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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax4

Z-value: 0.46

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Transcription factors associated with Pax4

Gene Symbol Gene ID Gene Info
Pax4
ENSMUSG00000029706.9 paired box 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax4mm10_v2_chr6_-_28447180_284471800.048.3e-01Click!

Activity profile of Pax4 motif

Sorted Z-values of Pax4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_88033328 0.85 ENSMUST00000078090.5
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr7_+_78913765 0.61 ENSMUST00000038142.8
Isg20
interferon-stimulated protein
chr7_+_78913436 0.58 ENSMUST00000121645.1
Isg20
interferon-stimulated protein
chr12_+_33314277 0.56 ENSMUST00000133549.1
Atxn7l1
ataxin 7-like 1
chr13_+_21717626 0.56 ENSMUST00000091754.2
Hist1h3h
histone cluster 1, H3h
chr17_+_26941420 0.52 ENSMUST00000081285.3
ENSMUST00000177932.1
Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
chr7_+_78913401 0.51 ENSMUST00000118867.1
Isg20
interferon-stimulated protein
chr7_+_43440782 0.51 ENSMUST00000040227.1
Cldnd2
claudin domain containing 2
chr19_+_55180716 0.50 ENSMUST00000154886.1
ENSMUST00000120936.1
Tectb
tectorin beta
chr2_-_160313616 0.49 ENSMUST00000109475.2
Gm826
predicted gene 826
chr12_+_33314375 0.49 ENSMUST00000155386.1
Atxn7l1
ataxin 7-like 1
chr13_+_109632760 0.47 ENSMUST00000135275.1
Pde4d
phosphodiesterase 4D, cAMP specific
chr2_-_114175274 0.45 ENSMUST00000102543.4
Aqr
aquarius
chr19_-_6015152 0.43 ENSMUST00000025891.8
Capn1
calpain 1
chr4_+_136357423 0.43 ENSMUST00000182167.1
Gm17388
predicted gene, 17388
chr17_-_23645264 0.42 ENSMUST00000024696.7
Mmp25
matrix metallopeptidase 25
chr19_-_6015769 0.40 ENSMUST00000164843.1
Capn1
calpain 1
chr4_+_147132038 0.39 ENSMUST00000084149.3
Gm13139
predicted gene 13139
chr7_+_81114799 0.36 ENSMUST00000026820.4
Slc28a1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1
chr14_+_53704007 0.36 ENSMUST00000103664.4
Trav5-4
T cell receptor alpha variable 5-4
chr12_-_84218835 0.35 ENSMUST00000046266.6
Elmsan1
ELM2 and Myb/SANT-like domain containing 1
chr11_+_98907801 0.34 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chrX_-_53209724 0.33 ENSMUST00000174390.1
Plac1
placental specific protein 1
chrX_+_9199865 0.31 ENSMUST00000069763.2
Lancl3
LanC lantibiotic synthetase component C-like 3 (bacterial)
chr10_+_119992916 0.31 ENSMUST00000105261.2
Grip1
glutamate receptor interacting protein 1
chr19_+_3972322 0.28 ENSMUST00000143380.1
Aldh3b2
aldehyde dehydrogenase 3 family, member B2
chr12_+_71048338 0.27 ENSMUST00000135709.1
Arid4a
AT rich interactive domain 4A (RBP1-like)
chr15_-_79164477 0.26 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr16_-_88774201 0.26 ENSMUST00000054223.2
2310057N15Rik
RIKEN cDNA 2310057N15 gene
chr4_+_136284708 0.25 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr11_+_62574523 0.25 ENSMUST00000018651.7
Trpv2
transient receptor potential cation channel, subfamily V, member 2
chr10_-_62792243 0.25 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr5_+_66676098 0.25 ENSMUST00000031131.9
Uchl1
ubiquitin carboxy-terminal hydrolase L1
chr10_+_26822560 0.25 ENSMUST00000135866.1
Arhgap18
Rho GTPase activating protein 18
chr8_+_8689666 0.25 ENSMUST00000179702.1
B930078G14Rik
RIKEN cDNA B930078G14 gene
chr7_+_58658181 0.25 ENSMUST00000168747.1
Atp10a
ATPase, class V, type 10A
chr11_+_87127052 0.24 ENSMUST00000041282.6
Trim37
tripartite motif-containing 37
chr8_-_4217261 0.23 ENSMUST00000168386.2
BC068157
cDNA sequence BC068157
chrM_+_11734 0.22 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr17_+_69383024 0.22 ENSMUST00000112674.1
Zbtb14
zinc finger and BTB domain containing 14
chr17_+_17402672 0.21 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr13_-_66851513 0.21 ENSMUST00000169322.1
Gm17404
predicted gene, 17404
chr17_+_35108279 0.21 ENSMUST00000037849.2
Ly6g5c
lymphocyte antigen 6 complex, locus G5C
chr16_-_36666067 0.20 ENSMUST00000089620.4
Cd86
CD86 antigen
chr4_+_6365650 0.20 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
Sdcbp
syndecan binding protein
chr5_-_121502980 0.20 ENSMUST00000079368.3
Adam1b
a disintegrin and metallopeptidase domain 1b
chr16_-_13730970 0.20 ENSMUST00000023364.6
Pla2g10
phospholipase A2, group X
chr4_-_58987095 0.19 ENSMUST00000030069.6
Ptgr1
prostaglandin reductase 1
chr4_+_136284658 0.19 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr6_+_48613180 0.19 ENSMUST00000061720.4
Zfp775
zinc finger protein 775
chr19_+_53140430 0.19 ENSMUST00000111741.2
Add3
adducin 3 (gamma)
chr2_+_22895583 0.18 ENSMUST00000152170.1
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr19_-_10482874 0.18 ENSMUST00000038842.3
Ppp1r32
protein phosphatase 1, regulatory subunit 32
chr7_-_45366714 0.18 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr2_-_114654943 0.18 ENSMUST00000028640.7
ENSMUST00000102542.3
Dph6
diphthamine biosynthesis 6
chr7_+_24862193 0.17 ENSMUST00000052897.4
ENSMUST00000170837.2
Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr2_+_22895482 0.17 ENSMUST00000053729.7
Pdss1
prenyl (solanesyl) diphosphate synthase, subunit 1
chr5_+_124552845 0.17 ENSMUST00000071057.7
Ddx55
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
chr10_-_95673451 0.17 ENSMUST00000099328.1
Anapc15-ps
anaphase prompoting complex C subunit 15, pseudogene
chr16_-_13730443 0.16 ENSMUST00000115807.2
Pla2g10
phospholipase A2, group X
chr9_-_101198999 0.16 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr2_-_114654861 0.15 ENSMUST00000055144.7
Dph6
diphthamine biosynthesis 6
chr17_+_35059035 0.15 ENSMUST00000007255.6
ENSMUST00000174493.1
Ddah2
dimethylarginine dimethylaminohydrolase 2
chr15_+_78597047 0.15 ENSMUST00000043069.5
Cyth4
cytohesin 4
chr2_-_33086366 0.15 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr16_+_15637844 0.14 ENSMUST00000023352.8
Prkdc
protein kinase, DNA activated, catalytic polypeptide
chr8_-_70700070 0.14 ENSMUST00000116172.1
Gm11175
predicted gene 11175
chr7_-_104279732 0.14 ENSMUST00000051795.9
Trim5
tripartite motif-containing 5
chr4_+_146610961 0.13 ENSMUST00000130825.1
Gm13248
predicted gene 13248
chr13_-_66852017 0.13 ENSMUST00000059329.6
Gm17449
predicted gene, 17449
chrX_+_73192222 0.12 ENSMUST00000101486.4
Xlr3b
X-linked lymphocyte-regulated 3B
chr6_+_136518820 0.12 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chrX_-_48877711 0.12 ENSMUST00000114928.1
Gm595
predicted gene 595
chr5_+_76951382 0.12 ENSMUST00000141687.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase
chr3_+_20057802 0.11 ENSMUST00000002502.5
Hltf
helicase-like transcription factor
chr4_+_156235999 0.11 ENSMUST00000179543.1
ENSMUST00000179886.1
Noc2l
nucleolar complex associated 2 homolog (S. cerevisiae)
chr1_-_65032738 0.11 ENSMUST00000162800.1
ENSMUST00000069142.5
Akr1cl
aldo-keto reductase family 1, member C-like
chr16_-_14291355 0.10 ENSMUST00000090287.3
Myh11
myosin, heavy polypeptide 11, smooth muscle
chr4_+_150281573 0.10 ENSMUST00000105682.2
Rere
arginine glutamic acid dipeptide (RE) repeats
chr10_+_127421208 0.10 ENSMUST00000168780.1
R3hdm2
R3H domain containing 2
chr6_-_130337502 0.10 ENSMUST00000088017.4
ENSMUST00000111998.2
Klra3
killer cell lectin-like receptor, subfamily A, member 3
chr11_+_43587040 0.10 ENSMUST00000056256.2
4933415A04Rik
RIKEN cDNA 4933415A04 gene
chr13_+_38204928 0.07 ENSMUST00000091641.5
ENSMUST00000178564.1
Snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr4_+_125066672 0.07 ENSMUST00000052183.6
Snip1
Smad nuclear interacting protein 1
chrX_-_9662950 0.07 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr13_-_55528511 0.07 ENSMUST00000047877.4
Dok3
docking protein 3
chr15_-_88978958 0.07 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chrX_-_155128409 0.06 ENSMUST00000076671.3
1700042B14Rik
RIKEN cDNA 1700042B14 gene
chr12_-_90738438 0.06 ENSMUST00000082432.3
Dio2
deiodinase, iodothyronine, type II
chr10_+_90071095 0.06 ENSMUST00000183109.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_125506385 0.06 ENSMUST00000028633.6
Fbn1
fibrillin 1
chr4_+_155831272 0.05 ENSMUST00000139651.1
ENSMUST00000084097.5
Aurkaip1
aurora kinase A interacting protein 1
chr13_-_101768154 0.05 ENSMUST00000055518.6
Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr5_-_116288944 0.05 ENSMUST00000086483.3
Ccdc60
coiled-coil domain containing 60
chr16_-_45844228 0.05 ENSMUST00000076333.5
Phldb2
pleckstrin homology-like domain, family B, member 2
chr3_+_95624971 0.05 ENSMUST00000058230.6
ENSMUST00000037983.4
Ensa
endosulfine alpha
chr10_-_64090241 0.04 ENSMUST00000133588.1
Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr14_-_56159579 0.04 ENSMUST00000015578.4
Gzmg
granzyme G
chr11_+_117484368 0.04 ENSMUST00000092394.3
Gm11733
predicted gene 11733
chr6_+_65590382 0.03 ENSMUST00000114236.1
Tnip3
TNFAIP3 interacting protein 3
chr1_-_4360256 0.03 ENSMUST00000027032.4
Rp1
retinitis pigmentosa 1 (human)
chr2_-_105904484 0.03 ENSMUST00000122965.1
Elp4
elongation protein 4 homolog (S. cerevisiae)
chr9_+_36832684 0.02 ENSMUST00000034630.8
Fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr15_-_59374149 0.02 ENSMUST00000022976.4
E430025E21Rik
RIKEN cDNA E430025E21 gene
chr9_+_32696005 0.02 ENSMUST00000034534.6
ENSMUST00000050797.7
ENSMUST00000184887.1
Ets1
E26 avian leukemia oncogene 1, 5' domain
chr14_-_12823031 0.02 ENSMUST00000067491.6
ENSMUST00000177814.1
ENSMUST00000112658.1
ENSMUST00000112657.2
Cadps
Ca2+-dependent secretion activator
chrX_+_142227923 0.02 ENSMUST00000042329.5
Nxt2
nuclear transport factor 2-like export factor 2
chr15_-_50890041 0.02 ENSMUST00000077935.5
Trps1
trichorhinophalangeal syndrome I (human)
chr16_-_45844303 0.02 ENSMUST00000036355.6
Phldb2
pleckstrin homology-like domain, family B, member 2
chr1_-_74935549 0.01 ENSMUST00000094844.3
Ccdc108
coiled-coil domain containing 108
chr15_-_50889691 0.01 ENSMUST00000165201.2
ENSMUST00000184458.1
Trps1
trichorhinophalangeal syndrome I (human)
chr6_+_67115671 0.01 ENSMUST00000181304.1
A430010J10Rik
RIKEN cDNA A430010J10 gene
chr5_+_76951307 0.00 ENSMUST00000031160.9
ENSMUST00000120912.1
ENSMUST00000117536.1
Paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:0051977 lysophospholipid transport(GO:0051977)
0.1 0.4 GO:0015851 nucleobase transport(GO:0015851) pyrimidine nucleobase transport(GO:0015855)
0.1 0.2 GO:0002644 negative regulation of tolerance induction(GO:0002644)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0060022 hard palate development(GO:0060022)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.3 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326) somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.1 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:1990462 omegasome(GO:1990462)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.3 GO:0051233 spindle midzone(GO:0051233)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0008859 exoribonuclease II activity(GO:0008859)
0.1 0.4 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)
0.1 0.4 GO:0000010 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.1 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.2 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0031493 nucleosomal histone binding(GO:0031493)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening