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GSE58827: Dynamics of the Mouse Liver
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Results for E2f1
Z-value: 5.77
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Transcription factors associated with E2f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f1 | mm39_v1_chr2_-_154411765_154411812 | 0.96 | 3.5e-20 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 171.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 6.4 | 148.1 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 4.9 | 146.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 1.0 | 94.9 | GO:0051225 | spindle assembly(GO:0051225) |
| 2.8 | 88.1 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 1.9 | 81.5 | GO:0006779 | porphyrin-containing compound biosynthetic process(GO:0006779) |
| 4.6 | 78.3 | GO:0033280 | response to vitamin D(GO:0033280) |
| 4.6 | 74.2 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 7.5 | 67.6 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 22.5 | 67.5 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.5 | 264.8 | GO:0042555 | MCM complex(GO:0042555) |
| 2.2 | 135.8 | GO:0005657 | replication fork(GO:0005657) |
| 20.3 | 121.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.3 | 88.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.5 | 82.1 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 1.3 | 75.4 | GO:0015030 | Cajal body(GO:0015030) |
| 5.6 | 66.7 | GO:0000796 | condensin complex(GO:0000796) |
| 1.1 | 66.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 7.6 | 60.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.6 | 60.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 187.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 20.3 | 121.6 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.5 | 96.9 | GO:0042393 | histone binding(GO:0042393) |
| 11.5 | 92.0 | GO:0031493 | nucleosomal histone binding(GO:0031493) |
| 2.0 | 82.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 22.5 | 67.6 | GO:0052895 | norspermine:oxygen oxidoreductase activity(GO:0052894) N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity(GO:0052895) |
| 0.8 | 62.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.0 | 60.9 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 3.0 | 60.6 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.5 | 59.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 341.0 | PID E2F PATHWAY | E2F transcription factor network |
| 5.3 | 291.0 | PID ATR PATHWAY | ATR signaling pathway |
| 2.2 | 123.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 117.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.4 | 49.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.5 | 39.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.8 | 38.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.9 | 31.9 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.7 | 26.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.9 | 26.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.9 | 269.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 6.5 | 150.2 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 6.2 | 136.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.9 | 106.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 5.0 | 89.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 4.7 | 88.7 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 1.2 | 77.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.8 | 75.5 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 1.9 | 69.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 1.3 | 68.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |