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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Insm1

Z-value: 1.48

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Transcription factors associated with Insm1

Gene Symbol Gene ID Gene Info
Insm1
ENSMUSG00000068154.4 insulinoma-associated 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Insm1mm10_v2_chr2_+_146221921_1462219210.411.4e-02Click!

Activity profile of Insm1 motif

Sorted Z-values of Insm1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_78914216 6.39 ENSMUST00000120331.2
Isg20
interferon-stimulated protein
chr7_+_78913765 6.05 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chr7_+_79660196 5.21 ENSMUST00000035977.7
Ticrr
TOPBP1-interacting checkpoint and replication regulator
chr10_-_19851459 4.88 ENSMUST00000059805.4
Slc35d3
solute carrier family 35, member D3
chr7_-_126369543 4.29 ENSMUST00000032997.6
Lat
linker for activation of T cells
chr13_-_21780616 4.14 ENSMUST00000080511.2
Hist1h1b
histone cluster 1, H1b
chr7_+_27473761 3.38 ENSMUST00000068641.6
Sertad3
SERTA domain containing 3
chr4_-_44710408 3.26 ENSMUST00000134968.2
ENSMUST00000173821.1
ENSMUST00000174319.1
ENSMUST00000173733.1
ENSMUST00000172866.1
ENSMUST00000165417.2
ENSMUST00000107825.2
ENSMUST00000102932.3
ENSMUST00000107827.2
ENSMUST00000107826.2
Pax5
paired box gene 5
chr8_+_95055094 3.15 ENSMUST00000058479.6
Ccdc135
coiled-coil domain containing 135
chr7_+_127746775 3.09 ENSMUST00000033081.7
Fbxl19
F-box and leucine-rich repeat protein 19
chr2_+_109280738 3.09 ENSMUST00000028527.7
Kif18a
kinesin family member 18A
chr4_-_108383349 3.06 ENSMUST00000053157.6
Fam159a
family with sequence similarity 159, member A
chr12_-_12940600 3.02 ENSMUST00000130990.1
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr7_-_110982049 2.97 ENSMUST00000142368.1
Mrvi1
MRV integration site 1
chr2_+_91082362 2.87 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr7_-_110982443 2.85 ENSMUST00000005751.6
Mrvi1
MRV integration site 1
chr6_+_38109320 2.72 ENSMUST00000031851.3
Tmem213
transmembrane protein 213
chr7_+_144838590 2.65 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr19_+_4154606 2.61 ENSMUST00000061086.8
Ptprcap
protein tyrosine phosphatase, receptor type, C polypeptide-associated protein
chr4_-_88033328 2.58 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_+_46450892 2.58 ENSMUST00000102926.4
Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr17_-_25952565 2.58 ENSMUST00000162431.1
A930017K11Rik
RIKEN cDNA A930017K11 gene
chr4_-_3938354 2.50 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr15_-_75888754 2.46 ENSMUST00000184858.1
Mroh6
maestro heat-like repeat family member 6
chr12_-_70111920 2.43 ENSMUST00000169074.1
ENSMUST00000021468.7
Nin
ninein
chr5_-_137741601 2.43 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr4_+_134315112 2.28 ENSMUST00000105875.1
ENSMUST00000030638.6
Trim63
tripartite motif-containing 63
chr7_+_141131268 2.23 ENSMUST00000026568.8
Ptdss2
phosphatidylserine synthase 2
chr2_+_29889785 2.18 ENSMUST00000113763.1
ENSMUST00000113757.1
ENSMUST00000113756.1
ENSMUST00000133233.1
ENSMUST00000113759.2
ENSMUST00000113755.1
ENSMUST00000137558.1
ENSMUST00000046571.7
Odf2
outer dense fiber of sperm tails 2
chr5_-_137741102 2.15 ENSMUST00000149512.1
Nyap1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr2_+_29889720 2.10 ENSMUST00000113767.1
Odf2
outer dense fiber of sperm tails 2
chr2_+_25242929 1.92 ENSMUST00000114355.1
ENSMUST00000060818.1
Rnf208
ring finger protein 208
chr10_-_116473875 1.88 ENSMUST00000068233.4
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr7_-_126463100 1.86 ENSMUST00000032974.6
Atp2a1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chrX_+_9199865 1.82 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr4_+_119637704 1.76 ENSMUST00000024015.2
Guca2a
guanylate cyclase activator 2a (guanylin)
chr6_-_131316398 1.76 ENSMUST00000121078.1
Styk1
serine/threonine/tyrosine kinase 1
chr7_+_4740137 1.69 ENSMUST00000130215.1
ENSMUST00000108582.3
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr3_-_104818266 1.68 ENSMUST00000168015.1
Mov10
Moloney leukemia virus 10
chr7_-_110982169 1.67 ENSMUST00000154466.1
Mrvi1
MRV integration site 1
chr10_-_42276688 1.66 ENSMUST00000175881.1
ENSMUST00000056974.3
Foxo3
forkhead box O3
chr3_-_104818539 1.66 ENSMUST00000106774.1
ENSMUST00000106775.1
ENSMUST00000166979.1
ENSMUST00000136148.1
Mov10
Moloney leukemia virus 10
chr7_+_4740111 1.66 ENSMUST00000098853.2
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr2_-_152831665 1.63 ENSMUST00000156688.1
ENSMUST00000007803.5
Bcl2l1
BCL2-like 1
chr7_+_4740178 1.58 ENSMUST00000108583.2
Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr2_+_11172382 1.58 ENSMUST00000028118.3
Prkcq
protein kinase C, theta
chr11_+_85171096 1.48 ENSMUST00000018623.3
1700125H20Rik
RIKEN cDNA 1700125H20 gene
chr6_+_128438757 1.48 ENSMUST00000144745.1
Gm10069
predicted gene 10069
chr3_-_104818224 1.44 ENSMUST00000002297.5
Mov10
Moloney leukemia virus 10
chr2_-_152831112 1.35 ENSMUST00000128172.1
Bcl2l1
BCL2-like 1
chr3_+_134236483 1.30 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4
CXXC finger 4
chr6_-_38109548 1.29 ENSMUST00000114908.1
Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr5_-_122900267 1.28 ENSMUST00000031435.7
Kdm2b
lysine (K)-specific demethylase 2B
chr17_-_35516780 1.27 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19
transcription factor 19
chr4_-_153482768 1.22 ENSMUST00000105646.2
Ajap1
adherens junction associated protein 1
chrX_+_68678712 1.21 ENSMUST00000114654.1
ENSMUST00000114655.1
ENSMUST00000114657.2
ENSMUST00000114653.1
Fmr1
fragile X mental retardation syndrome 1
chr2_+_52072823 1.19 ENSMUST00000112693.2
ENSMUST00000069794.5
Rif1
Rap1 interacting factor 1 homolog (yeast)
chr1_-_172027269 1.16 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chrX_-_166585679 1.14 ENSMUST00000000412.2
Egfl6
EGF-like-domain, multiple 6
chrX_+_68678541 1.13 ENSMUST00000088546.5
Fmr1
fragile X mental retardation syndrome 1
chr15_-_99370427 1.12 ENSMUST00000081224.7
ENSMUST00000120633.1
ENSMUST00000088233.6
Fmnl3
formin-like 3
chr7_-_19715395 1.09 ENSMUST00000032555.9
ENSMUST00000093552.5
Tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr8_+_81342556 1.08 ENSMUST00000172167.1
ENSMUST00000169116.1
ENSMUST00000109852.2
ENSMUST00000172031.1
Inpp4b
inositol polyphosphate-4-phosphatase, type II
chr4_+_130047840 1.05 ENSMUST00000044565.8
ENSMUST00000132251.1
Col16a1
collagen, type XVI, alpha 1
chr17_+_3114957 1.03 ENSMUST00000076734.6
Scaf8
SR-related CTD-associated factor 8
chr10_+_80805233 1.02 ENSMUST00000036016.4
Amh
anti-Mullerian hormone
chr7_+_66060338 0.98 ENSMUST00000153609.1
Snrpa1
small nuclear ribonucleoprotein polypeptide A'
chr1_+_87620306 0.98 ENSMUST00000169754.1
Inpp5d
inositol polyphosphate-5-phosphatase D
chr1_+_87620334 0.94 ENSMUST00000042275.8
ENSMUST00000168783.1
Inpp5d
inositol polyphosphate-5-phosphatase D
chrX_+_153006461 0.94 ENSMUST00000095755.3
Usp51
ubiquitin specific protease 51
chr7_+_100372224 0.93 ENSMUST00000051777.8
ENSMUST00000098259.4
C2cd3
C2 calcium-dependent domain containing 3
chr1_-_172027251 0.85 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr14_-_55116935 0.84 ENSMUST00000022819.5
Jph4
junctophilin 4
chr7_-_118995211 0.81 ENSMUST00000008878.8
Gprc5b
G protein-coupled receptor, family C, group 5, member B
chr19_+_6975048 0.79 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_5056706 0.75 ENSMUST00000144802.1
Ccdc106
coiled-coil domain containing 106
chr6_+_4902913 0.73 ENSMUST00000175889.1
ENSMUST00000168998.2
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr4_+_129960760 0.72 ENSMUST00000139884.1
1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr12_+_77239036 0.71 ENSMUST00000062804.7
Fut8
fucosyltransferase 8
chr8_+_71469186 0.70 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
Dda1
DET1 and DDB1 associated 1
chr12_+_3891728 0.69 ENSMUST00000172689.1
ENSMUST00000111186.1
Dnmt3a
DNA methyltransferase 3A
chr14_-_20668269 0.69 ENSMUST00000057090.5
ENSMUST00000117386.1
Synpo2l
synaptopodin 2-like
chr7_+_4690760 0.68 ENSMUST00000048248.7
Brsk1
BR serine/threonine kinase 1
chr10_+_75518042 0.66 ENSMUST00000020397.8
Snrpd3
small nuclear ribonucleoprotein D3
chr3_+_145938004 0.61 ENSMUST00000039571.7
2410004B18Rik
RIKEN cDNA 2410004B18 gene
chr7_-_45016224 0.56 ENSMUST00000085383.2
Scaf1
SR-related CTD-associated factor 1
chr18_+_34777008 0.51 ENSMUST00000043775.7
Kdm3b
KDM3B lysine (K)-specific demethylase 3B
chr4_-_130174691 0.46 ENSMUST00000132545.2
ENSMUST00000175992.1
ENSMUST00000105999.2
Tinagl1
tubulointerstitial nephritis antigen-like 1
chr9_-_44881274 0.44 ENSMUST00000002095.3
ENSMUST00000114689.1
ENSMUST00000128768.1
Kmt2a
lysine (K)-specific methyltransferase 2A
chr5_+_53590453 0.43 ENSMUST00000113865.1
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
chr5_-_125434048 0.42 ENSMUST00000169485.1
Dhx37
DEAH (Asp-Glu-Ala-His) box polypeptide 37
chr14_+_54625305 0.41 ENSMUST00000097177.4
Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
chr2_-_127521358 0.41 ENSMUST00000028850.8
ENSMUST00000103215.4
Kcnip3
Kv channel interacting protein 3, calsenilin
chr7_-_30552255 0.41 ENSMUST00000108165.1
ENSMUST00000153594.1
BC053749
cDNA sequence BC053749
chr8_+_124897877 0.41 ENSMUST00000034467.5
Sprtn
SprT-like N-terminal domain
chr7_+_4690604 0.39 ENSMUST00000120836.1
Brsk1
BR serine/threonine kinase 1
chrX_+_68678624 0.39 ENSMUST00000114656.1
Fmr1
fragile X mental retardation syndrome 1
chr17_-_46680870 0.38 ENSMUST00000165007.1
ENSMUST00000071841.5
Klhdc3
kelch domain containing 3
chr12_-_114406773 0.35 ENSMUST00000177949.1
Ighv6-4
immunoglobulin heavy variable V6-4
chr7_+_100159241 0.32 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr15_+_78983041 0.32 ENSMUST00000109687.1
ENSMUST00000109688.1
ENSMUST00000130663.2
Triobp
TRIO and F-actin binding protein
chr4_-_134245579 0.32 ENSMUST00000030644.7
Zfp593
zinc finger protein 593
chr17_-_32166879 0.28 ENSMUST00000087723.3
Notch3
notch 3
chr2_-_72980402 0.28 ENSMUST00000066003.6
ENSMUST00000102689.3
Sp3
trans-acting transcription factor 3
chr5_+_149184648 0.27 ENSMUST00000122160.1
ENSMUST00000100410.3
ENSMUST00000119685.1
Uspl1
ubiquitin specific peptidase like 1
chr11_-_115813621 0.25 ENSMUST00000041684.4
ENSMUST00000156812.1
Caskin2
CASK-interacting protein 2
chr5_+_149184555 0.23 ENSMUST00000050472.9
Uspl1
ubiquitin specific peptidase like 1
chr17_+_47688992 0.22 ENSMUST00000156118.1
Frs3
fibroblast growth factor receptor substrate 3
chr6_+_42286676 0.22 ENSMUST00000031894.6
Clcn1
chloride channel 1
chr12_+_51593315 0.19 ENSMUST00000164782.2
ENSMUST00000085412.5
Coch
coagulation factor C homolog (Limulus polyphemus)
chr15_+_100423193 0.18 ENSMUST00000148928.1
Gm5475
predicted gene 5475
chr6_+_4903350 0.17 ENSMUST00000175962.1
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr8_+_105413614 0.17 ENSMUST00000109355.2
Lrrc36
leucine rich repeat containing 36
chr5_+_77265454 0.15 ENSMUST00000080359.5
Rest
RE1-silencing transcription factor
chr9_+_106477269 0.14 ENSMUST00000047721.8
Rrp9
RRP9, small subunit (SSU) processome component, homolog (yeast)
chr5_+_149184678 0.12 ENSMUST00000139474.1
ENSMUST00000117878.1
Uspl1
ubiquitin specific peptidase like 1
chr11_+_106084577 0.12 ENSMUST00000002044.9
Map3k3
mitogen-activated protein kinase kinase kinase 3
chr6_+_42286709 0.11 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr6_+_6863269 0.10 ENSMUST00000160937.2
ENSMUST00000171311.1
Dlx6
distal-less homeobox 6
chr7_+_48789003 0.10 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13
zinc finger, DHHC domain containing 13
chr16_-_67620880 0.09 ENSMUST00000114292.1
ENSMUST00000120898.1
Cadm2
cell adhesion molecule 2
chr12_+_95692212 0.09 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr1_+_192190771 0.09 ENSMUST00000078470.5
ENSMUST00000110844.1
Kcnh1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr11_-_115699461 0.08 ENSMUST00000106497.1
Grb2
growth factor receptor bound protein 2
chr2_+_178141920 0.08 ENSMUST00000103066.3
Phactr3
phosphatase and actin regulator 3
chr7_+_6286589 0.07 ENSMUST00000170776.1
Zfp667
zinc finger protein 667
chr7_+_6286573 0.07 ENSMUST00000086327.5
Zfp667
zinc finger protein 667
chr7_+_5057161 0.06 ENSMUST00000045543.5
Ccdc106
coiled-coil domain containing 106
chr2_+_28205648 0.05 ENSMUST00000102879.3
ENSMUST00000028177.4
Olfm1
olfactomedin 1
chr10_-_82623190 0.03 ENSMUST00000183363.1
ENSMUST00000079648.5
ENSMUST00000185168.1
1190007I07Rik
RIKEN cDNA 1190007I07 gene
chr10_-_116473418 0.02 ENSMUST00000087965.4
ENSMUST00000164271.1
Kcnmb4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr9_+_108808356 0.01 ENSMUST00000035218.7
Nckipsd
NCK interacting protein with SH3 domain
chr7_+_141461075 0.01 ENSMUST00000053670.5
Efcab4a
EF-hand calcium binding domain 4A
chr7_+_26061495 0.00 ENSMUST00000005669.7
Cyp2b13
cytochrome P450, family 2, subfamily b, polypeptide 13
chr2_+_174330006 0.00 ENSMUST00000109085.1
ENSMUST00000109087.1
ENSMUST00000109084.1
Gnas
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

Network of associatons between targets according to the STRING database.

First level regulatory network of Insm1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.4 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
1.6 4.9 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
1.2 4.8 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.9 2.7 GO:1901254 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.8 2.3 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.7 3.0 GO:0046898 response to cycloheximide(GO:0046898)
0.7 2.0 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.7 5.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.6 1.9 GO:0090076 positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) maintenance of mitochondrion location(GO:0051659) relaxation of skeletal muscle(GO:0090076)
0.6 2.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.6 2.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.5 7.5 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.5 1.9 GO:0045659 negative regulation of neutrophil differentiation(GO:0045659)
0.4 1.2 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.4 1.5 GO:0035712 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.3 1.0 GO:0001546 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.3 2.4 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.3 1.2 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
0.3 2.7 GO:0030916 otic vesicle formation(GO:0030916)
0.3 1.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.3 3.0 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.2 4.3 GO:0006968 cellular defense response(GO:0006968)
0.2 1.7 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.2 0.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 0.4 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) regulation of cell adhesion involved in heart morphogenesis(GO:0061344) blood vessel endothelial cell fate specification(GO:0097101) positive regulation of ephrin receptor signaling pathway(GO:1901189)
0.2 3.3 GO:0021670 lateral ventricle development(GO:0021670)
0.2 0.9 GO:0061511 centriole elongation(GO:0061511)
0.2 0.7 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.2 1.9 GO:0005513 detection of calcium ion(GO:0005513)
0.2 2.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 0.6 GO:0030576 Cajal body organization(GO:0030576)
0.1 1.3 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 2.5 GO:0060736 prostate gland growth(GO:0060736)
0.1 3.1 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.3 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 2.6 GO:0043486 histone exchange(GO:0043486)
0.1 0.4 GO:2001025 positive regulation of response to drug(GO:2001025)
0.1 0.5 GO:0072718 response to cisplatin(GO:0072718)
0.1 0.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 1.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 1.1 GO:0046855 inositol phosphate dephosphorylation(GO:0046855)
0.0 1.8 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.3 GO:0072104 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 1.3 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 3.2 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.1 GO:0033622 integrin activation(GO:0033622)
0.0 0.9 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.4 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 3.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.1 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 3.5 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.5 2.0 GO:0060187 cell pole(GO:0060187)
0.5 2.4 GO:0036449 microtubule minus-end(GO:0036449)
0.4 3.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.3 1.9 GO:0031673 H zone(GO:0031673)
0.3 4.3 GO:0097539 ciliary transition fiber(GO:0097539)
0.3 13.1 GO:0015030 Cajal body(GO:0015030)
0.3 3.0 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 0.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 0.7 GO:0005683 U7 snRNP(GO:0005683)
0.2 1.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.2 GO:0001940 male pronucleus(GO:0001940)
0.1 1.2 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 1.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 5.8 GO:0001772 immunological synapse(GO:0001772)
0.1 0.8 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 6.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.0 GO:0005686 U2 snRNP(GO:0005686)
0.1 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 3.2 GO:0000786 nucleosome(GO:0000786)
0.0 3.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 3.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 3.3 GO:0001650 fibrillar center(GO:0001650)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 4.8 GO:0005769 early endosome(GO:0005769)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.7 GO:0030863 cortical cytoskeleton(GO:0030863)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 12.4 GO:0008859 exoribonuclease II activity(GO:0008859)
0.6 6.7 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.4 2.7 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 1.8 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.3 1.6 GO:0030620 U2 snRNA binding(GO:0030620)
0.3 1.9 GO:0051425 PTB domain binding(GO:0051425)
0.3 3.0 GO:0051434 BH3 domain binding(GO:0051434)
0.3 2.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 1.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.2 2.9 GO:0051525 NFAT protein binding(GO:0051525)
0.2 0.6 GO:0070122 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.2 3.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.1 GO:0015288 porin activity(GO:0015288)
0.1 2.3 GO:0031432 titin binding(GO:0031432)
0.1 0.4 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 0.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 3.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 1.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 1.1 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.7 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 1.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 4.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0034511 U3 snoRNA binding(GO:0034511)
0.0 1.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.7 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 1.0 GO:0043175 RNA polymerase core enzyme binding(GO:0043175)
0.0 0.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 4.8 GO:0004386 helicase activity(GO:0004386)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 2.8 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0043236 laminin binding(GO:0043236)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 3.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.0 PID ALK2 PATHWAY ALK2 signaling events
0.1 4.3 PID PLK1 PATHWAY PLK1 signaling events
0.1 5.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 4.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 12.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 5.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 4.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.7 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 3.1 REACTOME KINESINS Genes involved in Kinesins
0.1 1.9 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 0.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation