ISMARA results: Irf2_Irf1_Irf8_Irf9

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.87

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 Ensembl NCBI MGI UniProt	ENSMUSG00000031627.7	interferon regulatory factor 2
Irf1 Ensembl NCBI MGI UniProt	ENSMUSG00000018899.10	interferon regulatory factor 1
Irf8 Ensembl NCBI MGI UniProt	ENSMUSG00000041515.3	interferon regulatory factor 8
Irf9 Ensembl NCBI MGI UniProt	ENSMUSG00000002325.8	interferon regulatory factor 9
Irf7 Ensembl NCBI MGI UniProt	ENSMUSG00000025498.8	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf1	mm10_v2_chr11_+_53770458_53770509	0.51	1.5e-03	Click!
Irf7	mm10_v2_chr7_-_141266415_141266481	0.49	2.3e-03	Click!
Irf2	mm10_v2_chr8_+_46739745_46739791	0.37	2.6e-02	Click!
Irf8	mm10_v2_chr8_+_120736352_120736385	-0.34	4.4e-02	Click!
Irf9	mm10_v2_chr14_+_55604550_55604579	0.22	1.9e-01	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_+_77729091 Show fit	33.28	ENSMUST00000109775.2	Apol9b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9b
chr1_+_130826676 Show fit	19.85	ENSMUST00000027675.7	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr1_+_130826762 Show fit	18.74	ENSMUST00000133792.1	Pigr Ensembl NCBI MGI UniProt Show fit	polymeric immunoglobulin receptor
chr15_-_77411034 Show fit	17.58	ENSMUST00000089452.5 ENSMUST00000081776.3	Apol9a Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 9a
chr2_-_173218879 Show fit	16.47	ENSMUST00000109116.2 ENSMUST00000029018.7	Zbp1 Ensembl NCBI MGI UniProt Show fit	Z-DNA binding protein 1
chr4_+_42629719 Show fit	14.27	ENSMUST00000166898.2	Gm2564 Ensembl NCBI MGI UniProt Show fit	predicted gene 2564
chr8_-_71537402 Show fit	13.78	ENSMUST00000051672.7	Bst2 Ensembl NCBI MGI UniProt Show fit	bone marrow stromal cell antigen 2
chr19_+_34607927 Show fit	13.35	ENSMUST00000076249.5	I830012O16Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA I830012O16 gene
chr8_-_45333189 Show fit	12.55	ENSMUST00000095328.4	Cyp4v3 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 4, subfamily v, polypeptide 3
chr19_+_34640871 Show fit	12.19	ENSMUST00000102824.3	Ifit1 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr18_+_60212080 Show fit	12.06	ENSMUST00000031549.5	Gm4951 Ensembl NCBI MGI UniProt Show fit	predicted gene 4951
chr2_+_122147680 Show fit	11.55	ENSMUST00000102476.4	B2m Ensembl NCBI MGI UniProt Show fit	beta-2 microglobulin
chr19_-_11050500 Show fit	11.53	ENSMUST00000099676.4	AW112010 Ensembl NCBI MGI UniProt Show fit	expressed sequence AW112010
chr5_-_105239533 Show fit	11.52	ENSMUST00000065588.6	Gbp10 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 10
chr11_+_70459940 Show fit	10.96	ENSMUST00000147289.1 ENSMUST00000126105.1	Zmynd15 Ensembl NCBI MGI UniProt Show fit	zinc finger, MYND-type containing 15
chr11_+_70459611 Show fit	10.76	ENSMUST00000039093.3	Zmynd15 Ensembl NCBI MGI UniProt Show fit	zinc finger, MYND-type containing 15
chr7_-_141010759 Show fit	10.64	ENSMUST00000026565.6	Ifitm3 Ensembl NCBI MGI UniProt Show fit	interferon induced transmembrane protein 3
chr11_+_49087022 Show fit	10.50	ENSMUST00000046704.6	Ifi47 Ensembl NCBI MGI UniProt Show fit	interferon gamma inducible protein 47
chr1_-_162984519 Show fit	10.16	ENSMUST00000028010.7	Fmo3 Ensembl NCBI MGI UniProt Show fit	flavin containing monooxygenase 3
chr3_-_151749877 Show fit	9.57	ENSMUST00000029671.7	Ifi44 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein 44
chr19_+_34583528 Show fit	9.53	ENSMUST00000102825.3	Ifit3 Ensembl NCBI MGI UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 3
chr16_+_43363855 Show fit	9.38	ENSMUST00000156367.1	Zbtb20 Ensembl NCBI MGI UniProt Show fit	zinc finger and BTB domain containing 20
chr10_+_40629987 Show fit	9.22	ENSMUST00000019977.7	Ddo Ensembl NCBI MGI UniProt Show fit	D-aspartate oxidase
chr16_+_23609895 Show fit	8.61	ENSMUST00000038423.5	Rtp4 Ensembl NCBI MGI UniProt Show fit	receptor transporter protein 4
chr8_-_84773381 Show fit	8.45	ENSMUST00000109764.1	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr3_-_113574758 Show fit	8.44	ENSMUST00000106540.1	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr3_-_113574242 Show fit	8.28	ENSMUST00000142505.2	Amy1 Ensembl NCBI MGI UniProt Show fit	amylase 1, salivary
chr7_-_141266415 Show fit	8.27	ENSMUST00000106023.1 ENSMUST00000097952.2 ENSMUST00000026571.4	Irf7 Ensembl NCBI MGI UniProt Show fit	interferon regulatory factor 7
chr12_+_103434211 Show fit	8.11	ENSMUST00000079294.5 ENSMUST00000076788.5 ENSMUST00000076702.5 ENSMUST00000066701.6 ENSMUST00000085065.5 ENSMUST00000140838.1	Ifi27 Ensembl NCBI MGI UniProt Show fit	interferon, alpha-inducible protein 27
chr11_-_53859187 Show fit	8.09	ENSMUST00000117316.1 ENSMUST00000120776.1 ENSMUST00000121435.1	Gm12216 Ensembl NCBI MGI UniProt Show fit	predicted gene 12216
chr11_-_49064202 Show fit	8.00	ENSMUST00000046745.6	Tgtp2 Ensembl NCBI MGI UniProt Show fit	T cell specific GTPase 2
chr11_-_48992226 Show fit	7.97	ENSMUST00000059930.2 ENSMUST00000068063.3	Gm12185 Ensembl NCBI MGI UniProt Show fit Tgtp1 Ensembl NCBI MGI UniProt Show fit	predicted gene 12185 T cell specific GTPase 1
chr2_+_102706356 Show fit	7.86	ENSMUST00000123759.1 ENSMUST00000111212.1 ENSMUST00000005220.4	Slc1a2 Ensembl NCBI MGI UniProt Show fit	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr7_-_14446570 Show fit	7.85	ENSMUST00000063509.4	2810007J24Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2810007J24 gene
chr15_-_77596110 Show fit	7.77	ENSMUST00000089465.4	Apol10b Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 10B
chr15_-_77533312 Show fit	7.74	ENSMUST00000062562.5	Apol7c Ensembl NCBI MGI UniProt Show fit	apolipoprotein L 7c
chr9_+_20868628 Show fit	7.64	ENSMUST00000043911.7	A230050P20Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA A230050P20 gene
chr7_-_14446651 Show fit	7.58	ENSMUST00000125941.1	2810007J24Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 2810007J24 gene
chr1_+_52119438 Show fit	7.54	ENSMUST00000070968.7	Stat1 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 1
chr17_-_36042690 Show fit	7.44	ENSMUST00000058801.8 ENSMUST00000080015.5 ENSMUST00000077960.6	H2-T22 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, T region locus 22
chr9_-_106476104 Show fit	7.43	ENSMUST00000156426.1	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr9_-_106476372 Show fit	7.40	ENSMUST00000123555.1 ENSMUST00000125850.1	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr17_-_34187219 Show fit	7.36	ENSMUST00000173831.1	Psmb9 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr3_+_142620596 Show fit	7.28	ENSMUST00000165774.1	Gbp2 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2
chr18_+_60376029 Show fit	7.18	ENSMUST00000066912.5 ENSMUST00000032473.6	Iigp1 Ensembl NCBI MGI UniProt Show fit	interferon inducible GTPase 1
chr9_-_106476590 Show fit	7.15	ENSMUST00000112479.2	Parp3 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 3
chr1_-_173599074 Show fit	7.13	ENSMUST00000150649.1 ENSMUST00000180215.1 ENSMUST00000097462.2	Pydc4 Ensembl NCBI MGI UniProt Show fit	pyrin domain containing 4
chr1_+_167618246 Show fit	7.03	ENSMUST00000111380.1	Rxrg Ensembl NCBI MGI UniProt Show fit	retinoid X receptor gamma
chr4_-_42756543 Show fit	6.88	ENSMUST00000102957.3	Ccl19 Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 19
chr9_+_77921908 Show fit	6.45	ENSMUST00000133757.1	Elovl5 Ensembl NCBI MGI UniProt Show fit	ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr16_+_97536079 Show fit	6.44	ENSMUST00000024112.7	Mx2 Ensembl NCBI MGI UniProt Show fit	myxovirus (influenza virus) resistance 2
chr17_-_34862122 Show fit	6.41	ENSMUST00000154526.1	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr11_-_48871408 Show fit	6.36	ENSMUST00000097271.2	Irgm1 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 1
chr5_+_114923234 Show fit	6.34	ENSMUST00000031540.4 ENSMUST00000112143.3	Oasl1 Ensembl NCBI MGI UniProt Show fit	2'-5' oligoadenylate synthetase-like 1
chr6_-_23839137 Show fit	6.32	ENSMUST00000166458.2 ENSMUST00000142913.2 ENSMUST00000115357.1 ENSMUST00000069074.7 ENSMUST00000115361.2 ENSMUST00000018122.7 ENSMUST00000115355.1 ENSMUST00000115356.2	Cadps2 Ensembl NCBI MGI UniProt Show fit	Ca2+-dependent activator protein for secretion 2
chr11_-_48871344 Show fit	6.30	ENSMUST00000049519.3	Irgm1 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 1
chr6_-_39118211 Show fit	6.22	ENSMUST00000038398.6	Parp12 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 12
chr4_-_42773993 Show fit	6.19	ENSMUST00000095114.4	Ccl21a Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 21A (serine)
chr11_-_70459957 Show fit	6.16	ENSMUST00000019064.2	Cxcl16 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 16
chr1_+_175631996 Show fit	6.00	ENSMUST00000040250.8	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chrX_+_59999436 Show fit	6.00	ENSMUST00000033477.4	F9 Ensembl NCBI MGI UniProt Show fit	coagulation factor IX
chr11_+_72301613 Show fit	5.99	ENSMUST00000151440.1 ENSMUST00000146233.1 ENSMUST00000140842.2	Xaf1 Ensembl NCBI MGI UniProt Show fit	XIAP associated factor 1
chr1_-_150466165 Show fit	5.99	ENSMUST00000162367.1 ENSMUST00000161611.1 ENSMUST00000161320.1 ENSMUST00000159035.1	Prg4 Ensembl NCBI MGI UniProt Show fit	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
chr11_+_119393060 Show fit	5.94	ENSMUST00000131035.2 ENSMUST00000093902.5	Rnf213 Ensembl NCBI MGI UniProt Show fit	ring finger protein 213
chr3_+_142560052 Show fit	5.90	ENSMUST00000106222.2	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr1_+_175632169 Show fit	5.89	ENSMUST00000097458.3	Kmo Ensembl NCBI MGI UniProt Show fit	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr1_+_173673651 Show fit	5.86	ENSMUST00000085876.4	Pydc3 Ensembl NCBI MGI UniProt Show fit	pyrin domain containing 3
chr17_+_36121666 Show fit	5.67	ENSMUST00000173128.1	Gm19684 Ensembl NCBI MGI UniProt Show fit	predicted gene, 19684
chr4_+_42255767 Show fit	5.66	ENSMUST00000178864.1	Ccl21b Ensembl NCBI MGI UniProt Show fit	chemokine (C-C motif) ligand 21B (leucine)
chr6_-_23839420 Show fit	5.58	ENSMUST00000115358.2 ENSMUST00000163871.2	Cadps2 Ensembl NCBI MGI UniProt Show fit	Ca2+-dependent activator protein for secretion 2
chr17_-_34862473 Show fit	5.57	ENSMUST00000025229.4 ENSMUST00000176203.2 ENSMUST00000128767.1	Cfb Ensembl NCBI MGI UniProt Show fit	complement factor B
chr4_-_40239779 Show fit	5.51	ENSMUST00000037907.6	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_-_51972990 Show fit	5.48	ENSMUST00000145481.1 ENSMUST00000112705.2	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr3_+_142560351 Show fit	5.44	ENSMUST00000106221.1	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr5_-_105293699 Show fit	5.41	ENSMUST00000050011.8	Gbp6 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 6
chr3_+_142560108 Show fit	5.41	ENSMUST00000128609.1 ENSMUST00000029935.7	Gbp3 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 3
chr6_+_121245903 Show fit	5.39	ENSMUST00000032198.9	Usp18 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 18
chr7_+_51878967 Show fit	5.34	ENSMUST00000051912.6	Gas2 Ensembl NCBI MGI UniProt Show fit	growth arrest specific 2
chr17_+_34187545 Show fit	5.31	ENSMUST00000170086.1	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_126933229 Show fit	5.25	ENSMUST00000028844.4	Sppl2a Ensembl NCBI MGI UniProt Show fit	signal peptide peptidase like 2A
chr8_+_61928081 Show fit	5.22	ENSMUST00000154398.1 ENSMUST00000093485.2 ENSMUST00000156980.1 ENSMUST00000070631.7	Ddx60 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr11_+_58199556 Show fit	5.09	ENSMUST00000035266.4 ENSMUST00000094169.4 ENSMUST00000168280.1 ENSMUST00000058704.8	Igtp Ensembl NCBI MGI UniProt Show fit Irgm2 Ensembl NCBI MGI UniProt Show fit	interferon gamma induced GTPase immunity-related GTPase family M member 2
chr17_+_34187789 Show fit	5.09	ENSMUST00000041633.8	Tap1 Ensembl NCBI MGI UniProt Show fit	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr7_+_51879041 Show fit	4.91	ENSMUST00000107591.2	Gas2 Ensembl NCBI MGI UniProt Show fit	growth arrest specific 2
chr1_+_156035705 Show fit	4.87	ENSMUST00000111754.2 ENSMUST00000133152.1	Tor1aip2 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 2
chr19_+_56397100 Show fit	4.85	ENSMUST00000026062.9	Casp7 Ensembl NCBI MGI UniProt Show fit	caspase 7
chr2_-_77170534 Show fit	4.81	ENSMUST00000111833.2	Ccdc141 Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 141
chr11_-_100704217 Show fit	4.76	ENSMUST00000017974.6	Dhx58 Ensembl NCBI MGI UniProt Show fit	DEXH (Asp-Glu-X-His) box polypeptide 58
chr2_-_62646146 Show fit	4.75	ENSMUST00000112459.3 ENSMUST00000028259.5	Ifih1 Ensembl NCBI MGI UniProt Show fit	interferon induced with helicase C domain 1
chr16_+_43364145 Show fit	4.73	ENSMUST00000148775.1	Zbtb20 Ensembl NCBI MGI UniProt Show fit	zinc finger and BTB domain containing 20
chr6_+_128662379 Show fit	4.61	ENSMUST00000032518.4	Clec2h Ensembl NCBI MGI UniProt Show fit	C-type lectin domain family 2, member h
chr3_+_60081861 Show fit	4.60	ENSMUST00000029326.5	Sucnr1 Ensembl NCBI MGI UniProt Show fit	succinate receptor 1
chr6_+_57580992 Show fit	4.60	ENSMUST00000031817.8	Herc6 Ensembl NCBI MGI UniProt Show fit	hect domain and RLD 6
chr4_+_41903610 Show fit	4.58	ENSMUST00000098128.3	Gm21541 Ensembl NCBI MGI UniProt Show fit	predicted gene, 21541
chr4_+_42114817 Show fit	4.57	ENSMUST00000098123.3	Gm13304 Ensembl NCBI MGI UniProt Show fit	predicted gene 13304
chr16_+_35938470 Show fit	4.56	ENSMUST00000114878.1	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr15_+_99392882 Show fit	4.56	ENSMUST00000023749.8	Tmbim6 Ensembl NCBI MGI UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr15_-_76243401 Show fit	4.52	ENSMUST00000165738.1 ENSMUST00000075689.6	Parp10 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 10
chr7_+_119526269 Show fit	4.51	ENSMUST00000066465.1	Acsm5 Ensembl NCBI MGI UniProt Show fit	acyl-CoA synthetase medium-chain family member 5
chr6_-_85869128 Show fit	4.45	ENSMUST00000045008.7	Cml2 Ensembl NCBI MGI UniProt Show fit	camello-like 2
chr18_-_60273267 Show fit	4.44	ENSMUST00000090260.4	Gm4841 Ensembl NCBI MGI UniProt Show fit	predicted gene 4841
chr18_-_61536522 Show fit	4.43	ENSMUST00000171629.1	Arhgef37 Ensembl NCBI MGI UniProt Show fit	Rho guanine nucleotide exchange factor (GEF) 37
chr2_+_58755177 Show fit	4.34	ENSMUST00000102755.3	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr13_+_4434306 Show fit	4.29	ENSMUST00000021630.8	Akr1c6 Ensembl NCBI MGI UniProt Show fit	aldo-keto reductase family 1, member C6
chr17_-_34000257 Show fit	4.29	ENSMUST00000087189.6 ENSMUST00000173075.1 ENSMUST00000172760.1 ENSMUST00000172912.1 ENSMUST00000025181.10	H2-K1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, K1, K region
chr13_+_4059565 Show fit	4.26	ENSMUST00000041768.6	Akr1c14 Ensembl NCBI MGI UniProt Show fit	aldo-keto reductase family 1, member C14
chr16_-_24393588 Show fit	4.21	ENSMUST00000181640.1	1110054M08Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 1110054M08 gene
chr2_+_58754910 Show fit	4.21	ENSMUST00000059102.6	Upp2 Ensembl NCBI MGI UniProt Show fit	uridine phosphorylase 2
chr16_+_35938972 Show fit	4.19	ENSMUST00000023622.6 ENSMUST00000114877.1	Parp9 Ensembl NCBI MGI UniProt Show fit	poly (ADP-ribose) polymerase family, member 9
chr3_+_142594847 Show fit	4.10	ENSMUST00000029936.4	Gbp2b Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 2b
chr11_-_78984946 Show fit	4.09	ENSMUST00000108268.3	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr3_-_98630309 Show fit	4.02	ENSMUST00000044094.4	Hsd3b5 Ensembl NCBI MGI UniProt Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
chr5_-_92348871 Show fit	4.01	ENSMUST00000038816.6 ENSMUST00000118006.1	Cxcl10 Ensembl NCBI MGI UniProt Show fit	chemokine (C-X-C motif) ligand 10
chr17_+_33919332 Show fit	3.99	ENSMUST00000025161.7	Tapbp Ensembl NCBI MGI UniProt Show fit	TAP binding protein
chr9_+_5345450 Show fit	3.96	ENSMUST00000151332.1	Casp12 Ensembl NCBI MGI UniProt Show fit	caspase 12
chr1_-_153851189 Show fit	3.94	ENSMUST00000059607.6	5830403L16Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 5830403L16 gene
chr4_-_46536096 Show fit	3.94	ENSMUST00000102924.2	Trim14 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 14
chr4_-_46536134 Show fit	3.91	ENSMUST00000046897.6	Trim14 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 14
chr1_-_173490933 Show fit	3.90	ENSMUST00000160565.2	Gm4955 Ensembl NCBI MGI UniProt Show fit	predicted gene 4955
chr9_+_5345414 Show fit	3.88	ENSMUST00000027009.4	Casp12 Ensembl NCBI MGI UniProt Show fit	caspase 12
chr11_+_58215028 Show fit	3.87	ENSMUST00000108836.1	Irgm2 Ensembl NCBI MGI UniProt Show fit	immunity-related GTPase family M member 2
chr8_-_105938384 Show fit	3.84	ENSMUST00000034369.8	Psmb10 Ensembl NCBI MGI UniProt Show fit	proteasome (prosome, macropain) subunit, beta type 10
chr8_-_93279717 Show fit	3.82	ENSMUST00000034178.8	Ces1f Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1F
chr14_-_7994563 Show fit	3.81	ENSMUST00000026315.7	Dnase1l3 Ensembl NCBI MGI UniProt Show fit	deoxyribonuclease 1-like 3
chr18_-_3299537 Show fit	3.75	ENSMUST00000129435.1 ENSMUST00000122958.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr10_-_34127955 Show fit	3.69	ENSMUST00000062784.6	Fam26f Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 26, member F
chr1_+_13668739 Show fit	3.66	ENSMUST00000088542.3	Xkr9 Ensembl NCBI MGI UniProt Show fit	X Kell blood group precursor related family member 9 homolog
chr17_+_37193889 Show fit	3.64	ENSMUST00000038844.6	Ubd Ensembl NCBI MGI UniProt Show fit	ubiquitin D
chr2_+_72054598 Show fit	3.58	ENSMUST00000028525.5	Rapgef4 Ensembl NCBI MGI UniProt Show fit	Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_31218421 Show fit	3.58	ENSMUST00000115107.1	AB041803 Ensembl NCBI MGI UniProt Show fit	cDNA sequence AB041803
chr11_-_78984831 Show fit	3.50	ENSMUST00000073001.4 ENSMUST00000108269.3	Lgals9 Ensembl NCBI MGI UniProt Show fit	lectin, galactose binding, soluble 9
chr6_-_125231772 Show fit	3.48	ENSMUST00000043422.7	Tapbpl Ensembl NCBI MGI UniProt Show fit	TAP binding protein-like
chr13_-_23710714 Show fit	3.46	ENSMUST00000091707.6 ENSMUST00000006787.7 ENSMUST00000091706.6	Hfe Ensembl NCBI MGI UniProt Show fit	hemochromatosis
chr1_-_172590463 Show fit	3.44	ENSMUST00000065679.6	Slamf8 Ensembl NCBI MGI UniProt Show fit	SLAM family member 8
chr6_+_34745952 Show fit	3.41	ENSMUST00000123823.1 ENSMUST00000136907.1 ENSMUST00000126181.1	Cald1 Ensembl NCBI MGI UniProt Show fit	caldesmon 1
chr2_+_68117713 Show fit	3.40	ENSMUST00000112346.2	B3galt1 Ensembl NCBI MGI UniProt Show fit	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_24049389 Show fit	3.38	ENSMUST00000051416.5	Hnmt Ensembl NCBI MGI UniProt Show fit	histamine N-methyltransferase
chr7_+_104244449 Show fit	3.38	ENSMUST00000106849.2 ENSMUST00000060315.5	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr17_+_35439155 Show fit	3.37	ENSMUST00000071951.6 ENSMUST00000078205.7 ENSMUST00000116598.3 ENSMUST00000076256.7	H2-Q7 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 7
chr5_+_67260794 Show fit	3.29	ENSMUST00000161369.1	Tmem33 Ensembl NCBI MGI UniProt Show fit	transmembrane protein 33
chr8_+_70083509 Show fit	3.24	ENSMUST00000007738.9	Hapln4 Ensembl NCBI MGI UniProt Show fit	hyaluronan and proteoglycan link protein 4
chr1_+_156035392 Show fit	3.21	ENSMUST00000111757.3	Tor1aip2 Ensembl NCBI MGI UniProt Show fit	torsin A interacting protein 2
chr7_+_104244465 Show fit	3.21	ENSMUST00000106848.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr2_-_51973219 Show fit	3.19	ENSMUST00000028314.2	Nmi Ensembl NCBI MGI UniProt Show fit	N-myc (and STAT) interactor
chr15_+_75862310 Show fit	3.18	ENSMUST00000023238.4	Gsdmd Ensembl NCBI MGI UniProt Show fit	gasdermin D
chr16_-_35939082 Show fit	3.18	ENSMUST00000081933.7 ENSMUST00000114885.1	Dtx3l Ensembl NCBI MGI UniProt Show fit	deltex 3-like (Drosophila)
chr13_+_51846673 Show fit	3.11	ENSMUST00000021903.2	Gadd45g Ensembl NCBI MGI UniProt Show fit	growth arrest and DNA-damage-inducible 45 gamma
chr7_+_107567445 Show fit	3.11	ENSMUST00000120990.1	Olfml1 Ensembl NCBI MGI UniProt Show fit	olfactomedin-like 1
chr7_+_104244496 Show fit	3.05	ENSMUST00000106854.1 ENSMUST00000143414.1	Trim34a Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 34A
chr3_+_27317028 Show fit	2.96	ENSMUST00000046383.5 ENSMUST00000174840.1	Tnfsf10 Ensembl NCBI MGI UniProt Show fit	tumor necrosis factor (ligand) superfamily, member 10
chr3_+_142530329 Show fit	2.94	ENSMUST00000171263.1 ENSMUST00000045097.9	Gbp7 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 7
chr15_-_76014318 Show fit	2.91	ENSMUST00000060807.5	Fam83h Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 83, member H
chr6_+_124512615 Show fit	2.90	ENSMUST00000068593.7	C1ra Ensembl NCBI MGI UniProt Show fit	complement component 1, r subcomponent A
chr13_+_33004528 Show fit	2.90	ENSMUST00000006391.4	Serpinb9 Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade B, member 9
chr3_+_81932601 Show fit	2.83	ENSMUST00000029649.2	Ctso Ensembl NCBI MGI UniProt Show fit	cathepsin O
chr4_+_135728116 Show fit	2.83	ENSMUST00000102546.3	Il22ra1 Ensembl NCBI MGI UniProt Show fit	interleukin 22 receptor, alpha 1
chr5_-_105139539 Show fit	2.81	ENSMUST00000100961.4 ENSMUST00000031235.6 ENSMUST00000100962.3	Gbp9 Ensembl NCBI MGI UniProt Show fit Gbp8 Ensembl NCBI MGI UniProt Show fit Gbp4 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9 guanylate-binding protein 8 guanylate binding protein 4
chr18_-_3299452 Show fit	2.81	ENSMUST00000126578.1	Crem Ensembl NCBI MGI UniProt Show fit	cAMP responsive element modulator
chr1_-_155146755 Show fit	2.80	ENSMUST00000027744.8	Mr1 Ensembl NCBI MGI UniProt Show fit	major histocompatibility complex, class I-related
chr13_+_74639866 Show fit	2.76	ENSMUST00000169114.1	Erap1 Ensembl NCBI MGI UniProt Show fit	endoplasmic reticulum aminopeptidase 1
chr12_+_37241633 Show fit	2.75	ENSMUST00000049874.7	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr5_-_105110292 Show fit	2.74	ENSMUST00000031238.6	Gbp9 Ensembl NCBI MGI UniProt Show fit	guanylate-binding protein 9
chr2_+_43555321 Show fit	2.70	ENSMUST00000028223.2	Kynu Ensembl NCBI MGI UniProt Show fit	kynureninase (L-kynurenine hydrolase)
chr4_-_40239700 Show fit	2.69	ENSMUST00000142055.1	Ddx58 Ensembl NCBI MGI UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr6_-_38354243 Show fit	2.68	ENSMUST00000114900.1	Zc3hav1 Ensembl NCBI MGI UniProt Show fit	zinc finger CCCH type, antiviral 1
chr19_-_7966000 Show fit	2.68	ENSMUST00000182102.1 ENSMUST00000075619.4	Slc22a27 Ensembl NCBI MGI UniProt Show fit	solute carrier family 22, member 27
chr12_+_37241729 Show fit	2.67	ENSMUST00000160768.1	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr18_+_60293372 Show fit	2.66	ENSMUST00000171297.1	F830016B08Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA F830016B08 gene
chr15_-_76307101 Show fit	2.66	ENSMUST00000171340.1	Oplah Ensembl NCBI MGI UniProt Show fit	5-oxoprolinase (ATP-hydrolysing)
chr5_-_91402905 Show fit	2.64	ENSMUST00000121044.2	Btc Ensembl NCBI MGI UniProt Show fit	betacellulin, epidermal growth factor family member
chr3_-_86999284 Show fit	2.64	ENSMUST00000063869.5 ENSMUST00000029717.2	Cd1d1 Ensembl NCBI MGI UniProt Show fit	CD1d1 antigen
chr16_+_26581704 Show fit	2.63	ENSMUST00000096129.2 ENSMUST00000166294.2 ENSMUST00000174202.1 ENSMUST00000023156.6	Il1rap Ensembl NCBI MGI UniProt Show fit	interleukin 1 receptor accessory protein
chr3_+_142496924 Show fit	2.61	ENSMUST00000090127.2	Gbp5 Ensembl NCBI MGI UniProt Show fit	guanylate binding protein 5
chr9_-_50555170 Show fit	2.60	ENSMUST00000119103.1	Bco2 Ensembl NCBI MGI UniProt Show fit	beta-carotene oxygenase 2
chr10_+_39612934 Show fit	2.59	ENSMUST00000019987.6	Traf3ip2 Ensembl NCBI MGI UniProt Show fit	TRAF3 interacting protein 2
chr8_-_3748941 Show fit	2.58	ENSMUST00000012847.1	Cd209a Ensembl NCBI MGI UniProt Show fit	CD209a antigen
chr2_+_43555342 Show fit	2.57	ENSMUST00000112826.1 ENSMUST00000050511.6	Kynu Ensembl NCBI MGI UniProt Show fit	kynureninase (L-kynurenine hydrolase)
chr1_+_130865669 Show fit	2.57	ENSMUST00000038829.5	Faim3 Ensembl NCBI MGI UniProt Show fit	Fas apoptotic inhibitory molecule 3
chr2_-_126783416 Show fit	2.57	ENSMUST00000130356.1 ENSMUST00000028842.2	Usp50 Ensembl NCBI MGI UniProt Show fit	ubiquitin specific peptidase 50
chr2_+_27676440 Show fit	2.55	ENSMUST00000129514.1	Rxra Ensembl NCBI MGI UniProt Show fit	retinoid X receptor alpha
chr17_+_35262730 Show fit	2.55	ENSMUST00000172785.1	H2-D1 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, D region locus 1
chr17_+_35470083 Show fit	2.51	ENSMUST00000174525.1 ENSMUST00000068291.6	H2-Q10 Ensembl NCBI MGI UniProt Show fit	histocompatibility 2, Q region locus 10
chr12_+_37242030 Show fit	2.50	ENSMUST00000160390.1	Agmo Ensembl NCBI MGI UniProt Show fit	alkylglycerol monooxygenase
chr6_-_54972603 Show fit	2.49	ENSMUST00000060655.8	Nod1 Ensembl NCBI MGI UniProt Show fit	nucleotide-binding oligomerization domain containing 1
chr8_-_111338152 Show fit	2.46	ENSMUST00000056157.7 ENSMUST00000120432.1	Mlkl Ensembl NCBI MGI UniProt Show fit	mixed lineage kinase domain-like
chr14_+_41105359 Show fit	2.46	ENSMUST00000047286.6	Mat1a Ensembl NCBI MGI UniProt Show fit	methionine adenosyltransferase I, alpha
chr10_-_92375367 Show fit	2.40	ENSMUST00000182870.1	Gm20757 Ensembl NCBI MGI UniProt Show fit	predicted gene, 20757
chr19_+_8898090 Show fit	2.39	ENSMUST00000096246.3	Ganab Ensembl NCBI MGI UniProt Show fit	alpha glucosidase 2 alpha neutral subunit
chr17_+_31433054 Show fit	2.37	ENSMUST00000136384.1	Pde9a Ensembl NCBI MGI UniProt Show fit	phosphodiesterase 9A
chr8_-_3878549 Show fit	2.36	ENSMUST00000011445.6	Cd209d Ensembl NCBI MGI UniProt Show fit	CD209d antigen
chr10_+_128270546 Show fit	2.34	ENSMUST00000105238.3 ENSMUST00000085708.2	Stat2 Ensembl NCBI MGI UniProt Show fit	signal transducer and activator of transcription 2
chr8_-_84800024 Show fit	2.34	ENSMUST00000126806.1 ENSMUST00000076715.6	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr19_-_24861828 Show fit	2.34	ENSMUST00000047666.4	Pgm5 Ensembl NCBI MGI UniProt Show fit	phosphoglucomutase 5
chr8_-_84800344 Show fit	2.33	ENSMUST00000099070.3	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr4_+_155582476 Show fit	2.32	ENSMUST00000105612.1	Nadk Ensembl NCBI MGI UniProt Show fit	NAD kinase
chr2_-_77170592 Show fit	2.32	ENSMUST00000164114.2 ENSMUST00000049544.7	Ccdc141 Ensembl NCBI MGI UniProt Show fit	coiled-coil domain containing 141
chr3_+_138313279 Show fit	2.30	ENSMUST00000013455.6 ENSMUST00000106247.1	Adh6a Ensembl NCBI MGI UniProt Show fit	alcohol dehydrogenase 6A (class V)
chr10_+_4611971 Show fit	2.29	ENSMUST00000105590.1 ENSMUST00000067086.7	Esr1 Ensembl NCBI MGI UniProt Show fit	estrogen receptor 1 (alpha)
chr19_-_21472552 Show fit	2.28	ENSMUST00000087600.3	Gda Ensembl NCBI MGI UniProt Show fit	guanine deaminase
chr2_+_19371636 Show fit	2.28	ENSMUST00000023856.8	Msrb2 Ensembl NCBI MGI UniProt Show fit	methionine sulfoxide reductase B2

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.6	38.6	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
7.3	22.0	GO:1990166	protein localization to site of double-strand break(GO:1990166)
4.4	13.1	GO:2000547	regulation of dendritic cell dendrite assembly(GO:2000547)
3.5	3.5	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
3.5	41.6	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
3.3	10.0	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
3.1	176.4	GO:0035456	response to interferon-beta(GO:0035456)
3.1	9.2	GO:0006533	aspartate catabolic process(GO:0006533)
2.9	8.7	GO:1902524	positive regulation of protein K48-linked ubiquitination(GO:1902524)
2.9	17.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
2.8	8.3	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
2.1	2.1	GO:1904933	regulation of cell proliferation in midbrain(GO:1904933)
2.0	12.2	GO:0035549	interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)
2.0	10.0	GO:1904721	regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.9	17.1	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
1.8	9.0	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
1.6	4.9	GO:0072734	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.6	6.4	GO:1903896	positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.5	4.5	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
1.5	11.9	GO:1990504	dense core granule exocytosis(GO:1990504)
1.5	1.5	GO:0002488	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
1.4	4.3	GO:0009753	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.3	5.3	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
1.3	3.8	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
1.1	3.4	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
1.1	7.9	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0	2.9	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.9	3.6	GO:1904457	positive regulation of neuronal action potential(GO:1904457)
0.9	3.5	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.9	70.7	GO:0034341	response to interferon-gamma(GO:0034341)
0.8	2.5	GO:0018900	dichloromethane metabolic process(GO:0018900)
0.8	13.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.8	14.5	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.8	2.3	GO:0046098	guanine metabolic process(GO:0046098)
0.7	6.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.7	8.1	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.7	4.4	GO:1900170	negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.7	9.5	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.7	3.4	GO:1902623	leukocyte chemotaxis involved in inflammatory response(GO:0002232) negative regulation of neutrophil migration(GO:1902623)
0.7	2.0	GO:0071211	protein targeting to vacuole involved in autophagy(GO:0071211)
0.7	5.2	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.7	2.0	GO:0060809	CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.6	8.0	GO:0097264	self proteolysis(GO:0097264)
0.6	2.5	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.6	1.8	GO:0045013	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.6	1.1	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.6	2.3	GO:0030091	protein repair(GO:0030091)
0.6	1.7	GO:1903538	meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.6	1.7	GO:0002014	vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.5	1.6	GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.5	6.5	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.5	2.1	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.5	1.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.5	2.1	GO:0071449	cellular response to lipid hydroperoxide(GO:0071449)
0.5	2.6	GO:0006447	regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.5	8.0	GO:0046485	ether lipid metabolic process(GO:0046485)
0.5	1.5	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.5	3.4	GO:0052805	imidazole-containing compound catabolic process(GO:0052805)
0.5	9.0	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.5	1.4	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.4	0.4	GO:1990009	retinal cell apoptotic process(GO:1990009)
0.4	17.7	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.4	3.5	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.4	2.2	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.4	2.2	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.4	2.5	GO:0003383	apical constriction(GO:0003383)
0.4	11.5	GO:0035634	response to stilbenoid(GO:0035634)
0.4	1.2	GO:0032474	otolith morphogenesis(GO:0032474) otolith development(GO:0048840)
0.4	0.8	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.4	2.3	GO:0006741	NADP biosynthetic process(GO:0006741)
0.4	0.8	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.4	1.1	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.4	12.2	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4	2.3	GO:0060751	Sertoli cell proliferation(GO:0060011) prostate epithelial cord elongation(GO:0060523) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.4	1.5	GO:0010901	negative regulation of cytokine secretion involved in immune response(GO:0002740) regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.4	1.5	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.4	3.8	GO:0042095	interferon-gamma biosynthetic process(GO:0042095)
0.4	10.2	GO:0017144	drug metabolic process(GO:0017144)
0.4	1.1	GO:0006011	UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.4	0.7	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.4	0.7	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.3	1.0	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.3	1.4	GO:0032385	positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373)
0.3	1.7	GO:0060455	negative regulation of gastric acid secretion(GO:0060455)
0.3	1.0	GO:0061763	multivesicular body-lysosome fusion(GO:0061763)
0.3	7.9	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.3	2.6	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.3	0.9	GO:0048698	negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.3	2.8	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3	1.8	GO:0044375	regulation of peroxisome size(GO:0044375)
0.3	0.9	GO:0002223	stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.3	0.3	GO:2000836	positive regulation of androgen secretion(GO:2000836)
0.3	2.1	GO:0072086	specification of loop of Henle identity(GO:0072086)
0.3	2.6	GO:0072602	interleukin-4 secretion(GO:0072602)
0.3	2.0	GO:0051138	positive regulation of NK T cell differentiation(GO:0051138)
0.3	1.4	GO:0070495	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3	1.7	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.3	1.1	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.3	0.5	GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.3	1.6	GO:0051204	protein insertion into mitochondrial membrane(GO:0051204)
0.3	1.3	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.3	1.6	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.3	2.6	GO:0035810	positive regulation of urine volume(GO:0035810)
0.3	1.6	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
0.3	0.8	GO:1905051	regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053)
0.3	4.3	GO:0010623	programmed cell death involved in cell development(GO:0010623)
0.3	13.2	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
0.3	1.8	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.3	7.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.2	2.2	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.2	2.2	GO:0032494	response to peptidoglycan(GO:0032494)
0.2	1.0	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.2	0.7	GO:0006553	lysine metabolic process(GO:0006553)
0.2	1.7	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.2	1.2	GO:0019348	dolichol metabolic process(GO:0019348)
0.2	0.7	GO:0060220	camera-type eye photoreceptor cell fate commitment(GO:0060220) negative regulation of neural retina development(GO:0061076) negative regulation of retina development in camera-type eye(GO:1902867) negative regulation of amacrine cell differentiation(GO:1902870)
0.2	0.2	GO:0018307	enzyme active site formation(GO:0018307)
0.2	0.7	GO:1901026	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.2	1.4	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.2	2.9	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2	0.2	GO:2000793	cell proliferation involved in heart valve development(GO:2000793)
0.2	0.4	GO:0071316	cellular response to nicotine(GO:0071316)
0.2	1.2	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.2	1.2	GO:0015889	cobalamin transport(GO:0015889)
0.2	0.4	GO:1905169	protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2	1.5	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.2	0.2	GO:2000911	positive regulation of cholesterol import(GO:1904109) positive regulation of sterol import(GO:2000911)
0.2	0.9	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2	0.4	GO:0070933	histone H4 deacetylation(GO:0070933)
0.2	1.7	GO:0071763	nuclear membrane organization(GO:0071763)
0.2	1.8	GO:0014029	neural crest formation(GO:0014029)
0.2	1.8	GO:0032815	negative regulation of natural killer cell activation(GO:0032815)
0.2	1.4	GO:0097475	motor neuron migration(GO:0097475)
0.2	1.8	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2	1.1	GO:0033227	dsRNA transport(GO:0033227)
0.2	0.5	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.2	0.7	GO:0006624	vacuolar protein processing(GO:0006624)
0.2	0.9	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.2	0.7	GO:0034769	basement membrane disassembly(GO:0034769)
0.2	0.7	GO:0043328	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.2	0.8	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.2	3.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.2	2.5	GO:2000778	positive regulation of interleukin-6 secretion(GO:2000778)
0.2	0.8	GO:0098886	modification of dendritic spine(GO:0098886)
0.2	0.3	GO:0048687	positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.2	0.5	GO:0051030	RNA import into nucleus(GO:0006404) snRNA transport(GO:0051030)
0.2	7.8	GO:0019882	antigen processing and presentation(GO:0019882)
0.2	0.5	GO:1902966	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2	2.4	GO:0033327	Leydig cell differentiation(GO:0033327)
0.2	0.5	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.2	0.5	GO:1902037	negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.2	0.6	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.2	0.8	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.2	2.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.1	1.9	GO:0032836	glomerular basement membrane development(GO:0032836)
0.1	1.5	GO:0021678	third ventricle development(GO:0021678)
0.1	0.9	GO:1901317	regulation of sperm motility(GO:1901317)
0.1	1.5	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	1.2	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.1	2.4	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.1	5.5	GO:0051642	centrosome localization(GO:0051642)
0.1	1.1	GO:0035902	response to immobilization stress(GO:0035902)
0.1	1.9	GO:0019321	pentose metabolic process(GO:0019321)
0.1	4.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	1.6	GO:0070932	histone H3 deacetylation(GO:0070932)
0.1	1.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.1	0.4	GO:0071288	substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) cellular response to mercury ion(GO:0071288)
0.1	2.4	GO:0006491	N-glycan processing(GO:0006491)
0.1	1.3	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.1	1.6	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.1	0.4	GO:0003360	brainstem development(GO:0003360)
0.1	0.5	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1	1.9	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.1	3.0	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1	1.2	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	1.0	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.1	15.3	GO:0019395	fatty acid oxidation(GO:0019395)
0.1	0.5	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1	2.6	GO:0061462	protein localization to lysosome(GO:0061462)
0.1	1.5	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.1	4.3	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1	0.8	GO:0060613	fat pad development(GO:0060613)
0.1	2.2	GO:0046931	pore complex assembly(GO:0046931)
0.1	1.3	GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.1	4.5	GO:0070207	protein homotrimerization(GO:0070207)
0.1	1.4	GO:0051967	negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1	19.0	GO:0007286	spermatid development(GO:0007286)
0.1	1.0	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
0.1	0.3	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1	1.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	0.7	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.1	0.7	GO:0039019	pronephric nephron development(GO:0039019)
0.1	0.3	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	1.5	GO:0015747	urate transport(GO:0015747)
0.1	0.7	GO:0007296	vitellogenesis(GO:0007296)
0.1	0.7	GO:0016266	O-glycan processing(GO:0016266)
0.1	0.7	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	0.4	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.1	1.7	GO:0008053	mitochondrial fusion(GO:0008053)
0.1	0.8	GO:0048245	mast cell chemotaxis(GO:0002551) eosinophil chemotaxis(GO:0048245)
0.1	0.8	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.1	0.7	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.1	0.5	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.1	0.3	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.1	0.5	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	0.8	GO:0033133	positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.1	0.5	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
0.1	0.5	GO:0060278	regulation of ovulation(GO:0060278)
0.1	0.8	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.1	0.8	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.1	1.0	GO:0031953	negative regulation of protein autophosphorylation(GO:0031953)
0.1	2.1	GO:0019433	triglyceride catabolic process(GO:0019433)
0.1	1.9	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.1	0.6	GO:0006983	ER overload response(GO:0006983)
0.1	1.1	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.3	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.1	10.8	GO:0016052	carbohydrate catabolic process(GO:0016052)
0.1	1.4	GO:0046069	cGMP catabolic process(GO:0046069)
0.1	0.6	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.1	1.2	GO:0072189	ureter development(GO:0072189)
0.1	0.4	GO:0090168	Golgi reassembly(GO:0090168)
0.1	1.7	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1	0.2	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.1	0.9	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1	0.4	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.1	0.5	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.7	GO:0007343	egg activation(GO:0007343)
0.1	0.4	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.2	GO:0021852	pyramidal neuron migration(GO:0021852)
0.1	0.5	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1	1.0	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1	1.3	GO:0051923	sulfation(GO:0051923)
0.1	0.6	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.1	2.8	GO:0044380	protein localization to cytoskeleton(GO:0044380)
0.1	1.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	0.2	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.1	0.7	GO:0006450	regulation of translational fidelity(GO:0006450)
0.1	0.6	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.1	0.7	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1	3.0	GO:0006695	cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.1	4.5	GO:0006637	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1	0.9	GO:0008298	intracellular mRNA localization(GO:0008298)
0.1	0.4	GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1	0.7	GO:1990403	embryonic brain development(GO:1990403)
0.1	0.4	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.1	0.6	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996) regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.1	0.9	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.1	0.6	GO:0009062	fatty acid catabolic process(GO:0009062)
0.1	1.2	GO:0015813	L-glutamate transport(GO:0015813)
0.1	2.4	GO:0010390	histone monoubiquitination(GO:0010390)
0.1	1.6	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1	0.1	GO:0060025	regulation of synaptic activity(GO:0060025)
0.1	0.7	GO:1902170	cellular response to reactive nitrogen species(GO:1902170)
0.1	2.2	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.1	0.3	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.1	0.8	GO:0043248	proteasome assembly(GO:0043248)
0.1	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.1	0.1	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.1	0.5	GO:0002755	MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.1	0.4	GO:0015808	L-alanine transport(GO:0015808)
0.1	1.0	GO:0032689	negative regulation of interferon-gamma production(GO:0032689)
0.1	0.2	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.4	GO:0031987	locomotion involved in locomotory behavior(GO:0031987)
0.0	0.3	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.0	0.5	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.9	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.5	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.3	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.4	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.2	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0	0.8	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:1903999	regulation of eating behavior(GO:1903998) negative regulation of eating behavior(GO:1903999) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.0	0.9	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	1.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.3	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	0.2	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.5	GO:0022904	respiratory electron transport chain(GO:0022904)
0.0	0.3	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	3.0	GO:0030193	regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0	0.4	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	1.0	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	5.8	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0	1.0	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.0	3.4	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.4	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.3	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	2.0	GO:0006749	glutathione metabolic process(GO:0006749)
0.0	0.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.5	GO:1903541	regulation of exosomal secretion(GO:1903541) positive regulation of exosomal secretion(GO:1903543)
0.0	0.6	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.8	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.2	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.9	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.8	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.9	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	1.1	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	2.3	GO:0006006	glucose metabolic process(GO:0006006)
0.0	0.1	GO:0021623	oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.0	0.6	GO:0007143	female meiotic division(GO:0007143)
0.0	1.0	GO:0006360	transcription from RNA polymerase I promoter(GO:0006360)
0.0	0.0	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.7	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	1.1	GO:0061001	regulation of dendritic spine morphogenesis(GO:0061001)
0.0	0.9	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.0	0.1	GO:0051096	regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0	0.2	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	6.1	GO:0009116	nucleoside metabolic process(GO:0009116)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.2	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.0	0.3	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.2	GO:1904219	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.2	GO:1902306	negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.2	GO:0045779	negative regulation of bone resorption(GO:0045779)
0.0	0.4	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.8	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.6	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.2	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.1	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	0.2	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.3	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.0	1.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923)
0.0	0.2	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.0	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0006583	melanin biosynthetic process from tyrosine(GO:0006583)
0.0	0.3	GO:0009072	aromatic amino acid family metabolic process(GO:0009072)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.2	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654) regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:0090272	negative regulation of fibroblast growth factor production(GO:0090272)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	0.0	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:2000381	negative regulation of mesoderm development(GO:2000381)
0.0	0.3	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	58.2	GO:0020003	symbiont-containing vacuole(GO:0020003)
2.7	32.3	GO:0042612	MHC class I protein complex(GO:0042612)
2.2	11.2	GO:1990111	spermatoproteasome complex(GO:1990111)
2.1	17.0	GO:0042825	TAP complex(GO:0042825)
1.6	6.5	GO:0097447	dendritic tree(GO:0097447)
1.1	8.6	GO:0045098	type III intermediate filament(GO:0045098)
0.9	14.1	GO:0044754	autolysosome(GO:0044754)
0.9	38.6	GO:0055038	recycling endosome membrane(GO:0055038)
0.9	5.2	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.9	7.8	GO:0030478	actin cap(GO:0030478)
0.7	3.6	GO:0044316	cone cell pedicle(GO:0044316)
0.6	1.1	GO:0030870	Mre11 complex(GO:0030870)
0.5	2.3	GO:0005914	spot adherens junction(GO:0005914)
0.4	2.6	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.4	3.5	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.4	1.2	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.4	17.0	GO:0035861	site of double-strand break(GO:0035861)
0.4	1.9	GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3	2.3	GO:0097550	transcriptional preinitiation complex(GO:0097550)
0.3	1.9	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3	2.5	GO:0033269	internode region of axon(GO:0033269)
0.3	2.2	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.3	2.2	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.3	1.5	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.3	3.0	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.3	1.2	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.3	1.5	GO:0071986	Ragulator complex(GO:0071986)
0.3	0.8	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.3	1.0	GO:0043202	lysosomal lumen(GO:0043202)
0.2	2.4	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.2	23.0	GO:0042734	presynaptic membrane(GO:0042734)
0.2	0.7	GO:0043540	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2	0.7	GO:0000814	ESCRT II complex(GO:0000814)
0.2	0.9	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.2	6.8	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.2	2.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.2	1.2	GO:0045293	mRNA editing complex(GO:0045293)
0.2	3.6	GO:0016235	aggresome(GO:0016235)
0.2	1.4	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.2	2.4	GO:0042611	MHC protein complex(GO:0042611)
0.2	1.0	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.2	0.9	GO:0072487	MSL complex(GO:0072487)
0.2	0.8	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2	1.2	GO:0070695	FHF complex(GO:0070695)
0.1	6.5	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	0.4	GO:0043512	inhibin A complex(GO:0043512)
0.1	1.2	GO:0005839	proteasome core complex(GO:0005839)
0.1	1.7	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.1	3.2	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	2.4	GO:0043186	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1	1.0	GO:0000439	core TFIIH complex(GO:0000439)
0.1	0.4	GO:0044307	dendritic branch(GO:0044307)
0.1	1.2	GO:0005579	membrane attack complex(GO:0005579)
0.1	16.6	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.1	1.7	GO:0043196	varicosity(GO:0043196)
0.1	1.4	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	50.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	17.1	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	0.4	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110) CNTFR-CLCF1 complex(GO:0097059)
0.1	3.0	GO:0045095	keratin filament(GO:0045095)
0.1	0.4	GO:0002111	BRCA2-BRAF35 complex(GO:0002111)
0.1	1.6	GO:0031527	filopodium membrane(GO:0031527)
0.1	0.3	GO:0071942	XPC complex(GO:0071942)
0.1	1.8	GO:0005922	connexon complex(GO:0005922)
0.1	0.5	GO:0051286	cell tip(GO:0051286)
0.1	0.2	GO:1990462	omegasome(GO:1990462)
0.1	0.4	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.1	5.5	GO:0005811	lipid particle(GO:0005811)
0.1	10.6	GO:0072562	blood microparticle(GO:0072562)
0.1	1.2	GO:0000124	SAGA complex(GO:0000124)
0.1	3.2	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	1.0	GO:0017119	Golgi transport complex(GO:0017119)
0.1	1.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1	1.3	GO:0009925	basal plasma membrane(GO:0009925)
0.1	0.8	GO:0045179	apical cortex(GO:0045179)
0.1	1.4	GO:0033270	paranode region of axon(GO:0033270)
0.1	0.4	GO:0001520	outer dense fiber(GO:0001520)
0.1	0.6	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.1	0.3	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	0.5	GO:0030061	mitochondrial crista(GO:0030061)
0.1	0.5	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	0.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.4	GO:0042587	glycogen granule(GO:0042587)
0.1	1.7	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	6.0	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	0.2	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	1.2	GO:0002080	acrosomal membrane(GO:0002080)
0.0	1.6	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.5	GO:0005642	annulate lamellae(GO:0005642)
0.0	20.4	GO:0045177	apical part of cell(GO:0045177)
0.0	0.5	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.2	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	2.1	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	5.6	GO:0005923	bicellular tight junction(GO:0005923)
0.0	6.4	GO:0005770	late endosome(GO:0005770)
0.0	0.7	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.9	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.4	GO:0031931	TORC1 complex(GO:0031931)
0.0	3.9	GO:0005604	basement membrane(GO:0005604)
0.0	2.4	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	0.7	GO:0045277	respiratory chain complex IV(GO:0045277)
0.0	0.2	GO:0097441	basilar dendrite(GO:0097441)
0.0	2.4	GO:0031301	integral component of organelle membrane(GO:0031301)
0.0	0.9	GO:0030175	filopodium(GO:0030175)
0.0	27.3	GO:0005783	endoplasmic reticulum(GO:0005783)
0.0	0.3	GO:0070069	cytochrome complex(GO:0070069)
0.0	1.6	GO:0030662	coated vesicle membrane(GO:0030662)
0.0	0.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.5	GO:0033176	proton-transporting V-type ATPase complex(GO:0033176)
0.0	3.4	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	0.4	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0036156	inner dynein arm(GO:0036156)
0.0	7.7	GO:0031966	mitochondrial membrane(GO:0031966)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	1.4	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	4.6	GO:0043235	receptor complex(GO:0043235)
0.0	2.6	GO:0000139	Golgi membrane(GO:0000139)
0.0	66.1	GO:0005829	cytosol(GO:0005829)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.6	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.2	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	26.7	GO:0005615	extracellular space(GO:0005615)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	2.1	GO:0031965	nuclear membrane(GO:0031965)
0.0	0.2	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.4	GO:0005902	microvillus(GO:0005902)
0.0	1.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.9	GO:0000922	spindle pole(GO:0000922)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.5	GO:0055037	recycling endosome(GO:0055037)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.2	15.5	GO:0003692	left-handed Z-DNA binding(GO:0003692)
3.9	39.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)
2.6	7.9	GO:0050479	glyceryl-ether monooxygenase activity(GO:0050479)
2.4	22.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
2.4	17.0	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
2.4	16.7	GO:0004556	alpha-amylase activity(GO:0004556)
2.3	9.2	GO:0003884	D-amino-acid oxidase activity(GO:0003884)
2.2	8.6	GO:0031849	olfactory receptor binding(GO:0031849)
2.0	24.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
2.0	11.9	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
1.7	6.9	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
1.7	8.6	GO:0004850	uridine phosphorylase activity(GO:0004850)
1.7	10.0	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
1.4	4.3	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
1.4	4.3	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
1.4	4.1	GO:0019002	GMP binding(GO:0019002)
1.3	5.3	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
1.3	7.9	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
1.1	7.6	GO:0016936	galactoside binding(GO:0016936)
1.1	4.3	GO:0003844	1,4-alpha-glucan branching enzyme activity(GO:0003844)
1.0	38.3	GO:0008009	chemokine activity(GO:0008009)
1.0	10.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.0	10.8	GO:0050700	CARD domain binding(GO:0050700)
1.0	9.6	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.9	7.5	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.9	13.9	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.9	13.8	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.9	4.4	GO:0004883	glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.9	1.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.8	3.4	GO:0047275	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8	2.5	GO:0047651	hydrolase activity, acting on acid halide bonds(GO:0016824) hydrolase activity, acting on acid halide bonds, in C-halide compounds(GO:0019120) alkylhalidase activity(GO:0047651)
0.8	2.5	GO:0042015	interleukin-20 binding(GO:0042015)
0.8	18.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.8	2.3	GO:0031798	type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.7	2.0	GO:0004658	propionyl-CoA carboxylase activity(GO:0004658)
0.7	7.4	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7	2.6	GO:0002114	interleukin-33 receptor activity(GO:0002114)
0.7	5.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.6	1.9	GO:0019150	D-ribulokinase activity(GO:0019150)
0.6	1.9	GO:0005118	sevenless binding(GO:0005118)
0.6	4.5	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.6	15.4	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6	2.9	GO:1990254	keratin filament binding(GO:1990254)
0.5	2.2	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.5	6.5	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.5	1.5	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.5	1.5	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.5	3.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.4	2.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.4	8.9	GO:0042605	peptide antigen binding(GO:0042605)
0.4	0.8	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.4	2.3	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.4	2.7	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.4	1.4	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4	3.2	GO:1901612	cardiolipin binding(GO:1901612)
0.3	1.0	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.3	1.4	GO:1904121	propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121)
0.3	1.4	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.3	2.8	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.3	5.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.3	2.4	GO:0015288	porin activity(GO:0015288)
0.3	2.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3	2.3	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.3	1.3	GO:0045131	pre-mRNA branch point binding(GO:0045131)
0.3	2.8	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.3	8.1	GO:0005521	lamin binding(GO:0005521)
0.3	2.1	GO:0070699	type II activin receptor binding(GO:0070699)
0.3	1.2	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.3	4.0	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.3	2.3	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.3	92.1	GO:0003924	GTPase activity(GO:0003924)
0.3	0.8	GO:0001716	L-amino-acid oxidase activity(GO:0001716)
0.3	2.0	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.3	8.3	GO:0001671	ATPase activator activity(GO:0001671)
0.3	7.4	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3	4.5	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3	1.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2	1.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.2	0.7	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.2	4.7	GO:0005537	mannose binding(GO:0005537)
0.2	1.6	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.2	0.9	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2	0.9	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.2	1.7	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2	4.5	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2	1.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.2	2.9	GO:0019203	carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.2	5.4	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.2	0.6	GO:0005110	frizzled-2 binding(GO:0005110)
0.2	1.2	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2	3.6	GO:0070628	proteasome binding(GO:0070628)
0.2	0.6	GO:0050145	nucleoside phosphate kinase activity(GO:0050145)
0.2	16.5	GO:0003725	double-stranded RNA binding(GO:0003725)
0.2	0.4	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.2	0.8	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2	0.7	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.2	1.3	GO:0001642	group III metabotropic glutamate receptor activity(GO:0001642)
0.2	0.5	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.2	0.5	GO:0070052	collagen V binding(GO:0070052)
0.2	2.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.2	1.1	GO:0032557	pyrimidine ribonucleotide binding(GO:0032557)
0.1	0.7	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.1	2.4	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1	1.0	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	3.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.4	GO:0005302	L-tyrosine transmembrane transporter activity(GO:0005302)
0.1	1.2	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.1	0.5	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.1	0.5	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	1.2	GO:0031419	cobalamin binding(GO:0031419)
0.1	0.5	GO:0008147	structural constituent of bone(GO:0008147)
0.1	0.4	GO:0033038	bitter taste receptor activity(GO:0033038)
0.1	0.4	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.1	1.9	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.6	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.1	15.3	GO:0004497	monooxygenase activity(GO:0004497)
0.1	0.6	GO:0034584	piRNA binding(GO:0034584)
0.1	1.6	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1	0.5	GO:0043758	acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1	0.5	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	2.3	GO:0003951	NAD+ kinase activity(GO:0003951)
0.1	0.4	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	18.7	GO:0042826	histone deacetylase binding(GO:0042826)
0.1	1.4	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	1.7	GO:0051400	BH domain binding(GO:0051400)
0.1	1.8	GO:0017166	vinculin binding(GO:0017166)
0.1	0.9	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1	0.4	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	1.6	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.1	0.7	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.1	0.7	GO:0001515	opioid peptide activity(GO:0001515)
0.1	1.5	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.1	0.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	0.5	GO:0061133	endopeptidase activator activity(GO:0061133)
0.1	2.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.1	1.0	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1	0.6	GO:0034046	poly(G) binding(GO:0034046)
0.1	4.7	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1	4.2	GO:0030552	cAMP binding(GO:0030552)
0.1	1.1	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.1	4.0	GO:0030332	cyclin binding(GO:0030332)
0.1	0.7	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.1	2.1	GO:0071837	HMG box domain binding(GO:0071837)
0.1	2.3	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1	0.8	GO:0019957	C-C chemokine binding(GO:0019957)
0.1	0.2	GO:0004140	dephospho-CoA kinase activity(GO:0004140)
0.1	0.6	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	0.3	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.1	2.8	GO:0005044	scavenger receptor activity(GO:0005044)
0.1	2.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	13.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	0.9	GO:0042288	MHC class I protein binding(GO:0042288)
0.1	0.3	GO:0005093	Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1	0.4	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	0.2	GO:0008176	tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.1	0.4	GO:0045340	mercury ion binding(GO:0045340)
0.1	0.6	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1	1.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	16.4	GO:0001047	core promoter binding(GO:0001047)
0.1	1.7	GO:0005542	folic acid binding(GO:0005542)
0.1	0.3	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	2.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.1	0.4	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.1	0.4	GO:0000400	four-way junction DNA binding(GO:0000400)
0.1	0.9	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.1	5.5	GO:0101005	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1	2.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	1.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.1	2.5	GO:0043531	ADP binding(GO:0043531)
0.1	3.4	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.1	0.2	GO:0004471	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.1	0.4	GO:0032184	SUMO polymer binding(GO:0032184)
0.1	0.7	GO:0002161	aminoacyl-tRNA editing activity(GO:0002161)
0.0	0.4	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.8	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.7	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	1.0	GO:0008276	protein methyltransferase activity(GO:0008276)
0.0	0.2	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	2.0	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.4	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.7	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.9	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	3.2	GO:0005518	collagen binding(GO:0005518)
0.0	0.2	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	1.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.7	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	3.5	GO:0008170	N-methyltransferase activity(GO:0008170)
0.0	1.2	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	2.3	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.4	GO:0032795	heterotrimeric G-protein binding(GO:0032795)
0.0	0.2	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.5	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.6	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.5	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	2.0	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.2	GO:0005042	netrin receptor activity(GO:0005042)
0.0	1.0	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.8	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.5	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	1.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.0	0.1	GO:0031531	thyrotropin-releasing hormone receptor binding(GO:0031531)
0.0	0.2	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.2	GO:0098821	BMP receptor activity(GO:0098821)
0.0	1.5	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.6	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.8	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.8	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.7	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	2.2	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	1.1	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	2.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	1.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.0	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.2	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	2.3	GO:0019905	syntaxin binding(GO:0019905)
0.0	0.2	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	1.7	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.2	GO:0001158	enhancer sequence-specific DNA binding(GO:0001158)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.2	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.2	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.5	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	2.5	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
0.0	0.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.4	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	0.1	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	1.4	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	8.0	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0	0.1	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.2	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.6	GO:0051087	chaperone binding(GO:0051087)
0.0	2.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	11.4	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.5	13.7	ST G ALPHA S PATHWAY	G alpha s Pathway
0.4	29.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	39.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	16.8	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.3	13.9	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.2	2.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	0.6	PID IL27 PATHWAY	IL27-mediated signaling events
0.1	9.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	5.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	6.3	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	3.4	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	3.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	4.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.1	1.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	2.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	3.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	1.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	1.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	5.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	6.1	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.1	2.3	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	4.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	0.5	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	1.4	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	2.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	10.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	1.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	0.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	1.5	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	4.7	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	1.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.8	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.7	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.3	PID SHP2 PATHWAY	SHP2 signaling
0.0	1.7	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	1.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	0.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	3.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	1.2	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.7	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	3.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.7	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.9	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.4	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.4	PID P73PATHWAY	p73 transcription factor network
0.0	0.5	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	0.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.4	PID ILK PATHWAY	Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.1	12.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
1.1	21.7	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
1.0	13.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.9	16.8	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.8	15.5	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.8	14.7	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.7	15.3	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.6	27.0	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	2.2	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.5	15.7	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5	5.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.5	6.0	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.4	20.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	9.7	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.4	7.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.3	15.5	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3	3.3	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.3	2.4	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.3	1.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	3.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.2	6.2	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.2	10.2	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.2	1.9	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	1.5	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.2	7.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	15.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	1.9	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1	1.6	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	2.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1	2.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	0.7	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	9.7	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1	2.0	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	1.0	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	0.8	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	4.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	2.5	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	2.9	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	0.9	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	8.5	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	0.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.5	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	2.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.1	2.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	1.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.1	1.5	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	2.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.5	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.1	0.5	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	4.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	1.7	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1	1.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1	0.5	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1	0.8	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	2.6	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	0.3	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	1.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	2.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	0.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	5.0	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	1.1	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.6	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	2.2	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0	2.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.3	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.9	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.9	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.4	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.6	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0	0.6	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	1.0	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	1.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	1.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.5	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.7	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.4	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.9	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	1.0	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.6	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.5	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.4	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	1.0	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	2.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.87

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: