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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Trp73

Z-value: 0.60

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Transcription factors associated with Trp73

Gene Symbol Gene ID Gene Info
Trp73
ENSMUSG00000029026.10 transformation related protein 73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trp73mm10_v2_chr4_-_154097105_154097173-0.029.3e-01Click!

Activity profile of Trp73 motif

Sorted Z-values of Trp73 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_72824482 2.02 ENSMUST00000047328.4
Igfbp2
insulin-like growth factor binding protein 2
chr4_-_49383576 1.39 ENSMUST00000107698.1
Acnat2
acyl-coenzyme A amino acid N-acyltransferase 2
chr9_+_108662098 0.75 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr4_-_49451134 0.73 ENSMUST00000107697.1
ENSMUST00000095086.2
Acnat1
acyl-coenzyme A amino acid N-acyltransferase 1
chr18_-_32036941 0.71 ENSMUST00000134663.1
Myo7b
myosin VIIB
chr14_+_34085978 0.70 ENSMUST00000022519.8
Anxa8
annexin A8
chr11_-_33578933 0.66 ENSMUST00000020366.1
ENSMUST00000135350.1
Gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr4_-_115781012 0.65 ENSMUST00000106521.1
Tex38
testis expressed 38
chr14_+_34086008 0.65 ENSMUST00000120077.1
Anxa8
annexin A8
chr17_+_29090969 0.62 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr7_-_140882274 0.62 ENSMUST00000026559.7
Sirt3
sirtuin 3
chr14_+_53665912 0.61 ENSMUST00000181768.1
Trav3-3
T cell receptor alpha variable 3-3
chr13_+_48261427 0.59 ENSMUST00000021810.1
Id4
inhibitor of DNA binding 4
chr9_-_58158498 0.59 ENSMUST00000168864.2
Islr
immunoglobulin superfamily containing leucine-rich repeat
chr12_-_84876479 0.52 ENSMUST00000163189.1
ENSMUST00000110254.2
ENSMUST00000002073.6
Ltbp2
latent transforming growth factor beta binding protein 2
chr8_+_27085520 0.50 ENSMUST00000178514.1
ENSMUST00000033876.7
Gpr124
G protein-coupled receptor 124
chr9_-_58313189 0.50 ENSMUST00000061799.8
Loxl1
lysyl oxidase-like 1
chr11_-_95146263 0.46 ENSMUST00000021241.6
Dlx4
distal-less homeobox 4
chr14_+_52855614 0.45 ENSMUST00000181038.1
Trav14d-1
T cell receptor alpha variable 14D-1
chr5_-_103629279 0.41 ENSMUST00000031263.1
Slc10a6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr8_+_27085835 0.40 ENSMUST00000165366.2
Gpr124
G protein-coupled receptor 124
chr15_+_76696725 0.39 ENSMUST00000023203.4
Gpt
glutamic pyruvic transaminase, soluble
chr2_+_119237351 0.39 ENSMUST00000028783.7
Spint1
serine protease inhibitor, Kunitz type 1
chr19_-_7105729 0.39 ENSMUST00000113383.2
Flrt1
fibronectin leucine rich transmembrane protein 1
chr9_-_44713196 0.38 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1
pleckstrin homology-like domain, family B, member 1
chr3_-_89245159 0.38 ENSMUST00000090924.6
Trim46
tripartite motif-containing 46
chr9_-_67760208 0.36 ENSMUST00000068526.5
M5C1000I18Rik
RIKEN cDNA M5C1000I18 gene
chr2_+_119237531 0.36 ENSMUST00000110817.2
Spint1
serine protease inhibitor, Kunitz type 1
chr6_+_29398920 0.35 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136
coiled-coil domain containing 136
chr4_+_119232896 0.31 ENSMUST00000121111.2
ENSMUST00000030393.6
ENSMUST00000102662.4
Lepre1
leprecan 1
chr2_+_119237453 0.30 ENSMUST00000110816.1
Spint1
serine protease inhibitor, Kunitz type 1
chr1_+_55088132 0.30 ENSMUST00000075242.6
Hspe1
heat shock protein 1 (chaperonin 10)
chr10_+_128194631 0.28 ENSMUST00000123291.1
Gls2
glutaminase 2 (liver, mitochondrial)
chr8_-_70659645 0.27 ENSMUST00000070173.7
Pgpep1
pyroglutamyl-peptidase I
chr11_-_102230091 0.27 ENSMUST00000008999.5
Hdac5
histone deacetylase 5
chr12_+_84875769 0.27 ENSMUST00000171853.1
D030025P21Rik
RIKEN cDNA D030025P21 gene
chr3_-_89245829 0.26 ENSMUST00000041022.8
Trim46
tripartite motif-containing 46
chr7_-_31054815 0.26 ENSMUST00000071697.4
ENSMUST00000108110.3
Fxyd1
FXYD domain-containing ion transport regulator 1
chr18_+_56432116 0.26 ENSMUST00000070166.5
Gramd3
GRAM domain containing 3
chr11_+_114851142 0.25 ENSMUST00000133245.1
ENSMUST00000122967.2
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr15_+_99055164 0.25 ENSMUST00000047104.7
ENSMUST00000024249.3
Prph
peripherin
chr12_-_45074457 0.24 ENSMUST00000053768.6
Stxbp6
syntaxin binding protein 6 (amisyn)
chr2_+_150909565 0.24 ENSMUST00000028948.4
Gins1
GINS complex subunit 1 (Psf1 homolog)
chr15_+_78428564 0.24 ENSMUST00000166142.2
ENSMUST00000162517.1
ENSMUST00000089414.4
Kctd17
potassium channel tetramerisation domain containing 17
chr3_+_89245952 0.23 ENSMUST00000040888.5
Krtcap2
keratinocyte associated protein 2
chr15_-_76198147 0.22 ENSMUST00000072692.4
Plec
plectin
chr11_+_114851507 0.22 ENSMUST00000177952.1
Gprc5c
G protein-coupled receptor, family C, group 5, member C
chr1_-_87089928 0.22 ENSMUST00000027455.6
Alppl2
alkaline phosphatase, placental-like 2
chr11_-_102230127 0.21 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
Hdac5
histone deacetylase 5
chr13_-_55021196 0.20 ENSMUST00000153665.1
Hk3
hexokinase 3
chr13_-_55021287 0.20 ENSMUST00000148221.1
ENSMUST00000052949.6
Hk3
hexokinase 3
chr2_-_90904827 0.20 ENSMUST00000005647.3
Ndufs3
NADH dehydrogenase (ubiquinone) Fe-S protein 3
chr19_-_47138280 0.20 ENSMUST00000140512.1
ENSMUST00000035822.1
Calhm2
calcium homeostasis modulator 2
chr17_+_33940660 0.20 ENSMUST00000025170.9
Wdr46
WD repeat domain 46
chr3_-_107931579 0.20 ENSMUST00000133947.2
ENSMUST00000124215.1
ENSMUST00000106688.1
ENSMUST00000106687.2
Gstm7
glutathione S-transferase, mu 7
chr2_-_164857671 0.20 ENSMUST00000059954.7
Pltp
phospholipid transfer protein
chr11_+_98026918 0.19 ENSMUST00000017548.6
Rpl19
ribosomal protein L19
chr11_-_103344651 0.19 ENSMUST00000041385.7
Arhgap27
Rho GTPase activating protein 27
chr11_-_120348513 0.17 ENSMUST00000071555.6
Actg1
actin, gamma, cytoplasmic 1
chr15_-_7398233 0.17 ENSMUST00000058593.3
Egflam
EGF-like, fibronectin type III and laminin G domains
chr1_+_135729147 0.16 ENSMUST00000027677.7
Csrp1
cysteine and glycine-rich protein 1
chr19_-_11283813 0.16 ENSMUST00000067673.6
Ms4a5
membrane-spanning 4-domains, subfamily A, member 5
chr8_+_84125989 0.16 ENSMUST00000093380.4
Podnl1
podocan-like 1
chr5_-_139819906 0.15 ENSMUST00000147328.1
Tmem184a
transmembrane protein 184a
chr15_-_7398334 0.15 ENSMUST00000096494.4
Egflam
EGF-like, fibronectin type III and laminin G domains
chr7_+_140881898 0.14 ENSMUST00000026560.7
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr11_+_57801575 0.14 ENSMUST00000020826.5
Sap30l
SAP30-like
chr12_-_45074112 0.14 ENSMUST00000120531.1
ENSMUST00000143376.1
Stxbp6
syntaxin binding protein 6 (amisyn)
chr1_+_153665274 0.13 ENSMUST00000152114.1
ENSMUST00000111812.1
Rgs8
regulator of G-protein signaling 8
chr16_+_5146985 0.13 ENSMUST00000165810.1
Sec14l5
SEC14-like 5 (S. cerevisiae)
chr17_+_28232723 0.13 ENSMUST00000002320.8
Ppard
peroxisome proliferator activator receptor delta
chr1_-_23256406 0.13 ENSMUST00000097807.1
Gm6420
predicted gene 6420
chr1_-_39478734 0.13 ENSMUST00000054462.5
Tbc1d8
TBC1 domain family, member 8
chr4_+_101068983 0.13 ENSMUST00000038463.8
ENSMUST00000106955.1
Raver2
ribonucleoprotein, PTB-binding 2
chr19_+_46304709 0.13 ENSMUST00000073116.5
Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr19_-_4943049 0.13 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
Peli3
pellino 3
chr14_-_24245913 0.12 ENSMUST00000073687.6
ENSMUST00000090398.4
Dlg5
discs, large homolog 5 (Drosophila)
chrX_+_10717451 0.12 ENSMUST00000156321.1
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr4_-_11386757 0.11 ENSMUST00000108313.1
ENSMUST00000108311.2
Esrp1
epithelial splicing regulatory protein 1
chrX_+_10717390 0.11 ENSMUST00000115524.1
ENSMUST00000008179.6
Mid1ip1
Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))
chr6_+_83054653 0.10 ENSMUST00000092618.6
Aup1
ancient ubiquitous protein 1
chr4_+_62583568 0.10 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr3_+_159839729 0.10 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr15_+_30172570 0.10 ENSMUST00000081728.5
Ctnnd2
catenin (cadherin associated protein), delta 2
chr2_-_164857542 0.09 ENSMUST00000109316.1
ENSMUST00000156255.1
ENSMUST00000128110.1
ENSMUST00000109317.3
Pltp
phospholipid transfer protein
chr7_+_140882430 0.09 ENSMUST00000164681.1
ENSMUST00000163610.1
Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr7_-_5014645 0.09 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr5_-_92083455 0.08 ENSMUST00000169094.1
ENSMUST00000167918.1
G3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr3_-_89402650 0.08 ENSMUST00000168325.1
ENSMUST00000057431.5
Lenep
lens epithelial protein
chr8_-_85067982 0.07 ENSMUST00000177563.1
Gm5741
predicted gene 5741
chr11_+_46404720 0.07 ENSMUST00000063166.5
Fam71b
family with sequence similarity 71, member B
chr10_-_67912620 0.07 ENSMUST00000064656.7
Zfp365
zinc finger protein 365
chr5_-_30545836 0.07 ENSMUST00000065486.2
Cib4
calcium and integrin binding family member 4
chr10_+_52391606 0.06 ENSMUST00000067085.4
Nepn
nephrocan
chr10_+_127677064 0.06 ENSMUST00000118612.1
ENSMUST00000048099.4
Tmem194
transmembrane protein 194
chr4_-_45489794 0.06 ENSMUST00000146236.1
Shb
src homology 2 domain-containing transforming protein B
chr4_-_11386679 0.05 ENSMUST00000043781.7
ENSMUST00000108310.1
Esrp1
epithelial splicing regulatory protein 1
chr19_-_50030735 0.05 ENSMUST00000071866.1
Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr7_-_65371210 0.04 ENSMUST00000102592.3
Tjp1
tight junction protein 1
chr11_-_95699143 0.04 ENSMUST00000062249.2
Gm9796
predicted gene 9796
chr15_-_76374926 0.04 ENSMUST00000071119.6
Tssk5
testis-specific serine kinase 5
chr7_-_4514368 0.04 ENSMUST00000166161.1
Tnnt1
troponin T1, skeletal, slow
chr1_-_154725920 0.03 ENSMUST00000004214.8
Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr5_-_30960326 0.03 ENSMUST00000074840.5
Preb
prolactin regulatory element binding
chr5_+_118169712 0.03 ENSMUST00000054836.6
Hrk
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr10_+_39369750 0.03 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn
Fyn proto-oncogene
chr13_+_12702362 0.02 ENSMUST00000104944.2
Gm2399
predicted gene 2399
chr16_-_17125106 0.02 ENSMUST00000093336.6
2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr7_+_25282179 0.02 ENSMUST00000163320.1
ENSMUST00000005578.6
Cic
capicua homolog (Drosophila)
chr14_+_53776930 0.02 ENSMUST00000103670.2
Trav3-4
T cell receptor alpha variable 3-4
chr5_-_30960236 0.02 ENSMUST00000088063.2
Preb
prolactin regulatory element binding
chr19_-_47157764 0.01 ENSMUST00000178630.1
Calhm3
calcium homeostasis modulator 3
chr11_+_60931998 0.01 ENSMUST00000019076.3
Map2k3
mitogen-activated protein kinase kinase 3
chr10_+_127642975 0.00 ENSMUST00000092074.5
ENSMUST00000120279.1
Stat6
signal transducer and activator of transcription 6

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:1904970 brush border assembly(GO:1904970)
0.1 2.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 0.8 GO:0015879 carnitine transport(GO:0015879)
0.1 0.6 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 0.6 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.1 0.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.1 1.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.3 GO:1903278 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0 0.1 GO:0002268 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.4 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 0.6 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.4 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.5 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0 0.1 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.0 0.1 GO:0018992 germ-line sex determination(GO:0018992)
0.0 0.2 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.1 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.5 GO:0097435 fibril organization(GO:0097435)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331) protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776) positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 0.0 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.4 GO:0035383 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.2 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0044299 C-fiber(GO:0044299)
0.0 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0002080 acrosomal membrane(GO:0002080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 0.5 GO:0005118 sevenless binding(GO:0005118)
0.1 0.8 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0016501 prostacyclin receptor activity(GO:0016501)
0.0 0.4 GO:0019158 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 1.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.6 GO:0070403 NAD+ binding(GO:0070403)
0.0 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex