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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxc6

Z-value: 0.60

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Transcription factors associated with Hoxc6

Gene Symbol Gene ID Gene Info
Hoxc6
ENSMUSG00000001661.4 homeobox C6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc6mm10_v2_chr15_+_103009479_1030095070.212.1e-01Click!

Activity profile of Hoxc6 motif

Sorted Z-values of Hoxc6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_113532288 1.60 ENSMUST00000132353.1
Amy2a1
amylase 2a1
chr7_-_14123042 1.50 ENSMUST00000098809.2
Sult2a3
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
chr3_-_145032765 1.49 ENSMUST00000029919.5
Clca3
chloride channel calcium activated 3
chr14_+_27000362 1.09 ENSMUST00000035433.8
Hesx1
homeobox gene expressed in ES cells
chr3_-_92485886 0.78 ENSMUST00000054599.7
Sprr1a
small proline-rich protein 1A
chr11_-_109472611 0.65 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr6_+_128399881 0.62 ENSMUST00000120405.1
Nrip2
nuclear receptor interacting protein 2
chr6_-_65144908 0.62 ENSMUST00000031982.4
Hpgds
hematopoietic prostaglandin D synthase
chr6_+_128399766 0.57 ENSMUST00000001561.5
Nrip2
nuclear receptor interacting protein 2
chr6_+_36388055 0.52 ENSMUST00000172278.1
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr3_+_146150174 0.51 ENSMUST00000098524.4
Mcoln2
mucolipin 2
chr10_-_61784014 0.49 ENSMUST00000020283.4
H2afy2
H2A histone family, member Y2
chrX_-_94212638 0.48 ENSMUST00000113922.1
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr5_+_24413406 0.47 ENSMUST00000049346.5
Asic3
acid-sensing (proton-gated) ion channel 3
chrX_+_49463926 0.45 ENSMUST00000130558.1
Arhgap36
Rho GTPase activating protein 36
chr13_+_93304066 0.44 ENSMUST00000109493.1
Homer1
homer homolog 1 (Drosophila)
chr13_+_93304799 0.43 ENSMUST00000080127.5
Homer1
homer homolog 1 (Drosophila)
chr15_+_91673175 0.42 ENSMUST00000060642.6
Lrrk2
leucine-rich repeat kinase 2
chr16_-_21995478 0.41 ENSMUST00000074230.4
ENSMUST00000060673.6
Liph
lipase, member H
chr10_-_100589205 0.39 ENSMUST00000054471.8
4930430F08Rik
RIKEN cDNA 4930430F08 gene
chr7_+_45554893 0.37 ENSMUST00000107752.3
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr1_-_138175238 0.37 ENSMUST00000182536.1
Ptprc
protein tyrosine phosphatase, receptor type, C
chr7_-_115846080 0.36 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr6_+_52177498 0.35 ENSMUST00000070587.3
5730596B20Rik
RIKEN cDNA 5730596B20 gene
chr1_-_138175283 0.35 ENSMUST00000182755.1
ENSMUST00000183262.1
ENSMUST00000027645.7
ENSMUST00000112036.2
ENSMUST00000182283.1
Ptprc
protein tyrosine phosphatase, receptor type, C
chr1_-_138175126 0.33 ENSMUST00000183301.1
Ptprc
protein tyrosine phosphatase, receptor type, C
chr19_-_11660516 0.32 ENSMUST00000135994.1
ENSMUST00000121793.1
ENSMUST00000069681.3
Plac1l
placenta-specific 1-like
chrX_-_94212685 0.31 ENSMUST00000050328.8
Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr11_-_94782500 0.30 ENSMUST00000162809.2
Tmem92
transmembrane protein 92
chr11_-_94782703 0.30 ENSMUST00000100554.1
Tmem92
transmembrane protein 92
chr19_+_11469353 0.28 ENSMUST00000165310.1
Ms4a6c
membrane-spanning 4-domains, subfamily A, member 6C
chr18_+_53551594 0.27 ENSMUST00000115398.1
Prdm6
PR domain containing 6
chr6_-_141773810 0.27 ENSMUST00000148411.1
Gm5724
predicted gene 5724
chr2_+_150786735 0.23 ENSMUST00000045441.7
Pygb
brain glycogen phosphorylase
chr15_+_44619551 0.23 ENSMUST00000022964.7
Ebag9
estrogen receptor-binding fragment-associated gene 9
chrX_+_164162167 0.23 ENSMUST00000131543.1
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr16_-_58718724 0.22 ENSMUST00000089318.3
Gpr15
G protein-coupled receptor 15
chr5_-_110046486 0.22 ENSMUST00000167969.1
Gm17655
predicted gene, 17655
chr7_-_24299310 0.21 ENSMUST00000145131.1
Zfp61
zinc finger protein 61
chr3_+_5218516 0.21 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr1_-_22315792 0.21 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr4_+_132351768 0.21 ENSMUST00000172202.1
Gm17300
predicted gene, 17300
chr9_+_107551516 0.21 ENSMUST00000093786.2
ENSMUST00000122225.1
Rassf1
Ras association (RalGDS/AF-6) domain family member 1
chr4_-_132351636 0.21 ENSMUST00000105951.1
Rcc1
regulator of chromosome condensation 1
chr3_+_136670076 0.21 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr4_-_147642496 0.20 ENSMUST00000133006.1
ENSMUST00000037565.7
ENSMUST00000105720.1
2610305D13Rik
RIKEN cDNA 2610305D13 gene
chr15_+_100154379 0.20 ENSMUST00000023768.6
ENSMUST00000108971.2
Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr3_+_151437887 0.20 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr10_+_37139558 0.20 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr5_+_17574268 0.19 ENSMUST00000030568.7
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr15_-_50889043 0.18 ENSMUST00000183997.1
ENSMUST00000183757.1
Trps1
trichorhinophalangeal syndrome I (human)
chr3_+_66985680 0.18 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_66985647 0.16 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1
arginine/serine-rich coiled-coil 1
chr3_+_66985700 0.16 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1
arginine/serine-rich coiled-coil 1
chr10_-_70655934 0.16 ENSMUST00000162144.1
ENSMUST00000162793.1
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr7_+_45554937 0.16 ENSMUST00000133242.3
Hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr3_+_129213920 0.15 ENSMUST00000042587.10
Pitx2
paired-like homeodomain transcription factor 2
chr11_-_23895208 0.15 ENSMUST00000102863.2
ENSMUST00000020513.3
Papolg
poly(A) polymerase gamma
chr11_-_111800870 0.14 ENSMUST00000124855.1
Gm11674
predicted gene 11674
chr15_-_50889691 0.14 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1
trichorhinophalangeal syndrome I (human)
chr14_+_53845234 0.13 ENSMUST00000103674.4
Trav19
T cell receptor alpha variable 19
chr7_-_16285454 0.13 ENSMUST00000174270.1
Ccdc9
coiled-coil domain containing 9
chr4_+_107707030 0.12 ENSMUST00000140321.1
1700047F07Rik
RIKEN cDNA 1700047F07 gene
chr6_-_53978662 0.12 ENSMUST00000166545.1
Cpvl
carboxypeptidase, vitellogenic-like
chr9_-_27155418 0.12 ENSMUST00000167074.1
ENSMUST00000034472.8
Jam3
junction adhesion molecule 3
chr1_+_19208914 0.12 ENSMUST00000027059.4
Tfap2b
transcription factor AP-2 beta
chr17_-_35115428 0.12 ENSMUST00000172854.1
ENSMUST00000062657.4
Ly6g5b
lymphocyte antigen 6 complex, locus G5B
chr3_+_5218546 0.11 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr6_-_3494587 0.10 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr10_+_112083345 0.10 ENSMUST00000148897.1
ENSMUST00000020434.3
Glipr1l2
GLI pathogenesis-related 1 like 2
chr8_-_9976294 0.10 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr7_+_123123870 0.09 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr4_+_107707056 0.09 ENSMUST00000147654.1
1700047F07Rik
RIKEN cDNA 1700047F07 gene
chr7_+_83148644 0.09 ENSMUST00000066005.5
A530021J07Rik
Riken cDNA A530021J07 gene
chr2_-_51149100 0.09 ENSMUST00000154545.1
ENSMUST00000017288.2
Rnd3
Rho family GTPase 3
chr17_+_12876034 0.08 ENSMUST00000075296.2
Mrgprh
MAS-related GPR, member H
chr10_-_107719978 0.08 ENSMUST00000050702.7
Ptprq
protein tyrosine phosphatase, receptor type, Q
chr18_+_56572822 0.08 ENSMUST00000008445.5
Phax
phosphorylated adaptor for RNA export
chr19_+_6364557 0.06 ENSMUST00000155973.1
Sf1
splicing factor 1
chr6_-_129917650 0.06 ENSMUST00000118060.1
Klra5
killer cell lectin-like receptor, subfamily A, member 5
chr3_+_5218589 0.06 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr7_-_19604444 0.05 ENSMUST00000086041.5
Clasrp
CLK4-associating serine/arginine rich protein
chr4_+_99656299 0.04 ENSMUST00000087285.3
Foxd3
forkhead box D3
chr5_-_23616528 0.03 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr19_+_11518493 0.03 ENSMUST00000025580.3
Ms4a6b
membrane-spanning 4-domains, subfamily A, member 6B
chr7_+_5020376 0.02 ENSMUST00000076251.4
Zfp865
zinc finger protein 865
chrX_+_102802963 0.02 ENSMUST00000118218.1
Dmrtc1c1
DMRT-like family C1c1
chr9_-_21760275 0.01 ENSMUST00000098942.4
Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr13_-_64903888 0.01 ENSMUST00000091554.4
Cntnap3
contactin associated protein-like 3
chr11_-_24075054 0.01 ENSMUST00000068360.1
A830031A19Rik
RIKEN cDNA A830031A19 gene
chr4_+_33062999 0.00 ENSMUST00000108162.1
ENSMUST00000024035.2
Gabrr2
gamma-aminobutyric acid (GABA) C receptor, subunit rho 2
chr16_-_56712825 0.00 ENSMUST00000136394.1
Tfg
Trk-fused gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:2000473 immunoglobulin biosynthetic process(GO:0002378) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 1.1 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.5 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.1 0.5 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.2 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.9 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.2 GO:0015827 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
0.1 0.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.3 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 0.8 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.5 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.1 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.2 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044753 amphisome(GO:0044753)
0.1 0.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.8 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 0.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 0.6 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.4 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.5 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.1 0.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 1.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors