ISMARA results: Mybl1

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Mybl1

Z-value: 3.01

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Transcription factors associated with Mybl1

Gene Symbol	Gene ID	Gene Info
Mybl1 Ensembl NCBI MGI UniProt	ENSMUSG00000025912.10	myeloblastosis oncogene-like 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Mybl1	mm10_v2_chr1_-_9700209_9700329	0.46	5.0e-03	Click!

Activity profile of Mybl1 motif

Sorted Z-values of Mybl1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_79886302 Show fit	22.74	ENSMUST00000046091.5	Elane Ensembl NCBI MGI UniProt Show fit	elastase, neutrophil expressed
chr19_-_11640828 Show fit	21.71	ENSMUST00000112984.2	Ms4a3 Ensembl NCBI MGI UniProt Show fit	membrane-spanning 4-domains, subfamily A, member 3
chr14_-_56102458 Show fit	17.85	ENSMUST00000015583.1	Ctsg Ensembl NCBI MGI UniProt Show fit	cathepsin G
chr11_+_87793722 Show fit	17.12	ENSMUST00000143021.2	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr11_+_87793470 Show fit	16.17	ENSMUST00000020779.4	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr11_+_58918004 Show fit	15.52	ENSMUST00000108818.3 ENSMUST00000020792.5	Btnl10 Ensembl NCBI MGI UniProt Show fit	butyrophilin-like 10
chr4_-_119189949 Show fit	15.20	ENSMUST00000124626.1	Ermap Ensembl NCBI MGI UniProt Show fit	erythroblast membrane-associated protein
chr4_-_46413486 Show fit	13.87	ENSMUST00000071096.2	Hemgn Ensembl NCBI MGI UniProt Show fit	hemogen
chr11_+_58640394 Show fit	13.51	ENSMUST00000075084.4	Trim58 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 58
chr8_+_94172618 Show fit	12.92	ENSMUST00000034214.6	Mt2 Ensembl NCBI MGI UniProt Show fit	metallothionein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.1	33.3	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
3.9	27.0	GO:0070942	neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
1.3	23.1	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
7.6	22.7	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079) neutrophil mediated killing of fungus(GO:0070947)
0.2	18.2	GO:0051225	spindle assembly(GO:0051225)
0.2	15.0	GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.4	14.0	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	13.6	GO:0051301	cell division(GO:0051301)
1.8	12.9	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
2.1	12.6	GO:0006868	glutamine transport(GO:0006868)

Showing 1 to 10 of 286 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	33.0	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.8	28.9	GO:0035371	microtubule plus-end(GO:0035371)
0.2	22.1	GO:0017053	transcriptional repressor complex(GO:0017053)
0.2	21.6	GO:0036126	sperm flagellum(GO:0036126)
0.0	17.5	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2	14.9	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	14.5	GO:0005925	focal adhesion(GO:0005925)
1.8	14.4	GO:0005833	hemoglobin complex(GO:0005833)
0.1	9.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	9.5	GO:0005913	cell-cell adherens junction(GO:0005913)

Showing 1 to 10 of 142 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	33.3	GO:0004601	peroxidase activity(GO:0004601)
0.7	28.1	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.1	22.8	GO:0008201	heparin binding(GO:0008201)
0.1	21.1	GO:0004386	helicase activity(GO:0004386)
0.1	16.8	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	13.1	GO:0003682	chromatin binding(GO:0003682)
2.5	12.6	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.2	11.7	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.1	11.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.0	10.0	GO:0043532	angiostatin binding(GO:0043532)

Showing 1 to 10 of 186 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	33.0	PID IL23 PATHWAY	IL23-mediated signaling events
0.6	30.2	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3	19.1	PID PLK1 PATHWAY	PLK1 signaling events
0.3	13.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.3	10.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	10.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	10.2	PID E2F PATHWAY	E2F transcription factor network
0.0	6.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	5.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	5.7	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	43.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.4	39.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.5	14.0	REACTOME KINESINS	Genes involved in Kinesins
0.1	12.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.3	11.0	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.3	10.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	10.1	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	9.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	9.0	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.5	8.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway

Showing 1 to 10 of 87 entries

Results for Mybl1

Z-value: 3.01

Motif logo

Transcription factors associated with Mybl1

Activity-expression correlation:

Activity profile of Mybl1 motif

Sorted Z-values of Mybl1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mybl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: