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GSE58827: Dynamics of the Mouse Liver
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Results for E2f4
Z-value: 3.82
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Transcription factors associated with E2f4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2f4 | mm39_v1_chr8_+_106024294_106024367 | 0.97 | 2.0e-22 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2f4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 99.9 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
| 1.8 | 73.9 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 3.9 | 69.9 | GO:0015816 | glycine transport(GO:0015816) |
| 2.8 | 50.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 1.2 | 41.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 41.5 | GO:0051301 | cell division(GO:0051301) |
| 0.9 | 41.4 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
| 13.1 | 39.4 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 1.3 | 36.0 | GO:0010544 | negative regulation of platelet activation(GO:0010544) |
| 0.3 | 35.2 | GO:0007051 | spindle organization(GO:0007051) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 111.3 | GO:0005634 | nucleus(GO:0005634) |
| 0.2 | 56.7 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 50.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 50.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 7.5 | 45.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.1 | 44.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 41.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 6.6 | 39.4 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 35.2 | GO:0000922 | spindle pole(GO:0000922) |
| 2.6 | 30.7 | GO:0008278 | cohesin complex(GO:0008278) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 66.1 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 6.3 | 44.0 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.9 | 41.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.1 | 41.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 2.3 | 39.4 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.0 | 38.6 | GO:0042802 | identical protein binding(GO:0042802) |
| 5.7 | 33.9 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.3 | 30.7 | GO:0005518 | collagen binding(GO:0005518) |
| 7.7 | 30.6 | GO:0071207 | histone pre-mRNA stem-loop binding(GO:0071207) |
| 0.5 | 30.6 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 66.8 | PID E2F PATHWAY | E2F transcription factor network |
| 1.5 | 62.6 | PID ATM PATHWAY | ATM pathway |
| 1.1 | 51.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.4 | 44.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.2 | 41.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 34.7 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.2 | 30.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 27.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 20.6 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 18.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 98.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.0 | 71.6 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.0 | 66.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.6 | 58.6 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 2.3 | 36.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 1.4 | 31.8 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 2.6 | 30.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 2.4 | 30.6 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.5 | 28.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.8 | 27.7 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |