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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Pax8

Z-value: 0.39

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Transcription factors associated with Pax8

Gene Symbol Gene ID Gene Info
ENSMUSG00000026976.9 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475596_24475605-0.372.4e-02Click!

Activity profile of Pax8 motif

Sorted Z-values of Pax8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_52863299 0.58 ENSMUST00000103616.3
T cell receptor alpha variable 15D-1-DV6D-1
chr13_-_62607499 0.56 ENSMUST00000091563.4
RIKEN cDNA 6720489N17 gene
chr5_-_87591582 0.55 ENSMUST00000031201.7
sulfotransferase family 1E, member 1
chr1_-_139608282 0.53 ENSMUST00000170441.2
complement factor H-related 3
chr14_+_53676141 0.50 ENSMUST00000103662.4
T cell receptor alpha variable 9-4
chr7_+_112742025 0.48 ENSMUST00000164363.1
TEA domain family member 1
chr16_+_34784917 0.27 ENSMUST00000023538.8
myosin, light polypeptide kinase
chr2_+_177508570 0.23 ENSMUST00000108940.2
predicted gene 14403
chr11_-_49114874 0.21 ENSMUST00000109201.1
olfactory receptor 1396
chr6_+_127072902 0.21 ENSMUST00000000186.6
fibroblast growth factor 23
chr9_+_109052828 0.19 ENSMUST00000124432.1
shisa homolog 5 (Xenopus laevis)
chrX_+_82948861 0.19 ENSMUST00000114000.1
dystrophin, muscular dystrophy
chrX_-_7572843 0.19 ENSMUST00000132788.1
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr2_-_150255591 0.19 ENSMUST00000063463.5
predicted gene 21994
chr13_-_62520451 0.18 ENSMUST00000082203.6
ENSMUST00000101547.4
zinc finger protein 934
chr13_-_66852017 0.16 ENSMUST00000059329.6
predicted gene, 17449
chr7_-_30861470 0.15 ENSMUST00000052700.3
free fatty acid receptor 1
chr9_-_103230262 0.14 ENSMUST00000165296.1
ENSMUST00000112645.1
ENSMUST00000166836.1
transferrin
predicted gene 20425
chr9_-_103230415 0.14 ENSMUST00000035158.9
transferrin
chr7_-_29906087 0.14 ENSMUST00000053521.8
zinc finger protein 27
chr12_+_71048338 0.13 ENSMUST00000135709.1
AT rich interactive domain 4A (RBP1-like)
chr7_+_114768767 0.10 ENSMUST00000151464.1
inscuteable homolog (Drosophila)
chr10_+_18845071 0.10 ENSMUST00000019998.7
PERP, TP53 apoptosis effector
chr5_+_91074611 0.10 ENSMUST00000031324.4
epiregulin
chr1_+_174050375 0.10 ENSMUST00000062665.3
olfactory receptor 432
chr15_+_54410755 0.09 ENSMUST00000036737.3
collectin sub-family member 10
chr11_+_78499087 0.09 ENSMUST00000017488.4
vitronectin
chr4_+_103313806 0.09 ENSMUST00000035780.3
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chrX_-_105391770 0.09 ENSMUST00000136406.1
ENSMUST00000150604.1
RIKEN cDNA 5330434G04 gene
chr7_+_107595051 0.08 ENSMUST00000040056.7
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_105391726 0.08 ENSMUST00000142109.1
RIKEN cDNA 5330434G04 gene
chr1_+_65186727 0.08 ENSMUST00000097707.4
ENSMUST00000081154.7
phosphoinositide kinase, FYVE finger containing
chr13_-_62777089 0.07 ENSMUST00000167516.2
predicted gene 5141
chr7_-_42578588 0.07 ENSMUST00000179470.1
predicted gene, 21028
chr12_-_20900867 0.07 ENSMUST00000079237.5
zinc finger protein 125
chr7_+_114768736 0.07 ENSMUST00000117543.1
inscuteable homolog (Drosophila)
chr1_-_92518515 0.06 ENSMUST00000062353.4
olfactory receptor 1414
chr6_+_139736895 0.06 ENSMUST00000111868.3
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
chr15_-_101869695 0.05 ENSMUST00000087996.5
keratin 77
chr12_+_84996487 0.04 ENSMUST00000101202.3
YLP motif containing 1
chr8_-_64849818 0.04 ENSMUST00000034017.7
kelch-like 2, Mayven
chr7_-_141100526 0.03 ENSMUST00000097958.2
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr16_-_19408078 0.03 ENSMUST00000052516.4
olfactory receptor 165
chr5_+_100196611 0.03 ENSMUST00000066813.1
predicted gene 9932
chr1_+_6487231 0.03 ENSMUST00000140079.1
ENSMUST00000131494.1
suppression of tumorigenicity 18
chr7_+_12897800 0.02 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
zinc finger and SCAN domain containing 22
chr12_-_28582515 0.02 ENSMUST00000110917.1
ENSMUST00000020965.7
allantoicase
chr19_+_46075842 0.01 ENSMUST00000165017.1
nucleolar and coiled-body phosphoprotein 1
chr9_+_32116040 0.00 ENSMUST00000174641.1
Rho GTPase activating protein 32
chr17_+_21691860 0.00 ENSMUST00000072133.4
predicted gene 10226

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.2 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.2 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.3 GO:0070447 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.5 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.2 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.0 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.3 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:2001069 glycogen binding(GO:2001069)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0072510 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.3 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.5 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression