ISMARA results: Elf1_Elf2_Etv2

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GSE58827: Dynamics of the Mouse Liver

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Results for Elf1_Elf2_Etv2_Elf4

Z-value: 5.38

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Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Gene Symbol	Gene ID	Gene Info
Elf1 Ensembl NCBI MGI UniProt	ENSMUSG00000036461.17	E74-like factor 1
Elf2 Ensembl NCBI MGI UniProt	ENSMUSG00000037174.19	E74-like factor 2
Etv2 Ensembl NCBI MGI UniProt	ENSMUSG00000006311.9	ets variant 2
Elf4 Ensembl NCBI MGI UniProt	ENSMUSG00000031103.13	E74-like factor 4 (ets domain transcription factor)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Elf4	mm39_v1_chrX_-_47543029_47543071	0.93	2.2e-16	Click!
Elf2	mm39_v1_chr3_-_51248032_51248130	0.84	1.7e-10	Click!
Elf1	mm39_v1_chr14_+_79753055_79753148	0.54	6.3e-04	Click!
Etv2	mm39_v1_chr7_-_30335277_30335277	0.32	5.7e-02	Click!

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_90603013 Show fit	52.78	ENSMUST00000069960.12 ENSMUST00000117167.2	S100a9 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A9 (calgranulin B)
chr11_+_87684299 Show fit	46.33	ENSMUST00000020779.11	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr16_-_18630722 Show fit	41.47	ENSMUST00000000028.14 ENSMUST00000115585.2	Cdc45 Ensembl NCBI MGI UniProt Show fit	cell division cycle 45
chr11_+_87684548 Show fit	40.34	ENSMUST00000143021.9	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr19_-_9876815 Show fit	40.16	ENSMUST00000237147.2 ENSMUST00000025562.9	Incenp Ensembl NCBI MGI UniProt Show fit	inner centromere protein
chr5_+_90920294 Show fit	36.34	ENSMUST00000031320.8	Pf4 Ensembl NCBI MGI UniProt Show fit	platelet factor 4
chr2_+_91480460 Show fit	33.95	ENSMUST00000111331.9	Arhgap1 Ensembl NCBI MGI UniProt Show fit	Rho GTPase activating protein 1
chr7_-_126641593 Show fit	33.05	ENSMUST00000032915.8	Kif22 Ensembl NCBI MGI UniProt Show fit	kinesin family member 22
chr1_-_132318039 Show fit	32.38	ENSMUST00000132435.2	Tmcc2 Ensembl NCBI MGI UniProt Show fit	transmembrane and coiled-coil domains 2
chr6_-_125168637 Show fit	32.14	ENSMUST00000043848.11	Ncapd2 Ensembl NCBI MGI UniProt Show fit	non-SMC condensin I complex, subunit D2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	195.2	GO:0002181	cytoplasmic translation(GO:0002181)
0.7	128.8	GO:0000398	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
4.6	119.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
1.5	116.3	GO:0070527	platelet aggregation(GO:0070527)
2.5	102.8	GO:0007080	mitotic metaphase plate congression(GO:0007080)
3.9	101.6	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
32.7	98.1	GO:0002148	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
2.1	97.3	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
13.0	78.0	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.7	76.3	GO:0000910	cytokinesis(GO:0000910)

Showing 1 to 10 of 1,031 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	340.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
4.3	266.4	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
1.6	166.5	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
2.0	152.9	GO:0005871	kinesin complex(GO:0005871)
2.2	146.0	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2	145.7	GO:0005730	nucleolus(GO:0005730)
0.4	120.3	GO:0016607	nuclear speck(GO:0016607)
0.4	112.8	GO:0031965	nuclear membrane(GO:0031965)
6.3	106.4	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.5	84.9	GO:0001650	fibrillar center(GO:0001650)

Showing 1 to 10 of 407 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	378.5	GO:0003723	RNA binding(GO:0003723)
1.9	336.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	230.4	GO:0045296	cadherin binding(GO:0045296)
0.7	145.0	GO:0042393	histone binding(GO:0042393)
0.4	138.0	GO:0030695	GTPase regulator activity(GO:0030695)
0.9	129.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.0	115.1	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.9	93.7	GO:0003777	microtubule motor activity(GO:0003777)
1.4	91.2	GO:0031491	nucleosome binding(GO:0031491)
1.3	90.5	GO:0003743	translation initiation factor activity(GO:0003743)

Showing 1 to 10 of 600 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	205.0	PID RB 1PATHWAY	Regulation of retinoblastoma protein
3.5	201.7	PID AURORA B PATHWAY	Aurora B signaling
2.6	142.1	PID ATR PATHWAY	ATR signaling pathway
1.5	115.1	PID RAC1 PATHWAY	RAC1 signaling pathway
2.7	114.7	PID AURORA A PATHWAY	Aurora A signaling
1.2	89.2	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.7	87.5	PID IL23 PATHWAY	IL23-mediated signaling events
0.9	86.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
2.0	85.9	PID PLK1 PATHWAY	PLK1 signaling events
2.3	81.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions

Showing 1 to 10 of 127 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	579.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
2.8	168.2	REACTOME G1 PHASE	Genes involved in G1 Phase
1.6	140.3	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
8.3	132.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.6	122.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.4	116.4	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
1.6	110.9	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
5.2	108.3	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.5	106.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
3.1	98.7	REACTOME KINESINS	Genes involved in Kinesins

Showing 1 to 10 of 184 entries

Results for Elf1_Elf2_Etv2_Elf4

Z-value: 5.38

Motif logo

Transcription factors associated with Elf1_Elf2_Etv2_Elf4

Activity-expression correlation:

Activity profile of Elf1_Elf2_Etv2_Elf4 motif

Sorted Z-values of Elf1_Elf2_Etv2_Elf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Elf1_Elf2_Etv2_Elf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: