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GSE58827: Dynamics of the Mouse Liver
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Results for Gata2_Gata1
Z-value: 5.28
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Transcription factors associated with Gata2_Gata1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gata1 | mm39_v1_chrX_-_7834057_7834149 | 0.87 | 9.3e-12 | Click! |
| Gata2 | mm39_v1_chr6_+_88175312_88175316 | 0.81 | 2.7e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gata2_Gata1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 175.8 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 9.1 | 136.5 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 11.3 | 136.1 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.8 | 127.7 | GO:0007586 | digestion(GO:0007586) |
| 34.6 | 103.8 | GO:0018160 | peptidyl-pyrromethane cofactor linkage(GO:0018160) |
| 28.9 | 86.8 | GO:0002215 | defense response to nematode(GO:0002215) |
| 1.8 | 84.3 | GO:0032094 | response to food(GO:0032094) |
| 3.3 | 83.4 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 1.1 | 82.8 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
| 9.7 | 77.6 | GO:0006735 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 566.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 132.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.7 | 128.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.6 | 120.0 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.4 | 105.3 | GO:0000793 | condensed chromosome(GO:0000793) |
| 1.8 | 77.6 | GO:0097228 | sperm principal piece(GO:0097228) |
| 1.2 | 70.0 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 62.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 4.1 | 62.0 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 7.0 | 55.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 367.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 5.3 | 165.5 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 2.3 | 134.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 12.0 | 120.0 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.6 | 107.8 | GO:0005178 | integrin binding(GO:0005178) |
| 34.6 | 103.8 | GO:0004418 | hydroxymethylbilane synthase activity(GO:0004418) |
| 7.3 | 88.1 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 9.7 | 77.6 | GO:0019158 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 68.4 | GO:0008047 | enzyme activator activity(GO:0008047) |
| 0.2 | 61.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 178.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 102.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 1.9 | 86.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 2.1 | 74.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.6 | 62.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.9 | 54.4 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.5 | 49.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.7 | 41.6 | PID EPO PATHWAY | EPO signaling pathway |
| 0.6 | 37.7 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.7 | 34.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 147.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.8 | 138.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 3.0 | 93.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 1.3 | 77.7 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 1.2 | 68.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.8 | 62.6 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 44.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.4 | 34.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.9 | 33.8 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 1.8 | 27.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |