ISMARA results: Six6

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Six6

Z-value: 2.96

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Transcription factors associated with Six6

Gene Symbol	Gene ID	Gene Info
Six6 Ensembl NCBI MGI UniProt	ENSMUSG00000021099.5	sine oculis-related homeobox 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Six6	mm10_v2_chr12_+_72939724_72939758	0.25	1.3e-01	Click!

Activity profile of Six6 motif

Sorted Z-values of Six6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_117797660 Show fit	25.87	ENSMUST00000106331.1	6030468B19Rik Ensembl NCBI MGI UniProt Show fit	RIKEN cDNA 6030468B19 gene
chr4_+_134864536 Show fit	24.45	ENSMUST00000030627.7	Rhd Ensembl NCBI MGI UniProt Show fit	Rh blood group, D antigen
chr17_+_48247759 Show fit	20.75	ENSMUST00000048065.5	Trem3 Ensembl NCBI MGI UniProt Show fit	triggering receptor expressed on myeloid cells 3
chr6_-_41314700 Show fit	19.80	ENSMUST00000064324.5	Try5 Ensembl NCBI MGI UniProt Show fit	trypsin 5
chr17_-_28560704 Show fit	19.65	ENSMUST00000114785.1 ENSMUST00000025062.3	Clps Ensembl NCBI MGI UniProt Show fit	colipase, pancreatic
chr16_-_36408349 Show fit	19.38	ENSMUST00000023619.6	Stfa2 Ensembl NCBI MGI UniProt Show fit	stefin A2
chr6_+_41458923 Show fit	18.46	ENSMUST00000031910.7	Prss1 Ensembl NCBI MGI UniProt Show fit	protease, serine, 1 (trypsin 1)
chr16_-_16863975 Show fit	16.48	ENSMUST00000100136.3	Igll1 Ensembl NCBI MGI UniProt Show fit	immunoglobulin lambda-like polypeptide 1
chr8_+_57455898 Show fit	15.98	ENSMUST00000034023.3	Scrg1 Ensembl NCBI MGI UniProt Show fit	scrapie responsive gene 1
chr3_+_108364882 Show fit	15.01	ENSMUST00000090563.5	Mybphl Ensembl NCBI MGI UniProt Show fit	myosin binding protein H-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Six6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	59.6	GO:0007586	digestion(GO:0007586)
12.4	37.3	GO:0072488	ammonium transmembrane transport(GO:0072488)
4.8	28.6	GO:0034441	plasma lipoprotein particle oxidation(GO:0034441)
3.0	20.8	GO:0070945	neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1	17.9	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
2.4	16.6	GO:0014005	microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.5	16.5	GO:0006910	phagocytosis, recognition(GO:0006910)
0.9	15.0	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.5	14.5	GO:0015701	bicarbonate transport(GO:0015701)
1.0	11.3	GO:0071294	cellular response to zinc ion(GO:0071294)

Showing 1 to 10 of 94 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	34.8	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	32.2	GO:0005615	extracellular space(GO:0005615)
0.0	30.8	GO:0005576	extracellular region(GO:0005576)
1.3	28.6	GO:0034362	low-density lipoprotein particle(GO:0034362)
1.1	20.3	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	16.9	GO:0031965	nuclear membrane(GO:0031965)
0.4	16.6	GO:0008305	integrin complex(GO:0008305)
0.6	15.0	GO:0005859	muscle myosin complex(GO:0005859)
0.2	14.5	GO:0014704	intercalated disc(GO:0014704)
1.6	11.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	37.3	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.2	37.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.9	28.6	GO:0047499	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
2.3	20.8	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.8	20.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.2	19.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	17.5	GO:0008047	enzyme activator activity(GO:0008047)
2.4	16.6	GO:0001851	complement component C3b binding(GO:0001851)
0.8	15.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.7	14.5	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)

Showing 1 to 10 of 74 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	28.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	27.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	16.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	10.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	10.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	7.3	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	4.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.2	3.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	3.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	2.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	24.9	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2	21.0	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.5	19.6	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.6	18.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	14.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4	12.9	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.6	10.0	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	9.5	REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	Genes involved in Lipid digestion, mobilization, and transport
0.4	9.1	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.2	5.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 34 entries

Results for Six6

Z-value: 2.96

Motif logo

Transcription factors associated with Six6

Activity-expression correlation:

Activity profile of Six6 motif

Sorted Z-values of Six6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Six6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: