ISMARA results: Ets1

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GSE58827: Dynamics of the Mouse Liver

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Results for Ets1

Z-value: 3.19

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Transcription factors associated with Ets1

Gene Symbol	Gene ID	Gene Info
Ets1 Ensembl NCBI MGI UniProt	ENSMUSG00000032035.17	E26 avian leukemia oncogene 1, 5' domain

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ets1	mm39_v1_chr9_+_32607301_32607417	0.77	4.5e-08	Click!

Activity profile of Ets1 motif

Sorted Z-values of Ets1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_90603013 Show fit	33.69	ENSMUST00000069960.12 ENSMUST00000117167.2	S100a9 Ensembl NCBI MGI UniProt Show fit	S100 calcium binding protein A9 (calgranulin B)
chr11_+_87684299 Show fit	30.66	ENSMUST00000020779.11	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr10_+_79722081 Show fit	29.01	ENSMUST00000046091.7	Elane Ensembl NCBI MGI UniProt Show fit	elastase, neutrophil expressed
chr7_-_126817639 Show fit	25.49	ENSMUST00000152267.8 ENSMUST00000106314.8	Septin1 Ensembl NCBI MGI UniProt Show fit	septin 1
chr7_-_126817475 Show fit	25.36	ENSMUST00000106313.8 ENSMUST00000142356.3	Septin1 Ensembl NCBI MGI UniProt Show fit	septin 1
chr7_-_126736979 Show fit	24.91	ENSMUST00000049931.6	Spn Ensembl NCBI MGI UniProt Show fit	sialophorin
chr11_+_87684548 Show fit	22.24	ENSMUST00000143021.9	Mpo Ensembl NCBI MGI UniProt Show fit	myeloperoxidase
chr10_+_79715448 Show fit	21.24	ENSMUST00000006679.15	Prtn3 Ensembl NCBI MGI UniProt Show fit	proteinase 3
chr2_-_27974889 Show fit	20.90	ENSMUST00000028179.15 ENSMUST00000117486.8 ENSMUST00000135472.2	Fcnb Ensembl NCBI MGI UniProt Show fit	ficolin B
chr9_-_20864096 Show fit	19.70	ENSMUST00000004202.17	Dnmt1 Ensembl NCBI MGI UniProt Show fit	DNA methyltransferase (cytosine-5) 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	62.5	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
17.6	52.9	GO:0002149	hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
1.3	38.3	GO:2001223	negative regulation of neuron migration(GO:2001223)
6.1	36.6	GO:1903336	endosome localization(GO:0032439) negative regulation of vacuolar transport(GO:1903336)
11.2	33.7	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1	29.9	GO:0000398	RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
9.7	29.0	GO:0070947	antimicrobial peptide biosynthetic process(GO:0002777) antibacterial peptide biosynthetic process(GO:0002780) neutrophil mediated killing of fungus(GO:0070947)
0.8	28.8	GO:0048268	clathrin coat assembly(GO:0048268)
3.2	28.5	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.6	27.8	GO:0006284	base-excision repair(GO:0006284)

Showing 1 to 10 of 494 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	92.7	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
1.2	84.9	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5	68.1	GO:0017053	transcriptional repressor complex(GO:0017053)
1.0	57.1	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	55.2	GO:0031012	extracellular matrix(GO:0031012)
0.6	52.1	GO:0030118	clathrin coat(GO:0030118)
3.1	51.9	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
2.9	43.7	GO:0043020	NADPH oxidase complex(GO:0043020)
0.7	41.1	GO:0001772	immunological synapse(GO:0001772)
0.4	39.5	GO:0071013	catalytic step 2 spliceosome(GO:0071013)

Showing 1 to 10 of 244 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	132.8	GO:0030695	GTPase regulator activity(GO:0030695)
0.4	75.5	GO:0003735	structural constituent of ribosome(GO:0003735)
1.2	71.1	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
1.1	47.8	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
3.0	39.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2	37.8	GO:0042393	histone binding(GO:0042393)
0.5	36.2	GO:0050840	extracellular matrix binding(GO:0050840)
4.2	33.7	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.6	32.5	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.4	31.5	GO:0004601	peroxidase activity(GO:0004601)

Showing 1 to 10 of 332 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	74.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.7	65.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.1	50.6	PID IL23 PATHWAY	IL23-mediated signaling events
1.0	50.4	PID AURORA A PATHWAY	Aurora A signaling
0.7	50.4	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	49.3	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.9	46.3	PID ATR PATHWAY	ATR signaling pathway
0.6	44.6	PID RAC1 PATHWAY	RAC1 signaling pathway
0.8	41.7	PID BCR 5PATHWAY	BCR signaling pathway
1.7	39.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Showing 1 to 10 of 85 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	145.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.6	98.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	56.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.6	41.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.8	39.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.8	37.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.8	35.5	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.7	32.4	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
1.9	30.9	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.4	30.1	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing

Showing 1 to 10 of 128 entries

Results for Ets1

Z-value: 3.19

Motif logo

Transcription factors associated with Ets1

Activity-expression correlation:

Activity profile of Ets1 motif

Sorted Z-values of Ets1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: