ISMARA results: Tfcp2

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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Tfcp2

Z-value: 2.91

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Transcription factors associated with Tfcp2

Gene Symbol	Gene ID	Gene Info
Tfcp2 Ensembl NCBI MGI UniProt	ENSMUSG00000009733.8	transcription factor CP2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfcp2	mm10_v2_chr15_-_100551959_100552010	0.32	5.5e-02	Click!

Activity profile of Tfcp2 motif

Sorted Z-values of Tfcp2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_75571522 Show fit	16.60	ENSMUST00000143226.1 ENSMUST00000124259.1	Ggt1 Ensembl NCBI MGI UniProt Show fit	gamma-glutamyltransferase 1
chr8_+_57511833 Show fit	16.03	ENSMUST00000067925.6	Hmgb2 Ensembl NCBI MGI UniProt Show fit	high mobility group box 2
chr19_-_34166037 Show fit	13.74	ENSMUST00000025686.7	Ankrd22 Ensembl NCBI MGI UniProt Show fit	ankyrin repeat domain 22
chr8_+_94172618 Show fit	13.02	ENSMUST00000034214.6	Mt2 Ensembl NCBI MGI UniProt Show fit	metallothionein 2
chr10_+_43579161 Show fit	12.61	ENSMUST00000058714.8	Cd24a Ensembl NCBI MGI UniProt Show fit	CD24a antigen
chr17_-_48451510 Show fit	12.51	ENSMUST00000024794.5	Tspo2 Ensembl NCBI MGI UniProt Show fit	translocator protein 2
chr7_+_96211656 Show fit	12.31	ENSMUST00000107165.1	Tenm4 Ensembl NCBI MGI UniProt Show fit	teneurin transmembrane protein 4
chr11_+_116532441 Show fit	11.34	ENSMUST00000106386.1 ENSMUST00000145737.1 ENSMUST00000155102.1 ENSMUST00000063446.6	Sphk1 Ensembl NCBI MGI UniProt Show fit	sphingosine kinase 1
chr5_+_106964319 Show fit	10.85	ENSMUST00000031221.5 ENSMUST00000117196.2 ENSMUST00000076467.6	Cdc7 Ensembl NCBI MGI UniProt Show fit	cell division cycle 7 (S. cerevisiae)
chr11_-_99438143 Show fit	10.64	ENSMUST00000017743.2	Krt20 Ensembl NCBI MGI UniProt Show fit	keratin 20

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfcp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	16.6	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
2.3	16.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
2.8	13.9	GO:0071104	response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
4.6	13.8	GO:0006592	ornithine biosynthetic process(GO:0006592)
1.9	13.0	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
4.2	12.6	GO:0002842	positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
3.1	12.3	GO:0060912	cardiac cell fate specification(GO:0060912)
0.7	12.2	GO:0030953	astral microtubule organization(GO:0030953)
1.9	11.3	GO:0019371	cyclooxygenase pathway(GO:0019371)
1.8	10.9	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)

Showing 1 to 10 of 122 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	35.1	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	13.0	GO:0000793	condensed chromosome(GO:0000793)
0.5	12.6	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.2	10.9	GO:0045171	intercellular bridge(GO:0045171)
0.0	10.7	GO:0030054	cell junction(GO:0030054)
1.6	9.8	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	9.6	GO:0005882	intermediate filament(GO:0005882)
1.0	7.3	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	7.1	GO:0017053	transcriptional repressor complex(GO:0017053)
1.7	6.8	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)

Showing 1 to 10 of 66 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	26.4	GO:0050786	RAGE receptor binding(GO:0050786)
1.4	16.6	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.9	13.9	GO:0050693	LBD domain binding(GO:0050693)
4.6	13.8	GO:0004349	glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.8	12.6	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.2	12.5	GO:0015485	cholesterol binding(GO:0015485)
0.2	12.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
1.6	11.3	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.7	11.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	10.8	GO:0005179	hormone activity(GO:0005179)

Showing 1 to 10 of 96 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	21.4	PID AURORA A PATHWAY	Aurora A signaling
0.1	15.6	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	12.0	PID E2F PATHWAY	E2F transcription factor network
0.4	11.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	10.8	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.2	10.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	10.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	9.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	4.9	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	4.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Showing 1 to 10 of 26 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
1.0	16.0	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.9	15.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	13.8	REACTOME HEMOSTASIS	Genes involved in Hemostasis
0.5	12.8	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.3	12.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4	9.8	REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX	Genes involved in Activation of the pre-replicative complex
0.1	9.8	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1	9.7	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	8.5	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events

Showing 1 to 10 of 37 entries

Results for Tfcp2

Z-value: 2.91

Motif logo

Transcription factors associated with Tfcp2

Activity-expression correlation:

Activity profile of Tfcp2 motif

Sorted Z-values of Tfcp2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfcp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: