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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Nr1i2
Z-value: 1.24
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Transcription factors associated with Nr1i2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1i2 | mm10_v2_chr16_-_38294774_38294838 | -0.26 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_60582152 Show fit | 10.61 |
ENSMUST00000098047.2
|
major urinary protein 10 |
|
| chr4_-_61674094 Show fit | 10.32 |
ENSMUST00000098040.3
|
major urinary protein 18 |
|
| chr4_-_60421933 Show fit | 9.95 |
ENSMUST00000107506.2
ENSMUST00000122381.1 ENSMUST00000118759.1 ENSMUST00000122177.1 |
major urinary protein 9 |
|
| chr4_-_61303998 Show fit | 9.93 |
ENSMUST00000071005.8
ENSMUST00000075206.5 |
major urinary protein 14 |
|
| chr4_-_62087261 Show fit | 9.88 |
ENSMUST00000107488.3
ENSMUST00000107472.1 ENSMUST00000084531.4 |
major urinary protein 3 |
|
| chr4_-_60222580 Show fit | 9.45 |
ENSMUST00000095058.4
ENSMUST00000163931.1 |
major urinary protein 8 |
|
| chr4_-_61303802 Show fit | 9.40 |
ENSMUST00000125461.1
|
major urinary protein 14 |
|
| chr4_-_60662358 Show fit | 7.66 |
ENSMUST00000084544.4
ENSMUST00000098046.3 |
major urinary protein 11 |
|
| chr4_-_60139857 Show fit | 7.09 |
ENSMUST00000107490.4
ENSMUST00000074700.2 |
major urinary protein 2 |
|
| chr4_-_61835185 Show fit | 6.07 |
ENSMUST00000082287.2
|
major urinary protein 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nr1i2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.2 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.6 | 7.0 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 1.4 | 5.6 | GO:0016103 | diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653) |
| 0.0 | 5.3 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 1.6 | 4.7 | GO:0018879 | biphenyl metabolic process(GO:0018879) |
| 0.9 | 4.4 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.1 | 3.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 3.7 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 3.7 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 0.9 | 3.6 | GO:0042196 | chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 6.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 5.1 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 4.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 4.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 2.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 2.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 2.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 2.1 | GO:0043197 | dendritic spine(GO:0043197) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.2 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.3 | 9.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 3.1 | 9.2 | GO:0052871 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) |
| 0.0 | 6.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.9 | 5.6 | GO:0008401 | retinoic acid 4-hydroxylase activity(GO:0008401) |
| 1.1 | 4.4 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 4.3 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.3 | 3.4 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.5 | 3.1 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 3.1 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 2.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 8.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 5.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.1 | 4.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 3.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.0 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 3.0 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 2.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 2.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 2.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |