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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Nrf1
Z-value: 4.00
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | mm10_v2_chr6_+_30047979_30048049 | -0.32 | 5.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_18991245 Show fit | 13.16 |
ENSMUST00000130268.1
ENSMUST00000059331.8 ENSMUST00000131087.1 |
Myb-related transcription factor, partner of profilin |
|
| chr8_+_70083509 Show fit | 11.39 |
ENSMUST00000007738.9
|
hyaluronan and proteoglycan link protein 4 |
|
| chr12_-_110696289 Show fit | 7.72 |
ENSMUST00000021698.6
|
heat shock protein 90, alpha (cytosolic), class A member 1 |
|
| chr7_+_24587543 Show fit | 7.41 |
ENSMUST00000077191.6
|
ethylmalonic encephalopathy 1 |
|
| chr9_+_59617284 Show fit | 6.70 |
ENSMUST00000026267.8
ENSMUST00000050483.7 |
poly (ADP-ribose) polymerase family, member 6 |
|
| chr1_-_136260873 Show fit | 6.62 |
ENSMUST00000086395.5
|
G protein-coupled receptor 25 |
|
| chr8_+_114133557 Show fit | 6.39 |
ENSMUST00000073521.5
ENSMUST00000066514.6 |
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr8_+_114133601 Show fit | 5.94 |
ENSMUST00000109109.1
|
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr8_+_114133635 Show fit | 5.82 |
ENSMUST00000147605.1
ENSMUST00000134593.1 |
nudix (nucleoside diphosphate linked moiety X)-type motif 7 |
|
| chr12_-_110696248 Show fit | 5.81 |
ENSMUST00000124156.1
|
heat shock protein 90, alpha (cytosolic), class A member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 24.6 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 22.0 | GO:0006457 | protein folding(GO:0006457) |
| 3.4 | 20.3 | GO:0045583 | regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585) |
| 4.5 | 18.2 | GO:0034031 | coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) |
| 0.8 | 14.8 | GO:0045717 | negative regulation of fatty acid biosynthetic process(GO:0045717) |
| 0.1 | 13.9 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.2 | 10.0 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 1.0 | 9.4 | GO:1900034 | regulation of cellular response to heat(GO:1900034) |
| 0.2 | 9.3 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.7 | 9.2 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 151.8 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 31.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.5 | 26.1 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 4.0 | 19.9 | GO:0097226 | sperm mitochondrial sheath(GO:0097226) |
| 0.4 | 12.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.6 | 11.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 10.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.2 | 9.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.4 | 9.4 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 1.1 | 9.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 19.9 | GO:0002135 | CTP binding(GO:0002135) |
| 3.6 | 18.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 5.7 | 17.1 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.3 | 14.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 14.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 13.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.2 | 13.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 12.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 12.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 11.2 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 19.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 16.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 13.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 10.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 7.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.4 | 7.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 6.0 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 5.2 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 5.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 4.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.1 | 22.1 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 14.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.5 | 13.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.7 | 11.8 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.5 | 11.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 11.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.4 | 10.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 10.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.3 | 9.4 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |