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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Thra

Z-value: 0.83

Motif logo

Transcription factors associated with Thra

Gene Symbol Gene ID Gene Info
ENSMUSG00000058756.7 thyroid hormone receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thramm10_v2_chr11_+_98741805_987418160.474.1e-03Click!

Activity profile of Thra motif

Sorted Z-values of Thra motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_7967817 5.97 ENSMUST00000033502.7
GATA binding protein 1
chr9_-_44288535 4.20 ENSMUST00000161354.1
ATP-binding cassette, sub-family G (WHITE), member 4
chr9_+_111019284 4.02 ENSMUST00000035077.3
lactotransferrin
chr9_-_44288332 3.26 ENSMUST00000161408.1
ATP-binding cassette, sub-family G (WHITE), member 4
chrX_-_102252154 2.99 ENSMUST00000050551.3
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr2_-_84822546 2.84 ENSMUST00000028471.5
smoothelin-like 1
chr4_+_44300876 2.81 ENSMUST00000045607.5
maternal embryonic leucine zipper kinase
chr13_+_95696851 2.77 ENSMUST00000022182.4
coagulation factor II (thrombin) receptor-like 2
chr11_-_70255329 2.74 ENSMUST00000108574.2
ENSMUST00000000329.2
arachidonate 12-lipoxygenase
chr9_-_44288131 2.71 ENSMUST00000160384.1
ATP-binding cassette, sub-family G (WHITE), member 4
chr2_+_131186942 2.66 ENSMUST00000028804.8
ENSMUST00000079857.8
cell division cycle 25B
chr3_+_114030532 2.63 ENSMUST00000123619.1
ENSMUST00000092155.5
collagen, type XI, alpha 1
chrX_-_135210672 2.50 ENSMUST00000033783.1
transcription elongation factor A (SII)-like 6
chr6_+_86628174 2.43 ENSMUST00000043400.6
aspartic peptidase, retroviral-like 1
chr12_+_109545390 2.25 ENSMUST00000146701.1
maternally expressed 3
chr11_+_69965396 2.19 ENSMUST00000018713.6
claudin 7
chr13_+_44729794 2.13 ENSMUST00000172830.1
jumonji, AT rich interactive domain 2
chr6_+_113531675 2.12 ENSMUST00000036340.5
ENSMUST00000101051.2
Fanconi anemia, complementation group D2
chr10_-_88146867 2.06 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
PARP1 binding protein
chr11_-_33513736 2.03 ENSMUST00000102815.3
RAN binding protein 17
chr15_-_5244164 1.83 ENSMUST00000120563.1
prostaglandin E receptor 4 (subtype EP4)
chr15_-_5244178 1.82 ENSMUST00000047379.8
prostaglandin E receptor 4 (subtype EP4)
chr15_+_73723131 1.73 ENSMUST00000165541.1
ENSMUST00000167582.1
protein tyrosine phosphatase 4a3
chr4_-_156255327 1.73 ENSMUST00000179919.1
sterile alpha motif domain containing 11
chr3_+_122729158 1.72 ENSMUST00000066728.5
phosphodiesterase 5A, cGMP-specific
chr7_+_140093388 1.71 ENSMUST00000026540.8
proline-rich acidic protein 1
chr7_+_142441808 1.71 ENSMUST00000105971.1
ENSMUST00000145287.1
troponin I, skeletal, fast 2
chr7_-_100514800 1.60 ENSMUST00000054923.7
DnaJ (Hsp40) related, subfamily B, member 13
chr9_-_21963568 1.57 ENSMUST00000006397.5
erythropoietin receptor
chr11_-_33513626 1.53 ENSMUST00000037522.7
RAN binding protein 17
chr19_-_46044914 1.52 ENSMUST00000026252.7
LIM domain binding 1
chr7_+_19411086 1.41 ENSMUST00000003643.1
creatine kinase, muscle
chr4_-_140774196 1.40 ENSMUST00000026381.6
peptidyl arginine deiminase, type IV
chrX_+_136666375 1.35 ENSMUST00000060904.4
ENSMUST00000113100.1
ENSMUST00000128040.1
transcription elongation factor A (SII)-like 3
chr10_-_62527438 1.34 ENSMUST00000160987.1
serglycin
chr17_+_21555046 1.32 ENSMUST00000079242.3
zinc finger protein 52
chr11_-_40733373 1.32 ENSMUST00000020579.8
hyaluronan mediated motility receptor (RHAMM)
chr7_+_35802593 1.31 ENSMUST00000052454.2
RIKEN cDNA E130304I02 gene
chrX_-_143827391 1.30 ENSMUST00000087316.5
calpain 6
chrX_+_101449078 1.21 ENSMUST00000033674.5
integrin beta 1 binding protein 2
chr5_+_110839973 1.21 ENSMUST00000066160.1
checkpoint kinase 2
chr13_+_44729535 1.20 ENSMUST00000174068.1
jumonji, AT rich interactive domain 2
chr18_+_60774675 1.14 ENSMUST00000118551.1
ribosomal protein S14
chr4_-_49597860 1.14 ENSMUST00000042750.2
transmembrane protein 246
chr16_-_19983005 1.13 ENSMUST00000058839.8
kelch-like 6
chrX_-_8145679 1.12 ENSMUST00000115619.1
ENSMUST00000115617.3
ENSMUST00000040010.3
RNA binding motif protein 3
chr1_-_84839304 1.07 ENSMUST00000027421.6
thyroid hormone receptor interactor 12
chr11_-_29547820 1.07 ENSMUST00000102844.3
ribosomal protein S27A
chr18_+_60774510 1.07 ENSMUST00000025511.3
ribosomal protein S14
chr4_-_49597425 1.05 ENSMUST00000150664.1
transmembrane protein 246
chr8_-_105707933 1.04 ENSMUST00000013299.9
enkurin domain containing 1
chr1_-_163994767 1.03 ENSMUST00000097493.3
ENSMUST00000045876.6
cDNA sequence BC055324
chr17_+_80307396 1.01 ENSMUST00000068175.5
Rho guanine nucleotide exchange factor (GEF) 33
chr7_+_28441026 0.99 ENSMUST00000135686.1
glia maturation factor, gamma
chr10_-_62527413 0.98 ENSMUST00000160643.1
serglycin
chr5_-_134946917 0.98 ENSMUST00000051401.2
claudin 4
chr7_+_28440927 0.97 ENSMUST00000078845.6
glia maturation factor, gamma
chr5_-_110839757 0.97 ENSMUST00000056937.5
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr3_+_96172327 0.96 ENSMUST00000076372.4
splicing factor 3b, subunit 4
chr2_+_32525013 0.96 ENSMUST00000150621.1
predicted gene 13412
chr8_+_120537423 0.93 ENSMUST00000118136.1
genetic suppressor element 1
chr13_-_59744921 0.91 ENSMUST00000180139.1
RIKEN cDNA 1700014D04 gene
chr19_-_5986143 0.90 ENSMUST00000041827.7
solute carrier family 22 (organic anion transporter), member 20
chr15_+_103018936 0.82 ENSMUST00000165375.1
homeobox C4
chr5_-_110839575 0.81 ENSMUST00000145318.1
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr14_-_79481268 0.81 ENSMUST00000022601.5
WW domain binding protein 4
chr14_-_55106547 0.79 ENSMUST00000036041.8
adaptor protein complex AP-1, gamma 2 subunit
chr11_+_85171096 0.77 ENSMUST00000018623.3
RIKEN cDNA 1700125H20 gene
chr7_+_27258725 0.76 ENSMUST00000079258.6
numb-like
chr6_-_83054415 0.75 ENSMUST00000113962.1
ENSMUST00000089645.6
ENSMUST00000113963.1
HtrA serine peptidase 2
chr7_+_12922290 0.74 ENSMUST00000108539.1
ENSMUST00000004554.7
ENSMUST00000147435.1
ENSMUST00000137329.1
ribosomal protein S5
chr19_-_6858179 0.72 ENSMUST00000113440.1
coiled-coil domain containing 88B
chr1_-_167466780 0.70 ENSMUST00000036643.4
leucine rich repeat containing 52
chr17_-_74294834 0.70 ENSMUST00000078459.6
mediator of cell motility 1
chr2_+_22895482 0.69 ENSMUST00000053729.7
prenyl (solanesyl) diphosphate synthase, subunit 1
chr19_-_46327121 0.68 ENSMUST00000041391.4
ENSMUST00000096029.5
pleckstrin and Sec7 domain containing
chr1_+_131910458 0.68 ENSMUST00000062264.6
nuclear casein kinase and cyclin-dependent kinase substrate 1
chrX_-_57338598 0.67 ENSMUST00000033468.4
ENSMUST00000114736.1
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_+_97450136 0.67 ENSMUST00000107601.1
Rho GTPase activating protein 23
chr7_+_45514619 0.66 ENSMUST00000107761.1
tubby-like protein 2
chr7_+_100472985 0.66 ENSMUST00000032958.7
ENSMUST00000107059.1
uncoupling protein 3 (mitochondrial, proton carrier)
chr4_+_156215920 0.65 ENSMUST00000105572.1
RIKEN cDNA 2310042D19 gene
chr4_-_41048124 0.64 ENSMUST00000030136.6
aquaporin 7
chr6_+_120836201 0.63 ENSMUST00000009256.2
BCL2-like 13 (apoptosis facilitator)
chr2_+_22895583 0.61 ENSMUST00000152170.1
prenyl (solanesyl) diphosphate synthase, subunit 1
chrX_-_166585679 0.60 ENSMUST00000000412.2
EGF-like-domain, multiple 6
chrX_-_53269020 0.60 ENSMUST00000114838.1
family with sequence similarity 122, member B
chr3_-_52104891 0.60 ENSMUST00000121440.1
mastermind like 3 (Drosophila)
chr7_+_130865835 0.58 ENSMUST00000075181.4
ENSMUST00000048180.5
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr3_-_95307132 0.58 ENSMUST00000015846.2
annexin A9
chr1_+_160044564 0.57 ENSMUST00000168359.1
RIKEN cDNA 4930523C07 gene
chr7_-_126976092 0.56 ENSMUST00000181859.1
RIKEN cDNA D830044I16 gene
chr13_+_54192106 0.54 ENSMUST00000038101.3
histamine receptor H2
chr2_+_130406478 0.52 ENSMUST00000055421.4
transmembrane 239
chr3_+_95164306 0.49 ENSMUST00000107217.1
ENSMUST00000168321.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr5_-_74065736 0.49 ENSMUST00000145016.1
ubiquitin specific peptidase 46
chr14_-_118706180 0.48 ENSMUST00000036554.6
ENSMUST00000166646.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
chr2_+_112265809 0.48 ENSMUST00000110991.2
solute carrier family 12, member 6
chr7_-_3821812 0.48 ENSMUST00000153846.1
predicted gene 15448
chrX_+_145119501 0.48 ENSMUST00000096301.4
zinc finger, CCHC domain containing 16
chr16_-_76403673 0.47 ENSMUST00000052867.7
predicted gene 9843
chr11_-_85139939 0.47 ENSMUST00000108075.2
ubiquitin specific peptidase 32
chr10_-_13324160 0.46 ENSMUST00000105545.4
phosphatase and actin regulator 2
chr1_+_152807877 0.46 ENSMUST00000027754.6
neutrophil cytosolic factor 2
chr15_+_101412402 0.46 ENSMUST00000068904.8
keratin 7
chr4_+_33310306 0.44 ENSMUST00000108153.2
ENSMUST00000029942.7
RNA guanylyltransferase and 5'-phosphatase
chr5_-_137625069 0.44 ENSMUST00000031732.7
F-box protein 24
chr17_+_48264270 0.44 ENSMUST00000059873.7
ENSMUST00000154335.1
ENSMUST00000136272.1
ENSMUST00000125426.1
ENSMUST00000153420.1
triggering receptor expressed on myeloid cells-like 4
chr9_+_44240668 0.43 ENSMUST00000092426.3
coiled-coil domain containing 153
chr4_-_83021102 0.43 ENSMUST00000071708.5
Fras1 related extracellular matrix protein 1
chr1_-_170306332 0.43 ENSMUST00000179801.1
predicted gene 7694
chr14_+_79481164 0.42 ENSMUST00000040131.5
E74-like factor 1
chr2_+_152911311 0.41 ENSMUST00000028970.7
myosin, light polypeptide kinase 2, skeletal muscle
chr19_+_8617991 0.41 ENSMUST00000010250.2
solute carrier family 22 (organic anion transporter), member 6
chr7_-_126975400 0.39 ENSMUST00000180704.1
RIKEN cDNA D830044I16 gene
chr10_-_88379051 0.38 ENSMUST00000138159.1
DNA-damage regulated autophagy modulator 1
chr1_+_74542881 0.37 ENSMUST00000113749.1
ENSMUST00000067916.6
ENSMUST00000113745.1
ENSMUST00000113747.1
ENSMUST00000113750.1
phospholipase C, delta 4
chr2_+_129592818 0.37 ENSMUST00000153491.1
ENSMUST00000161620.1
ENSMUST00000179001.1
signal-regulatory protein alpha
chr12_+_78861693 0.37 ENSMUST00000071230.7
eukaryotic translation initiation factor 2, subunit 1 alpha
chr9_+_64235201 0.36 ENSMUST00000039011.3
ubiquitin carboxyl-terminal esterase L4
chr4_+_131873608 0.36 ENSMUST00000053819.3
serine/arginine-rich splicing factor 4
chr3_+_95160449 0.36 ENSMUST00000090823.1
ENSMUST00000090821.3
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr11_+_40733936 0.36 ENSMUST00000127382.1
NudC domain containing 2
chr16_+_20694908 0.34 ENSMUST00000056518.6
family with sequence similarity 131, member A
chr14_+_58070547 0.34 ENSMUST00000165526.1
fibroblast growth factor 9
chr11_+_31872100 0.34 ENSMUST00000020543.6
ENSMUST00000109412.2
cytoplasmic polyadenylation element binding protein 4
chr11_+_4986824 0.33 ENSMUST00000009234.9
ENSMUST00000109897.1
adaptor protein complex AP-1, beta 1 subunit
chr1_+_134193432 0.33 ENSMUST00000038445.6
myosin binding protein H
chr11_+_115475645 0.32 ENSMUST00000035240.6
armadillo repeat containing 7
chr15_-_78529617 0.32 ENSMUST00000023075.8
C1q and tumor necrosis factor related protein 6
chr14_+_20929416 0.32 ENSMUST00000022369.7
vinculin
chr10_-_13324250 0.32 ENSMUST00000105543.1
phosphatase and actin regulator 2
chr5_+_35057059 0.31 ENSMUST00000050709.3
docking protein 7
chr10_+_88146992 0.31 ENSMUST00000052355.7
nucleoporin 37
chr4_-_137766474 0.30 ENSMUST00000139951.1
alkaline phosphatase, liver/bone/kidney
chr7_+_45684398 0.29 ENSMUST00000107742.2
ENSMUST00000183120.1
netrin 5
chr18_+_9958147 0.29 ENSMUST00000025137.7
THO complex 1
chr10_+_88147061 0.29 ENSMUST00000169309.1
nucleoporin 37
chr5_-_116392766 0.28 ENSMUST00000153818.1
RIKEN cDNA 4930562A09 gene
chr9_-_99358518 0.28 ENSMUST00000042158.6
extended synaptotagmin-like protein 3
chr19_-_37176055 0.28 ENSMUST00000142973.1
ENSMUST00000154376.1
cytoplasmic polyadenylation element binding protein 3
chr12_-_81333129 0.27 ENSMUST00000085238.6
ENSMUST00000182208.1
solute carrier family 8 (sodium/calcium exchanger), member 3
chr19_+_8764934 0.27 ENSMUST00000184663.1
nuclear RNA export factor 1
chr12_-_90738438 0.27 ENSMUST00000082432.3
deiodinase, iodothyronine, type II
chr12_+_86678685 0.27 ENSMUST00000021681.3
vasohibin 1
chr7_-_4778141 0.26 ENSMUST00000094892.5
interleukin 11
chr17_-_17855188 0.25 ENSMUST00000003762.6
hyaluronan synthase1
chr11_+_54100924 0.25 ENSMUST00000093107.5
ENSMUST00000019050.5
ENSMUST00000174616.1
ENSMUST00000129499.1
ENSMUST00000126840.1
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
chr4_-_126202757 0.25 ENSMUST00000080919.5
thyroid hormone receptor associated protein 3
chr11_+_40733639 0.25 ENSMUST00000020578.4
NudC domain containing 2
chr5_+_53590215 0.24 ENSMUST00000037618.6
recombination signal binding protein for immunoglobulin kappa J region
chr14_+_101653967 0.23 ENSMUST00000002289.6
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr4_+_124880899 0.23 ENSMUST00000059343.6
Eph receptor A10
chr1_+_106861144 0.23 ENSMUST00000086701.6
ENSMUST00000112730.1
serine (or cysteine) peptidase inhibitor, clade B, member 5
chr12_-_111672290 0.23 ENSMUST00000001304.7
creatine kinase, brain
chr19_-_56389877 0.23 ENSMUST00000166203.1
ENSMUST00000167239.1
ENSMUST00000040711.8
ENSMUST00000095947.4
ENSMUST00000073536.6
nebulin-related anchoring protein
chr4_+_126148457 0.23 ENSMUST00000106150.2
eva-1 homolog B (C. elegans)
chr4_-_126202583 0.23 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
thyroid hormone receptor associated protein 3
chr19_-_42431778 0.21 ENSMUST00000048630.6
cartilage acidic protein 1
chr17_+_35016576 0.21 ENSMUST00000007245.1
ENSMUST00000172499.1
von Willebrand factor A domain containing 7
chr17_-_32388885 0.20 ENSMUST00000087703.5
ENSMUST00000170603.1
widely-interspaced zinc finger motifs
chr15_+_102990576 0.20 ENSMUST00000001703.6
homeobox C8
chr10_+_127195240 0.20 ENSMUST00000181578.1
RIKEN cDNA F420014N23 gene
chr12_+_79029150 0.19 ENSMUST00000039928.5
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr6_+_119236507 0.19 ENSMUST00000037434.6
calcium channel, voltage-dependent, alpha 2/delta subunit 4
chr12_+_44328882 0.19 ENSMUST00000020939.8
ENSMUST00000110748.2
neuron-glia-CAM-related cell adhesion molecule
chr16_+_20696175 0.19 ENSMUST00000128273.1
family with sequence similarity 131, member A
chr18_+_42275353 0.18 ENSMUST00000046972.7
ENSMUST00000091920.5
RNA binding motif protein 27
chr17_-_12992227 0.17 ENSMUST00000007007.7
Wilms' tumour 1-associating protein
chr4_+_94739276 0.17 ENSMUST00000073939.6
ENSMUST00000102798.1
endothelial-specific receptor tyrosine kinase
chr1_+_74791516 0.17 ENSMUST00000006718.8
wingless related MMTV integration site 10a
chr16_-_26526744 0.17 ENSMUST00000165687.1
transmembrane protein 207
chr12_+_102469123 0.17 ENSMUST00000179218.1
golgi autoantigen, golgin subfamily a, 5
chr10_+_60399726 0.17 ENSMUST00000164428.1
predicted gene, 17455
chr7_+_3290553 0.17 ENSMUST00000096744.5
myeloid-associated differentiation marker
chr8_+_72443874 0.15 ENSMUST00000064853.6
ENSMUST00000121902.1
RIKEN cDNA 1700030K09 gene
chr16_-_31275277 0.14 ENSMUST00000060188.7
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr15_+_99702278 0.14 ENSMUST00000023759.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr11_+_7063423 0.14 ENSMUST00000020706.4
adenylate cyclase 1
chr7_-_102250086 0.13 ENSMUST00000106923.1
ENSMUST00000098230.4
ras homolog gene family, member G
chr1_+_160195215 0.13 ENSMUST00000135680.1
ENSMUST00000097193.2
mitochondrial ribosomal protein S14
chr7_-_105482197 0.12 ENSMUST00000047040.2
protein kinase C, delta binding protein
chr4_-_20778527 0.10 ENSMUST00000119374.1
Na+/K+ transporting ATPase interacting 3
chr11_+_75650501 0.10 ENSMUST00000102505.3
myosin IC
chr4_-_141664063 0.10 ENSMUST00000084203.4
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr6_+_90269106 0.10 ENSMUST00000058039.2
vomeronasal 1 receptor 54
chr2_-_157279519 0.10 ENSMUST00000143663.1
maestro heat-like repeat family member 8
chr14_-_46575847 0.10 ENSMUST00000151828.1
predicted gene 15219
chr14_+_32513486 0.10 ENSMUST00000066807.6
excision repair cross-complementing rodent repair deficiency, complementation group 6
chr16_-_10790902 0.09 ENSMUST00000050864.5
protamine 3
chr10_+_126978690 0.09 ENSMUST00000105256.2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr10_+_94198955 0.09 ENSMUST00000020209.9
ENSMUST00000179990.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr11_+_101984270 0.08 ENSMUST00000176722.1
ENSMUST00000175972.1
RIKEN cDNA 1700006E09 gene
chr8_+_72107040 0.08 ENSMUST00000055735.4
olfactory receptor 374
chr4_+_118409331 0.07 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)
chr11_+_70023905 0.07 ENSMUST00000124568.2
discs, large homolog 4 (Drosophila)
chr2_-_25234227 0.07 ENSMUST00000006638.7
solute carrier family 34 (sodium phosphate), member 3
chr3_-_96172384 0.06 ENSMUST00000180958.1
predicted gene, 17690
chr13_+_113351603 0.06 ENSMUST00000135096.1
cDNA sequence BC067074
chr4_-_135272798 0.06 ENSMUST00000037099.8
chloride intracellular channel 4 (mitochondrial)

Network of associatons between targets according to the STRING database.

First level regulatory network of Thra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.0 GO:0030221 basophil differentiation(GO:0030221)
1.2 3.6 GO:0032690 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of integrin activation(GO:0033624) negative regulation of interleukin-1 alpha secretion(GO:0050712) regulation of matrix metallopeptidase secretion(GO:1904464) matrix metallopeptidase secretion(GO:1990773) positive regulation of ovarian follicle development(GO:2000386) regulation of antral ovarian follicle growth(GO:2000387) positive regulation of antral ovarian follicle growth(GO:2000388) negative regulation of eosinophil migration(GO:2000417)
0.7 4.0 GO:1902732 antifungal humoral response(GO:0019732) positive regulation of chondrocyte proliferation(GO:1902732)
0.7 2.0 GO:0071846 actin filament debranching(GO:0071846)
0.6 3.0 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.6 2.3 GO:0033370 protein localization to secretory granule(GO:0033366) protein localization to mast cell secretory granule(GO:0033367) protease localization to mast cell secretory granule(GO:0033368) maintenance of protein location in mast cell secretory granule(GO:0033370) T cell secretory granule organization(GO:0033371) maintenance of protease location in mast cell secretory granule(GO:0033373) protein localization to T cell secretory granule(GO:0033374) protease localization to T cell secretory granule(GO:0033375) maintenance of protein location in T cell secretory granule(GO:0033377) maintenance of protease location in T cell secretory granule(GO:0033379) granzyme B localization to T cell secretory granule(GO:0033380) maintenance of granzyme B location in T cell secretory granule(GO:0033382)
0.5 2.7 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.5 1.6 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.4 1.7 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.4 1.2 GO:0098763 mitotic cell cycle phase(GO:0098763)
0.4 2.7 GO:0007144 female meiosis I(GO:0007144)
0.4 1.5 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.4 2.6 GO:0035989 tendon development(GO:0035989)
0.4 1.1 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.3 1.4 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.3 1.8 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.3 0.8 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.2 0.7 GO:0060382 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.2 3.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 2.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.2 0.5 GO:0001698 gastrin-induced gastric acid secretion(GO:0001698)
0.2 2.8 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.2 0.5 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 2.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 1.7 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.1 3.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.6 GO:0070295 glycerol transport(GO:0015793) renal water absorption(GO:0070295)
0.1 0.7 GO:1904923 regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.1 0.5 GO:0006742 NADP catabolic process(GO:0006742)
0.1 2.2 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.1 1.3 GO:0015747 urate transport(GO:0015747)
0.1 1.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.4 GO:0031446 regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.1 0.8 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 6.4 GO:0033344 cholesterol efflux(GO:0033344)
0.1 2.8 GO:0014823 response to activity(GO:0014823)
0.1 0.3 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.2 GO:0060853 Notch signaling pathway involved in heart induction(GO:0003137) epidermal cell fate specification(GO:0009957) regulation of Notch signaling pathway involved in heart induction(GO:0035480) positive regulation of Notch signaling pathway involved in heart induction(GO:0035481) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.1 1.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.1 2.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 0.4 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 0.4 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0048296 regulation of isotype switching to IgA isotypes(GO:0048296)
0.1 1.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 0.3 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.1 0.3 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.4 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 1.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 1.1 GO:0002467 germinal center formation(GO:0002467)
0.1 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.5 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 2.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.7 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0 1.8 GO:0009409 response to cold(GO:0009409)
0.0 3.6 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.4 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.5 GO:0032310 prostaglandin secretion(GO:0032310)
0.0 1.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.2 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.7 GO:0042832 defense response to protozoan(GO:0042832)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.3 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.2 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.2 2.3 GO:0042629 mast cell granule(GO:0042629)
0.2 2.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 0.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 3.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.7 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 4.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.2 GO:0031430 M band(GO:0031430)
0.1 0.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.2 GO:0005927 muscle tendon junction(GO:0005927)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 6.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.9 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0036396 MIS complex(GO:0036396)
0.0 0.3 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.1 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 2.5 GO:0000922 spindle pole(GO:0000922)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 1.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 10.2 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.7 2.8 GO:0015057 thrombin receptor activity(GO:0015057)
0.7 2.7 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.5 3.6 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.4 6.0 GO:0008301 DNA binding, bending(GO:0008301)
0.4 3.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.3 1.3 GO:0050347 trans-hexaprenyltranstransferase activity(GO:0000010) trans-octaprenyltranstransferase activity(GO:0050347)
0.3 1.7 GO:0042731 PH domain binding(GO:0042731)
0.3 1.4 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.3 1.6 GO:0004111 creatine kinase activity(GO:0004111)
0.2 2.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.2 3.0 GO:0050693 LBD domain binding(GO:0050693)
0.2 2.8 GO:0005523 tropomyosin binding(GO:0005523)
0.2 1.7 GO:0031014 troponin T binding(GO:0031014)
0.2 0.5 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
0.2 2.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.4 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.1 4.0 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 0.6 GO:0015254 glycerol channel activity(GO:0015254)
0.1 1.5 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.7 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.3 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 2.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.1 3.9 GO:0050699 WW domain binding(GO:0050699)
0.1 0.5 GO:0004969 histamine receptor activity(GO:0004969)
0.1 3.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.4 GO:0032027 myosin light chain kinase activity(GO:0004687) myosin light chain binding(GO:0032027)
0.1 1.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 0.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.6 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 2.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 3.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.3 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.6 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.3 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.5 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.3 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 3.3 PID ATM PATHWAY ATM pathway
0.1 5.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 1.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 3.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID EPO PATHWAY EPO signaling pathway
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 3.6 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.3 3.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 2.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 1.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 4.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 3.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0 0.4 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 5.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 3.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.4 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.9 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 1.0 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.1 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex