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GSE58827: Dynamics of the Mouse Liver
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Results for Fli1
Z-value: 1.89
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Transcription factors associated with Fli1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Fli1 | mm39_v1_chr9_-_32452885_32452898 | -0.65 | 1.7e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_40175709 Show fit | 54.83 |
ENSMUST00000051846.13
|
cytochrome P450, family 2, subfamily c, polypeptide 70 |
|
| chr9_-_57590926 Show fit | 40.45 |
ENSMUST00000034860.5
|
cytochrome P450, family 1, subfamily a, polypeptide 2 |
|
| chr8_-_25066313 Show fit | 33.13 |
ENSMUST00000121992.2
|
indoleamine 2,3-dioxygenase 2 |
|
| chr5_-_89583469 Show fit | 25.48 |
ENSMUST00000200534.2
|
vitamin D binding protein |
|
| chr7_-_26638802 Show fit | 25.17 |
ENSMUST00000170227.3
|
cytochrome P450, family 2, subfamily a, polypeptide 22 |
|
| chr7_-_13571334 Show fit | 16.88 |
ENSMUST00000108522.5
|
sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 |
|
| chr17_-_32643131 Show fit | 16.80 |
ENSMUST00000236386.2
|
peptidoglycan recognition protein 2 |
|
| chr17_-_32643067 Show fit | 16.71 |
ENSMUST00000237130.2
|
peptidoglycan recognition protein 2 |
|
| chr13_-_4573312 Show fit | 11.53 |
ENSMUST00000221564.2
ENSMUST00000078239.5 ENSMUST00000080361.13 |
aldo-keto reductase family 1, member C20 |
|
| chr11_-_5865124 Show fit | 8.69 |
ENSMUST00000109823.9
ENSMUST00000109822.8 |
glucokinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Fli1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 80.0 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 10.1 | 40.5 | GO:0018894 | dibenzo-p-dioxin metabolic process(GO:0018894) |
| 5.6 | 33.5 | GO:0032827 | peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253) negative regulation of natural killer cell differentiation(GO:0032824) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827) |
| 3.0 | 33.1 | GO:0042436 | tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218) |
| 1.2 | 25.5 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.7 | 16.9 | GO:0051923 | sulfation(GO:0051923) |
| 0.2 | 14.1 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 11.5 | GO:0006694 | steroid biosynthetic process(GO:0006694) |
| 1.0 | 9.4 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 2.2 | 8.7 | GO:0071449 | cellular response to lipid hydroperoxide(GO:0071449) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 48.8 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 45.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 26.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 13.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 12.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 11.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 9.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.5 | 8.7 | GO:0045180 | basal cortex(GO:0045180) |
| 0.1 | 8.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.7 | 7.2 | GO:0045098 | type III intermediate filament(GO:0045098) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 80.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 6.7 | 40.5 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 5.6 | 33.5 | GO:0016019 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019) |
| 11.0 | 33.1 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 6.4 | 25.5 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 2.4 | 16.9 | GO:0050656 | alcohol sulfotransferase activity(GO:0004027) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.1 | 14.1 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.4 | 12.5 | GO:1900750 | glutathione binding(GO:0043295) oligopeptide binding(GO:1900750) |
| 0.4 | 11.5 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.3 | 9.4 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 10.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.3 | 6.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 6.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 4.4 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 4.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 3.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 2.5 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 2.3 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.5 | 40.5 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 2.4 | 33.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.6 | 25.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 1.2 | 16.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 14.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 13.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 11.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 8.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 7.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.4 | 7.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |