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avrg: GSE58827: Dynamics of the Mouse Liver

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Results for Zbtb49

Z-value: 1.19

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Transcription factors associated with Zbtb49

Gene Symbol Gene ID Gene Info
Zbtb49
ENSMUSG00000029127.9 zinc finger and BTB domain containing 49

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb49mm10_v2_chr5_-_38220400_38220459-0.537.9e-04Click!

Activity profile of Zbtb49 motif

Sorted Z-values of Zbtb49 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_39649046 5.28 ENSMUST00000067328.6
Cyp2c67
cytochrome P450, family 2, subfamily c, polypeptide 67
chr7_-_140154712 5.25 ENSMUST00000059241.7
Sprn
shadow of prion protein
chr18_-_61911783 4.82 ENSMUST00000049378.8
ENSMUST00000166783.1
Ablim3
actin binding LIM protein family, member 3
chr15_-_34495180 4.30 ENSMUST00000022946.5
Hrsp12
heat-responsive protein 12
chr17_+_24736673 4.16 ENSMUST00000101800.5
Msrb1
methionine sulfoxide reductase B1
chr17_+_24736639 4.03 ENSMUST00000115262.1
Msrb1
methionine sulfoxide reductase B1
chr6_+_71199827 3.72 ENSMUST00000067492.7
Fabp1
fatty acid binding protein 1, liver
chr15_-_3303521 3.69 ENSMUST00000165386.1
Ccdc152
coiled-coil domain containing 152
chr19_-_39812744 1.96 ENSMUST00000162507.1
ENSMUST00000160476.1
Cyp2c40
cytochrome P450, family 2, subfamily c, polypeptide 40
chr8_+_105000824 1.90 ENSMUST00000172032.2
Ces2h
carboxylesterase 2H
chr5_+_35814424 1.63 ENSMUST00000114203.1
Ablim2
actin-binding LIM protein 2
chr1_-_183369529 1.40 ENSMUST00000069922.5
Mia3
melanoma inhibitory activity 3
chr7_-_98199481 1.34 ENSMUST00000098278.2
B3gnt6
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
chr12_-_28552303 1.30 ENSMUST00000020963.7
Dcdc2c
doublecortin domain containing 2C
chr16_-_70382385 1.09 ENSMUST00000072455.4
4930423O20Rik
RIKEN cDNA 4930423O20 gene
chr9_+_40269430 0.95 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 0.95 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b
sodium channel, voltage-gated, type III, beta
chr5_+_108629990 0.83 ENSMUST00000078323.6
ENSMUST00000120327.1
Tmem175
transmembrane protein 175
chr9_+_45430293 0.82 ENSMUST00000034592.8
Dscaml1
Down syndrome cell adhesion molecule like 1
chr3_+_154597197 0.81 ENSMUST00000155385.1
ENSMUST00000029850.8
Cryz
crystallin, zeta
chr2_-_167240588 0.79 ENSMUST00000088041.4
ENSMUST00000018113.7
Ptgis
prostaglandin I2 (prostacyclin) synthase
chr9_+_40269273 0.77 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr3_-_53017195 0.76 ENSMUST00000036665.4
Cog6
component of oligomeric golgi complex 6
chr5_+_108629791 0.72 ENSMUST00000063272.6
Tmem175
transmembrane protein 175
chr6_+_59208870 0.69 ENSMUST00000062626.3
Tigd2
tigger transposable element derived 2
chr5_-_108629712 0.55 ENSMUST00000046603.8
Gak
cyclin G associated kinase
chr14_-_68655804 0.52 ENSMUST00000111072.1
ENSMUST00000022642.5
Adam28
a disintegrin and metallopeptidase domain 28
chr3_+_154597352 0.42 ENSMUST00000140644.1
ENSMUST00000144764.1
ENSMUST00000155232.1
Cryz
crystallin, zeta
chr1_+_32172711 0.26 ENSMUST00000027226.5
Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr15_-_100422991 0.26 ENSMUST00000138843.1
ENSMUST00000023774.5
Slc11a2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr12_-_21417356 0.26 ENSMUST00000103002.1
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr14_-_122465677 0.24 ENSMUST00000039118.6
Zic5
zinc finger protein of the cerebellum 5
chr1_-_74951651 0.12 ENSMUST00000164097.1
Ihh
Indian hedgehog
chr15_-_102257449 0.11 ENSMUST00000043172.8
Rarg
retinoic acid receptor, gamma
chr15_+_100423193 0.09 ENSMUST00000148928.1
Gm5475
predicted gene 5475
chr15_-_102257306 0.06 ENSMUST00000135466.1
Rarg
retinoic acid receptor, gamma
chr1_+_42851233 0.01 ENSMUST00000057208.9
Mrps9
mitochondrial ribosomal protein S9

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb49

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 8.2 GO:0030091 protein repair(GO:0030091)
0.3 2.7 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.2 3.7 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 7.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.2 0.5 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.1 1.6 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 1.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.2 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 0.3 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 1.9 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.1 4.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.1 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) camera-type eye photoreceptor cell fate commitment(GO:0060220)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 5.2 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0045179 apical cortex(GO:0045179)
0.2 2.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 4.8 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 3.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.5 1.4 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.4 1.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.4 2.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 7.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.1 1.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.3 GO:0015094 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 1.3 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.8 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 0.5 GO:0030332 cyclin binding(GO:0030332)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 3.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.3 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins