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GSE58827: Dynamics of the Mouse Liver
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Results for Chd1_Pml
Z-value: 4.62
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Transcription factors associated with Chd1_Pml
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Chd1 | mm39_v1_chr17_+_15925205_15925256 | 0.64 | 2.5e-05 | Click! |
| Pml | mm39_v1_chr9_-_58156935_58156969 | -0.32 | 5.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Chd1_Pml
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 50.4 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.8 | 36.2 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 1.1 | 31.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 2.6 | 30.9 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.9 | 24.4 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 2.0 | 22.0 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 3.1 | 21.5 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
| 2.3 | 21.1 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 1.3 | 19.8 | GO:0060211 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 1.5 | 19.7 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 221.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.3 | 102.4 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 93.2 | GO:0005768 | endosome(GO:0005768) |
| 0.3 | 64.0 | GO:0043296 | apical junction complex(GO:0043296) |
| 0.3 | 63.4 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.7 | 53.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 1.6 | 42.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 35.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 33.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.2 | 29.9 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 131.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.4 | 51.7 | GO:0101005 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.6 | 41.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.2 | 40.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.6 | 37.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.3 | 34.2 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.6 | 34.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 31.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.8 | 31.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.8 | 31.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 60.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.9 | 55.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.6 | 49.8 | PID FOXO PATHWAY | FoxO family signaling |
| 0.6 | 35.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 35.2 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.7 | 31.5 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.5 | 30.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.4 | 29.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.5 | 29.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.5 | 28.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 45.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 1.2 | 40.9 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.2 | 40.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 1.3 | 36.2 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.8 | 36.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 1.2 | 35.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.9 | 27.9 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.4 | 25.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.8 | 25.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 1.2 | 23.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |