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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Nr2f6

Z-value: 1.70

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Transcription factors associated with Nr2f6

Gene Symbol Gene ID Gene Info
Nr2f6
ENSMUSG00000002393.8 nuclear receptor subfamily 2, group F, member 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_71381977-0.634.4e-05Click!

Activity profile of Nr2f6 motif

Sorted Z-values of Nr2f6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_33794008 9.17 ENSMUST00000115044.1
Muc13
mucin 13, epithelial transmembrane
chr16_+_33794345 9.16 ENSMUST00000023520.6
Muc13
mucin 13, epithelial transmembrane
chr10_-_79788924 9.09 ENSMUST00000020573.6
Prss57
protease, serine 57
chr5_+_76840597 7.85 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
C530008M17Rik
RIKEN cDNA C530008M17 gene
chr2_+_155611175 7.07 ENSMUST00000092995.5
Myh7b
myosin, heavy chain 7B, cardiac muscle, beta
chr19_+_10001669 6.70 ENSMUST00000121418.1
Rab3il1
RAB3A interacting protein (rabin3)-like 1
chr11_+_32283511 6.40 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chr5_-_137741601 5.36 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1
neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1
chr11_-_33513736 5.09 ENSMUST00000102815.3
Ranbp17
RAN binding protein 17
chr11_+_116198853 4.82 ENSMUST00000021130.6
Ten1
TEN1 telomerase capping complex subunit
chr19_+_47228804 4.51 ENSMUST00000111807.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr11_+_58379036 4.45 ENSMUST00000013787.4
ENSMUST00000108826.2
Lypd8
LY6/PLAUR domain containing 8
chr1_+_135799833 4.16 ENSMUST00000148201.1
Tnni1
troponin I, skeletal, slow 1
chr2_+_24336846 3.84 ENSMUST00000114487.2
Il1rn
interleukin 1 receptor antagonist
chr3_-_89418287 3.61 ENSMUST00000029679.3
Cks1b
CDC28 protein kinase 1b
chr1_+_172499948 3.56 ENSMUST00000111230.1
Tagln2
transgelin 2
chr7_+_98494222 3.52 ENSMUST00000165205.1
Lrrc32
leucine rich repeat containing 32
chr9_+_110344185 3.46 ENSMUST00000142100.1
Scap
SREBF chaperone
chr2_-_164743182 3.41 ENSMUST00000103096.3
Wfdc3
WAP four-disulfide core domain 3
chr18_+_21072329 3.40 ENSMUST00000082235.4
Mep1b
meprin 1 beta
chr4_+_140906344 3.40 ENSMUST00000030765.6
Padi2
peptidyl arginine deiminase, type II
chr11_-_33513626 3.31 ENSMUST00000037522.7
Ranbp17
RAN binding protein 17
chr2_+_164805082 3.28 ENSMUST00000052107.4
Zswim3
zinc finger SWIM-type containing 3
chr7_+_43427622 3.20 ENSMUST00000177164.2
Lim2
lens intrinsic membrane protein 2
chr1_+_91145103 3.16 ENSMUST00000094698.1
Rbm44
RNA binding motif protein 44
chr13_+_112288451 3.08 ENSMUST00000022275.6
ENSMUST00000056047.7
ENSMUST00000165593.1
Ankrd55
ankyrin repeat domain 55
chr2_+_25242929 3.04 ENSMUST00000114355.1
ENSMUST00000060818.1
Rnf208
ring finger protein 208
chr1_+_63176818 2.94 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chrX_+_101449078 2.94 ENSMUST00000033674.5
Itgb1bp2
integrin beta 1 binding protein 2
chr17_+_47672720 2.89 ENSMUST00000152724.1
Usp49
ubiquitin specific peptidase 49
chr1_+_74409376 2.87 ENSMUST00000027366.6
Vil1
villin 1
chr8_+_117095854 2.77 ENSMUST00000034308.8
ENSMUST00000167370.1
ENSMUST00000176860.1
Bcmo1
beta-carotene 15,15'-monooxygenase
chr10_-_93589621 2.69 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr8_+_71469186 2.68 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
Dda1
DET1 and DDB1 associated 1
chr13_-_24761861 2.59 ENSMUST00000006898.3
ENSMUST00000110382.2
Gmnn
geminin
chr13_-_59769751 2.49 ENSMUST00000057115.6
Isca1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr13_+_112288516 2.47 ENSMUST00000168684.1
Ankrd55
ankyrin repeat domain 55
chr18_-_70472429 2.43 ENSMUST00000067556.3
4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr2_+_25242227 2.34 ENSMUST00000154498.1
Rnf208
ring finger protein 208
chr2_+_91082362 2.33 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_+_114003833 2.27 ENSMUST00000086599.4
Dao
D-amino acid oxidase
chr10_-_35711891 2.25 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr5_+_114004781 2.19 ENSMUST00000161610.1
Dao
D-amino acid oxidase
chr15_-_95528702 2.16 ENSMUST00000166170.1
Nell2
NEL-like 2
chr2_+_75832168 2.15 ENSMUST00000047232.7
ENSMUST00000111952.2
Agps
alkylglycerone phosphate synthase
chr19_-_10001625 2.15 ENSMUST00000117346.1
Best1
bestrophin 1
chr1_-_120270253 2.12 ENSMUST00000112639.1
Steap3
STEAP family member 3
chr5_+_31698050 2.02 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
Bre
brain and reproductive organ-expressed protein
chr6_+_125145235 1.94 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1
intermediate filament family orphan 1
chr14_-_70176787 1.93 ENSMUST00000153735.1
Pdlim2
PDZ and LIM domain 2
chr7_-_19950729 1.92 ENSMUST00000043440.6
Igsf23
immunoglobulin superfamily, member 23
chr5_+_31697960 1.90 ENSMUST00000114515.2
Bre
brain and reproductive organ-expressed protein
chr10_-_13324160 1.85 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr2_-_119229885 1.85 ENSMUST00000076084.5
Ppp1r14d
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr11_+_4986824 1.81 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr2_+_158028687 1.79 ENSMUST00000109518.1
ENSMUST00000029180.7
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr11_+_101442298 1.79 ENSMUST00000077856.6
Rpl27
ribosomal protein L27
chr1_+_171388954 1.76 ENSMUST00000056449.8
Arhgap30
Rho GTPase activating protein 30
chr10_-_80102653 1.71 ENSMUST00000042771.7
Sbno2
strawberry notch homolog 2 (Drosophila)
chr4_+_132564051 1.71 ENSMUST00000070690.7
Ptafr
platelet-activating factor receptor
chr2_-_158028423 1.67 ENSMUST00000029179.4
Tti1
TELO2 interacting protein 1
chr5_+_31697665 1.66 ENSMUST00000080598.7
Bre
brain and reproductive organ-expressed protein
chr17_+_48264270 1.66 ENSMUST00000059873.7
ENSMUST00000154335.1
ENSMUST00000136272.1
ENSMUST00000125426.1
ENSMUST00000153420.1
Treml4
triggering receptor expressed on myeloid cells-like 4
chr6_+_85431970 1.61 ENSMUST00000045693.7
Smyd5
SET and MYND domain containing 5
chr11_+_101442440 1.60 ENSMUST00000107249.1
Rpl27
ribosomal protein L27
chr12_-_55080098 1.59 ENSMUST00000021406.5
2700097O09Rik
RIKEN cDNA 2700097O09 gene
chr1_+_74506044 1.58 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr5_+_117120120 1.55 ENSMUST00000111978.1
Taok3
TAO kinase 3
chr6_+_6248659 1.51 ENSMUST00000181633.1
ENSMUST00000176283.1
ENSMUST00000175814.1
ENSMUST00000181192.1
Gm20619
predicted gene 20619
chr1_-_120271074 1.50 ENSMUST00000112641.1
Steap3
STEAP family member 3
chr7_-_28598140 1.47 ENSMUST00000040531.8
ENSMUST00000108283.1
Samd4b
Pak4
sterile alpha motif domain containing 4B
p21 protein (Cdc42/Rac)-activated kinase 4
chr10_+_93589413 1.46 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr5_+_135187251 1.44 ENSMUST00000002825.5
Baz1b
bromodomain adjacent to zinc finger domain, 1B
chr4_-_137048695 1.42 ENSMUST00000049583.7
Zbtb40
zinc finger and BTB domain containing 40
chr10_-_22731918 1.42 ENSMUST00000095794.3
Tbpl1
TATA box binding protein-like 1
chr17_+_49615104 1.41 ENSMUST00000162854.1
Kif6
kinesin family member 6
chr7_-_98119482 1.40 ENSMUST00000138627.1
ENSMUST00000107127.1
ENSMUST00000107128.1
Myo7a
myosin VIIA
chr2_+_158028481 1.39 ENSMUST00000103123.3
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr2_-_119229849 1.39 ENSMUST00000110820.2
Ppp1r14d
protein phosphatase 1, regulatory (inhibitor) subunit 14D
chr4_+_129461581 1.38 ENSMUST00000048162.8
ENSMUST00000138013.1
Bsdc1
BSD domain containing 1
chr3_+_4211716 1.35 ENSMUST00000170943.1
Gm8775
predicted gene 8775
chr19_+_45998131 1.34 ENSMUST00000181820.1
4930505N22Rik
RIKEN cDNA 4930505N22 gene
chr10_-_13324250 1.32 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr1_+_136683375 1.30 ENSMUST00000181524.1
Gm19705
predicted gene, 19705
chr18_+_70472660 1.29 ENSMUST00000174118.1
Stard6
StAR-related lipid transfer (START) domain containing 6
chr8_+_11713259 1.28 ENSMUST00000134409.1
1700128E19Rik
RIKEN cDNA 1700128E19 gene
chr9_+_118506226 1.28 ENSMUST00000084820.4
Golga4
golgi autoantigen, golgin subfamily a, 4
chr7_-_19715395 1.25 ENSMUST00000032555.9
ENSMUST00000093552.5
Tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr5_-_31697598 1.23 ENSMUST00000031018.7
Rbks
ribokinase
chr2_-_59160644 1.17 ENSMUST00000077687.5
Ccdc148
coiled-coil domain containing 148
chr2_-_32775330 1.14 ENSMUST00000161089.1
ENSMUST00000066478.2
ENSMUST00000161950.1
Ttc16
tetratricopeptide repeat domain 16
chr2_+_158794807 1.14 ENSMUST00000029186.7
ENSMUST00000109478.2
ENSMUST00000156893.1
Dhx35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr10_-_119240006 1.12 ENSMUST00000020315.6
Cand1
cullin associated and neddylation disassociated 1
chr3_-_95133989 1.11 ENSMUST00000172572.2
ENSMUST00000173462.2
Scnm1
sodium channel modifier 1
chr9_+_108460518 1.08 ENSMUST00000061209.5
Ccdc71
coiled-coil domain containing 71
chr2_+_158028733 1.07 ENSMUST00000152452.1
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr4_+_110397661 1.02 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4
ATP/GTP binding protein-like 4
chr4_+_110397764 1.01 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4
ATP/GTP binding protein-like 4
chr18_+_70472559 0.99 ENSMUST00000168249.2
Stard6
StAR-related lipid transfer (START) domain containing 6
chr10_+_128303322 0.96 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr3_-_8923796 0.93 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chr11_-_118093702 0.92 ENSMUST00000018719.3
Dnah17
dynein, axonemal, heavy chain 17
chr16_+_92612755 0.91 ENSMUST00000180989.1
Gm26626
predicted gene, 26626
chr10_-_14705459 0.90 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1
Vps20-associated 1 homolog (S. cerevisiae)
chr6_-_83156393 0.89 ENSMUST00000153148.1
ENSMUST00000125894.1
Wdr54
WD repeat domain 54
chr11_+_115475645 0.87 ENSMUST00000035240.6
Armc7
armadillo repeat containing 7
chr7_+_45897429 0.85 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr18_+_70472406 0.84 ENSMUST00000114959.2
Stard6
StAR-related lipid transfer (START) domain containing 6
chr11_-_94782500 0.79 ENSMUST00000162809.2
Tmem92
transmembrane protein 92
chr18_+_63708689 0.77 ENSMUST00000072726.5
Wdr7
WD repeat domain 7
chr2_+_180710117 0.76 ENSMUST00000029090.2
Gid8
GID complex subunit 8 homolog (S. cerevisiae)
chr19_-_45998479 0.76 ENSMUST00000045396.7
9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr19_-_47536997 0.76 ENSMUST00000182808.1
ENSMUST00000049369.9
Obfc1
oligonucleotide/oligosaccharide-binding fold containing 1
chr2_-_32775584 0.71 ENSMUST00000161430.1
Ttc16
tetratricopeptide repeat domain 16
chr6_+_84008540 0.69 ENSMUST00000113821.1
ENSMUST00000113823.1
Dysf
dysferlin
chr11_-_99244058 0.68 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr9_-_109746089 0.66 ENSMUST00000071917.3
Fbxw26
F-box and WD-40 domain protein 26
chr10_+_128747850 0.64 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr16_-_4624984 0.64 ENSMUST00000014445.6
Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr4_-_117682233 0.63 ENSMUST00000102687.3
Dmap1
DNA methyltransferase 1-associated protein 1
chr4_-_130174691 0.63 ENSMUST00000132545.2
ENSMUST00000175992.1
ENSMUST00000105999.2
Tinagl1
tubulointerstitial nephritis antigen-like 1
chr18_+_70472621 0.60 ENSMUST00000164223.1
Stard6
StAR-related lipid transfer (START) domain containing 6
chr11_-_75439489 0.59 ENSMUST00000043696.2
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr2_+_153345809 0.59 ENSMUST00000109790.1
Asxl1
additional sex combs like 1
chr5_+_150018675 0.58 ENSMUST00000065745.3
ENSMUST00000110496.1
Rxfp2
relaxin/insulin-like family peptide receptor 2
chr13_-_55571118 0.58 ENSMUST00000021957.6
Fam193b
family with sequence similarity 193, member B
chr11_-_97352016 0.58 ENSMUST00000093942.4
Gpr179
G protein-coupled receptor 179
chr11_-_75439551 0.57 ENSMUST00000128330.1
Serpinf2
serine (or cysteine) peptidase inhibitor, clade F, member 2
chr11_-_83592981 0.55 ENSMUST00000019071.3
Ccl6
chemokine (C-C motif) ligand 6
chr9_+_108392820 0.55 ENSMUST00000035234.4
1700102P08Rik
RIKEN cDNA 1700102P08 gene
chr9_-_44767792 0.51 ENSMUST00000034607.9
Arcn1
archain 1
chr11_-_94782703 0.51 ENSMUST00000100554.1
Tmem92
transmembrane protein 92
chr15_-_81871883 0.51 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr14_+_57798182 0.49 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chrX_-_148615153 0.49 ENSMUST00000112755.2
Gm8334
predicted gene 8334
chr5_+_134176358 0.49 ENSMUST00000180674.1
B230377A18Rik
RIKEN cDNA B230377A18 gene
chr6_-_116716888 0.47 ENSMUST00000056623.6
Tmem72
transmembrane protein 72
chr7_-_89941196 0.46 ENSMUST00000117354.1
l7Rn6
lethal, Chr 7, Rinchik 6
chr9_+_21002737 0.43 ENSMUST00000003386.5
Mrpl4
mitochondrial ribosomal protein L4
chr12_-_57197311 0.41 ENSMUST00000044634.5
Slc25a21
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
chr3_+_95134088 0.41 ENSMUST00000066386.5
Lysmd1
LysM, putative peptidoglycan-binding, domain containing 1
chr4_+_85205120 0.40 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr14_+_57798620 0.39 ENSMUST00000111268.1
Sap18
Sin3-associated polypeptide 18
chr9_+_104547267 0.36 ENSMUST00000098443.2
Cpne4
copine IV
chr7_-_89941084 0.36 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6
lethal, Chr 7, Rinchik 6
chr2_+_71719417 0.36 ENSMUST00000079720.5
Gm1631
predicted gene 1631
chr2_-_180709985 0.34 ENSMUST00000103057.1
ENSMUST00000103055.1
Dido1
death inducer-obliterator 1
chr7_+_31059342 0.33 ENSMUST00000039775.7
Lgi4
leucine-rich repeat LGI family, member 4
chr12_+_74288735 0.32 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr8_+_66511732 0.29 ENSMUST00000002025.3
Tktl2
transketolase-like 2
chr16_+_44139821 0.27 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_+_141078188 0.26 ENSMUST00000106039.2
Pkp3
plakophilin 3
chr15_+_86214431 0.26 ENSMUST00000063414.8
Tbc1d22a
TBC1 domain family, member 22a
chr13_-_73328442 0.24 ENSMUST00000022097.5
Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr17_-_34850162 0.24 ENSMUST00000046022.9
Skiv2l
superkiller viralicidic activity 2-like (S. cerevisiae)
chr1_-_74284636 0.18 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp
angio-associated migratory protein
chr6_+_84008915 0.17 ENSMUST00000168387.1
Dysf
dysferlin
chr12_-_104751900 0.17 ENSMUST00000041987.6
Dicer1
dicer 1, ribonuclease type III
chr17_-_35132050 0.13 ENSMUST00000025249.6
Apom
apolipoprotein M
chr5_-_31202215 0.12 ENSMUST00000176245.1
ENSMUST00000177310.1
ENSMUST00000114590.1
Zfp513
zinc finger protein 513
chr17_-_23586214 0.11 ENSMUST00000115516.3
Zfp13
zinc finger protein 13
chr2_-_164200076 0.11 ENSMUST00000063251.2
Wfdc15a
WAP four-disulfide core domain 15A
chr12_-_93929102 0.08 ENSMUST00000180321.1
Gm9726
predicted gene 9726
chr2_-_26237368 0.08 ENSMUST00000036187.8
Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr14_+_57798156 0.07 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr11_-_84870812 0.07 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr17_+_30954679 0.06 ENSMUST00000066981.5
ENSMUST00000066554.6
ENSMUST00000114555.1
Umodl1
uromodulin-like 1
chr14_+_57798637 0.06 ENSMUST00000111267.1
Sap18
Sin3-associated polypeptide 18
chrX_+_6415736 0.05 ENSMUST00000143641.3
Shroom4
shroom family member 4
chr15_+_89532816 0.05 ENSMUST00000167173.1
Shank3
SH3/ankyrin domain gene 3
chr4_-_118409219 0.03 ENSMUST00000075406.5
Szt2
seizure threshold 2
chr6_+_114403666 0.02 ENSMUST00000161650.1
Hrh1
histamine receptor H1
chr6_-_137649211 0.01 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8
epidermal growth factor receptor pathway substrate 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr2f6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 GO:0036088 D-serine catabolic process(GO:0036088) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
1.1 18.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.8 3.4 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.8 3.8 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.8 2.3 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 3.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
0.7 2.9 GO:1902896 terminal web assembly(GO:1902896)
0.6 2.9 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.5 2.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.5 4.6 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.4 2.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.4 1.7 GO:1904306 regulation of voltage-gated chloride channel activity(GO:1902941) positive regulation of voltage-gated chloride channel activity(GO:1902943) positive regulation of gastro-intestinal system smooth muscle contraction(GO:1904306)
0.4 4.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.4 2.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.4 1.4 GO:0046075 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.3 1.7 GO:0071105 response to interleukin-11(GO:0071105)
0.3 2.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 1.2 GO:0006014 D-ribose metabolic process(GO:0006014)
0.3 1.7 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 3.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.2 6.4 GO:0035634 response to stilbenoid(GO:0035634)
0.2 4.2 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.8 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.2 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.9 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.6 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 1.2 GO:0010757 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) negative regulation of plasminogen activation(GO:0010757)
0.1 3.5 GO:0006991 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 1.4 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.1 0.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.1 2.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 8.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.4 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 1.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 5.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.7 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 3.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.1 1.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 3.4 GO:1901998 toxin transport(GO:1901998)
0.1 1.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 2.9 GO:0006414 translational elongation(GO:0006414)
0.1 4.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 2.6 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0032290 peripheral nervous system myelin formation(GO:0032290) regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 3.2 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 5.4 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0010726 positive regulation of hydrogen peroxide metabolic process(GO:0010726)
0.0 1.3 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0043928 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.0 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.0 0.6 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 3.2 GO:0035304 regulation of protein dephosphorylation(GO:0035304)
0.0 2.7 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 0.9 GO:0003341 cilium movement(GO:0003341)
0.0 0.3 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0034774 secretory granule lumen(GO:0034774) cytoplasmic membrane-bounded vesicle lumen(GO:0060205)
1.3 6.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 2.7 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.5 7.1 GO:0097512 cardiac myofibril(GO:0097512)
0.5 2.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 4.8 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.3 4.2 GO:0005861 troponin complex(GO:0005861)
0.3 1.0 GO:0031251 PAN complex(GO:0031251)
0.2 0.2 GO:0055087 Ski complex(GO:0055087)
0.2 1.4 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.2 1.4 GO:0002139 stereocilia coupling link(GO:0002139)
0.2 3.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 1.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.9 GO:0032433 filopodium tip(GO:0032433)
0.1 1.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.0 GO:0061574 ASAP complex(GO:0061574)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 4.5 GO:0097440 apical dendrite(GO:0097440)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.1 8.4 GO:0005643 nuclear pore(GO:0005643)
0.1 1.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 0.9 GO:0016342 catenin complex(GO:0016342)
0.1 0.9 GO:0036157 outer dynein arm(GO:0036157)
0.1 3.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.3 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.3 GO:0005914 spot adherens junction(GO:0005914)
0.0 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 3.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 13.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.6 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 4.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 4.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.9 GO:0030018 Z disc(GO:0030018)
0.0 0.9 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0070578 RISC-loading complex(GO:0070578)
0.0 2.0 GO:0005814 centriole(GO:0005814)
0.0 1.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.8 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 2.2 GO:0043204 perikaryon(GO:0043204)
0.0 1.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0031720 haptoglobin binding(GO:0031720)
1.3 3.8 GO:0045353 interleukin-1, Type II receptor binding(GO:0005151) interleukin-1 Type I receptor antagonist activity(GO:0045352) interleukin-1 Type II receptor antagonist activity(GO:0045353)
1.1 4.5 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.9 3.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.8 8.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.7 3.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.5 3.6 GO:0052851 ferric-chelate reductase activity(GO:0000293) cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.4 2.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.7 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.3 2.3 GO:0019808 polyamine binding(GO:0019808)
0.2 1.2 GO:0015288 porin activity(GO:0015288)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 6.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 6.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 1.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 5.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.9 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 11.4 GO:0008201 heparin binding(GO:0008201)
0.1 9.4 GO:0003774 motor activity(GO:0003774)
0.1 1.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 1.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 3.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.2 GO:0070883 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) pre-miRNA binding(GO:0070883)
0.0 2.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.2 GO:0005254 chloride channel activity(GO:0005254)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 1.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 1.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.4 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0 0.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 18.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 3.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 3.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.0 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 2.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.6 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 5.9 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 3.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 2.6 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 1.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 6.3 REACTOME TRANSLATION Genes involved in Translation
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 3.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives