ISMARA results: Nr1h4

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr1h4

Z-value: 2.70

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Transcription factors associated with Nr1h4

Gene Symbol	Gene ID	Gene Info
Nr1h4 Ensembl NCBI MGI UniProt	ENSMUSG00000047638.9	nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nr1h4	mm10_v2_chr10_-_89506631_89506658	0.88	9.1e-13	Click!

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_93079965 Show fit	26.90	ENSMUST00000109582.1	Ces1b Ensembl NCBI MGI UniProt Show fit	carboxylesterase 1B
chr9_-_65422773 Show fit	17.08	ENSMUST00000065894.5	Slc51b Ensembl NCBI MGI UniProt Show fit	solute carrier family 51, beta subunit
chr7_-_99695809 Show fit	13.27	ENSMUST00000107086.2	Slco2b1 Ensembl NCBI MGI UniProt Show fit	solute carrier organic anion transporter family, member 2b1
chr4_+_133553370 Show fit	11.16	ENSMUST00000042706.2	Nr0b2 Ensembl NCBI MGI UniProt Show fit	nuclear receptor subfamily 0, group B, member 2
chr7_-_105600103 Show fit	10.76	ENSMUST00000033185.8	Hpx Ensembl NCBI MGI UniProt Show fit	hemopexin
chr11_+_72435511 Show fit	10.60	ENSMUST00000076443.3	Ggt6 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 6
chr11_+_72435565 Show fit	10.21	ENSMUST00000100903.2	Ggt6 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 6
chr11_+_72435534 Show fit	10.07	ENSMUST00000108499.1	Ggt6 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 6
chr2_-_69342600 Show fit	10.03	ENSMUST00000102709.1 ENSMUST00000102710.3 ENSMUST00000180142.1	Abcb11 Ensembl NCBI MGI UniProt Show fit	ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr6_+_141629499 Show fit	9.66	ENSMUST00000042812.6	Slco1b2 Ensembl NCBI MGI UniProt Show fit	solute carrier organic anion transporter family, member 1b2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	30.9	GO:0006751	glutathione catabolic process(GO:0006751)
1.9	17.1	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.2	15.4	GO:0070206	protein trimerization(GO:0070206)
2.3	14.0	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2	13.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
3.3	13.3	GO:0071718	sodium-independent icosanoid transport(GO:0071718)
2.9	11.6	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.1	11.2	GO:0032024	positive regulation of insulin secretion(GO:0032024)
2.2	10.8	GO:0015886	heme transport(GO:0015886)
1.7	10.0	GO:0046618	drug export(GO:0046618)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.3	GO:0072562	blood microparticle(GO:0072562)
0.2	14.0	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2	13.3	GO:0009925	basal plasma membrane(GO:0009925)
0.5	11.6	GO:0042627	chylomicron(GO:0042627)
0.8	10.0	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	9.8	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	9.3	GO:0016328	lateral plasma membrane(GO:0016328)
0.1	9.2	GO:0036064	ciliary basal body(GO:0036064)
0.0	9.2	GO:0005740	mitochondrial envelope(GO:0005740)
0.2	8.9	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	33.0	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
2.6	30.9	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	29.0	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
0.1	16.5	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.1	15.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.3	14.0	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.2	13.4	GO:0008395	steroid hydroxylase activity(GO:0008395)
1.4	11.6	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4	11.2	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
2.7	10.8	GO:0015232	heme transporter activity(GO:0015232)

Showing 1 to 10 of 77 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	35.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	16.6	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.4	9.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	6.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	4.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	3.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	3.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	1.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	1.7	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	1.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	14.6	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	14.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.6	14.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
1.2	13.3	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.4	11.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.6	10.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.2	7.0	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.5	6.5	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.2	5.9	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	5.4	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Showing 1 to 10 of 35 entries

Results for Nr1h4

Z-value: 2.70

Motif logo

Transcription factors associated with Nr1h4

Activity-expression correlation:

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: