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GSE58827: Dynamics of the Mouse Liver
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Results for Bptf
Z-value: 2.29
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Transcription factors associated with Bptf
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Bptf | mm39_v1_chr11_-_107022940_107022993 | -0.24 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_60618357 Show fit | 39.82 |
ENSMUST00000084544.5
ENSMUST00000098046.10 |
major urinary protein 11 |
|
| chr4_-_61437704 Show fit | 31.72 |
ENSMUST00000095051.6
ENSMUST00000107483.8 |
major urinary protein 16 |
|
| chr4_-_60377932 Show fit | 29.21 |
ENSMUST00000107506.9
ENSMUST00000122381.8 ENSMUST00000118759.8 ENSMUST00000132829.3 |
major urinary protein 9 |
|
| chr4_-_60139857 Show fit | 27.40 |
ENSMUST00000107490.5
ENSMUST00000074700.9 |
major urinary protein 2 |
|
| chr4_-_61592331 Show fit | 25.60 |
ENSMUST00000098040.4
|
major urinary protein 18 |
|
| chr4_-_61700450 Show fit | 24.12 |
ENSMUST00000107477.2
ENSMUST00000080606.9 |
major urinary protein 19 |
|
| chr4_-_60777462 Show fit | 23.14 |
ENSMUST00000211875.2
|
major urinary protein 22 |
|
| chr4_-_61514108 Show fit | 22.95 |
ENSMUST00000107484.2
|
major urinary protein 17 |
|
| chr4_-_60538151 Show fit | 21.52 |
ENSMUST00000098047.3
|
major urinary protein 10 |
|
| chr4_-_61357980 Show fit | 21.25 |
ENSMUST00000095049.5
|
major urinary protein 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Bptf
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 55.7 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 0.6 | 18.7 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 2.8 | 17.1 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.0 | 12.8 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.6 | 12.6 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 1.8 | 8.9 | GO:0001692 | histamine metabolic process(GO:0001692) |
| 0.5 | 8.9 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.3 | 8.1 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.1 | 8.1 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.5 | 8.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 55.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 12.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.3 | 10.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 9.4 | GO:0005811 | lipid particle(GO:0005811) |
| 1.5 | 8.9 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.4 | 6.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 6.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 6.2 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.4 | 5.7 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 5.7 | GO:0032420 | stereocilium(GO:0032420) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 6.4 | 32.2 | GO:0005186 | pheromone activity(GO:0005186) |
| 0.3 | 25.9 | GO:0005550 | pheromone binding(GO:0005550) |
| 0.4 | 14.1 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 1.7 | 11.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.3 | 11.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 10.1 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 0.2 | 9.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 8.1 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 1.3 | 7.5 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 12.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 6.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 5.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 3.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 2.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 2.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 2.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.1 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 1.0 | 11.5 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 9.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.3 | 8.3 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 6.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 6.2 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.5 | 6.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.4 | 5.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 5.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |