72 ENSMUST00000129446.1
ENSMUST00000032220.8
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr2_-_36104060 0.72 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6
LIM homeobox protein 6
chrX_+_133908441 0.72 ENSMUST00000113304.1
Srpx2
sushi-repeat-containing protein, X-linked 2
chr2_+_163506808 0.70 ENSMUST00000143911.1
Hnf4a
hepatic nuclear factor 4, alpha
chr5_+_138363719 0.69 ENSMUST00000100526.2
Gm10874
predicted gene 10874
chr9_+_43829963 0.67 ENSMUST00000180221.1
Gm3898
predicted gene 3898
chr11_+_99873389 0.67 ENSMUST00000093936.3
Krtap9-1
keratin associated protein 9-1
chr2_+_130576170 0.66 ENSMUST00000028764.5
Oxt
oxytocin
chr11_+_96194299 0.66 ENSMUST00000062709.3
Hoxb13
homeobox B13
chr10_-_34044302 0.65 ENSMUST00000048052.5
Fam26d
family with sequence similarity 26, member D
chr7_+_103550368 0.64 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr3_+_89266552 0.58 ENSMUST00000040824.1
Dpm3
dolichyl-phosphate mannosyltransferase polypeptide 3
chr2_+_80315461 0.58 ENSMUST00000028392.7
Dnajc10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr11_-_55607733 0.57 ENSMUST00000108853.1
ENSMUST00000075603.4
Glra1
glycine receptor, alpha 1 subunit
chr5_-_62766153 0.57 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_124965248 0.57 ENSMUST00000129976.1
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr6_-_125165707 0.56 ENSMUST00000118875.1
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr8_-_94012558 0.54 ENSMUST00000053766.6
Amfr
autocrine motility factor receptor
chr4_+_102254739 0.53 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr6_-_124965485 0.52 ENSMUST00000112439.2
Cops7a
COP9 (constitutive photomorphogenic) homolog, subunit 7a (Arabidopsis thaliana)
chr1_+_194619815 0.52 ENSMUST00000027952.5
Plxna2
plexin A2
chr11_-_100029868 0.50 ENSMUST00000073890.3
Krt33b
keratin 33B
chr5_+_92809372 0.50 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr15_-_101573883 0.47 ENSMUST00000042957.5
Krt75
keratin 75
chr7_+_43690418 0.47 ENSMUST00000056329.6
Klk14
kallikrein related-peptidase 14
chr17_+_46681038 0.46 ENSMUST00000002845.6
Mea1
male enhanced antigen 1
chr7_-_29906087 0.45 ENSMUST00000053521.8
Zfp27
zinc finger protein 27
chr1_+_17601893 0.41 ENSMUST00000088476.2
Pi15
peptidase inhibitor 15
chr9_+_37208291 0.41 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr2_-_26122769 0.40 ENSMUST00000140993.1
ENSMUST00000028300.5
Nacc2
nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
chr2_-_144527341 0.38 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1
double zinc ribbon and ankyrin repeat domains 1
chr3_+_69222412 0.37 ENSMUST00000183126.1
Arl14
ADP-ribosylation factor-like 14
chr1_-_144249134 0.37 ENSMUST00000172388.1
Rgs1
regulator of G-protein signaling 1
chr2_+_74695601 0.36 ENSMUST00000152027.1
Gm14396
predicted gene 14396
chr14_+_124005355 0.36 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr9_+_75775355 0.35 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr14_+_13454010 0.33 ENSMUST00000112656.2
Synpr
synaptoporin
chr10_+_23920356 0.32 ENSMUST00000051532.4
Taar1
trace amine-associated receptor 1
chr15_+_25773985 0.31 ENSMUST00000125667.1
Myo10
myosin X
chr1_+_107361929 0.29 ENSMUST00000027566.2
Serpinb11
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
chrX_+_31336454 0.29 ENSMUST00000180197.1
Gm2784
predicted gene 2784
chr3_+_32436151 0.28 ENSMUST00000029201.7
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr5_+_71699918 0.28 ENSMUST00000031122.7
Gabrb1
gamma-aminobutyric acid (GABA) A receptor, subunit beta 1
chr3_-_146770218 0.27 ENSMUST00000106137.1
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr5_-_62765618 0.26 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr8_-_18741542 0.26 ENSMUST00000033846.6
Angpt2
angiopoietin 2
chr5_+_117841839 0.26 ENSMUST00000142742.2
Nos1
nitric oxide synthase 1, neuronal
chr14_+_54686171 0.25 ENSMUST00000038539.6
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr13_-_107890059 0.24 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr15_-_101438788 0.21 ENSMUST00000081945.3
Krt83
keratin 83
chr13_-_84064772 0.21 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr11_-_100105626 0.21 ENSMUST00000107416.2
Krt36
keratin 36
chr6_-_125165576 0.21 ENSMUST00000183272.1
ENSMUST00000182052.1
ENSMUST00000182277.1
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr11_-_99993992 0.21 ENSMUST00000105049.1
Krtap17-1
keratin associated protein 17-1
chr6_-_24168083 0.20 ENSMUST00000031713.8
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr4_-_129578535 0.19 ENSMUST00000052835.8
Fam167b
family with sequence similarity 167, member B
chr11_-_100041547 0.19 ENSMUST00000056362.2
Krt34
keratin 34
chr3_-_64509735 0.18 ENSMUST00000177184.1
Vmn2r5
vomeronasal 2, receptor 5
chr7_-_31051431 0.18 ENSMUST00000073892.4
Fxyd7
FXYD domain-containing ion transport regulator 7
chr2_+_73271925 0.18 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr5_+_43515513 0.18 ENSMUST00000167522.1
ENSMUST00000144558.1
ENSMUST00000076939.6
C1qtnf7
C1q and tumor necrosis factor related protein 7
chr8_-_41016295 0.17 ENSMUST00000131965.1
Mtus1
mitochondrial tumor suppressor 1
chr2_-_129371131 0.15 ENSMUST00000028881.7
Il1b
interleukin 1 beta
chr18_-_42899470 0.15 ENSMUST00000120632.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr1_-_63176653 0.14 ENSMUST00000027111.8
ENSMUST00000168099.2
Ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr1_+_60977898 0.14 ENSMUST00000027162.5
ENSMUST00000102827.3
Icos
inducible T cell co-stimulator
chr1_+_109993982 0.14 ENSMUST00000027542.6
Cdh7
cadherin 7, type 2
chr14_-_106101157 0.13 ENSMUST00000169588.1
Gm4775
predicted gene 4775
chr9_-_116175318 0.13 ENSMUST00000061101.4
ENSMUST00000035014.6
Tgfbr2
transforming growth factor, beta receptor II
chrX_+_169685191 0.12 ENSMUST00000112104.1
ENSMUST00000112107.1
Mid1
midline 1
chr3_+_3634145 0.12 ENSMUST00000108394.1
Hnf4g
hepatocyte nuclear factor 4, gamma
chr7_-_38019505 0.11 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr12_+_105604091 0.11 ENSMUST00000041229.4
Bdkrb1
bradykinin receptor, beta 1
chr5_-_142906702 0.11 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
Actb
actin, beta
chr2_+_143078467 0.10 ENSMUST00000028902.2
Otor
otoraplin
chr18_-_42899294 0.10 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr15_+_92597104 0.09 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr5_+_20702129 0.09 ENSMUST00000101556.4
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr17_-_25844417 0.08 ENSMUST00000176591.1
Rhot2
ras homolog gene family, member T2
chr3_+_76074270 0.07 ENSMUST00000038364.8
Fstl5
follistatin-like 5
chr6_-_23655129 0.07 ENSMUST00000104979.1
Rnf148
ring finger protein 148
chr4_-_73790602 0.07 ENSMUST00000058292.6
ENSMUST00000102837.2
Rasef
RAS and EF hand domain containing
chr19_+_55894508 0.06 ENSMUST00000142291.1
Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_178141920 0.05 ENSMUST00000103066.3
Phactr3
phosphatase and actin regulator 3
chr2_-_27463994 0.01 ENSMUST00000164296.1
Brd3
bromodomain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc10

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 11.0 GO:0034760 negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.8 4.2 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.8 3.1 GO:0014916 regulation of lung blood pressure(GO:0014916)
0.7 2.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.6 4.5 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.6 2.4 GO:0043380 regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 1.6 GO:0006507 GPI anchor release(GO:0006507)
0.5 1.5 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.5 1.5 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.4 2.6 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.4 2.6 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 1.3 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.3 0.9 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.3 1.6 GO:0006083 acetate metabolic process(GO:0006083)
0.3 5.1 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.3 2.8 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
0.2 0.7 GO:0042977 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.2 4.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 0.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 0.7 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.7 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 2.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.4 GO:1900477 negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter(GO:1900477)
0.1 2.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 2.7 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.3 GO:0021934 hindbrain tangential cell migration(GO:0021934)
0.1 1.8 GO:0000338 protein deneddylation(GO:0000338)
0.1 1.4 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 2.9 GO:0015813 L-glutamate transport(GO:0015813)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 0.6 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.3 GO:0044029 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.4 GO:0021502 neural fold elevation formation(GO:0021502)
0.1 0.1 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.1 0.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.6 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 1.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 1.5 GO:0014823 response to activity(GO:0014823)
0.1 0.3 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0003274 endocardial cushion fusion(GO:0003274) positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.0 1.4 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.0 0.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.3 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.8 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 1.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 1.1 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.3 GO:0030057 desmosome(GO:0030057)
0.2 2.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.1 GO:0045179 apical cortex(GO:0045179)
0.1 0.6 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 2.8 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.8 GO:0097452 GAIT complex(GO:0097452)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.6 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 1.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 1.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.4 GO:0005657 replication fork(GO:0005657)
0.0 2.5 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 3.8 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 1.6 GO:0000502 proteasome complex(GO:0000502)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.3 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 5.4 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
1.1 4.2 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.0 4.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.5 1.6 GO:0019807 aspartoacylase activity(GO:0019807)
0.5 3.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 1.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.3 3.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 2.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 0.8 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.2 0.7 GO:0070540 stearic acid binding(GO:0070540)
0.2 1.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.2 2.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.5 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.5 GO:0038132 neuregulin binding(GO:0038132)
0.2 2.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.6 GO:0030977 taurine binding(GO:0030977)
0.2 1.6 GO:0004630 phospholipase D activity(GO:0004630)
0.2 4.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.2 2.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.1 0.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1 1.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.1 0.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 2.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 9.6 GO:0005179 hormone activity(GO:0005179)
0.1 0.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 2.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 3.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.1 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.0 0.6 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.3 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 2.7 GO:0004386 helicase activity(GO:0004386)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 4.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 4.0 PID FOXO PATHWAY FoxO family signaling
0.1 1.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.6 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.4 PID IFNG PATHWAY IFN-gamma pathway
0.0 1.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 3.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 4.0 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.3 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 3.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters