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GSE58827: Dynamics of the Mouse Liver
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Results for Elf5
Z-value: 2.08
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Transcription factors associated with Elf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf5 | mm39_v1_chr2_+_103255165_103255178 | -0.28 | 9.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 39.8 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
| 0.2 | 26.3 | GO:0019395 | fatty acid oxidation(GO:0019395) |
| 4.8 | 24.1 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 21.9 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 1.0 | 20.4 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.5 | 16.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.5 | 16.3 | GO:0080184 | response to phenylpropanoid(GO:0080184) |
| 5.3 | 16.0 | GO:0018003 | peptidyl-lysine N6-acetylation(GO:0018003) |
| 2.1 | 14.8 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 3.5 | 13.9 | GO:0032379 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 95.2 | GO:0044429 | mitochondrial part(GO:0044429) |
| 0.3 | 54.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 5.0 | 39.8 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.0 | 31.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.1 | 31.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 23.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.5 | 21.7 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.3 | 20.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.6 | 16.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.3 | 15.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 24.1 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.6 | 22.6 | GO:0015149 | hexose transmembrane transporter activity(GO:0015149) |
| 0.4 | 19.0 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 1.5 | 16.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.3 | 16.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 2.5 | 14.8 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 3.5 | 13.9 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
| 0.9 | 13.9 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 2.2 | 13.3 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
| 0.7 | 12.9 | GO:0008430 | selenium binding(GO:0008430) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 14.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 13.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 11.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 10.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 8.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 7.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.2 | 7.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 6.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 6.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 5.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 20.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 19.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 17.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.7 | 17.1 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 1.1 | 15.6 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.7 | 11.6 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.8 | 11.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.3 | 10.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.4 | 10.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |