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GSE58827: Dynamics of the Mouse Liver
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Results for Aire
Z-value: 0.72
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Transcription factors associated with Aire
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Aire | mm39_v1_chr10_-_77879414_77879445 | -0.18 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_39275518 Show fit | 4.05 |
ENSMUST00000003137.15
|
cytochrome P450, family 2, subfamily c, polypeptide 29 |
|
| chr6_+_42222841 Show fit | 3.51 |
ENSMUST00000031897.8
|
glutathione S-transferase kappa 1 |
|
| chr10_-_95678786 Show fit | 2.89 |
ENSMUST00000211096.2
|
predicted gene, 33543 |
|
| chr10_-_95678748 Show fit | 2.81 |
ENSMUST00000210336.2
|
predicted gene, 33543 |
|
| chr5_+_8010445 Show fit | 2.67 |
ENSMUST00000115421.3
|
STEAP family member 4 |
|
| chr1_+_88128323 Show fit | 2.33 |
ENSMUST00000049289.9
|
UDP glucuronosyltransferase 1 family, polypeptide A2 |
|
| chr12_+_84098888 Show fit | 1.95 |
ENSMUST00000120927.8
ENSMUST00000021653.8 |
acyl-CoA thioesterase 3 |
|
| chr5_+_130398261 Show fit | 1.76 |
ENSMUST00000086029.10
|
calneuron 1 |
|
| chrM_+_11735 Show fit | 1.74 |
ENSMUST00000082418.1
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr5_+_31079177 Show fit | 1.67 |
ENSMUST00000031053.15
ENSMUST00000202752.2 |
ketohexokinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Aire
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 0.1 | 3.7 | GO:0030195 | negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047) |
| 0.0 | 3.5 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 1.0 | 2.9 | GO:0042853 | glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) L-alanine catabolic process(GO:0042853) |
| 0.0 | 2.9 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.3 | 2.7 | GO:0097461 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
| 0.1 | 2.5 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.2 | 2.3 | GO:0052696 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.7 | 2.0 | GO:0032789 | saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789) |
| 0.4 | 1.7 | GO:0034285 | response to sucrose(GO:0009744) response to disaccharide(GO:0034285) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 3.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 3.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.5 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 1.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.2 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.1 | 1.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 1.0 | GO:0045275 | respiratory chain complex III(GO:0045275) |
| 0.1 | 1.0 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.1 | 3.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.2 | 3.5 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.5 | 2.9 | GO:0008453 | alanine-glyoxylate transaminase activity(GO:0008453) |
| 0.0 | 2.8 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.3 | 2.7 | GO:0052851 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.1 | 2.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 2.0 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 2.0 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.2 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 1.2 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 1.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.4 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 1.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 1.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 0.8 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.8 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.6 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.5 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |