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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for UAAGACG

Z-value: 0.44

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miRNA associated with seed UAAGACG

NamemiRBASE accession
mmu-miR-208a-3p
MIMAT0000520
mmu-miR-208b-3p
MIMAT0004939

Activity profile of UAAGACG motif

Sorted Z-values of UAAGACG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_45470201 1.69 ENSMUST00000079390.6
Lin28b
lin-28 homolog B (C. elegans)
chr11_+_44617310 1.04 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
Ebf1
early B cell factor 1
chr11_+_98907801 0.93 ENSMUST00000092706.6
Cdc6
cell division cycle 6
chr14_-_31577318 0.86 ENSMUST00000112027.2
Colq
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr16_-_22657165 0.66 ENSMUST00000089925.3
Dgkg
diacylglycerol kinase, gamma
chr12_+_32378692 0.59 ENSMUST00000172332.2
Ccdc71l
coiled-coil domain containing 71 like
chr2_+_160645881 0.55 ENSMUST00000109468.2
Top1
topoisomerase (DNA) I
chr4_+_17853451 0.54 ENSMUST00000029881.3
Mmp16
matrix metallopeptidase 16
chr7_-_116038734 0.52 ENSMUST00000166877.1
Sox6
SRY-box containing gene 6
chr17_-_6655939 0.51 ENSMUST00000179554.1
Dynlt1f
dynein light chain Tctex-type 1F
chr6_-_39206782 0.50 ENSMUST00000002305.8
Jhdm1d
jumonji C domain-containing histone demethylase 1 homolog D (S. cerevisiae)
chr1_-_69685937 0.47 ENSMUST00000027146.2
Ikzf2
IKAROS family zinc finger 2
chr3_+_137864573 0.46 ENSMUST00000174561.1
ENSMUST00000173790.1
H2afz
H2A histone family, member Z
chr1_-_97661950 0.44 ENSMUST00000053033.7
ENSMUST00000149927.1
D1Ertd622e
DNA segment, Chr 1, ERATO Doi 622, expressed
chr17_-_6317474 0.44 ENSMUST00000169415.1
Dynlt1a
dynein light chain Tctex-type 1A
chr6_+_71707561 0.42 ENSMUST00000121469.1
Reep1
receptor accessory protein 1
chr3_+_109340627 0.40 ENSMUST00000046864.7
Vav3
vav 3 oncogene
chr17_-_51832666 0.39 ENSMUST00000144331.1
Satb1
special AT-rich sequence binding protein 1
chr5_+_67607873 0.39 ENSMUST00000087241.5
Shisa3
shisa homolog 3 (Xenopus laevis)
chr11_+_97415527 0.37 ENSMUST00000121799.1
Arhgap23
Rho GTPase activating protein 23
chr14_+_69029289 0.35 ENSMUST00000014957.8
Stc1
stanniocalcin 1
chr11_+_44518959 0.35 ENSMUST00000019333.3
Rnf145
ring finger protein 145
chr2_-_45113255 0.34 ENSMUST00000068415.4
ENSMUST00000127520.1
Zeb2
zinc finger E-box binding homeobox 2
chr8_-_8690493 0.33 ENSMUST00000048545.8
Arglu1
arginine and glutamate rich 1
chr3_-_116424007 0.33 ENSMUST00000090464.4
Cdc14a
CDC14 cell division cycle 14A
chr17_+_6601671 0.33 ENSMUST00000092966.4
Dynlt1c
dynein light chain Tctex-type 1C
chr5_+_123343834 0.32 ENSMUST00000120593.1
Bcl7a
B cell CLL/lymphoma 7A
chr4_+_141147911 0.32 ENSMUST00000030757.9
Fbxo42
F-box protein 42
chr11_+_68691906 0.29 ENSMUST00000102611.3
Myh10
myosin, heavy polypeptide 10, non-muscle
chr4_-_41314877 0.29 ENSMUST00000030145.8
Dcaf12
DDB1 and CUL4 associated factor 12
chr18_+_53176345 0.28 ENSMUST00000037850.5
Snx2
sorting nexin 2
chr2_-_6884975 0.28 ENSMUST00000114924.3
ENSMUST00000170438.1
ENSMUST00000114934.4
Celf2
CUGBP, Elav-like family member 2
chr3_+_136670076 0.28 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr16_+_17233560 0.28 ENSMUST00000090190.5
ENSMUST00000115698.2
Hic2
hypermethylated in cancer 2
chr12_-_69681795 0.26 ENSMUST00000183277.1
ENSMUST00000035773.7
Sos2
son of sevenless homolog 2 (Drosophila)
chr1_+_74506044 0.24 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr17_+_29549783 0.22 ENSMUST00000048677.7
Tbc1d22b
TBC1 domain family, member 22B
chr2_+_122028544 0.22 ENSMUST00000028668.7
Eif3j1
eukaryotic translation initiation factor 3, subunit J1
chr1_-_21961581 0.21 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
Kcnq5
potassium voltage-gated channel, subfamily Q, member 5
chr10_-_23349887 0.21 ENSMUST00000074366.6
ENSMUST00000092665.4
Eya4
eyes absent 4 homolog (Drosophila)
chr16_-_15594507 0.20 ENSMUST00000115776.1
ENSMUST00000115777.3
Ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr17_+_29093763 0.19 ENSMUST00000023829.6
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr6_-_54566484 0.18 ENSMUST00000019268.4
Scrn1
secernin 1
chr12_+_113014502 0.18 ENSMUST00000084891.4
Pacs2
phosphofurin acidic cluster sorting protein 2
chr1_-_119837613 0.17 ENSMUST00000064091.5
Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr19_+_21778325 0.17 ENSMUST00000096194.2
ENSMUST00000025663.6
Tmem2
transmembrane protein 2
chr4_-_56865135 0.17 ENSMUST00000107612.2
ENSMUST00000045142.8
Ctnnal1
catenin (cadherin associated protein), alpha-like 1
chr4_-_139131058 0.15 ENSMUST00000143971.1
Minos1
mitochondrial inner membrane organizing system 1
chr12_-_46818749 0.15 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr19_-_14597983 0.13 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_-_119783262 0.13 ENSMUST00000029780.7
Ptbp2
polypyrimidine tract binding protein 2
chr14_-_20546512 0.13 ENSMUST00000022355.4
ENSMUST00000161445.1
ENSMUST00000159027.1
Ppp3cb
protein phosphatase 3, catalytic subunit, beta isoform
chr15_+_96287518 0.13 ENSMUST00000134985.2
ENSMUST00000096250.4
Arid2
AT rich interactive domain 2 (ARID, RFX-like)
chr6_+_38433913 0.13 ENSMUST00000160583.1
Ubn2
ubinuclein 2
chr14_-_105176860 0.12 ENSMUST00000163545.1
Rbm26
RNA binding motif protein 26
chr6_-_100287441 0.12 ENSMUST00000101118.2
Rybp
RING1 and YY1 binding protein
chr17_+_83350925 0.12 ENSMUST00000096766.4
ENSMUST00000112363.2
ENSMUST00000049503.8
Eml4
echinoderm microtubule associated protein like 4
chr12_-_91590009 0.10 ENSMUST00000021345.6
Gtf2a1
general transcription factor II A, 1
chr3_+_89520152 0.08 ENSMUST00000000811.7
Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr1_-_64121456 0.08 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr8_+_117257019 0.08 ENSMUST00000166750.1
Cmip
c-Maf inducing protein
chr6_-_51469869 0.07 ENSMUST00000114459.1
ENSMUST00000069949.6
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_74691090 0.07 ENSMUST00000061745.3
Hoxd10
homeobox D10
chr11_-_19018956 0.06 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
Meis1
Meis homeobox 1
chr9_-_72111827 0.06 ENSMUST00000183404.1
ENSMUST00000184783.1
Tcf12
transcription factor 12
chr5_+_57718021 0.05 ENSMUST00000094783.3
ENSMUST00000068110.7
Pcdh7
protocadherin 7
chr13_-_111490111 0.04 ENSMUST00000047627.7
Gpbp1
GC-rich promoter binding protein 1
chr2_-_37647199 0.04 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr10_+_39369750 0.04 ENSMUST00000063091.6
ENSMUST00000099967.3
ENSMUST00000126486.1
Fyn
Fyn proto-oncogene
chr15_-_93275151 0.03 ENSMUST00000057896.4
ENSMUST00000049484.6
Gxylt1
glucoside xylosyltransferase 1
chr10_-_115315546 0.03 ENSMUST00000020343.7
Rab21
RAB21, member RAS oncogene family
chr14_-_61439831 0.03 ENSMUST00000022496.7
Kpna3
karyopherin (importin) alpha 3
chr13_+_94875600 0.02 ENSMUST00000022195.10
Otp
orthopedia homolog (Drosophila)
chr7_-_111082997 0.01 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
Eif4g2
eukaryotic translation initiation factor 4, gamma 2
chr7_-_66689589 0.01 ENSMUST00000124899.1
Asb7
ankyrin repeat and SOCS box-containing 7
chr4_-_126429501 0.01 ENSMUST00000069097.6
Ago3
argonaute RISC catalytic subunit 3
chr18_+_34220978 0.01 ENSMUST00000079362.5
ENSMUST00000115781.3
Apc
adenomatosis polyposis coli
chr3_-_122984404 0.01 ENSMUST00000090379.2
Usp53
ubiquitin specific peptidase 53
chr6_-_145865483 0.01 ENSMUST00000032386.4
Bhlhe41
basic helix-loop-helix family, member e41
chr9_+_72532214 0.01 ENSMUST00000163401.2
ENSMUST00000093820.3
Rfx7
regulatory factor X, 7
chr12_-_73047179 0.00 ENSMUST00000050029.7
Six1
sine oculis-related homeobox 1
chr6_+_77242644 0.00 ENSMUST00000159616.1
Lrrtm1
leucine rich repeat transmembrane neuronal 1
chr7_+_130577334 0.00 ENSMUST00000059145.7
ENSMUST00000084513.4
Tacc2
transforming, acidic coiled-coil containing protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.9 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.1 0.3 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.1 0.6 GO:0006265 DNA topological change(GO:0006265)
0.1 0.2 GO:0042275 error-free postreplication DNA repair(GO:0042275)
0.1 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.9 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.5 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.4 GO:0010764 negative regulation of fibroblast migration(GO:0010764) negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0 0.8 GO:0051984 positive regulation of chromosome segregation(GO:0051984)
0.0 0.3 GO:0051256 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0 0.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 0.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.4 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.2 GO:2000973 regulation of pro-B cell differentiation(GO:2000973)
0.0 0.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.5 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.4 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.1 0.6 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.4 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.3 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.4 GO:0035869 ciliary transition zone(GO:0035869)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 0.4 GO:0031849 olfactory receptor binding(GO:0031849)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.1 0.4 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol