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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Sox30

Z-value: 1.10

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Transcription factors associated with Sox30

Gene Symbol Gene ID Gene Info
Sox30
ENSMUSG00000040489.5 SRY (sex determining region Y)-box 30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox30mm10_v2_chr11_+_45980309_459803370.401.5e-02Click!

Activity profile of Sox30 motif

Sorted Z-values of Sox30 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_113291449 8.97 ENSMUST00000179568.1
Amy2a4
amylase 2a4
chr3_-_113324052 8.37 ENSMUST00000179314.1
Amy2a3
amylase 2a3
chr3_-_75270073 5.89 ENSMUST00000039047.4
Serpini2
serine (or cysteine) peptidase inhibitor, clade I, member 2
chr17_-_31144271 4.27 ENSMUST00000024826.7
Tff2
trefoil factor 2 (spasmolytic protein 1)
chr6_-_136922169 4.17 ENSMUST00000032343.6
Erp27
endoplasmic reticulum protein 27
chr14_+_116925379 2.94 ENSMUST00000088483.3
Gpc6
glypican 6
chr4_-_119189949 2.94 ENSMUST00000124626.1
Ermap
erythroblast membrane-associated protein
chr6_+_122513583 2.64 ENSMUST00000032210.7
ENSMUST00000148517.1
Mfap5
microfibrillar associated protein 5
chr9_-_103480328 2.54 ENSMUST00000124310.2
Bfsp2
beaded filament structural protein 2, phakinin
chr6_-_136781718 2.45 ENSMUST00000078095.6
ENSMUST00000032338.7
Gucy2c
guanylate cyclase 2c
chr6_+_122513643 2.37 ENSMUST00000118626.1
Mfap5
microfibrillar associated protein 5
chr15_-_36879816 2.29 ENSMUST00000100713.2
Gm10384
predicted gene 10384
chrX_+_93654863 2.00 ENSMUST00000113933.2
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr10_+_17796256 1.82 ENSMUST00000037964.6
Txlnb
taxilin beta
chr5_-_137072254 1.69 ENSMUST00000077523.3
ENSMUST00000041388.4
Serpine1
serine (or cysteine) peptidase inhibitor, clade E, member 1
chr19_+_34217588 1.68 ENSMUST00000119603.1
Stambpl1
STAM binding protein like 1
chr18_-_68429235 1.64 ENSMUST00000052347.6
Mc2r
melanocortin 2 receptor
chr6_-_12749193 1.64 ENSMUST00000046121.6
ENSMUST00000172356.1
Thsd7a
thrombospondin, type I, domain containing 7A
chr2_-_84822546 1.56 ENSMUST00000028471.5
Smtnl1
smoothelin-like 1
chr4_-_119190005 1.39 ENSMUST00000138395.1
ENSMUST00000156746.1
Ermap
erythroblast membrane-associated protein
chr11_+_3983704 1.27 ENSMUST00000063004.7
Gal3st1
galactose-3-O-sulfotransferase 1
chr10_-_62792243 1.18 ENSMUST00000020268.5
Ccar1
cell division cycle and apoptosis regulator 1
chr11_-_99244058 1.07 ENSMUST00000103132.3
ENSMUST00000038214.6
Krt222
keratin 222
chr6_-_122340200 0.97 ENSMUST00000159384.1
Phc1
polyhomeotic-like 1 (Drosophila)
chr3_-_9833617 0.94 ENSMUST00000108384.2
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr11_+_3983636 0.92 ENSMUST00000078757.1
Gal3st1
galactose-3-O-sulfotransferase 1
chr6_-_24168083 0.91 ENSMUST00000031713.8
Slc13a1
solute carrier family 13 (sodium/sulfate symporters), member 1
chr4_+_136284708 0.84 ENSMUST00000130223.1
Zfp46
zinc finger protein 46
chr9_-_60511003 0.82 ENSMUST00000098660.3
Thsd4
thrombospondin, type I, domain containing 4
chr18_+_37307445 0.75 ENSMUST00000056712.2
Pcdhb4
protocadherin beta 4
chrX_+_56786527 0.67 ENSMUST00000144600.1
Fhl1
four and a half LIM domains 1
chr4_+_48585193 0.66 ENSMUST00000107703.1
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr4_-_73950834 0.66 ENSMUST00000095023.1
ENSMUST00000030101.3
2310002L09Rik
RIKEN cDNA 2310002L09 gene
chr13_-_102958084 0.65 ENSMUST00000099202.3
ENSMUST00000172264.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_115133977 0.64 ENSMUST00000051400.7
Cyp4x1
cytochrome P450, family 4, subfamily x, polypeptide 1
chr12_-_99883429 0.63 ENSMUST00000046485.3
Efcab11
EF-hand calcium binding domain 11
chr6_-_3494587 0.63 ENSMUST00000049985.8
Hepacam2
HEPACAM family member 2
chr15_+_100038635 0.57 ENSMUST00000100203.3
Dip2b
DIP2 disco-interacting protein 2 homolog B (Drosophila)
chr5_-_62765618 0.55 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_+_135729147 0.52 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr18_-_62756275 0.51 ENSMUST00000067450.1
ENSMUST00000048109.5
2700046A07Rik
RIKEN cDNA 2700046A07 gene
chr4_+_136284658 0.49 ENSMUST00000144217.1
Zfp46
zinc finger protein 46
chr13_-_97747373 0.49 ENSMUST00000123535.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr10_-_53647080 0.48 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr3_-_102964124 0.46 ENSMUST00000058899.8
Nr1h5
nuclear receptor subfamily 1, group H, member 5
chr11_+_67238017 0.45 ENSMUST00000018632.4
Myh4
myosin, heavy polypeptide 4, skeletal muscle
chr4_+_48585135 0.35 ENSMUST00000030032.6
Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr19_-_24477356 0.34 ENSMUST00000099556.1
Fam122a
family with sequence similarity 122, member A
chr2_+_127909058 0.33 ENSMUST00000110344.1
Acoxl
acyl-Coenzyme A oxidase-like
chr3_-_9833653 0.33 ENSMUST00000161949.1
Pag1
phosphoprotein associated with glycosphingolipid microdomains 1
chr19_+_44293676 0.32 ENSMUST00000026221.5
Scd2
stearoyl-Coenzyme A desaturase 2
chr1_+_165485168 0.32 ENSMUST00000111440.1
ENSMUST00000027852.8
ENSMUST00000111439.1
Adcy10
adenylate cyclase 10
chr11_+_3649494 0.32 ENSMUST00000093389.2
Morc2a
microrchidia 2A
chr19_-_56822161 0.31 ENSMUST00000118592.1
A630007B06Rik
RIKEN cDNA A630007B06 gene
chr1_+_176814660 0.31 ENSMUST00000056773.8
ENSMUST00000027785.8
Sdccag8
serologically defined colon cancer antigen 8
chr9_-_32541589 0.29 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr11_+_43474276 0.28 ENSMUST00000173002.1
ENSMUST00000057679.3
C1qtnf2
C1q and tumor necrosis factor related protein 2
chr18_-_88927447 0.25 ENSMUST00000147313.1
Socs6
suppressor of cytokine signaling 6
chr5_-_17835857 0.22 ENSMUST00000082367.6
Cd36
CD36 antigen
chr2_-_65567465 0.21 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr7_+_90426312 0.20 ENSMUST00000061391.7
Ccdc89
coiled-coil domain containing 89
chr2_+_3713478 0.20 ENSMUST00000115053.2
Fam107b
family with sequence similarity 107, member B
chr2_-_85675173 0.18 ENSMUST00000099917.1
Olfr1006
olfactory receptor 1006
chr2_+_3114220 0.17 ENSMUST00000072955.5
Fam171a1
family with sequence similarity 171, member A1
chr17_-_79355082 0.17 ENSMUST00000068958.7
Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3
chr3_+_90476121 0.16 ENSMUST00000001042.8
Ilf2
interleukin enhancer binding factor 2
chr9_+_55541148 0.12 ENSMUST00000034869.4
Isl2
insulin related protein 2 (islet 2)
chr18_+_37725706 0.12 ENSMUST00000066149.6
Pcdhga9
protocadherin gamma subfamily A, 9
chr1_+_10056922 0.09 ENSMUST00000149214.1
Cspp1
centrosome and spindle pole associated protein 1
chr2_-_101883010 0.09 ENSMUST00000154525.1
Prr5l
proline rich 5 like
chr5_+_139211934 0.08 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1
Sad1 and UNC84 domain containing 1
chr4_+_109235632 0.07 ENSMUST00000030285.7
Calr4
calreticulin 4
chr4_+_137993016 0.05 ENSMUST00000105830.2
ENSMUST00000084215.5
ENSMUST00000058133.3
ENSMUST00000139759.1
Eif4g3
eukaryotic translation initiation factor 4 gamma, 3
chr18_+_37477768 0.04 ENSMUST00000051442.5
Pcdhb16
protocadherin beta 16
chr13_-_97747399 0.02 ENSMUST00000144993.1
5330416C01Rik
RIKEN cDNA 5330416C01 gene

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox30

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.3 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.6 1.7 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 2.2 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 5.2 GO:0097435 fibril organization(GO:0097435)
0.1 2.5 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 2.0 GO:0014823 response to activity(GO:0014823)
0.0 2.4 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.8 GO:0008272 sulfate transport(GO:0008272)
0.0 2.0 GO:0001541 ovarian follicle development(GO:0001541)
0.0 1.6 GO:0030819 positive regulation of cyclic nucleotide biosynthetic process(GO:0030804) positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 5.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.7 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.3 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 0.1 GO:0044821 nuclear matrix organization(GO:0043578) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) nuclear matrix anchoring at nuclear membrane(GO:0090292) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.3 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.3 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0038203 TORC2 signaling(GO:0038203)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.3 1.7 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.0 GO:0001739 sex chromatin(GO:0001739)
0.1 2.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 1.6 GO:0031430 M band(GO:0031430)
0.0 3.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0032982 myosin filament(GO:0032982)
0.0 2.6 GO:0031225 anchored component of membrane(GO:0031225)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.3 GO:0004556 alpha-amylase activity(GO:0004556)
1.3 5.0 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.5 2.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.4 2.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 4.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 1.6 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 2.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 2.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 7.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 1.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 1.8 GO:0019905 syntaxin binding(GO:0019905)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.8 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 5.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID SHP2 PATHWAY SHP2 signaling
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 1.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1 2.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling