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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr1h2

Z-value: 1.37

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Transcription factors associated with Nr1h2

Gene Symbol Gene ID Gene Info
Nr1h2
ENSMUSG00000060601.6 nuclear receptor subfamily 1, group H, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h2mm10_v2_chr7_-_44553901_44553955-0.473.9e-03Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_97417730 14.73 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr2_+_102658640 7.28 ENSMUST00000080210.3
Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr15_+_82452372 4.97 ENSMUST00000089129.5
Cyp2d9
cytochrome P450, family 2, subfamily d, polypeptide 9
chr19_-_46672883 4.00 ENSMUST00000026012.7
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
chr15_+_82555087 3.99 ENSMUST00000068861.6
Cyp2d12
cytochrome P450, family 2, subfamily d, polypeptide 12
chr6_+_125320633 3.79 ENSMUST00000176655.1
ENSMUST00000176110.1
Scnn1a
sodium channel, nonvoltage-gated 1 alpha
chr3_+_146597077 3.64 ENSMUST00000029837.7
ENSMUST00000121133.1
Uox
urate oxidase
chr4_+_43641262 3.58 ENSMUST00000123351.1
ENSMUST00000128549.1
Npr2
natriuretic peptide receptor 2
chr11_+_55098104 3.35 ENSMUST00000000608.7
Gm2a
GM2 ganglioside activator protein
chr6_-_119544282 3.22 ENSMUST00000119369.1
ENSMUST00000178696.1
Wnt5b
wingless-related MMTV integration site 5B
chr17_-_83846769 3.15 ENSMUST00000000687.7
Haao
3-hydroxyanthranilate 3,4-dioxygenase
chr17_+_24804312 2.77 ENSMUST00000024972.5
Meiob
meiosis specific with OB domains
chr1_-_139560158 2.74 ENSMUST00000160423.1
ENSMUST00000023965.5
Cfhr1
complement factor H-related 1
chr16_+_13940630 2.72 ENSMUST00000141971.1
ENSMUST00000124947.1
ENSMUST00000023360.7
ENSMUST00000143697.1
Mpv17l
Mpv17 transgene, kidney disease mutant-like
chr11_-_60210410 2.47 ENSMUST00000144942.1
Srebf1
sterol regulatory element binding transcription factor 1
chr3_+_62419668 2.39 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_-_12461432 2.32 ENSMUST00000143693.1
ENSMUST00000144283.1
ENSMUST00000099820.3
ENSMUST00000135166.1
Lgals8
lectin, galactose binding, soluble 8
chr2_+_155382186 2.29 ENSMUST00000134218.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr3_-_146596588 2.24 ENSMUST00000029836.4
Dnase2b
deoxyribonuclease II beta
chr8_-_70632419 2.24 ENSMUST00000110103.1
Gdf15
growth differentiation factor 15
chr11_+_84179852 2.04 ENSMUST00000136463.2
Acaca
acetyl-Coenzyme A carboxylase alpha
chr2_+_155381808 1.86 ENSMUST00000043237.7
ENSMUST00000174685.1
Trp53inp2
transformation related protein 53 inducible nuclear protein 2
chr9_+_77941274 1.83 ENSMUST00000134072.1
Elovl5
ELOVL family member 5, elongation of long chain fatty acids (yeast)
chr9_+_46240696 1.80 ENSMUST00000034585.6
Apoa4
apolipoprotein A-IV
chr8_-_106136792 1.78 ENSMUST00000146940.1
Esrp2
epithelial splicing regulatory protein 2
chr6_+_90462562 1.77 ENSMUST00000032174.5
Klf15
Kruppel-like factor 15
chr11_+_84179792 1.75 ENSMUST00000137500.2
ENSMUST00000130012.2
Acaca
acetyl-Coenzyme A carboxylase alpha
chr3_-_138186700 1.74 ENSMUST00000012186.4
4930579F01Rik
RIKEN cDNA 4930579F01 gene
chrX_+_10717390 1.72 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chrX_+_10717451 1.66 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr2_+_30266721 1.64 ENSMUST00000113645.1
ENSMUST00000133877.1
ENSMUST00000139719.1
ENSMUST00000113643.1
ENSMUST00000150695.1
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr8_-_106136890 1.62 ENSMUST00000115979.2
Esrp2
epithelial splicing regulatory protein 2
chr7_-_118705708 1.60 ENSMUST00000038791.8
Gde1
glycerophosphodiester phosphodiesterase 1
chr2_-_157571270 1.58 ENSMUST00000173378.1
Blcap
bladder cancer associated protein homolog (human)
chr2_+_155276297 1.58 ENSMUST00000029128.3
Map1lc3a
microtubule-associated protein 1 light chain 3 alpha
chr14_+_54968781 1.57 ENSMUST00000181782.1
D830015G02Rik
RIKEN cDNA D830015G02 gene
chr16_+_96205719 1.57 ENSMUST00000129904.1
Sh3bgr
SH3-binding domain glutamic acid-rich protein
chr8_-_84773381 1.54 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr2_-_26604267 1.48 ENSMUST00000028286.5
Agpat2
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
chr1_+_78657825 1.48 ENSMUST00000035779.8
Acsl3
acyl-CoA synthetase long-chain family member 3
chr17_-_35897073 1.47 ENSMUST00000150056.1
ENSMUST00000156817.1
ENSMUST00000146451.1
ENSMUST00000148482.1
2310061I04Rik
RIKEN cDNA 2310061I04 gene
chr6_-_90224438 1.45 ENSMUST00000076086.2
Vmn1r53
vomeronasal 1 receptor 53
chr1_-_131276914 1.44 ENSMUST00000161764.1
Ikbke
inhibitor of kappaB kinase epsilon
chr1_+_78657874 1.43 ENSMUST00000134566.1
ENSMUST00000142704.1
ENSMUST00000053760.5
Acsl3
Utp14b
acyl-CoA synthetase long-chain family member 3
UTP14, U3 small nucleolar ribonucleoprotein, homolog B (yeast)
chr2_-_155834845 1.40 ENSMUST00000029143.5
Fam83c
family with sequence similarity 83, member C
chr3_+_90514435 1.36 ENSMUST00000048138.6
ENSMUST00000181271.1
S100a13
S100 calcium binding protein A13
chr3_-_39359128 1.34 ENSMUST00000056409.2
Gm9845
predicted pseudogene 9845
chr2_+_30266513 1.30 ENSMUST00000091132.6
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr7_-_133776681 1.30 ENSMUST00000130182.1
ENSMUST00000106139.1
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr10_-_81600857 1.25 ENSMUST00000151858.1
ENSMUST00000142948.1
ENSMUST00000072020.2
Tle6
transducin-like enhancer of split 6, homolog of Drosophila E(spl)
chr1_+_57377593 1.23 ENSMUST00000042734.2
1700066M21Rik
RIKEN cDNA 1700066M21 gene
chr6_+_54429603 1.21 ENSMUST00000132855.1
ENSMUST00000126637.1
Wipf3
WAS/WASL interacting protein family, member 3
chr5_+_107331157 1.21 ENSMUST00000031215.8
ENSMUST00000112677.3
Brdt
bromodomain, testis-specific
chr16_-_37384915 1.19 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l
syntaxin binding protein 5-like
chr11_-_101119814 1.16 ENSMUST00000107295.3
Fam134c
family with sequence similarity 134, member C
chr17_-_56716788 1.15 ENSMUST00000067931.5
Vmac
vimentin-type intermediate filament associated coiled-coil protein
chr16_-_37384940 1.11 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l
syntaxin binding protein 5-like
chr7_+_67647405 1.11 ENSMUST00000032774.8
ENSMUST00000107471.1
Ttc23
tetratricopeptide repeat domain 23
chr7_-_80371197 1.10 ENSMUST00000098346.3
Man2a2
mannosidase 2, alpha 2
chr10_+_18845071 1.07 ENSMUST00000019998.7
Perp
PERP, TP53 apoptosis effector
chr9_-_35199877 1.04 ENSMUST00000176021.1
ENSMUST00000176531.1
ENSMUST00000176685.1
ENSMUST00000177129.1
Tirap
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
chr15_+_85832301 1.03 ENSMUST00000146088.1
Ttc38
tetratricopeptide repeat domain 38
chr11_-_101119889 1.01 ENSMUST00000017946.5
Fam134c
family with sequence similarity 134, member C
chr17_-_56218881 1.01 ENSMUST00000038794.4
Dpp9
dipeptidylpeptidase 9
chr4_-_42168603 0.99 ENSMUST00000098121.3
Gm13305
predicted gene 13305
chr15_+_65787023 0.96 ENSMUST00000015146.9
ENSMUST00000173858.1
ENSMUST00000172756.1
ENSMUST00000174856.1
Efr3a
EFR3 homolog A (S. cerevisiae)
chr7_+_49759100 0.96 ENSMUST00000085272.5
Htatip2
HIV-1 tat interactive protein 2, homolog (human)
chr2_-_65238573 0.96 ENSMUST00000090896.3
ENSMUST00000155082.1
Cobll1
Cobl-like 1
chr4_-_63154130 0.95 ENSMUST00000030041.4
Ambp
alpha 1 microglobulin/bikunin
chr19_+_46707443 0.92 ENSMUST00000003655.7
As3mt
arsenic (+3 oxidation state) methyltransferase
chr15_-_79328201 0.90 ENSMUST00000173163.1
ENSMUST00000047816.8
ENSMUST00000172403.2
ENSMUST00000173632.1
Pla2g6
phospholipase A2, group VI
chrX_-_102644210 0.88 ENSMUST00000052012.7
ENSMUST00000043596.5
ENSMUST00000119229.1
ENSMUST00000122022.1
ENSMUST00000120270.1
ENSMUST00000113611.2
Phka1
phosphorylase kinase alpha 1
chr1_-_164458345 0.86 ENSMUST00000027863.7
Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr18_+_17019051 0.84 ENSMUST00000147119.1
ENSMUST00000153022.1
1700001G01Rik
RIKEN cDNA 1700001G01 gene
chr7_-_78783026 0.84 ENSMUST00000032841.5
Mrpl46
mitochondrial ribosomal protein L46
chr12_+_87147703 0.83 ENSMUST00000063117.8
Gstz1
glutathione transferase zeta 1 (maleylacetoacetate isomerase)
chr3_-_148989316 0.81 ENSMUST00000098518.2
Lphn2
latrophilin 2
chr15_-_79328154 0.81 ENSMUST00000166977.2
Pla2g6
phospholipase A2, group VI
chr11_+_101119938 0.81 ENSMUST00000043680.8
Tubg1
tubulin, gamma 1
chr12_+_108792946 0.78 ENSMUST00000021692.7
Yy1
YY1 transcription factor
chr1_+_33719863 0.77 ENSMUST00000088287.3
Rab23
RAB23, member RAS oncogene family
chr10_+_21425342 0.76 ENSMUST00000042671.4
1700021A07Rik
RIKEN cDNA 1700021A07 gene
chr13_+_55600055 0.76 ENSMUST00000133176.1
ENSMUST00000064701.6
B4galt7
xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
chr1_+_58711488 0.72 ENSMUST00000097722.2
ENSMUST00000114313.1
Cflar
CASP8 and FADD-like apoptosis regulator
chr1_+_131599239 0.72 ENSMUST00000027690.6
Avpr1b
arginine vasopressin receptor 1B
chr7_+_78783119 0.71 ENSMUST00000032840.4
Mrps11
mitochondrial ribosomal protein S11
chr17_-_79715034 0.70 ENSMUST00000024894.1
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr5_+_124328083 0.70 ENSMUST00000111477.1
ENSMUST00000077376.2
2810006K23Rik
RIKEN cDNA 2810006K23 gene
chr8_-_84237042 0.69 ENSMUST00000039480.5
Zswim4
zinc finger SWIM-type containing 4
chr19_+_42247544 0.66 ENSMUST00000122375.1
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr11_+_93996082 0.66 ENSMUST00000041956.7
Spag9
sperm associated antigen 9
chr2_-_65238625 0.66 ENSMUST00000112429.2
ENSMUST00000102726.1
ENSMUST00000112430.1
Cobll1
Cobl-like 1
chr16_-_38550173 0.65 ENSMUST00000036210.6
Poglut1
protein O-glucosyltransferase 1
chr4_-_119422355 0.64 ENSMUST00000106316.1
ENSMUST00000030385.6
Ppcs
phosphopantothenoylcysteine synthetase
chr18_-_9619460 0.64 ENSMUST00000062769.6
Cetn1
centrin 1
chr2_-_6951680 0.63 ENSMUST00000076071.2
Gm10115
predicted gene 10115
chr16_+_87784075 0.61 ENSMUST00000069809.4
2810407A14Rik
RIKEN cDNA 2810407A14 gene
chr11_-_30025915 0.61 ENSMUST00000058902.5
Eml6
echinoderm microtubule associated protein like 6
chr5_-_122779278 0.60 ENSMUST00000111668.3
Camkk2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr3_+_89245952 0.57 ENSMUST00000040888.5
Krtcap2
keratinocyte associated protein 2
chr7_+_114768767 0.57 ENSMUST00000151464.1
Insc
inscuteable homolog (Drosophila)
chr13_-_100552442 0.56 ENSMUST00000159515.1
ENSMUST00000160859.1
ENSMUST00000069756.4
Ocln
occludin
chr19_-_5845471 0.56 ENSMUST00000174287.1
ENSMUST00000173672.1
Neat1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr5_-_136565432 0.55 ENSMUST00000176172.1
Cux1
cut-like homeobox 1
chr5_+_117363513 0.55 ENSMUST00000111959.1
Wsb2
WD repeat and SOCS box-containing 2
chr12_-_87147883 0.53 ENSMUST00000037788.4
Pomt2
protein-O-mannosyltransferase 2
chr9_-_63399216 0.53 ENSMUST00000168665.1
2300009A05Rik
RIKEN cDNA 2300009A05 gene
chr15_+_88600280 0.51 ENSMUST00000066949.7
Zdhhc25
zinc finger, DHHC domain containing 25
chr3_-_51408925 0.50 ENSMUST00000038108.6
Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr11_+_58963790 0.46 ENSMUST00000075141.6
Trim17
tripartite motif-containing 17
chr17_+_49428359 0.46 ENSMUST00000165390.2
ENSMUST00000024797.9
ENSMUST00000173033.1
Mocs1
molybdenum cofactor synthesis 1
chr3_+_89246397 0.44 ENSMUST00000168900.1
Krtcap2
keratinocyte associated protein 2
chr2_+_131210501 0.44 ENSMUST00000110206.1
Ap5s1
adaptor-related protein 5 complex, sigma 1 subunit
chr5_+_67306941 0.43 ENSMUST00000162372.1
ENSMUST00000113676.2
Slc30a9
solute carrier family 30 (zinc transporter), member 9
chr7_+_114768736 0.42 ENSMUST00000117543.1
Insc
inscuteable homolog (Drosophila)
chr6_+_146861798 0.40 ENSMUST00000148099.1
Smco2
single-pass membrane protein with coiled-coil domains 2
chr5_-_136244865 0.39 ENSMUST00000005188.9
Sh2b2
SH2B adaptor protein 2
chr5_+_146481943 0.39 ENSMUST00000179032.1
Gm6408
predicted gene 6408
chr19_+_5041337 0.39 ENSMUST00000116567.2
Brms1
breast cancer metastasis-suppressor 1
chr13_+_23695791 0.39 ENSMUST00000041052.2
Hist1h1t
histone cluster 1, H1t
chr9_+_37208291 0.38 ENSMUST00000034632.8
Tmem218
transmembrane protein 218
chr7_+_125318334 0.36 ENSMUST00000060220.1
4930533L02Rik
RIKEN cDNA 4930533L02 gene
chr6_+_124663027 0.35 ENSMUST00000004381.7
Lpcat3
lysophosphatidylcholine acyltransferase 3
chr11_+_114091404 0.34 ENSMUST00000129365.1
1700025D23Rik
RIKEN cDNA 1700025D23 gene
chr10_+_21993890 0.33 ENSMUST00000092673.4
Sgk1
serum/glucocorticoid regulated kinase 1
chr13_+_102693596 0.32 ENSMUST00000172138.1
Cd180
CD180 antigen
chr19_+_11569447 0.31 ENSMUST00000087884.1
Gm10212
predicted pseudogene 10212
chr11_+_115834314 0.30 ENSMUST00000173289.1
ENSMUST00000137900.1
Llgl2
lethal giant larvae homolog 2 (Drosophila)
chr1_+_6214627 0.30 ENSMUST00000027040.6
Rb1cc1
RB1-inducible coiled-coil 1
chr2_+_131210363 0.30 ENSMUST00000110210.1
ENSMUST00000089506.5
ENSMUST00000110208.1
Ap5s1
adaptor-related protein 5 complex, sigma 1 subunit
chr6_-_99632376 0.29 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chr14_-_20730327 0.28 ENSMUST00000047490.5
Ndst2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr14_+_54686171 0.28 ENSMUST00000038539.6
1700123O20Rik
RIKEN cDNA 1700123O20 gene
chr5_+_31494736 0.28 ENSMUST00000076949.6
ENSMUST00000117700.1
Gpn1
GPN-loop GTPase 1
chr5_+_115466234 0.27 ENSMUST00000145785.1
ENSMUST00000031495.4
ENSMUST00000112071.1
ENSMUST00000125568.1
Pla2g1b
phospholipase A2, group IB, pancreas
chr12_+_105159690 0.27 ENSMUST00000085043.5
Tcl1b1
T cell leukemia/lymphoma 1B, 1
chr11_-_103697898 0.27 ENSMUST00000021329.7
Gosr2
golgi SNAP receptor complex member 2
chrX_-_155216444 0.26 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr9_+_65361049 0.26 ENSMUST00000147185.1
Gm514
predicted gene 514
chrX_-_155216338 0.25 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chr5_-_146185304 0.23 ENSMUST00000073721.5
1700001J03Rik
RIKEN cDNA 1700001J03 gene
chrX_-_53608979 0.22 ENSMUST00000123034.1
Gm14597
predicted gene 14597
chr1_+_31176404 0.21 ENSMUST00000062560.7
Lgsn
lengsin, lens protein with glutamine synthetase domain
chr11_+_82952095 0.20 ENSMUST00000108158.2
ENSMUST00000067443.2
Slfn5
schlafen 5
chr17_+_44777127 0.20 ENSMUST00000050630.7
Supt3
suppressor of Ty 3
chr1_+_38987806 0.20 ENSMUST00000027247.5
Pdcl3
phosducin-like 3
chr17_-_25985641 0.19 ENSMUST00000041641.8
Capn15
calpain 15
chr12_+_105563123 0.17 ENSMUST00000001652.5
Bdkrb2
bradykinin receptor, beta 2
chr14_-_72602945 0.17 ENSMUST00000162825.1
Fndc3a
fibronectin type III domain containing 3A
chr5_+_123015010 0.16 ENSMUST00000121652.1
ENSMUST00000051016.4
Orai1
ORAI calcium release-activated calcium modulator 1
chr10_-_60938123 0.16 ENSMUST00000036304.3
Pldi
polymorphic derived intron containing
chr12_-_21286097 0.16 ENSMUST00000173729.1
Itgb1bp1
integrin beta 1 binding protein 1
chr7_-_102888151 0.16 ENSMUST00000078191.2
Olfr569
olfactory receptor 569
chr7_-_25718976 0.16 ENSMUST00000002683.2
Ccdc97
coiled-coil domain containing 97
chr5_-_145032764 0.16 ENSMUST00000071421.4
Gm4871
predicted gene 4871
chr12_-_21286176 0.14 ENSMUST00000172834.1
ENSMUST00000076260.4
Itgb1bp1
integrin beta 1 binding protein 1
chr16_+_16870829 0.14 ENSMUST00000131063.1
Top3b
topoisomerase (DNA) III beta
chr15_+_78877172 0.13 ENSMUST00000041587.7
Gga1
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr7_-_104129792 0.13 ENSMUST00000053743.4
4931431F19Rik
RIKEN cDNA 4931431F19 gene
chr5_+_130219706 0.12 ENSMUST00000065329.6
Tmem248
transmembrane protein 248
chr7_-_27446599 0.09 ENSMUST00000011895.7
Sptbn4
spectrin beta, non-erythrocytic 4
chr2_+_154223737 0.09 ENSMUST00000045959.7
Bpifb5
BPI fold containing family B, member 5
chr11_+_78245743 0.08 ENSMUST00000002133.8
Sdf2
stromal cell derived factor 2
chr13_+_68582213 0.07 ENSMUST00000051784.8
Fastkd3
FAST kinase domains 3
chr4_-_46389391 0.07 ENSMUST00000086563.4
ENSMUST00000030015.5
5830415F09Rik
RIKEN cDNA 5830415F09 gene
chr9_-_42472198 0.06 ENSMUST00000128959.1
ENSMUST00000066148.5
ENSMUST00000138506.1
Tbcel
tubulin folding cofactor E-like
chr7_-_45179539 0.06 ENSMUST00000179443.1
Gm581
predicted gene 581
chr4_-_133545906 0.05 ENSMUST00000030665.6
Nudc
nuclear distribution gene C homolog (Aspergillus)
chr8_+_71592158 0.03 ENSMUST00000034264.4
ENSMUST00000138742.1
ENSMUST00000143441.1
Pgls
6-phosphogluconolactonase
chr8_+_18846251 0.03 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr5_-_17849783 0.03 ENSMUST00000170051.1
ENSMUST00000165232.1
Cd36
CD36 antigen
chr5_+_117357274 0.02 ENSMUST00000031309.9
Wsb2
WD repeat and SOCS box-containing 2
chr2_+_180589245 0.02 ENSMUST00000029087.3
Ogfr
opioid growth factor receptor
chr16_+_17894197 0.01 ENSMUST00000046937.2
Tssk1
testis-specific serine kinase 1
chr2_-_152596436 0.01 ENSMUST00000109834.2
Defb45
defensin beta 45
chr13_+_111255010 0.01 ENSMUST00000054716.3
Actbl2
actin, beta-like 2
chr14_+_50944499 0.00 ENSMUST00000178092.1
Pnp
purine-nucleoside phosphorylase

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.3 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
1.0 2.9 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.9 3.8 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.7 2.1 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.5 2.7 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.4 17.2 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.4 3.4 GO:0009313 ganglioside catabolic process(GO:0006689) oligosaccharide catabolic process(GO:0009313)
0.4 3.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.4 2.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.4 3.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte maturation(GO:1900194)
0.3 2.8 GO:0007144 female meiosis I(GO:0007144)
0.3 1.0 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.3 1.7 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of arachidonic acid secretion(GO:0090238) positive regulation of ceramide biosynthetic process(GO:2000304)
0.3 0.9 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.3 1.0 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.3 0.8 GO:0071707 immunoglobulin heavy chain V-D-J recombination(GO:0071707)
0.3 2.0 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 0.7 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.2 0.7 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) endothelial cell-cell adhesion(GO:0071603)
0.2 1.4 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.2 4.0 GO:0042448 progesterone metabolic process(GO:0042448)
0.2 3.6 GO:0046415 urate metabolic process(GO:0046415)
0.2 5.2 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
0.2 0.7 GO:1903943 skeletal muscle atrophy(GO:0014732) negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.2 0.5 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.2 0.7 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 0.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.6 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.1 9.0 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.1 1.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 1.1 GO:0006013 mannose metabolic process(GO:0006013)
0.1 1.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 1.5 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.1 0.7 GO:0048318 protein O-linked glycosylation via serine(GO:0018242) axial mesoderm development(GO:0048318)
0.1 0.5 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 2.4 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.6 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.1 0.7 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.1 3.8 GO:0050891 multicellular organismal water homeostasis(GO:0050891)
0.1 1.1 GO:0002934 desmosome organization(GO:0002934)
0.1 3.4 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 0.9 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.5 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 2.2 GO:1901739 regulation of myoblast fusion(GO:1901739) positive regulation of myoblast fusion(GO:1901741)
0.1 1.5 GO:0010884 positive regulation of lipid storage(GO:0010884)
0.1 1.8 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1 0.5 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 0.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.1 1.2 GO:0007141 male meiosis I(GO:0007141)
0.1 0.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.1 0.6 GO:0070673 response to interleukin-18(GO:0070673)
0.1 1.6 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 5.2 GO:0000045 autophagosome assembly(GO:0000045)
0.1 0.9 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.8 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.2 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.3 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 1.0 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 3.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 1.5 GO:0019236 response to pheromone(GO:0019236)
0.0 0.4 GO:0001922 B-1 B cell homeostasis(GO:0001922)
0.0 0.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 2.3 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:0097435 fibril organization(GO:0097435)
0.0 0.2 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0 0.6 GO:0030575 nuclear body organization(GO:0030575)
0.0 1.6 GO:0042439 ethanolamine-containing compound metabolic process(GO:0042439)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 1.0 GO:0060487 lung epithelial cell differentiation(GO:0060487)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0006265 DNA topological change(GO:0006265)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.8 GO:0097447 dendritic tree(GO:0097447)
0.2 7.3 GO:0030673 axolemma(GO:0030673)
0.2 3.8 GO:0034706 sodium channel complex(GO:0034706)
0.1 1.2 GO:0045098 type III intermediate filament(GO:0045098)
0.1 3.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.9 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.8 GO:0005827 polar microtubule(GO:0005827)
0.1 1.6 GO:0044754 autolysosome(GO:0044754)
0.1 0.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.8 GO:0042627 chylomicron(GO:0042627)
0.1 0.6 GO:0042382 paraspeckles(GO:0042382)
0.1 4.8 GO:0005776 autophagosome(GO:0005776)
0.1 1.0 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.8 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.7 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 10.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 3.7 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.4 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.6 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.3 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.8 3.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.7 3.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.7 3.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.6 2.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.5 2.5 GO:0032810 sterol response element binding(GO:0032810)
0.5 3.6 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.3 1.0 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.3 2.8 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 3.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.3 1.4 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704) IkappaB kinase activity(GO:0008384)
0.2 4.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 1.8 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 0.7 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.2 1.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2 5.7 GO:0070330 aromatase activity(GO:0070330)
0.2 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 1.7 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.2 1.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 3.1 GO:0019825 oxygen binding(GO:0019825)
0.2 1.8 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 1.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 0.5 GO:0019809 spermidine binding(GO:0019809)
0.1 0.8 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.9 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 4.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 1.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.7 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 0.9 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 1.0 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.7 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 1.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211)
0.1 0.6 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 0.3 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 0.7 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.2 GO:0019215 intermediate filament binding(GO:0019215)
0.1 3.2 GO:0005109 frizzled binding(GO:0005109)
0.1 0.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.5 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.7 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.2 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 2.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 4.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.8 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 13.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.0 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 3.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.2 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.7 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 8.5 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 3.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 7.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.3 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.1 3.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.4 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 2.5 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.1 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.8 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.7 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis