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GSE58827: Dynamics of the Mouse Liver
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Results for Cebpe
Z-value: 3.65
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Transcription factors associated with Cebpe
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cebpe | mm39_v1_chr14_-_54949596_54949631 | -0.79 | 9.1e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cebpe
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 152.6 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 3.7 | 112.4 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 6.7 | 93.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 7.4 | 89.3 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
| 3.4 | 51.0 | GO:0015747 | urate transport(GO:0015747) |
| 3.4 | 50.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.5 | 47.1 | GO:0006637 | acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383) |
| 15.6 | 46.8 | GO:0009087 | methionine catabolic process(GO:0009087) |
| 10.2 | 40.9 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 9.9 | 39.8 | GO:1901373 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 173.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.3 | 133.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 65.0 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 60.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 53.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 5.2 | 46.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.2 | 42.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 3.1 | 40.6 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.1 | 33.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.0 | 29.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 290.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 2.6 | 73.4 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 10.7 | 64.4 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 2.8 | 62.6 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 18.3 | 54.9 | GO:0005009 | insulin-activated receptor activity(GO:0005009) |
| 3.1 | 53.5 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 11.7 | 46.8 | GO:0004478 | methionine adenosyltransferase activity(GO:0004478) |
| 5.1 | 40.8 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 5.0 | 40.3 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 9.9 | 39.8 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 22.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.7 | 19.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.2 | 18.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 16.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 15.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.6 | 12.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 11.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 11.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.9 | 10.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 58.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 1.5 | 52.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 3.0 | 51.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 2.0 | 45.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 3.6 | 39.1 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.7 | 30.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.7 | 27.8 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 1.9 | 26.2 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.6 | 23.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.2 | 23.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |