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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Prop1
Z-value: 1.73
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Transcription factors associated with Prop1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Prop1 | mm10_v2_chr11_-_50953745_50953768 | -0.09 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39287074 Show fit | 15.95 |
ENSMUST00000003137.8
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr10_+_128971191 Show fit | 10.42 |
ENSMUST00000181142.1
|
RIKEN cDNA 9030616G12 gene |
|
| chr7_-_14446570 Show fit | 9.30 |
ENSMUST00000063509.4
|
RIKEN cDNA 2810007J24 gene |
|
| chr1_+_130826762 Show fit | 9.26 |
ENSMUST00000133792.1
|
polymeric immunoglobulin receptor |
|
| chr7_-_14446651 Show fit | 9.02 |
ENSMUST00000125941.1
|
RIKEN cDNA 2810007J24 gene |
|
| chr5_-_87091150 Show fit | 8.62 |
ENSMUST00000154455.1
|
UDP glucuronosyltransferase 2 family, polypeptide B36 |
|
| chr3_+_138415484 Show fit | 6.38 |
ENSMUST00000161312.1
ENSMUST00000013458.8 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
|
| chr17_+_79626669 Show fit | 6.37 |
ENSMUST00000086570.1
|
RIKEN cDNA 4921513D11 gene |
|
| chr4_-_96664112 Show fit | 6.26 |
ENSMUST00000030299.7
|
cytochrome P450, family 2, subfamily j, polypeptide 5 |
|
| chr9_+_78230644 Show fit | 6.08 |
ENSMUST00000098537.3
|
glutathione S-transferase, alpha 1 (Ya) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Prop1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 26.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 2.5 | 12.4 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.3 | 11.6 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 2.5 | 9.8 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.2 | 8.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.7 | 8.0 | GO:0072615 | interleukin-17 secretion(GO:0072615) |
| 0.3 | 7.4 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 2.1 | 6.3 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) |
| 0.2 | 6.1 | GO:0035634 | response to stilbenoid(GO:0035634) |
| 0.2 | 5.7 | GO:0097286 | iron ion import(GO:0097286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 9.1 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 8.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 8.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 4.9 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 4.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 1.1 | 4.2 | GO:0033165 | interphotoreceptor matrix(GO:0033165) |
| 0.0 | 4.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 3.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 3.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 15.9 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.3 | 13.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.5 | 12.5 | GO:0070330 | aromatase activity(GO:0070330) |
| 1.2 | 11.6 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 3.3 | 9.8 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.9 | 9.3 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 1.6 | 8.0 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.1 | 7.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 6.1 | GO:0043295 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.7 | 5.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 4.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.4 | 2.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 2.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 1.6 | 9.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 6.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 5.8 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.6 | 5.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 4.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 4.2 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.3 | 3.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 3.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 3.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |