ISMARA results: Hic1

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GSE58827: Dynamics of the Mouse Liver

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Results for Hic1

Z-value: 2.04

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Transcription factors associated with Hic1

Gene Symbol	Gene ID	Gene Info
Hic1 Ensembl NCBI MGI UniProt	ENSMUSG00000043099.5	hypermethylated in cancer 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hic1	mm39_v1_chr11_-_75060345_75060345	-0.27	1.1e-01	Click!

Activity profile of Hic1 motif

Sorted Z-values of Hic1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_94102255 Show fit	9.23	ENSMUST00000041589.6	Tob1 Ensembl NCBI MGI UniProt Show fit	transducer of ErbB-2.1
chr8_-_85526653 Show fit	8.71	ENSMUST00000126806.2 ENSMUST00000076715.13	Nfix Ensembl NCBI MGI UniProt Show fit	nuclear factor I/X
chr2_-_5719302 Show fit	8.24	ENSMUST00000044009.14	Camk1d Ensembl NCBI MGI UniProt Show fit	calcium/calmodulin-dependent protein kinase ID
chr5_-_110434026 Show fit	6.81	ENSMUST00000031472.12	Pxmp2 Ensembl NCBI MGI UniProt Show fit	peroxisomal membrane protein 2
chr4_+_141095415 Show fit	6.63	ENSMUST00000006380.5	Fam131c Ensembl NCBI MGI UniProt Show fit	family with sequence similarity 131, member C
chr9_-_42175522 Show fit	6.60	ENSMUST00000217513.2 ENSMUST00000052725.15	Sc5d Ensembl NCBI MGI UniProt Show fit	sterol-C5-desaturase
chr7_+_65511777 Show fit	6.56	ENSMUST00000055576.12 ENSMUST00000098391.11	Pcsk6 Ensembl NCBI MGI UniProt Show fit	proprotein convertase subtilisin/kexin type 6
chr8_+_96078886 Show fit	6.42	ENSMUST00000034243.7	Mmp15 Ensembl NCBI MGI UniProt Show fit	matrix metallopeptidase 15
chr9_-_42175496 Show fit	6.35	ENSMUST00000169609.2	Sc5d Ensembl NCBI MGI UniProt Show fit	sterol-C5-desaturase
chr3_-_121608809 Show fit	6.18	ENSMUST00000197383.5	Abcd3 Ensembl NCBI MGI UniProt Show fit	ATP-binding cassette, sub-family D (ALD), member 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.6	GO:0006695	cholesterol biosynthetic process(GO:0006695)
0.5	15.1	GO:0051639	actin filament network formation(GO:0051639)
2.2	13.0	GO:0099527	postsynapse to nucleus signaling pathway(GO:0099527)
2.1	12.9	GO:0032902	nerve growth factor production(GO:0032902)
3.0	11.9	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)
0.5	11.3	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.2	10.5	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
2.6	10.2	GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
1.4	10.1	GO:0070495	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1	10.1	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)

Showing 1 to 10 of 486 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	39.1	GO:0005739	mitochondrion(GO:0005739)
0.0	22.4	GO:0031966	mitochondrial membrane(GO:0031966)
0.2	18.2	GO:0009925	basal plasma membrane(GO:0009925)
0.7	14.1	GO:0043220	Schmidt-Lanterman incisure(GO:0043220)
0.3	13.0	GO:0005719	nuclear euchromatin(GO:0005719)
0.4	11.9	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
1.4	11.3	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	11.0	GO:0005776	autophagosome(GO:0005776)
0.1	10.7	GO:0043296	apical junction complex(GO:0043296)
0.3	9.7	GO:0005779	integral component of peroxisomal membrane(GO:0005779)

Showing 1 to 10 of 170 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	15.4	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.7	13.4	GO:0048406	nerve growth factor binding(GO:0048406)
0.2	12.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
1.3	11.9	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
1.6	11.3	GO:0097016	L27 domain binding(GO:0097016)
0.1	11.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
2.5	10.1	GO:0005008	hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4	10.0	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3	9.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.2	8.8	GO:0070064	proline-rich region binding(GO:0070064)

Showing 1 to 10 of 328 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	15.9	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	13.9	PID ARF6 PATHWAY	Arf6 signaling events
0.1	11.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	8.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.2	6.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	6.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	5.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	5.3	PID BMP PATHWAY	BMP receptor signaling
0.1	5.3	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 71 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	19.9	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.2	18.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.5	12.9	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	11.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.5	10.5	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.3	9.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.4	9.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.2	9.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.2	9.0	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.2	8.7	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions

Showing 1 to 10 of 112 entries

Results for Hic1

Z-value: 2.04

Motif logo

Transcription factors associated with Hic1

Activity-expression correlation:

Activity profile of Hic1 motif

Sorted Z-values of Hic1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hic1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: