ISMARA results: Runx2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Runx2_Bcl11a

Z-value: 3.82

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Transcription factors associated with Runx2_Bcl11a

Gene Symbol	Gene ID	Gene Info
Runx2 Ensembl NCBI MGI UniProt	ENSMUSG00000039153.10	runt related transcription factor 2
Bcl11a Ensembl NCBI MGI UniProt	ENSMUSG00000000861.9	B cell CLL/lymphoma 11A (zinc finger protein)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bcl11a	mm10_v2_chr11_+_24078022_24078076	0.82	1.3e-09	Click!
Runx2	mm10_v2_chr17_-_44735612_44735710	0.78	2.0e-08	Click!

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_87875524 Show fit	33.94	ENSMUST00000049768.3	Epx Ensembl NCBI MGI UniProt Show fit	eosinophil peroxidase
chr11_+_87793470 Show fit	26.91	ENSMUST00000020779.4	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr11_+_87793722 Show fit	25.34	ENSMUST00000143021.2	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr7_+_143005046 Show fit	25.24	ENSMUST00000009396.6	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32
chr4_-_46404224 Show fit	21.61	ENSMUST00000107764.2	Hemgn Ensembl NCBI MGI UniProt Show fit	hemogen
chr18_-_35649349 Show fit	20.89	ENSMUST00000025211.4	Mzb1 Ensembl NCBI MGI UniProt Show fit	marginal zone B and B1 cell-specific protein 1
chr5_+_90768511 Show fit	20.69	ENSMUST00000031319.6	Ppbp Ensembl NCBI MGI UniProt Show fit	pro-platelet basic protein
chr7_+_143005677 Show fit	19.86	ENSMUST00000082008.5 ENSMUST00000105925.1 ENSMUST00000105924.1	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32
chr7_+_143005638 Show fit	19.77	ENSMUST00000075172.5 ENSMUST00000105923.1	Tspan32 Ensembl NCBI MGI UniProt Show fit	tetraspanin 32
chr7_-_142661858 Show fit	18.83	ENSMUST00000145896.2	Igf2 Ensembl NCBI MGI UniProt Show fit	insulin-like growth factor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.9	79.3	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
17.4	52.3	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
5.0	39.7	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
11.4	34.1	GO:0002215	defense response to nematode(GO:0002215)
2.9	23.5	GO:1901748	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
1.2	22.2	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
4.2	20.9	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
6.1	18.3	GO:0060217	hemangioblast cell differentiation(GO:0060217)
0.2	18.1	GO:0042100	B cell proliferation(GO:0042100)
3.3	16.7	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)

Showing 1 to 10 of 355 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.7	70.7	GO:0070442	integrin alphaIIb-beta3 complex(GO:0070442)
4.0	63.7	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	56.2	GO:0005615	extracellular space(GO:0005615)
0.1	26.5	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
6.1	18.3	GO:0033193	Lsd1/2 complex(GO:0033193)
0.7	17.7	GO:0031528	microvillus membrane(GO:0031528)
4.2	16.8	GO:0044194	cytolytic granule(GO:0044194)
1.5	16.5	GO:0042629	mast cell granule(GO:0042629)
1.1	15.1	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	14.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)

Showing 1 to 10 of 164 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	79.2	GO:0004601	peroxidase activity(GO:0004601)
1.1	62.6	GO:0005158	insulin receptor binding(GO:0005158)
2.2	28.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	24.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.0	23.9	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.2	21.4	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.3	19.5	GO:0070888	E-box binding(GO:0070888)
0.1	17.2	GO:0017124	SH3 domain binding(GO:0017124)
1.8	16.0	GO:0019158	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4	15.9	GO:1990841	promoter-specific chromatin binding(GO:1990841)

Showing 1 to 10 of 252 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	60.8	PID IL23 PATHWAY	IL23-mediated signaling events
0.5	36.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.6	34.6	PID IL12 2PATHWAY	IL12-mediated signaling events
0.7	23.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.6	23.3	PID EPO PATHWAY	EPO signaling pathway
0.4	22.8	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	19.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.8	14.8	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	14.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.8	13.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Showing 1 to 10 of 74 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	36.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.7	33.2	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	25.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.1	22.6	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.4	17.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
1.2	16.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.4	16.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.4	15.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	15.3	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.3	13.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 110 entries

Results for Runx2_Bcl11a

Z-value: 3.82

Motif logo

Transcription factors associated with Runx2_Bcl11a

Activity-expression correlation:

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: