ISMARA results: Cebpb

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GSE58827: Dynamics of the Mouse Liver

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Results for Cebpb

Z-value: 2.07

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Transcription factors associated with Cebpb

Gene Symbol	Gene ID	Gene Info
Cebpb Ensembl NCBI MGI UniProt	ENSMUSG00000056501.4	CCAAT/enhancer binding protein (C/EBP), beta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Cebpb	mm39_v1_chr2_+_167530835_167530894	-0.07	7.0e-01	Click!

Activity profile of Cebpb motif

Sorted Z-values of Cebpb motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_109678685 Show fit	28.41	ENSMUST00000112022.5	Camp Ensembl NCBI MGI UniProt Show fit	cathelicidin antimicrobial peptide
chr7_+_13467422 Show fit	26.09	ENSMUST00000086148.8	Sult2a2 Ensembl NCBI MGI UniProt Show fit	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2
chr9_+_110248815 Show fit	23.01	ENSMUST00000035061.9	Ngp Ensembl NCBI MGI UniProt Show fit	neutrophilic granule protein
chrX_-_161747552 Show fit	19.67	ENSMUST00000038769.3	S100g Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein G
chr10_+_23727325 Show fit	18.30	ENSMUST00000020190.8	Vnn3 Ensembl NCBI MGI UniProt Show fit	vanin 3
chr2_-_32277773 Show fit	15.94	ENSMUST00000050785.14	Lcn2 Ensembl NCBI MGI UniProt Show fit	lipocalin 2
chr2_-_32278245 Show fit	15.71	ENSMUST00000192241.2	Lcn2 Ensembl NCBI MGI UniProt Show fit	lipocalin 2
chr11_-_99383938 Show fit	14.85	ENSMUST00000006969.8	Krt23 Ensembl NCBI MGI UniProt Show fit	keratin 23
chr8_-_46664321 Show fit	14.55	ENSMUST00000034049.5	Slc25a4 Ensembl NCBI MGI UniProt Show fit	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4
chr10_+_79722081 Show fit	13.96	ENSMUST00000046091.7	Elane Ensembl NCBI MGI UniProt Show fit	elastase, neutrophil expressed

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.5	31.6	GO:0015891	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
2.6	28.4	GO:0002227	innate immune response in mucosa(GO:0002227)
0.4	25.8	GO:0050819	negative regulation of coagulation(GO:0050819)
3.9	23.2	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
5.8	23.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
6.3	18.9	GO:0033189	response to vitamin A(GO:0033189)
0.4	18.3	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.6	17.8	GO:0030502	negative regulation of bone mineralization(GO:0030502)
5.5	16.4	GO:0009087	methionine catabolic process(GO:0009087)
0.4	15.1	GO:0006825	copper ion transport(GO:0006825)

Showing 1 to 10 of 131 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.2	GO:0016323	basolateral plasma membrane(GO:0016323)
1.3	28.4	GO:0042581	specific granule(GO:0042581)
0.4	23.2	GO:0015030	Cajal body(GO:0015030)
0.0	17.6	GO:0031410	cytoplasmic vesicle(GO:0031410)
0.1	17.4	GO:0031225	anchored component of membrane(GO:0031225)
0.1	15.8	GO:0016363	nuclear matrix(GO:0016363)
0.1	14.4	GO:0005741	mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
1.8	14.3	GO:0005577	fibrinogen complex(GO:0005577)
0.1	13.3	GO:0072562	blood microparticle(GO:0072562)
2.0	11.9	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)

Showing 1 to 10 of 65 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	40.9	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
3.6	25.1	GO:0050656	alcohol sulfotransferase activity(GO:0004027) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
4.6	23.2	GO:0008859	exoribonuclease II activity(GO:0008859)
0.4	22.5	GO:0008146	sulfotransferase activity(GO:0008146)
0.1	21.8	GO:0002020	protease binding(GO:0002020)
2.5	19.7	GO:0005499	vitamin D binding(GO:0005499)
0.2	18.8	GO:0042562	hormone binding(GO:0042562)
0.2	18.6	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
1.5	16.9	GO:0015217	ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
4.1	16.4	GO:0004478	methionine adenosyltransferase activity(GO:0004478)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	29.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.2	28.4	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.5	17.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	17.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	17.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3	14.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	12.8	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	12.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.2	9.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	7.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	43.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3	23.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.7	20.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.7	18.7	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.8	16.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.5	16.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.3	14.5	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.2	11.8	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.9	10.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.5	7.5	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins

Showing 1 to 10 of 53 entries

Results for Cebpb

Z-value: 2.07

Motif logo

Transcription factors associated with Cebpb

Activity-expression correlation:

Activity profile of Cebpb motif

Sorted Z-values of Cebpb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cebpb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: