ISMARA results: Id4

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Id4

Z-value: 2.00

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Transcription factors associated with Id4

Gene Symbol	Gene ID	Gene Info
Id4 Ensembl NCBI MGI UniProt	ENSMUSG00000021379.1	inhibitor of DNA binding 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Id4	mm10_v2_chr13_+_48261427_48261427	0.13	4.5e-01	Click!

Activity profile of Id4 motif

Sorted Z-values of Id4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_30924169 Show fit	11.23	ENSMUST00000074671.6	Hamp2 Ensembl NCBI MGI UniProt Show fit	hepcidin antimicrobial peptide 2
chr15_-_98677451 Show fit	8.74	ENSMUST00000120997.1 ENSMUST00000109149.2 ENSMUST00000003451.4	Rnd1 Ensembl NCBI MGI UniProt Show fit	Rho family GTPase 1
chr4_+_133553370 Show fit	8.46	ENSMUST00000042706.2	Nr0b2 Ensembl NCBI MGI UniProt Show fit	nuclear receptor subfamily 0, group B, member 2
chr7_+_44207307 Show fit	7.84	ENSMUST00000077354.4	Klk1b4 Ensembl NCBI MGI UniProt Show fit	kallikrein 1-related pepidase b4
chr11_+_72435565 Show fit	7.05	ENSMUST00000100903.2	Ggt6 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 6
chr16_-_18089022 Show fit	6.96	ENSMUST00000132241.1 ENSMUST00000139861.1 ENSMUST00000003620.5	Prodh Ensembl NCBI MGI UniProt Show fit	proline dehydrogenase
chr18_+_20558221 Show fit	6.96	ENSMUST00000121837.1	Dsg2 Ensembl NCBI MGI UniProt Show fit	desmoglein 2
chr7_+_44384604 Show fit	6.72	ENSMUST00000130707.1 ENSMUST00000130844.1	Syt3 Ensembl NCBI MGI UniProt Show fit	synaptotagmin III
chr7_+_44384803 Show fit	6.71	ENSMUST00000120262.1	Syt3 Ensembl NCBI MGI UniProt Show fit	synaptotagmin III
chr18_+_20558092 Show fit	6.33	ENSMUST00000120102.1	Dsg2 Ensembl NCBI MGI UniProt Show fit	desmoglein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Id4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	21.3	GO:1904073	regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
4.7	19.0	GO:0003165	Purkinje myocyte development(GO:0003165)
0.8	17.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
4.0	11.9	GO:1904274	tricellular tight junction assembly(GO:1904274)
2.8	11.2	GO:0034760	negative regulation of iron ion transport(GO:0034757) negative regulation of iron ion transmembrane transport(GO:0034760)
0.2	10.8	GO:0008333	endosome to lysosome transport(GO:0008333)
0.9	10.5	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2	10.4	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.7	10.2	GO:0006751	glutathione catabolic process(GO:0006751)
0.1	10.2	GO:0055088	lipid homeostasis(GO:0055088)

Showing 1 to 10 of 441 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	41.6	GO:0005739	mitochondrion(GO:0005739)
0.8	25.2	GO:0030057	desmosome(GO:0030057)
2.4	22.0	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.1	18.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	14.6	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0	12.3	GO:0005759	mitochondrial matrix(GO:0005759)
1.3	10.5	GO:0061689	tricellular tight junction(GO:0061689)
0.5	10.5	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.7	9.7	GO:0045179	apical cortex(GO:0045179)
0.4	9.1	GO:0034706	sodium channel complex(GO:0034706)

Showing 1 to 10 of 170 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	34.7	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.6	21.3	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.2	17.3	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3	16.0	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	12.6	GO:0003924	GTPase activity(GO:0003924)
0.1	12.5	GO:0017137	Rab GTPase binding(GO:0017137)
0.5	12.3	GO:0030228	lipoprotein particle receptor activity(GO:0030228)
0.0	12.3	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
2.0	10.2	GO:0032810	sterol response element binding(GO:0032810)
0.7	9.9	GO:0015245	fatty acid transporter activity(GO:0015245)

Showing 1 to 10 of 310 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	25.1	PID IGF1 PATHWAY	IGF1 pathway
0.3	20.4	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	11.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.1	10.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	9.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	9.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	7.8	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	6.5	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	6.3	PID FOXO PATHWAY	FoxO family signaling
0.1	6.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 62 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	29.0	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	23.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	23.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.9	11.8	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3	9.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.5	9.0	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	8.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.5	8.7	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3	7.7	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	7.7	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis

Showing 1 to 10 of 105 entries

Results for Id4

Z-value: 2.00

Motif logo

Transcription factors associated with Id4

Activity-expression correlation:

Activity profile of Id4 motif

Sorted Z-values of Id4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Id4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: