ISMARA results: Myod1

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Myod1

Z-value: 2.30

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Transcription factors associated with Myod1

Gene Symbol	Gene ID	Gene Info
Myod1 Ensembl NCBI MGI UniProt	ENSMUSG00000009471.3	myogenic differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Myod1	mm10_v2_chr7_+_46376467_46376480	0.67	8.7e-06	Click!

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_23139064 Show fit	30.79	ENSMUST00000033947.8	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr8_+_23139030 Show fit	28.96	ENSMUST00000121075.1	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr11_+_58640394 Show fit	16.64	ENSMUST00000075084.4	Trim58 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 58
chr12_+_109459843 Show fit	11.48	ENSMUST00000173812.1	Dlk1 Ensembl NCBI MGI UniProt Show fit	delta-like 1 homolog (Drosophila)
chr8_+_23139157 Show fit	10.66	ENSMUST00000174435.1	Ank1 Ensembl NCBI MGI UniProt Show fit	ankyrin 1, erythroid
chr1_-_132390301 Show fit	10.56	ENSMUST00000132435.1	Tmcc2 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 2
chr2_-_170406501 Show fit	10.48	ENSMUST00000154650.1	Bcas1 Ensembl NCBI MGI UniProt Show fit	breast carcinoma amplified sequence 1
chr7_+_142441808 Show fit	10.29	ENSMUST00000105971.1 ENSMUST00000145287.1	Tnni2 Ensembl NCBI MGI UniProt Show fit	troponin I, skeletal, fast 2
chr12_-_76709997 Show fit	10.19	ENSMUST00000166101.1	Sptb Ensembl NCBI MGI UniProt Show fit	spectrin beta, erythrocytic
chr17_+_36869567 Show fit	10.02	ENSMUST00000060524.9	Trim10 Ensembl NCBI MGI UniProt Show fit	tripartite motif-containing 10

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	81.5	GO:0006779	porphyrin-containing compound biosynthetic process(GO:0006779)
0.6	29.7	GO:0003009	skeletal muscle contraction(GO:0003009)
0.8	16.8	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
2.6	13.2	GO:0070103	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.1	12.8	GO:0042100	B cell proliferation(GO:0042100)
1.0	12.3	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
1.3	12.1	GO:0032264	IMP salvage(GO:0032264)
2.2	11.2	GO:0072138	mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
0.4	10.5	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1	9.6	GO:0006936	muscle contraction(GO:0006936)

Showing 1 to 10 of 213 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	79.6	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.5	29.6	GO:0031672	A band(GO:0031672)
1.4	25.1	GO:0005861	troponin complex(GO:0005861)
0.2	21.6	GO:0017053	transcriptional repressor complex(GO:0017053)
0.1	19.2	GO:0014069	postsynaptic density(GO:0014069)
0.2	13.8	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	13.8	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	11.5	GO:0031674	I band(GO:0031674)
0.6	11.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.8	10.3	GO:0005862	muscle thin filament tropomyosin(GO:0005862)

Showing 1 to 10 of 84 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.0	70.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.5	27.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	24.8	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.2	18.4	GO:0005523	tropomyosin binding(GO:0005523)
1.6	16.0	GO:0031014	troponin T binding(GO:0031014)
0.2	12.9	GO:0043425	bHLH transcription factor binding(GO:0043425)
1.3	12.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2	12.0	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3	11.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.4	11.0	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Showing 1 to 10 of 137 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	19.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.2	14.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	12.0	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	6.8	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	6.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	6.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	6.4	PID NOTCH PATHWAY	Notch signaling pathway
0.2	5.8	PID IGF1 PATHWAY	IGF1 pathway
0.0	5.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	5.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 38 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	79.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.1	56.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	17.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	13.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.6	12.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.5	11.2	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.3	10.2	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	8.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	8.3	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.5	6.4	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport

Showing 1 to 10 of 61 entries

Results for Myod1

Z-value: 2.30

Motif logo

Transcription factors associated with Myod1

Activity-expression correlation:

Activity profile of Myod1 motif

Sorted Z-values of Myod1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Myod1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: