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avrg: GSE58827: Dynamics of the Mouse Liver
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Results for Ubp1
Z-value: 1.73
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Transcription factors associated with Ubp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ubp1 | mm10_v2_chr9_+_113930934_113930987 | -0.66 | 9.9e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_13623967 Show fit | 11.39 |
ENSMUST00000108525.2
|
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5 |
|
| chr4_-_115496129 Show fit | 7.53 |
ENSMUST00000030487.2
|
cytochrome P450, family 4, subfamily a, polypeptide 14 |
|
| chr19_-_7802578 Show fit | 5.87 |
ENSMUST00000120522.1
ENSMUST00000065634.7 |
solute carrier family 22 (organic cation transporter), member 26 |
|
| chr7_-_14123042 Show fit | 5.02 |
ENSMUST00000098809.2
|
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3 |
|
| chr5_+_130448801 Show fit | 4.70 |
ENSMUST00000111288.2
|
calneuron 1 |
|
| chr7_+_26808880 Show fit | 4.24 |
ENSMUST00000040944.7
|
cytochrome P450, family 2, subfamily g, polypeptide 1 |
|
| chr10_+_127759780 Show fit | 4.23 |
ENSMUST00000128247.1
|
Protein Rdh9 |
|
| chr6_-_55175019 Show fit | 4.14 |
ENSMUST00000003569.5
|
indolethylamine N-methyltransferase |
|
| chr1_-_150465563 Show fit | 4.11 |
ENSMUST00000164600.1
ENSMUST00000111902.2 ENSMUST00000111901.2 ENSMUST00000006171.9 |
proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) |
|
| chr5_-_87092546 Show fit | 4.03 |
ENSMUST00000132667.1
ENSMUST00000145617.1 ENSMUST00000094649.4 |
UDP glucuronosyltransferase 2 family, polypeptide B36 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ubp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.1 | GO:0015747 | urate transport(GO:0015747) |
| 0.3 | 9.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.2 | 8.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.6 | 7.1 | GO:0043651 | linoleic acid metabolic process(GO:0043651) |
| 2.0 | 6.1 | GO:0002541 | plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 1.2 | 4.7 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.5 | 4.1 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 1.0 | 4.0 | GO:0042196 | chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197) |
| 0.7 | 4.0 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 3.7 | GO:0046688 | response to copper ion(GO:0046688) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 13.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 6.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 6.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 6.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 5.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 5.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.2 | 5.5 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 4.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 4.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 19.1 | GO:0004027 | alcohol sulfotransferase activity(GO:0004027) |
| 1.1 | 16.5 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.3 | 13.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.4 | 12.3 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 10.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.8 | 7.2 | GO:0071614 | linoleic acid epoxygenase activity(GO:0071614) |
| 1.2 | 7.2 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 2.2 | 6.7 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 0.3 | 6.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.9 | 6.0 | GO:0004046 | aminoacylase activity(GO:0004046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 3.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.6 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 5.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.5 | 4.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 4.6 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.3 | 3.7 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 3.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.5 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.2 | 3.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.1 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.2 | 3.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |