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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tbx3

Z-value: 0.56

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Transcription factors associated with Tbx3

Gene Symbol Gene ID Gene Info
Tbx3
ENSMUSG00000018604.12 T-box 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx3mm10_v2_chr5_+_119670825_1196708620.231.7e-01Click!

Activity profile of Tbx3 motif

Sorted Z-values of Tbx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_135759705 1.22 ENSMUST00000105854.1
Myom3
myomesin family, member 3
chr7_-_4522794 1.17 ENSMUST00000140424.1
Tnni3
troponin I, cardiac 3
chr3_-_123034943 1.03 ENSMUST00000029761.7
Myoz2
myozenin 2
chr19_+_7056731 1.02 ENSMUST00000040261.5
Macrod1
MACRO domain containing 1
chr11_+_73350839 0.82 ENSMUST00000120137.1
Olfr20
olfactory receptor 20
chr7_-_4522427 0.79 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr8_-_95306585 0.62 ENSMUST00000119870.2
ENSMUST00000093268.4
Cngb1
cyclic nucleotide gated channel beta 1
chr17_-_59013264 0.62 ENSMUST00000174122.1
ENSMUST00000025065.5
Nudt12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr7_+_107567445 0.51 ENSMUST00000120990.1
Olfml1
olfactomedin-like 1
chr14_+_67745229 0.49 ENSMUST00000111095.2
Gnrh1
gonadotropin releasing hormone 1
chr7_-_120145286 0.34 ENSMUST00000033207.4
Zp2
zona pellucida glycoprotein 2
chr1_-_31222604 0.33 ENSMUST00000127775.1
4931428L18Rik
RIKEN cDNA 4931428L18 gene
chr1_+_88095054 0.27 ENSMUST00000150634.1
ENSMUST00000058237.7
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
chr10_+_127514939 0.26 ENSMUST00000035735.9
Ndufa4l2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr10_+_116966274 0.24 ENSMUST00000033651.3
D630029K05Rik
RIKEN cDNA D630029K05 gene
chr16_+_17619503 0.23 ENSMUST00000165092.1
Smpd4
sphingomyelin phosphodiesterase 4
chr2_+_154551771 0.23 ENSMUST00000104928.1
Actl10
actin-like 10
chr1_+_93215899 0.21 ENSMUST00000138595.1
E030010N08Rik
RIKEN cDNA E030010N08 gene
chr19_+_7494033 0.21 ENSMUST00000170373.1
Atl3
atlastin GTPase 3
chr5_-_106926245 0.18 ENSMUST00000117588.1
Hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr19_+_11569447 0.17 ENSMUST00000087884.1
Gm10212
predicted pseudogene 10212
chr10_+_75406911 0.17 ENSMUST00000039925.7
Upb1
ureidopropionase, beta
chr7_-_44236098 0.15 ENSMUST00000037220.4
1700028J19Rik
RIKEN cDNA 1700028J19 gene
chr1_+_39535747 0.15 ENSMUST00000003219.8
Cnot11
CCR4-NOT transcription complex, subunit 11
chr11_+_31832660 0.15 ENSMUST00000132857.1
Gm12107
predicted gene 12107
chr7_+_140704165 0.13 ENSMUST00000080681.3
Olfr541
olfactory receptor 541
chr16_-_13730970 0.12 ENSMUST00000023364.6
Pla2g10
phospholipase A2, group X
chr4_-_128618609 0.12 ENSMUST00000074829.2
Tlr12
toll-like receptor 12
chr7_+_112374839 0.12 ENSMUST00000106645.1
Micalcl
MICAL C-terminal like
chr12_-_84361802 0.10 ENSMUST00000021659.1
ENSMUST00000065536.2
Fam161b
family with sequence similarity 161, member B
chrX_-_134476479 0.07 ENSMUST00000009740.2
Taf7l
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_+_108046411 0.07 ENSMUST00000095458.4
Smim15
small integral membrane protein 15
chr6_-_97060407 0.07 ENSMUST00000089295.4
Fam19a4
family with sequence similarity 19, member A4
chr10_-_18743691 0.06 ENSMUST00000019999.5
D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chr13_+_33484784 0.05 ENSMUST00000081927.2
Serpinb9g
serine (or cysteine) peptidase inhibitor, clade B, member 9g
chr16_+_17619341 0.05 ENSMUST00000006053.6
ENSMUST00000171435.1
ENSMUST00000163476.1
ENSMUST00000168101.1
ENSMUST00000165363.1
ENSMUST00000169662.1
ENSMUST00000090159.4
ENSMUST00000172182.1
ENSMUST00000163592.1
Smpd4
sphingomyelin phosphodiesterase 4
chr3_+_89246397 0.05 ENSMUST00000168900.1
Krtcap2
keratinocyte associated protein 2
chr19_+_5704367 0.05 ENSMUST00000052448.3
Kcnk7
potassium channel, subfamily K, member 7
chr1_-_31222644 0.03 ENSMUST00000135245.1
4931428L18Rik
RIKEN cDNA 4931428L18 gene
chr13_-_59706197 0.02 ENSMUST00000066510.6
Spata31d1a
spermatogenesis associated 31 subfamily D, member 1A
chr11_-_94507337 0.00 ENSMUST00000040692.8
Mycbpap
MYCBP associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 0.6 GO:0006742 NADP catabolic process(GO:0006742)
0.1 1.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0046271 coumarin metabolic process(GO:0009804) phenylpropanoid catabolic process(GO:0046271)
0.1 0.5 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.3 GO:0060468 prevention of polyspermy(GO:0060468)
0.0 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0051977 lysophospholipid transport(GO:0051977)
0.0 0.3 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.8 GO:0050907 detection of chemical stimulus involved in sensory perception(GO:0050907)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 1.0 GO:0030239 myofibril assembly(GO:0030239)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.5 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.2 GO:0031430 M band(GO:0031430)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0030172 troponin C binding(GO:0030172)
0.2 1.0 GO:0051373 FATZ binding(GO:0051373)
0.1 0.3 GO:0032190 acrosin binding(GO:0032190)
0.1 0.6 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.6 GO:0043855 cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.0 GO:0019213 deacetylase activity(GO:0019213)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.5 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction