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GSE58827: Dynamics of the Mouse Liver
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Results for E2f2_E2f5
Z-value: 6.46
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Transcription factors associated with E2f2_E2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f2 | mm39_v1_chr4_+_135899678_135899738 | 0.95 | 1.6e-18 | Click! |
| E2f5 | mm39_v1_chr3_+_14643669_14643756 | 0.49 | 2.2e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f2_E2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.0 | 372.2 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 12.7 | 291.6 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 6.8 | 225.7 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 25.5 | 203.8 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 30.6 | 122.2 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 9.3 | 111.6 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 4.3 | 77.5 | GO:0033280 | response to vitamin D(GO:0033280) |
| 6.6 | 72.8 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 8.1 | 64.8 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 21.3 | 63.8 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 30.7 | 491.5 | GO:0042555 | MCM complex(GO:0042555) |
| 47.0 | 281.7 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.3 | 264.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 3.2 | 208.1 | GO:0005657 | replication fork(GO:0005657) |
| 0.0 | 144.4 | GO:0005829 | cytosol(GO:0005829) |
| 15.0 | 75.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 1.3 | 74.3 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 12.4 | 62.0 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 7.5 | 59.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.6 | 58.9 | GO:0005776 | autophagosome(GO:0005776) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 47.0 | 281.7 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.8 | 277.1 | GO:0001047 | core promoter binding(GO:0001047) |
| 6.3 | 265.9 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 10.0 | 179.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 3.7 | 124.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 3.9 | 122.2 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 15.9 | 111.6 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.4 | 80.9 | GO:0042393 | histone binding(GO:0042393) |
| 3.7 | 77.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.2 | 74.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 460.2 | PID E2F PATHWAY | E2F transcription factor network |
| 8.3 | 414.3 | PID ATR PATHWAY | ATR signaling pathway |
| 11.3 | 203.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.3 | 165.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 15.5 | 154.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.0 | 76.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 55.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.9 | 54.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.2 | 34.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 2.4 | 30.9 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 34.1 | 546.1 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 24.7 | 544.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 16.0 | 224.6 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 7.9 | 133.8 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 2.6 | 115.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 69.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 69.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.0 | 49.4 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 1.0 | 43.5 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 4.3 | 42.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |