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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Hoxd11_Cdx1_Hoxc11

Z-value: 2.27

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Transcription factors associated with Hoxd11_Cdx1_Hoxc11

Gene Symbol Gene ID Gene Info
Hoxd11
ENSMUSG00000042499.12 homeobox D11
Cdx1
ENSMUSG00000024619.8 caudal type homeobox 1
Hoxc11
ENSMUSG00000001656.3 homeobox C11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc11mm10_v2_chr15_+_102954427_1029544270.564.1e-04Click!
Hoxd11mm10_v2_chr2_+_74681991_746820070.511.6e-03Click!
Cdx1mm10_v2_chr18_-_61036189_610362100.353.7e-02Click!

Activity profile of Hoxd11_Cdx1_Hoxc11 motif

Sorted Z-values of Hoxd11_Cdx1_Hoxc11 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_142661858 26.03 ENSMUST00000145896.2
Igf2
insulin-like growth factor 2
chr2_+_84988194 14.26 ENSMUST00000028466.5
Prg3
proteoglycan 3
chr14_-_37110087 9.22 ENSMUST00000179488.1
2610528A11Rik
RIKEN cDNA 2610528A11 gene
chrX_+_96455359 8.47 ENSMUST00000033553.7
Heph
hephaestin
chr1_+_107535508 7.94 ENSMUST00000182198.1
Serpinb10
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10
chr19_-_45812291 6.77 ENSMUST00000086993.4
Kcnip2
Kv channel-interacting protein 2
chr17_+_5799491 6.44 ENSMUST00000181484.1
3300005D01Rik
RIKEN cDNA 3300005D01 gene
chr1_-_45503282 6.34 ENSMUST00000086430.4
Col5a2
collagen, type V, alpha 2
chr2_+_155611175 5.90 ENSMUST00000092995.5
Myh7b
myosin, heavy chain 7B, cardiac muscle, beta
chr9_+_62858085 5.64 ENSMUST00000034777.6
ENSMUST00000163820.1
Calml4
calmodulin-like 4
chrX_+_106920618 5.32 ENSMUST00000060576.7
Lpar4
lysophosphatidic acid receptor 4
chr1_-_89933290 5.32 ENSMUST00000036954.7
Gbx2
gastrulation brain homeobox 2
chr10_+_119992916 5.25 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr10_+_45577811 5.17 ENSMUST00000037044.6
Hace1
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
chr17_-_43502773 5.09 ENSMUST00000024707.8
ENSMUST00000117137.1
Mep1a
meprin 1 alpha
chr17_+_71019548 5.07 ENSMUST00000073211.5
ENSMUST00000179759.1
Myom1
myomesin 1
chr9_+_65890237 4.72 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr17_+_71019503 4.70 ENSMUST00000024847.7
Myom1
myomesin 1
chr4_-_133968611 4.43 ENSMUST00000102552.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr3_-_123034943 4.43 ENSMUST00000029761.7
Myoz2
myozenin 2
chr15_+_81936753 4.38 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr15_-_78855517 4.38 ENSMUST00000044584.4
Lgals2
lectin, galactose-binding, soluble 2
chr5_-_73191848 4.35 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr19_+_53529100 4.31 ENSMUST00000038287.6
Dusp5
dual specificity phosphatase 5
chr4_+_11758147 4.22 ENSMUST00000029871.5
ENSMUST00000108303.1
Cdh17
cadherin 17
chr14_+_74640840 4.09 ENSMUST00000036653.3
Htr2a
5-hydroxytryptamine (serotonin) receptor 2A
chr1_-_163289214 4.08 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chrX_+_164140447 4.07 ENSMUST00000073973.4
Ace2
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
chr4_-_154636831 3.97 ENSMUST00000030902.6
ENSMUST00000105637.1
ENSMUST00000070313.7
ENSMUST00000105636.1
ENSMUST00000105638.2
ENSMUST00000097759.2
ENSMUST00000124771.1
Prdm16
PR domain containing 16
chr11_-_99244058 3.93 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr1_+_63176818 3.92 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr7_-_134232005 3.89 ENSMUST00000134504.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr15_+_81936911 3.85 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr13_-_84064772 3.75 ENSMUST00000182477.1
Gm17750
predicted gene, 17750
chr6_-_52226165 3.62 ENSMUST00000114425.2
Hoxa9
homeobox A9
chr17_+_5799616 3.60 ENSMUST00000181392.1
3300005D01Rik
RIKEN cDNA 3300005D01 gene
chr7_-_134232125 3.45 ENSMUST00000127524.1
Adam12
a disintegrin and metallopeptidase domain 12 (meltrin alpha)
chr6_-_139501907 3.41 ENSMUST00000170650.1
Rergl
RERG/RAS-like
chr5_-_73256555 3.33 ENSMUST00000171179.1
ENSMUST00000101127.5
Fryl
Fryl
furry homolog-like (Drosophila)
furry homolog-like (Drosophila)
chr19_-_7341792 3.21 ENSMUST00000164205.1
ENSMUST00000165286.1
ENSMUST00000168324.1
ENSMUST00000032557.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr8_+_69902178 3.19 ENSMUST00000050373.5
Tssk6
testis-specific serine kinase 6
chr4_-_133967296 3.15 ENSMUST00000105893.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr3_-_144760841 3.13 ENSMUST00000059091.5
Clca1
chloride channel calcium activated 1
chr14_+_65805832 3.08 ENSMUST00000022612.3
Pbk
PDZ binding kinase
chr2_-_32387760 3.07 ENSMUST00000050785.8
Lcn2
lipocalin 2
chr8_+_57332111 3.07 ENSMUST00000181638.1
5033428I22Rik
RIKEN cDNA 5033428I22 gene
chr14_+_65806066 3.05 ENSMUST00000139644.1
Pbk
PDZ binding kinase
chr9_-_39604124 3.01 ENSMUST00000042485.4
ENSMUST00000141370.1
AW551984
expressed sequence AW551984
chr19_-_7341848 2.92 ENSMUST00000171393.1
Mark2
MAP/microtubule affinity-regulating kinase 2
chr16_+_26463135 2.90 ENSMUST00000161053.1
ENSMUST00000115302.1
Cldn16
claudin 16
chr9_+_43310763 2.76 ENSMUST00000034511.5
Trim29
tripartite motif-containing 29
chr3_-_144819494 2.75 ENSMUST00000029929.7
Clca2
chloride channel calcium activated 2
chr11_+_96323253 2.73 ENSMUST00000093944.3
Hoxb3
homeobox B3
chr9_-_42124276 2.72 ENSMUST00000060989.8
Sorl1
sortilin-related receptor, LDLR class A repeats-containing
chr14_+_34053466 2.71 ENSMUST00000058725.3
Antxrl
anthrax toxin receptor-like
chr5_-_24030649 2.70 ENSMUST00000030849.6
Fam126a
family with sequence similarity 126, member A
chr4_-_88033328 2.70 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr18_-_32036941 2.70 ENSMUST00000134663.1
Myo7b
myosin VIIB
chr14_+_26894557 2.67 ENSMUST00000090337.4
ENSMUST00000165929.2
Asb14
ankyrin repeat and SOCS box-containing 14
chr8_+_57455898 2.65 ENSMUST00000034023.3
Scrg1
scrapie responsive gene 1
chr9_-_123678873 2.64 ENSMUST00000040960.6
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr15_+_85510812 2.60 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr4_-_136602641 2.51 ENSMUST00000105847.1
ENSMUST00000116273.2
Kdm1a
lysine (K)-specific demethylase 1A
chr3_+_122044428 2.45 ENSMUST00000013995.8
Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr15_-_79062866 2.45 ENSMUST00000151889.1
ENSMUST00000040676.4
Ankrd54
ankyrin repeat domain 54
chr9_-_123678782 2.45 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr19_+_60755947 2.43 ENSMUST00000088237.4
Nanos1
nanos homolog 1 (Drosophila)
chr7_+_25306085 2.42 ENSMUST00000119703.1
ENSMUST00000108409.1
Tmem145
transmembrane protein 145
chr11_-_120549695 2.40 ENSMUST00000034913.4
Fam195b
family with sequence similarity 195, member B
chr10_-_13324160 2.35 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr18_-_15063560 2.33 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr18_+_21072329 2.30 ENSMUST00000082235.4
Mep1b
meprin 1 beta
chr7_+_66109474 2.28 ENSMUST00000036372.6
Chsy1
chondroitin sulfate synthase 1
chrX_+_56447965 2.25 ENSMUST00000079663.6
Gm2174
predicted gene 2174
chr16_-_76022266 2.23 ENSMUST00000114240.1
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
chr17_-_35074485 2.22 ENSMUST00000007259.3
Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr11_+_96316684 2.11 ENSMUST00000049241.7
Hoxb4
homeobox B4
chr3_+_84666192 2.10 ENSMUST00000107682.1
Tmem154
transmembrane protein 154
chr9_+_110763646 2.09 ENSMUST00000079784.7
Myl3
myosin, light polypeptide 3
chr6_-_83536215 2.06 ENSMUST00000075161.5
Actg2
actin, gamma 2, smooth muscle, enteric
chr10_+_37139558 2.04 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr15_-_101491509 2.01 ENSMUST00000023718.7
5430421N21Rik
RIKEN cDNA 5430421N21 gene
chrX_+_153139941 1.97 ENSMUST00000039720.4
ENSMUST00000144175.2
Rragb
Ras-related GTP binding B
chr10_+_69787431 1.97 ENSMUST00000183240.1
Ank3
ankyrin 3, epithelial
chr7_-_135528645 1.96 ENSMUST00000053716.7
Clrn3
clarin 3
chr16_+_10812915 1.93 ENSMUST00000115822.1
Gm11172
predicted gene 11172
chr11_-_109472611 1.92 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr11_-_17008647 1.91 ENSMUST00000102881.3
Plek
pleckstrin
chr4_+_5724304 1.86 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr7_-_30612731 1.82 ENSMUST00000006476.4
Upk1a
uroplakin 1A
chr2_-_84822546 1.81 ENSMUST00000028471.5
Smtnl1
smoothelin-like 1
chr7_+_131032061 1.79 ENSMUST00000084509.3
Dmbt1
deleted in malignant brain tumors 1
chr17_-_78906899 1.76 ENSMUST00000042683.6
ENSMUST00000169544.1
Sult6b1
sulfotransferase family, cytosolic, 6B, member 1
chr16_+_37011758 1.76 ENSMUST00000071452.5
ENSMUST00000054034.6
Polq
polymerase (DNA directed), theta
chr6_-_87981482 1.74 ENSMUST00000056403.5
H1fx
H1 histone family, member X
chr17_-_70998010 1.73 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_+_56042123 1.72 ENSMUST00000015576.4
Mcpt2
mast cell protease 2
chr11_+_29463735 1.69 ENSMUST00000155854.1
Ccdc88a
coiled coil domain containing 88A
chr6_-_52218686 1.69 ENSMUST00000134367.2
Hoxa7
homeobox A7
chr6_-_12749193 1.68 ENSMUST00000046121.6
ENSMUST00000172356.1
Thsd7a
thrombospondin, type I, domain containing 7A
chr6_-_13839916 1.68 ENSMUST00000060442.7
Gpr85
G protein-coupled receptor 85
chr2_+_57997884 1.65 ENSMUST00000112616.1
ENSMUST00000166729.1
Galnt5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5
chr4_-_64046925 1.65 ENSMUST00000107377.3
Tnc
tenascin C
chr10_+_116177351 1.64 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr
protein tyrosine phosphatase, receptor type, R
chr1_-_172027251 1.54 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr9_-_64172879 1.52 ENSMUST00000176299.1
ENSMUST00000130127.1
ENSMUST00000176794.1
ENSMUST00000177045.1
Zwilch
zwilch kinetochore protein
chr6_+_125552948 1.50 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf
Von Willebrand factor homolog
chr10_-_30655859 1.49 ENSMUST00000092610.4
Ncoa7
nuclear receptor coactivator 7
chr18_-_6490808 1.49 ENSMUST00000028100.6
ENSMUST00000050542.5
Epc1
enhancer of polycomb homolog 1 (Drosophila)
chr3_-_49757257 1.48 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr2_-_170194033 1.47 ENSMUST00000180625.1
Gm17619
predicted gene, 17619
chr6_-_122340499 1.46 ENSMUST00000160843.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr19_+_33822908 1.44 ENSMUST00000042061.6
Gm5519
predicted pseudogene 5519
chr6_-_122340525 1.43 ENSMUST00000112600.2
Phc1
polyhomeotic-like 1 (Drosophila)
chr17_-_51826562 1.42 ENSMUST00000024720.4
ENSMUST00000129667.1
ENSMUST00000156051.1
ENSMUST00000169480.1
ENSMUST00000148559.1
Satb1
special AT-rich sequence binding protein 1
chr8_-_57653023 1.40 ENSMUST00000034021.5
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr17_+_80307396 1.38 ENSMUST00000068175.5
Arhgef33
Rho guanine nucleotide exchange factor (GEF) 33
chr4_-_133967893 1.36 ENSMUST00000100472.3
ENSMUST00000136327.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr2_-_114013619 1.32 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr19_-_50678642 1.29 ENSMUST00000072685.6
ENSMUST00000164039.2
Sorcs1
VPS10 domain receptor protein SORCS 1
chr8_+_25720054 1.29 ENSMUST00000068916.8
ENSMUST00000139836.1
Ppapdc1b
phosphatidic acid phosphatase type 2 domain containing 1B
chr13_+_19214103 1.29 ENSMUST00000103558.1
Tcrg-C1
T cell receptor gamma, constant 1
chr4_-_11981265 1.26 ENSMUST00000098260.2
Gm10604
predicted gene 10604
chr8_+_121116163 1.26 ENSMUST00000054691.6
Foxc2
forkhead box C2
chr6_-_24168083 1.26 ENSMUST00000031713.8
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chrX_+_56779437 1.24 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chr7_+_46861203 1.23 ENSMUST00000014545.4
Ldhc
lactate dehydrogenase C
chr18_+_69593361 1.23 ENSMUST00000114978.2
ENSMUST00000114977.1
Tcf4
transcription factor 4
chr1_-_152625212 1.23 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr18_-_62756275 1.21 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik
RIKEN cDNA 2700046A07 gene
chr16_-_56795823 1.19 ENSMUST00000023437.4
Gpr128
G protein-coupled receptor 128
chr14_+_76504185 1.18 ENSMUST00000177207.1
Tsc22d1
TSC22 domain family, member 1
chr1_-_128328311 1.15 ENSMUST00000073490.6
Lct
lactase
chr18_-_47333311 1.14 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr8_+_57320975 1.14 ENSMUST00000040104.3
Hand2
heart and neural crest derivatives expressed transcript 2
chr14_+_20674311 1.12 ENSMUST00000048657.8
Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chr1_+_58646608 1.11 ENSMUST00000081455.4
Gm10068
predicted gene 10068
chr3_-_89960562 1.11 ENSMUST00000069805.7
Atp8b2
ATPase, class I, type 8B, member 2
chr1_-_128102412 1.10 ENSMUST00000112538.1
ENSMUST00000086614.5
Zranb3
zinc finger, RAN-binding domain containing 3
chrX_-_74246534 1.10 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna
filamin, alpha
chr4_-_133967953 1.08 ENSMUST00000102553.4
Hmgn2
high mobility group nucleosomal binding domain 2
chr1_-_175688353 1.07 ENSMUST00000104984.1
Chml
choroideremia-like
chr5_+_137641334 1.05 ENSMUST00000177466.1
ENSMUST00000166099.2
Sap25
sin3 associated polypeptide
chr13_-_58354862 1.04 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr15_-_34356421 1.03 ENSMUST00000179647.1
9430069I07Rik
RIKEN cDNA 9430069I07 gene
chrX_+_13632769 0.99 ENSMUST00000096492.3
Gpr34
G protein-coupled receptor 34
chr11_-_19018956 0.99 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1
Meis homeobox 1
chr14_-_106101157 0.96 ENSMUST00000169588.1
Gm4775
predicted gene 4775
chr1_-_37496095 0.95 ENSMUST00000148047.1
ENSMUST00000143636.1
Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr11_-_19018714 0.92 ENSMUST00000177417.1
Meis1
Meis homeobox 1
chr2_-_140671462 0.90 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr15_-_42676967 0.90 ENSMUST00000022921.5
Angpt1
angiopoietin 1
chr11_-_100105626 0.90 ENSMUST00000107416.2
Krt36
keratin 36
chr2_+_36230426 0.86 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr15_+_11000716 0.86 ENSMUST00000117100.1
ENSMUST00000022851.7
Slc45a2
solute carrier family 45, member 2
chr17_+_35059035 0.85 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2
dimethylarginine dimethylaminohydrolase 2
chr1_-_172027269 0.84 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr15_+_100761741 0.83 ENSMUST00000023776.6
Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr9_-_21067093 0.83 ENSMUST00000115494.2
Zglp1
zinc finger, GATA-like protein 1
chr6_-_145047725 0.83 ENSMUST00000123930.1
Bcat1
branched chain aminotransferase 1, cytosolic
chr6_+_125215551 0.82 ENSMUST00000032487.7
ENSMUST00000100942.2
ENSMUST00000063588.8
Vamp1
vesicle-associated membrane protein 1
chr8_+_15057646 0.81 ENSMUST00000033842.3
Myom2
myomesin 2
chr1_-_176807124 0.79 ENSMUST00000057037.7
Cep170
centrosomal protein 170
chr11_-_97700327 0.79 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chrY_-_79667079 0.78 ENSMUST00000178903.1
Gm21242
predicted gene, 21242
chr3_-_63851251 0.77 ENSMUST00000162269.2
ENSMUST00000159676.2
ENSMUST00000175947.1
Plch1
phospholipase C, eta 1
chr15_-_98934522 0.77 ENSMUST00000077577.7
Tuba1b
tubulin, alpha 1B
chr15_+_6422240 0.77 ENSMUST00000163082.1
Dab2
disabled 2, mitogen-responsive phosphoprotein
chr10_+_116177217 0.75 ENSMUST00000148731.1
Ptprr
protein tyrosine phosphatase, receptor type, R
chr2_-_140671400 0.75 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr11_-_109473220 0.73 ENSMUST00000070872.6
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr1_-_144249134 0.71 ENSMUST00000172388.1
Rgs1
regulator of G-protein signaling 1
chr8_-_47352348 0.70 ENSMUST00000110367.2
Stox2
storkhead box 2
chr4_+_136284708 0.70 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr3_-_89349968 0.70 ENSMUST00000074582.6
ENSMUST00000107448.2
ENSMUST00000029676.5
Adam15
a disintegrin and metallopeptidase domain 15 (metargidin)
chr17_-_15826521 0.69 ENSMUST00000170578.1
Rgmb
RGM domain family, member B
chr1_+_164048214 0.69 ENSMUST00000027874.5
Sele
selectin, endothelial cell
chr11_+_98026918 0.69 ENSMUST00000017548.6
Rpl19
ribosomal protein L19
chr11_+_96282529 0.67 ENSMUST00000125410.1
Hoxb8
homeobox B8
chr3_-_87768966 0.66 ENSMUST00000174776.1
Pear1
platelet endothelial aggregation receptor 1
chr11_+_96282648 0.65 ENSMUST00000168043.1
Hoxb8
homeobox B8
chr16_+_45224315 0.64 ENSMUST00000102802.3
ENSMUST00000063654.4
Btla
B and T lymphocyte associated
chrX_+_150547375 0.64 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2
aminolevulinic acid synthase 2, erythroid
chr3_-_19265007 0.64 ENSMUST00000091314.4
Pde7a
phosphodiesterase 7A
chr6_-_132957919 0.64 ENSMUST00000082085.4
Tas2r131
taste receptor, type 2, member 131
chr6_-_52234902 0.64 ENSMUST00000125581.1
Hoxa10
homeobox A10
chr2_-_45112890 0.63 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr2_-_27463994 0.63 ENSMUST00000164296.1
Brd3
bromodomain containing 3
chr3_-_89349939 0.63 ENSMUST00000107446.1
Adam15
a disintegrin and metallopeptidase domain 15 (metargidin)
chr7_-_119459266 0.63 ENSMUST00000033255.5
Gp2
glycoprotein 2 (zymogen granule membrane)
chr5_+_31054766 0.62 ENSMUST00000013773.5
ENSMUST00000114646.1
Cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chrX_-_12673540 0.61 ENSMUST00000060108.6
1810030O07Rik
RIKEN cDNA 1810030O07 gene
chr3_+_3634145 0.60 ENSMUST00000108394.1
Hnf4g
hepatocyte nuclear factor 4, gamma
chr6_-_87335758 0.60 ENSMUST00000042025.9
Antxr1
anthrax toxin receptor 1
chr4_+_108479081 0.60 ENSMUST00000155068.1
Zcchc11
zinc finger, CCHC domain containing 11
chr13_-_101692624 0.59 ENSMUST00000035532.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chrX_+_111168340 0.59 ENSMUST00000075226.4
Gm10112
predicted pseudogene 10112
chr5_+_150259922 0.59 ENSMUST00000087204.5
Fry
furry homolog (Drosophila)
chr1_-_120270253 0.59 ENSMUST00000112639.1
Steap3
STEAP family member 3
chr11_-_100146120 0.59 ENSMUST00000007317.7
Krt19
keratin 19

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.3 GO:0045575 basophil activation(GO:0045575)
3.3 26.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.6 6.3 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
1.4 4.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
1.4 4.1 GO:0007208 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
1.4 6.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
1.3 5.1 GO:0035524 proline transmembrane transport(GO:0035524)
1.0 4.1 GO:0015801 aromatic amino acid transport(GO:0015801) tryptophan transport(GO:0015827)
1.0 1.9 GO:0070560 protein secretion by platelet(GO:0070560)
0.8 2.5 GO:0046098 guanine metabolic process(GO:0046098)
0.8 8.3 GO:0090527 actin filament reorganization(GO:0090527)
0.8 2.4 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.7 2.7 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) positive regulation of endocytic recycling(GO:2001137)
0.7 5.3 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.7 10.6 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.6 1.8 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.5 2.7 GO:1904970 brush border assembly(GO:1904970)
0.4 3.1 GO:1901678 iron coordination entity transport(GO:1901678)
0.4 1.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.4 1.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 2.4 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.4 2.6 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.4 1.1 GO:0036292 DNA rewinding(GO:0036292)
0.4 1.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.3 1.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 4.8 GO:0042118 endothelial cell activation(GO:0042118)
0.3 0.9 GO:0030210 heparin biosynthetic process(GO:0030210)
0.3 3.2 GO:0035092 sperm chromatin condensation(GO:0035092)
0.3 4.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.3 9.0 GO:0006825 copper ion transport(GO:0006825)
0.3 3.8 GO:0048664 neuron fate determination(GO:0048664)
0.2 1.0 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 1.2 GO:0019516 lactate oxidation(GO:0019516)
0.2 3.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 2.1 GO:0048539 bone marrow development(GO:0048539)
0.2 3.0 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.2 2.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 1.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.2 1.4 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.9 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 3.1 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.0 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 1.2 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.2 1.2 GO:0010288 response to lead ion(GO:0010288)
0.2 2.1 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.2 2.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 0.9 GO:0019371 cyclooxygenase pathway(GO:0019371) maintenance of blood-brain barrier(GO:0035633)
0.2 0.5 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.2 5.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 1.8 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 2.5 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.0 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.6 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.1 1.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.1 0.6 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 0.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 0.9 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.1 0.6 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 6.1 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.1 5.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.1 0.6 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 1.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 0.2 GO:0061591 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 1.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 1.3 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 1.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.9 GO:0006527 arginine catabolic process(GO:0006527)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 1.9 GO:0035855 megakaryocyte development(GO:0035855)
0.1 2.7 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.2 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.1 2.9 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 8.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 0.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 2.5 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 2.2 GO:1905144 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 5.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 1.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.1 2.3 GO:0019236 response to pheromone(GO:0019236)
0.1 3.9 GO:0006414 translational elongation(GO:0006414)
0.1 1.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 3.5 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 2.1 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 0.6 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.1 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 1.3 GO:0008272 sulfate transport(GO:0008272)
0.1 0.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.9 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 4.5 GO:0030239 myofibril assembly(GO:0030239)
0.1 0.2 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.6 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 1.1 GO:0014823 response to activity(GO:0014823)
0.1 2.9 GO:0016574 histone ubiquitination(GO:0016574)
0.0 1.1 GO:0045616 regulation of keratinocyte differentiation(GO:0045616)
0.0 1.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.4 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.7 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 1.0 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.0 0.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 1.9 GO:0006821 chloride transport(GO:0006821)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584) histone H3-K27 trimethylation(GO:0098532)
0.0 1.2 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.3 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 1.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.8 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.1 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.0 0.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 1.1 GO:0015914 phospholipid transport(GO:0015914)
0.0 0.3 GO:0034391 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 2.7 GO:0051928 positive regulation of calcium ion transport(GO:0051928)
0.0 0.1 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 1.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.0 0.8 GO:0048599 oocyte development(GO:0048599)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0008206 bile acid metabolic process(GO:0008206)
0.0 0.3 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.1 GO:1902572 regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.1 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.0 0.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 1.2 GO:0030168 platelet activation(GO:0030168)
0.0 1.3 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.0 1.1 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 0.1 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0048679 regulation of axon regeneration(GO:0048679)
0.0 3.2 GO:0016358 dendrite development(GO:0016358)
0.0 1.3 GO:0001508 action potential(GO:0001508)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0005588 collagen type V trimer(GO:0005588)
0.7 5.9 GO:0097427 microtubule bundle(GO:0097427)
0.7 3.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 2.4 GO:0060187 cell pole(GO:0060187)
0.6 15.7 GO:0032982 myosin filament(GO:0032982)
0.5 1.5 GO:1990423 RZZ complex(GO:1990423)
0.4 2.0 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.4 3.7 GO:0001739 sex chromatin(GO:0001739)
0.3 4.9 GO:0042589 zymogen granule membrane(GO:0042589)
0.3 1.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3 4.1 GO:0070852 cell body fiber(GO:0070852)
0.2 1.1 GO:0031523 Myb complex(GO:0031523)
0.2 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 0.8 GO:0070820 tertiary granule(GO:0070820)
0.2 0.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 0.5 GO:0072534 perineuronal net(GO:0072534)
0.2 2.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 2.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.5 GO:0016460 myosin II complex(GO:0016460)
0.1 2.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.6 GO:1990357 terminal web(GO:1990357)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.1 4.4 GO:0016235 aggresome(GO:0016235)
0.1 3.1 GO:0031672 A band(GO:0031672)
0.1 6.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 2.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.3 GO:1990391 DNA repair complex(GO:1990391)
0.0 12.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.1 GO:0055037 recycling endosome(GO:0055037)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 3.6 GO:0030018 Z disc(GO:0030018)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 4.2 GO:0005903 brush border(GO:0005903)
0.0 0.8 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0005771 multivesicular body(GO:0005771)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0060170 ciliary membrane(GO:0060170)
0.0 3.3 GO:0030427 site of polarized growth(GO:0030427)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.6 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 20.4 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.4 6.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.9 4.4 GO:0051373 FATZ binding(GO:0051373)
0.8 8.5 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.8 2.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.8 5.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.7 26.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.6 4.4 GO:0016936 galactoside binding(GO:0016936)
0.6 4.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.6 10.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.5 2.5 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.5 5.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.2 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.3 4.1 GO:0051378 serotonin binding(GO:0051378)
0.3 6.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 6.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.3 1.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 4.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 0.8 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.2 2.7 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 2.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.4 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.1 GO:0034988 mu-type opioid receptor binding(GO:0031852) Fc-gamma receptor I complex binding(GO:0034988)
0.2 0.9 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 0.6 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 1.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.2 5.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.2 1.6 GO:0045545 syndecan binding(GO:0045545)
0.2 1.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 1.8 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.2 1.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 3.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 6.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 16.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 2.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.7 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 3.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.0 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.8 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.3 GO:0019959 interleukin-8 binding(GO:0019959)
0.1 9.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 1.1 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.5 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.8 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.1 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.4 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.8 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 8.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 0.7 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.6 GO:0052851 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.8 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 1.0 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.7 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.3 GO:0008061 chitin binding(GO:0008061)
0.1 5.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 2.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 13.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 7.6 GO:0003774 motor activity(GO:0003774)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.7 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 2.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.2 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.7 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0051431 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.9 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.4 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.2 GO:0032564 dATP binding(GO:0032564)
0.0 1.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.3 GO:0002020 protease binding(GO:0002020)
0.0 0.9 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 28.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.3 10.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 12.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.3 5.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 5.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 8.1 PID NOTCH PATHWAY Notch signaling pathway
0.1 3.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 7.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.8 PID P73PATHWAY p73 transcription factor network
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 26.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.4 5.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.4 4.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 8.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 2.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 1.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 5.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 0.8 REACTOME GAP JUNCTION TRAFFICKING Genes involved in Gap junction trafficking
0.1 0.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 3.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 7.7 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 2.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 4.6 REACTOME TRANSLATION Genes involved in Translation
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 1.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.0 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation