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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox11

Z-value: 0.62

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Transcription factors associated with Sox11

Gene Symbol Gene ID Gene Info
Sox11
ENSMUSG00000063632.5 SRY (sex determining region Y)-box 11

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox11mm10_v2_chr12_-_27342696_27342726-0.572.5e-04Click!

Activity profile of Sox11 motif

Sorted Z-values of Sox11 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_60499332 4.15 ENSMUST00000135953.1
Mup1
major urinary protein 1
chr6_-_138079916 2.28 ENSMUST00000171804.1
Slc15a5
solute carrier family 15, member 5
chr11_-_84167466 1.85 ENSMUST00000050771.7
Gm11437
predicted gene 11437
chr1_-_175491130 1.31 ENSMUST00000027812.5
Rgs7
regulator of G protein signaling 7
chr10_+_34483400 1.08 ENSMUST00000019913.7
ENSMUST00000170771.1
Frk
fyn-related kinase
chr5_-_86518578 1.07 ENSMUST00000134179.1
Tmprss11g
transmembrane protease, serine 11g
chr13_+_4059565 0.96 ENSMUST00000041768.6
Akr1c14
aldo-keto reductase family 1, member C14
chr5_+_89028035 0.90 ENSMUST00000113216.2
ENSMUST00000134303.1
Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr5_+_14514918 0.81 ENSMUST00000030691.10
ENSMUST00000182407.1
Pclo
piccolo (presynaptic cytomatrix protein)
chr2_-_86347764 0.79 ENSMUST00000099894.2
Olfr1055
olfactory receptor 1055
chr1_-_162866502 0.73 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr2_-_89024099 0.71 ENSMUST00000099799.2
Olfr1217
olfactory receptor 1217
chr9_-_16378231 0.67 ENSMUST00000082170.5
Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr6_-_142278836 0.65 ENSMUST00000111825.3
Slco1a5
solute carrier organic anion transporter family, member 1a5
chr5_+_89027959 0.64 ENSMUST00000130041.1
Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr1_-_80213931 0.64 ENSMUST00000058748.1
Fam124b
family with sequence similarity 124, member B
chr16_-_44016387 0.55 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr16_-_38341812 0.54 ENSMUST00000114740.2
ENSMUST00000023501.8
Maats1
MYCBP-associated, testis expressed 1
chr11_-_69369377 0.53 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3
chromodomain helicase DNA binding protein 3
chr9_+_52047150 0.49 ENSMUST00000163153.1
Rdx
radixin
chr6_-_12109583 0.48 ENSMUST00000080891.5
Gm6578
predicted gene 6578
chr8_+_105326354 0.47 ENSMUST00000015000.5
ENSMUST00000098453.2
Tmem208
transmembrane protein 208
chr8_-_45294854 0.46 ENSMUST00000116473.2
Klkb1
kallikrein B, plasma 1
chrX_+_140907602 0.46 ENSMUST00000033806.4
Vsig1
V-set and immunoglobulin domain containing 1
chr1_-_171294937 0.44 ENSMUST00000111302.3
ENSMUST00000080001.2
Ufc1
ubiquitin-fold modifier conjugating enzyme 1
chr8_+_85432686 0.42 ENSMUST00000180883.1
1700051O22Rik
RIKEN cDNA 1700051O22 Gene
chr9_+_107888129 0.41 ENSMUST00000035202.2
Mon1a
MON1 homolog A (yeast)
chrM_+_7005 0.39 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr5_-_123141067 0.39 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526
expressed sequence AI480526
chr19_+_8837676 0.39 ENSMUST00000159634.1
Bscl2
Bernardinelli-Seip congenital lipodystrophy 2 homolog (human)
chr13_-_95478655 0.39 ENSMUST00000022186.3
S100z
S100 calcium binding protein, zeta
chr11_+_4873951 0.38 ENSMUST00000038570.2
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr2_-_127792467 0.37 ENSMUST00000135091.1
1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr13_-_21292679 0.34 ENSMUST00000004456.4
ENSMUST00000110491.1
Gpx5
glutathione peroxidase 5
chr1_+_177729814 0.33 ENSMUST00000016106.5
1700016C15Rik
RIKEN cDNA 1700016C15 gene
chr7_-_102759465 0.32 ENSMUST00000168007.1
ENSMUST00000060187.7
Olfr78
olfactory receptor 78
chr9_-_51102062 0.32 ENSMUST00000170947.1
4833427G06Rik
RIKEN cDNA 4833427G06 gene
chr3_+_67430096 0.32 ENSMUST00000077271.6
ENSMUST00000161009.1
Gfm1
G elongation factor, mitochondrial 1
chr9_+_32116040 0.32 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr3_-_75270073 0.32 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr2_-_134554348 0.31 ENSMUST00000028704.2
Hao1
hydroxyacid oxidase 1, liver
chr10_+_121365078 0.30 ENSMUST00000040344.6
Gns
glucosamine (N-acetyl)-6-sulfatase
chr7_+_105404568 0.29 ENSMUST00000033187.4
Cnga4
cyclic nucleotide gated channel alpha 4
chr2_+_15055274 0.29 ENSMUST00000069870.3
Arl5b
ADP-ribosylation factor-like 5B
chr2_+_157279026 0.29 ENSMUST00000116380.2
Rpn2
ribophorin II
chr12_+_8921598 0.29 ENSMUST00000020909.3
Laptm4a
lysosomal-associated protein transmembrane 4A
chr15_-_5108492 0.28 ENSMUST00000118365.2
Card6
caspase recruitment domain family, member 6
chr11_+_69364010 0.28 ENSMUST00000166700.1
Gm17305
predicted gene, 17305
chr2_-_127247768 0.27 ENSMUST00000003759.4
Ciao1
cytosolic iron-sulfur protein assembly 1
chr2_-_127247620 0.27 ENSMUST00000174030.1
ENSMUST00000174863.1
Ciao1
cytosolic iron-sulfur protein assembly 1
chr15_-_5108469 0.27 ENSMUST00000141020.1
Card6
caspase recruitment domain family, member 6
chr4_-_44072578 0.27 ENSMUST00000173383.1
Gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr14_+_51162260 0.26 ENSMUST00000075648.3
Ear5
eosinophil-associated, ribonuclease A family, member 5
chr13_+_40859768 0.26 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr1_+_44119952 0.25 ENSMUST00000114709.2
Bivm
basic, immunoglobulin-like variable motif containing
chrM_+_7759 0.25 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr14_-_121698417 0.24 ENSMUST00000040700.7
Dock9
dedicator of cytokinesis 9
chr7_-_73541738 0.24 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr2_+_157279065 0.23 ENSMUST00000029171.5
Rpn2
ribophorin II
chr12_-_54862783 0.23 ENSMUST00000078124.7
Cfl2
cofilin 2, muscle
chr11_+_98937669 0.22 ENSMUST00000107475.2
ENSMUST00000068133.3
Rara
retinoic acid receptor, alpha
chr5_+_121795034 0.22 ENSMUST00000162327.1
Atxn2
ataxin 2
chr7_+_70388305 0.22 ENSMUST00000080024.5
B130024G19Rik
RIKEN cDNA B130024G19 gene
chr5_-_87490869 0.22 ENSMUST00000147854.1
Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr10_+_90576252 0.21 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr16_-_93929512 0.20 ENSMUST00000177648.1
Cldn14
claudin 14
chr7_+_83631959 0.20 ENSMUST00000075418.7
ENSMUST00000117410.1
Stard5
StAR-related lipid transfer (START) domain containing 5
chr5_+_64812336 0.19 ENSMUST00000166409.1
Klf3
Kruppel-like factor 3 (basic)
chr1_+_174391046 0.19 ENSMUST00000075329.2
Olfr248
olfactory receptor 248
chr5_+_144100387 0.19 ENSMUST00000041804.7
Lmtk2
lemur tyrosine kinase 2
chr2_-_119662756 0.19 ENSMUST00000028768.1
ENSMUST00000110801.1
ENSMUST00000110802.1
Ndufaf1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chr5_-_148552783 0.18 ENSMUST00000079324.7
ENSMUST00000164904.1
Ubl3
ubiquitin-like 3
chr13_+_113108073 0.18 ENSMUST00000053398.6
Gm9848
predicted gene 9848
chr16_-_50330987 0.17 ENSMUST00000114488.1
Bbx
bobby sox homolog (Drosophila)
chr17_+_36772910 0.15 ENSMUST00000041531.6
H2-M10.5
histocompatibility 2, M region locus 10.5
chr17_-_29007925 0.15 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38
serine/threonine kinase 38
chrX_-_51801078 0.14 ENSMUST00000069509.3
ENSMUST00000114869.1
Usp26
ubiquitin specific peptidase 26
chr13_+_24327415 0.14 ENSMUST00000167746.1
Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr13_+_22293193 0.14 ENSMUST00000091735.1
Vmn1r196
vomeronasal 1 receptor 196
chr4_-_43030440 0.14 ENSMUST00000135660.1
Stoml2
stomatin (Epb7.2)-like 2
chr2_-_41789078 0.14 ENSMUST00000167270.2
Lrp1b
low density lipoprotein-related protein 1B (deleted in tumors)
chr4_+_59003121 0.13 ENSMUST00000095070.3
ENSMUST00000174664.1
Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr4_+_99656299 0.12 ENSMUST00000087285.3
Foxd3
forkhead box D3
chr5_-_145084030 0.12 ENSMUST00000151196.1
Kpna7
karyopherin alpha 7 (importin alpha 8)
chr14_-_51256112 0.12 ENSMUST00000061936.6
Ear11
eosinophil-associated, ribonuclease A family, member 11
chr4_+_33132503 0.11 ENSMUST00000029947.5
Gabrr1
gamma-aminobutyric acid (GABA) C receptor, subunit rho 1
chr9_+_51115999 0.11 ENSMUST00000114431.2
Btg4
B cell translocation gene 4
chr9_+_101074727 0.11 ENSMUST00000085177.3
Msl2
male-specific lethal 2 homolog (Drosophila)
chr4_+_135728116 0.11 ENSMUST00000102546.3
Il22ra1
interleukin 22 receptor, alpha 1
chr16_+_8830093 0.09 ENSMUST00000023150.5
1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr10_+_116966274 0.09 ENSMUST00000033651.3
D630029K05Rik
RIKEN cDNA D630029K05 gene
chr6_+_42405434 0.09 ENSMUST00000070178.4
Tas2r135
taste receptor, type 2, member 135
chr10_-_14718191 0.07 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr7_-_55962466 0.07 ENSMUST00000032635.7
ENSMUST00000152649.1
Nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)
chr17_+_35517100 0.06 ENSMUST00000164242.2
ENSMUST00000045956.7
Cchcr1
coiled-coil alpha-helical rod protein 1
chr5_-_86518562 0.05 ENSMUST00000140095.1
Tmprss11g
transmembrane protease, serine 11g
chr2_+_171253272 0.05 ENSMUST00000146542.1
Gm14266
predicted gene 14266
chr4_-_97584605 0.04 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_-_109278274 0.04 ENSMUST00000081631.3
Mettl15
methyltransferase like 15
chr6_-_136173492 0.03 ENSMUST00000111905.1
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr1_+_82233112 0.03 ENSMUST00000023262.5
Gm9747
predicted gene 9747
chr10_+_5639210 0.02 ENSMUST00000019906.4
Vip
vasoactive intestinal polypeptide
chr5_+_15516489 0.02 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr2_-_110761564 0.01 ENSMUST00000140777.1
Ano3
anoctamin 3
chr16_+_65520503 0.01 ENSMUST00000176330.1
ENSMUST00000004964.8
ENSMUST00000176038.1
Pou1f1
POU domain, class 1, transcription factor 1
chr4_-_97584612 0.01 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr2_-_36136773 0.00 ENSMUST00000028251.3
Rbm18
RNA binding motif protein 18
chrX_-_37104523 0.00 ENSMUST00000130324.1
Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.3 0.8 GO:0099526 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.5 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.3 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.1 0.5 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.1 0.5 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.1 0.3 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0009441 glycolate metabolic process(GO:0009441)
0.1 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.4 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.5 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.7 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:1900210 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.2 GO:0033572 transferrin transport(GO:0033572)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.8 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 1.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0035376 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.0 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.2 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0044317 rod spherule(GO:0044317)
0.1 0.5 GO:0097361 CIA complex(GO:0097361)
0.1 1.3 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.5 GO:0051286 cell tip(GO:0051286)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0005009 insulin-activated receptor activity(GO:0005009) pheromone activity(GO:0005186)
0.2 1.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.4 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.3 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1 1.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.7 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 1.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.3 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.3 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.0 0.3 GO:0005223 intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223)
0.0 0.1 GO:0030338 CMP-N-acetylneuraminate monooxygenase activity(GO:0030338)
0.0 0.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0032052 bile acid binding(GO:0032052)
0.0 0.2 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.7 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 2.0 GO:0015293 symporter activity(GO:0015293)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.5 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1