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GSE58827: Dynamics of the Mouse Liver
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Results for Ebf3
Z-value: 2.43
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Transcription factors associated with Ebf3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ebf3 | mm39_v1_chr7_-_136916123_136916174 | 0.43 | 9.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ebf3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 66.0 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.5 | 41.8 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 10.9 | 32.6 | GO:0030221 | basophil differentiation(GO:0030221) |
| 0.2 | 31.3 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.7 | 25.8 | GO:0051572 | negative regulation of histone H3-K4 methylation(GO:0051572) |
| 4.2 | 25.2 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.2 | 19.5 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 3.7 | 18.6 | GO:0034224 | cellular response to zinc ion starvation(GO:0034224) |
| 0.5 | 15.8 | GO:0045730 | respiratory burst(GO:0045730) |
| 3.0 | 15.2 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 78.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 41.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.2 | 31.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 31.3 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 3.6 | 25.2 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 20.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.0 | 18.2 | GO:0005861 | troponin complex(GO:0005861) |
| 1.1 | 15.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 15.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.4 | 13.7 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 41.8 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.0 | 36.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 1.8 | 32.6 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.2 | 31.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 25.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.3 | 20.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 19.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.4 | 18.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 16.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 1.6 | 15.7 | GO:0031014 | troponin T binding(GO:0031014) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 68.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 34.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 23.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.1 | 18.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 11.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 9.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.3 | 8.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 6.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 6.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 62.9 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.3 | 50.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 38.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 26.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.4 | 25.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.7 | 18.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.4 | 18.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 13.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 12.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 12.0 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |