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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Obox3

Z-value: 0.68

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Transcription factors associated with Obox3

Gene Symbol Gene ID Gene Info
Obox3
ENSMUSG00000066772.6 oocyte specific homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Obox3mm10_v2_chr7_-_15627876_156278760.391.8e-02Click!

Activity profile of Obox3 motif

Sorted Z-values of Obox3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_103843154 5.06 ENSMUST00000063957.4
Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr7_-_4752972 2.54 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
Cox6b2
cytochrome c oxidase subunit VIb polypeptide 2
chr7_-_110982443 2.51 ENSMUST00000005751.6
Mrvi1
MRV integration site 1
chr2_-_126500631 2.45 ENSMUST00000129187.1
Atp8b4
ATPase, class I, type 8B, member 4
chrX_+_134295225 2.12 ENSMUST00000037687.7
Tmem35
transmembrane protein 35
chr7_-_110982169 2.05 ENSMUST00000154466.1
Mrvi1
MRV integration site 1
chr5_-_65091584 2.00 ENSMUST00000043352.4
Tmem156
transmembrane protein 156
chr4_+_115000174 1.71 ENSMUST00000129957.1
Stil
Scl/Tal1 interrupting locus
chr4_+_115000156 1.55 ENSMUST00000030490.6
Stil
Scl/Tal1 interrupting locus
chr14_-_19977151 1.47 ENSMUST00000055100.7
ENSMUST00000162425.1
Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977040 1.43 ENSMUST00000159028.1
Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr1_-_52232296 1.33 ENSMUST00000114512.1
Gls
glutaminase
chr14_-_19977249 1.23 ENSMUST00000160013.1
Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr18_+_42511496 1.14 ENSMUST00000025375.7
Tcerg1
transcription elongation regulator 1 (CA150)
chr18_-_43393346 0.99 ENSMUST00000025379.7
Dpysl3
dihydropyrimidinase-like 3
chr6_+_4902913 0.90 ENSMUST00000175889.1
ENSMUST00000168998.2
Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr9_+_57825918 0.84 ENSMUST00000165858.1
Gm17231
predicted gene 17231
chr9_+_38719024 0.79 ENSMUST00000129598.1
Vwa5a
von Willebrand factor A domain containing 5A
chr1_+_17727034 0.76 ENSMUST00000159958.1
ENSMUST00000160305.1
ENSMUST00000095075.4
Crispld1
cysteine-rich secretory protein LCCL domain containing 1
chr10_-_127341583 0.75 ENSMUST00000026474.3
Gli1
GLI-Kruppel family member GLI1
chr7_+_142831227 0.75 ENSMUST00000097935.2
Gm6471
predicted gene 6471
chr12_+_81631369 0.73 ENSMUST00000036116.5
Ttc9
tetratricopeptide repeat domain 9
chr7_+_88430257 0.69 ENSMUST00000107256.2
Rab38
RAB38, member of RAS oncogene family
chr19_+_8617991 0.68 ENSMUST00000010250.2
Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr9_-_50617228 0.57 ENSMUST00000147671.1
ENSMUST00000145139.1
ENSMUST00000155435.1
AU019823
expressed sequence AU019823
chr3_-_19628669 0.56 ENSMUST00000119133.1
1700064H15Rik
RIKEN cDNA 1700064H15 gene
chr10_+_111972664 0.54 ENSMUST00000163048.1
ENSMUST00000174653.1
Krr1
KRR1, small subunit (SSU) processome component, homolog (yeast)
chr14_+_61138445 0.54 ENSMUST00000089394.3
ENSMUST00000119509.1
Sacs
sacsin
chr18_-_78057395 0.53 ENSMUST00000170760.2
Siglec15
sialic acid binding Ig-like lectin 15
chr1_+_118389058 0.52 ENSMUST00000049404.6
ENSMUST00000070989.7
ENSMUST00000165223.1
ENSMUST00000178710.1
Clasp1
CLIP associating protein 1
chr13_-_23369156 0.52 ENSMUST00000125328.1
ENSMUST00000145451.1
ENSMUST00000050101.2
Zfp322a
zinc finger protein 322A
chr18_-_60848911 0.49 ENSMUST00000177172.1
ENSMUST00000175934.1
ENSMUST00000176630.1
Tcof1
Treacher Collins Franceschetti syndrome 1, homolog
chr2_+_69722797 0.49 ENSMUST00000090858.3
Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr1_+_178187721 0.48 ENSMUST00000159284.1
Desi2
desumoylating isopeptidase 2
chr11_+_52004340 0.47 ENSMUST00000109076.1
Cdkl3
cyclin-dependent kinase-like 3
chr19_+_3768112 0.45 ENSMUST00000005518.9
ENSMUST00000113967.1
ENSMUST00000152935.1
ENSMUST00000176262.1
ENSMUST00000176407.1
ENSMUST00000176926.1
ENSMUST00000176512.1
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr11_-_114934351 0.43 ENSMUST00000106581.1
ENSMUST00000074300.2
Cd300lb
CD300 antigen like family member B
chr7_+_35802593 0.41 ENSMUST00000052454.2
E130304I02Rik
RIKEN cDNA E130304I02 gene
chr7_-_25788635 0.40 ENSMUST00000002677.4
ENSMUST00000085948.4
Axl
AXL receptor tyrosine kinase
chr9_-_50617428 0.39 ENSMUST00000131351.1
ENSMUST00000171462.1
AU019823
expressed sequence AU019823
chr11_-_68973840 0.38 ENSMUST00000038644.4
Rangrf
RAN guanine nucleotide release factor
chr4_-_34050038 0.36 ENSMUST00000084734.4
Spaca1
sperm acrosome associated 1
chr15_+_91231578 0.36 ENSMUST00000109284.2
CN725425
cDNA sequence CN725425
chr2_+_136892168 0.35 ENSMUST00000099311.2
Slx4ip
SLX4 interacting protein
chr1_-_119836999 0.34 ENSMUST00000163621.1
ENSMUST00000168303.1
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chrX_+_74424632 0.32 ENSMUST00000114129.2
ENSMUST00000132749.1
Ikbkg
inhibitor of kappaB kinase gamma
chr7_-_44986313 0.31 ENSMUST00000045325.6
ENSMUST00000085387.4
ENSMUST00000107840.1
ENSMUST00000107843.3
ENSMUST00000107842.3
Prmt1
protein arginine N-methyltransferase 1
chr19_+_3767953 0.27 ENSMUST00000113970.1
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr4_+_132768325 0.27 ENSMUST00000102561.4
Rpa2
replication protein A2
chr9_-_21312255 0.26 ENSMUST00000115433.3
ENSMUST00000003397.7
Ap1m2
adaptor protein complex AP-1, mu 2 subunit
chr19_+_3767397 0.26 ENSMUST00000113974.4
ENSMUST00000113972.2
ENSMUST00000113973.1
ENSMUST00000113977.2
ENSMUST00000052699.6
ENSMUST00000113968.2
Suv420h1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chrX_+_74424534 0.25 ENSMUST00000135165.1
ENSMUST00000114128.1
ENSMUST00000114133.2
ENSMUST00000004330.3
Ikbkg
inhibitor of kappaB kinase gamma
chr2_+_152962485 0.25 ENSMUST00000099197.2
ENSMUST00000103155.3
Ttll9
tubulin tyrosine ligase-like family, member 9
chr4_+_74242468 0.23 ENSMUST00000077851.3
Kdm4c
lysine (K)-specific demethylase 4C
chr5_+_62813823 0.23 ENSMUST00000170704.1
Gm17384
predicted gene, 17384
chr11_+_61065798 0.21 ENSMUST00000041944.2
ENSMUST00000108717.2
Kcnj12
potassium inwardly-rectifying channel, subfamily J, member 12
chr6_-_122340200 0.20 ENSMUST00000159384.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr7_+_48789003 0.20 ENSMUST00000118927.1
ENSMUST00000125280.1
Zdhhc13
zinc finger, DHHC domain containing 13
chr9_+_73113426 0.18 ENSMUST00000169399.1
ENSMUST00000034738.7
Rsl24d1
ribosomal L24 domain containing 1
chr13_+_41001002 0.18 ENSMUST00000046951.9
Pak1ip1
PAK1 interacting protein 1
chr4_+_62663620 0.16 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr1_-_155232710 0.14 ENSMUST00000035914.3
BC034090
cDNA sequence BC034090
chr17_+_8988333 0.14 ENSMUST00000024650.5
1700010I14Rik
RIKEN cDNA 1700010I14 gene
chr19_+_45149833 0.12 ENSMUST00000026236.9
Tlx1
T cell leukemia, homeobox 1
chr16_-_20316750 0.11 ENSMUST00000182741.1
Cyp2ab1
cytochrome P450, family 2, subfamily ab, polypeptide 1
chr9_+_108460518 0.11 ENSMUST00000061209.5
Ccdc71
coiled-coil domain containing 71
chr18_+_37496997 0.09 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19
chr4_+_74013442 0.07 ENSMUST00000098006.2
ENSMUST00000084474.5
Frmd3
FERM domain containing 3
chr17_+_8988348 0.06 ENSMUST00000151609.1
1700010I14Rik
RIKEN cDNA 1700010I14 gene
chr11_-_69237022 0.04 ENSMUST00000021259.2
ENSMUST00000108665.1
ENSMUST00000108664.1
Gucy2e
guanylate cyclase 2e
chr1_+_178187417 0.03 ENSMUST00000161075.1
ENSMUST00000027783.7
Desi2
desumoylating isopeptidase 2
chr15_+_81663889 0.03 ENSMUST00000023029.8
ENSMUST00000174229.1
ENSMUST00000172748.1
L3mbtl2
l(3)mbt-like 2 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of Obox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 0.8 GO:0060032 notochord regression(GO:0060032)
0.6 5.1 GO:0015671 oxygen transport(GO:0015671)
0.3 4.6 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.2 3.3 GO:0033504 floor plate development(GO:0033504)
0.2 0.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 1.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 0.7 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 0.4 GO:2000668 dendritic cell apoptotic process(GO:0097048) neutrophil clearance(GO:0097350) regulation of dendritic cell apoptotic process(GO:2000668)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.7 GO:0015747 urate transport(GO:0015747)
0.0 0.5 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.4 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.2 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.0 0.5 GO:0014029 neural crest formation(GO:0014029)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.6 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.3 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 2.5 GO:0007030 Golgi organization(GO:0007030)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.0 0.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.5 GO:0030517 negative regulation of axon extension(GO:0030517)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 2.5 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 4.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0097542 ciliary tip(GO:0097542)
0.0 4.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0034709 methylosome(GO:0034709)
0.0 3.3 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.4 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host cell(GO:0043657)
0.0 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0035650 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.2 1.3 GO:0004359 glutaminase activity(GO:0004359)
0.2 0.6 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.2 4.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 0.5 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 1.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.3 GO:0030519 snoRNP binding(GO:0030519)
0.1 2.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.7 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 1.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 4.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 1.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 2.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor