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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Prox1

Z-value: 1.08

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Transcription factors associated with Prox1

Gene Symbol Gene ID Gene Info
Prox1
ENSMUSG00000010175.7 prospero homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190170671_190170744-0.115.2e-01Click!

Activity profile of Prox1 motif

Sorted Z-values of Prox1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_51146757 10.17 ENSMUST00000080126.2
Rnase1
ribonuclease, RNase A family, 1 (pancreatic)
chr4_-_137430517 8.88 ENSMUST00000102522.4
Cela3b
chymotrypsin-like elastase family, member 3B
chr3_+_153844209 4.75 ENSMUST00000044089.3
Asb17
ankyrin repeat and SOCS box-containing 17
chr4_-_137409777 4.69 ENSMUST00000024200.6
Gm13011
predicted gene 13011
chr19_-_15924560 3.87 ENSMUST00000162053.1
Psat1
phosphoserine aminotransferase 1
chr18_-_68429235 3.62 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chr7_+_142441808 2.72 ENSMUST00000105971.1
ENSMUST00000145287.1
Tnni2
troponin I, skeletal, fast 2
chr17_+_29319183 2.54 ENSMUST00000114699.1
ENSMUST00000155348.1
Pi16
peptidase inhibitor 16
chr14_-_55944536 2.52 ENSMUST00000022834.6
Cma1
chymase 1, mast cell
chr4_-_68954351 2.30 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr10_-_80813486 1.96 ENSMUST00000181039.1
ENSMUST00000180438.1
Jsrp1
junctional sarcoplasmic reticulum protein 1
chr16_+_23146536 1.46 ENSMUST00000023593.5
ENSMUST00000171309.1
Adipoq
adiponectin, C1Q and collagen domain containing
chr6_+_60944472 1.45 ENSMUST00000129603.1
Mmrn1
multimerin 1
chr12_-_36042476 1.44 ENSMUST00000020896.8
Tspan13
tetraspanin 13
chr6_-_131388417 1.32 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3
Y box protein 3
chr4_-_133967235 1.27 ENSMUST00000123234.1
Hmgn2
high mobility group nucleosomal binding domain 2
chr12_-_83487708 1.25 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3
D4, zinc and double PHD fingers, family 3
chr4_+_130913264 1.23 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5
lysosomal-associated protein transmembrane 5
chr15_-_80014808 1.19 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr8_+_88289028 1.17 ENSMUST00000171456.1
Adcy7
adenylate cyclase 7
chr12_-_40223149 1.11 ENSMUST00000171553.1
ENSMUST00000001672.5
Ifrd1
interferon-related developmental regulator 1
chr17_+_47630690 1.01 ENSMUST00000024779.8
Usp49
ubiquitin specific peptidase 49
chr19_+_46056539 1.00 ENSMUST00000111899.1
ENSMUST00000099392.3
ENSMUST00000062322.4
Pprc1
peroxisome proliferative activated receptor, gamma, coactivator-related 1
chr4_+_140701466 0.98 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2
regulator of chromosome condensation 2
chr4_-_131821516 0.97 ENSMUST00000097860.2
Ptpru
protein tyrosine phosphatase, receptor type, U
chr18_-_20682963 0.82 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr4_+_99829437 0.71 ENSMUST00000124547.1
ENSMUST00000106994.1
Efcab7
EF-hand calcium binding domain 7
chr4_+_130913120 0.71 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr8_+_60632856 0.69 ENSMUST00000160719.1
Mfap3l
microfibrillar-associated protein 3-like
chr8_-_70476911 0.66 ENSMUST00000066597.5
ENSMUST00000166976.1
Klhl26
kelch-like 26
chr17_-_35516780 0.63 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
Tcf19
transcription factor 19
chr8_+_31111816 0.62 ENSMUST00000046941.7
Rnf122
ring finger protein 122
chr18_+_46850034 0.61 ENSMUST00000025358.2
4833403I15Rik
RIKEN cDNA 4833403I15 gene
chr17_-_70924958 0.59 ENSMUST00000180468.1
Gm26510
predicted gene, 26510
chr15_-_86186136 0.57 ENSMUST00000044332.9
Cerk
ceramide kinase
chr7_+_127777095 0.57 ENSMUST00000144406.1
Setd1a
SET domain containing 1A
chr8_+_60632818 0.57 ENSMUST00000161421.1
Mfap3l
microfibrillar-associated protein 3-like
chr2_-_26910569 0.54 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22
mediator complex subunit 22
chrX_-_73966329 0.49 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1
host cell factor C1
chr5_+_139252314 0.45 ENSMUST00000026976.5
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr12_+_111442653 0.44 ENSMUST00000109792.1
Tnfaip2
tumor necrosis factor, alpha-induced protein 2
chr5_+_139252343 0.43 ENSMUST00000130326.1
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr4_+_133176336 0.40 ENSMUST00000105912.1
Wasf2
WAS protein family, member 2
chr7_-_126861648 0.39 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e
INO80 complex subunit E
chr1_+_78816909 0.38 ENSMUST00000057262.6
Kcne4
potassium voltage-gated channel, Isk-related subfamily, gene 4
chr2_+_36230426 0.38 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr17_+_27839974 0.35 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr12_+_111442453 0.33 ENSMUST00000102745.3
Tnfaip2
tumor necrosis factor, alpha-induced protein 2
chr10_-_81496329 0.32 ENSMUST00000020463.7
Ncln
nicalin homolog (zebrafish)
chr2_+_78051155 0.30 ENSMUST00000145972.1
4930440I19Rik
RIKEN cDNA 4930440I19 gene
chr12_+_40222758 0.30 ENSMUST00000038121.4
Gm7008
predicted gene 7008
chr14_+_24293214 0.29 ENSMUST00000162224.1
ENSMUST00000163055.1
ENSMUST00000161740.1
ENSMUST00000160710.1
ENSMUST00000041413.5
E330034G19Rik
RIKEN cDNA E330034G19 gene
chr5_+_139211934 0.29 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1
Sad1 and UNC84 domain containing 1
chr5_+_24100578 0.27 ENSMUST00000030841.5
ENSMUST00000163409.1
Klhl7
kelch-like 7
chr4_+_117835387 0.21 ENSMUST00000169885.1
Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr10_-_81496313 0.21 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr1_+_161395409 0.21 ENSMUST00000028024.4
Tnfsf4
tumor necrosis factor (ligand) superfamily, member 4
chr2_+_128967383 0.20 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6
zinc finger CCCH type containing 6
chr11_+_4986824 0.19 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr7_+_28716846 0.19 ENSMUST00000108279.2
Fbxo17
F-box protein 17
chr11_-_115933464 0.17 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr2_+_78051220 0.13 ENSMUST00000144728.1
4930440I19Rik
RIKEN cDNA 4930440I19 gene
chr2_-_167062981 0.12 ENSMUST00000048988.7
Znfx1
zinc finger, NFX1-type containing 1
chr6_+_58640536 0.10 ENSMUST00000145161.1
ENSMUST00000114294.1
Abcg2
ATP-binding cassette, sub-family G (WHITE), member 2
chr7_-_127449109 0.10 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr17_-_37280418 0.09 ENSMUST00000077585.2
Olfr99
olfactory receptor 99
chr19_+_60144682 0.09 ENSMUST00000065383.4
E330013P04Rik
RIKEN cDNA E330013P04 gene
chr1_-_160792908 0.09 ENSMUST00000028049.7
Rabgap1l
RAB GTPase activating protein 1-like
chr17_+_86963279 0.05 ENSMUST00000139344.1
Rhoq
ras homolog gene family, member Q
chrX_-_43274786 0.04 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr2_+_136891501 0.03 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr7_-_101868667 0.03 ENSMUST00000150184.1
Folr1
folate receptor 1 (adult)
chr7_-_127448993 0.01 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr2_-_25847248 0.01 ENSMUST00000076989.6
Sohlh1
spermatogenesis and oogenesis specific basic helix-loop-helix 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Prox1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0072244 metanephric glomerular epithelium development(GO:0072244)
0.8 3.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.6 2.5 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.3 1.3 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2 1.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.2 0.5 GO:0019046 release from viral latency(GO:0019046)
0.2 2.5 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 10.2 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 0.9 GO:0071816 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 2.3 GO:0007614 short-term memory(GO:0007614)
0.1 0.4 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 4.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.1 1.2 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 0.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.2 GO:0002215 defense response to nematode(GO:0002215) memory T cell activation(GO:0035709) positive regulation of memory T cell differentiation(GO:0043382) negative regulation of T-helper 1 cell differentiation(GO:0045626) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 8.9 GO:0008203 cholesterol metabolic process(GO:0008203)
0.1 0.6 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1 1.1 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.8 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0097240 nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 3.6 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 1.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.0 0.1 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.0 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.5 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 1.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 GO:0005861 troponin complex(GO:0005861)
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 1.0 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 1.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 1.2 GO:0071565 nBAF complex(GO:0071565)
0.0 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.3 GO:0005921 gap junction(GO:0005921)
0.0 0.8 GO:0000145 exocyst(GO:0000145)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 10.2 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.6 3.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.3 2.7 GO:0031014 troponin T binding(GO:0031014)
0.2 0.6 GO:0001729 ceramide kinase activity(GO:0001729)
0.2 1.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.5 GO:0033691 sialic acid binding(GO:0033691)
0.1 1.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.6 GO:1990188 euchromatin binding(GO:1990188)
0.1 1.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 1.8 GO:0008483 transaminase activity(GO:0008483)
0.1 11.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 1.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 1.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 2.5 GO:0030414 peptidase inhibitor activity(GO:0030414)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.2 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.6 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 2.3 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 4.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters