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GSE58827: Dynamics of the Mouse Liver
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Results for Esr2
Z-value: 2.08
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Transcription factors associated with Esr2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esr2 | mm39_v1_chr12_-_76224025_76224039 | -0.19 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esr2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 25.2 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 2.1 | 22.8 | GO:0035754 | B cell chemotaxis(GO:0035754) |
| 0.3 | 21.1 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 5.1 | 20.3 | GO:0010901 | regulation of very-low-density lipoprotein particle remodeling(GO:0010901) |
| 1.2 | 20.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 17.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 5.7 | 17.2 | GO:0018931 | naphthalene metabolic process(GO:0018931) naphthalene-containing compound metabolic process(GO:0090420) |
| 1.4 | 15.7 | GO:0097460 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 1.3 | 15.3 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.5 | 14.2 | GO:0017144 | drug metabolic process(GO:0017144) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 82.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 57.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 47.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 40.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 30.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.6 | 29.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.2 | 28.0 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 2.3 | 27.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.3 | 17.3 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 17.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 48.4 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 4.9 | 29.4 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.2 | 27.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 6.6 | 26.3 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 24.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 22.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 5.2 | 20.8 | GO:0047016 | cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity(GO:0047016) |
| 0.5 | 16.0 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.6 | 14.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 12.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 54.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 17.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 12.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 11.0 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 10.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 6.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.3 | 5.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 4.7 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 3.8 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 52.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 44.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 30.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.0 | 29.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 24.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 4.2 | 12.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.9 | 12.6 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.9 | 12.3 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 11.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 10.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |