ISMARA results: Hnf1a

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GSE58827: Dynamics of the Mouse Liver

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Results for Hnf1a

Z-value: 2.22

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Transcription factors associated with Hnf1a

Gene Symbol	Gene ID	Gene Info
Hnf1a Ensembl NCBI MGI UniProt	ENSMUSG00000029556.13	HNF1 homeobox A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1a	mm39_v1_chr5_-_115109118_115109138	0.63	3.9e-05	Click!

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_+_51333816 Show fit	33.41	ENSMUST00000169895.3	Rnase4 Ensembl NCBI MGI UniProt Show fit	ribonuclease, RNase A family 4
chr7_+_140343652 Show fit	32.22	ENSMUST00000026552.9 ENSMUST00000209253.2 ENSMUST00000210235.2	Cyp2e1 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily e, polypeptide 1
chr5_+_90666791 Show fit	27.47	ENSMUST00000113179.9 ENSMUST00000128740.2	Afm Ensembl NCBI MGI UniProt Show fit	afamin
chr1_+_88139678 Show fit	26.95	ENSMUST00000073049.7	Ugt1a1 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A1
chr11_+_101258368 Show fit	26.28	ENSMUST00000019469.3	G6pc Ensembl NCBI MGI UniProt Show fit	glucose-6-phosphatase, catalytic
chr1_-_130589321 Show fit	25.79	ENSMUST00000137276.3	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr1_-_130589349 Show fit	25.50	ENSMUST00000027657.14	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr5_-_89605622 Show fit	24.53	ENSMUST00000049209.13	Gc Ensembl NCBI MGI UniProt Show fit	vitamin D binding protein
chr12_-_103739847 Show fit	21.79	ENSMUST00000078869.6	Serpina1d Ensembl NCBI MGI UniProt Show fit	serine (or cysteine) peptidase inhibitor, clade A, member 1D
chr6_+_141575226 Show fit	21.38	ENSMUST00000042812.9	Slco1b2 Ensembl NCBI MGI UniProt Show fit	solute carrier organic anion transporter family, member 1b2

Showing 1 to 10 of 115 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	64.7	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	61.4	GO:0043434	response to peptide hormone(GO:0043434)
0.2	33.4	GO:0009267	cellular response to starvation(GO:0009267)
1.1	31.2	GO:0017144	drug metabolic process(GO:0017144)
3.9	27.2	GO:1904073	regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
9.0	26.9	GO:0018879	biphenyl metabolic process(GO:0018879)
2.6	26.3	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.2	24.5	GO:0042359	vitamin D metabolic process(GO:0042359)
2.1	22.6	GO:0052696	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.4	22.1	GO:0051180	vitamin transport(GO:0051180)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	82.6	GO:0072562	blood microparticle(GO:0072562)
0.0	76.8	GO:0005794	Golgi apparatus(GO:0005794)
0.3	58.1	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
2.7	27.2	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
1.8	26.9	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	22.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	18.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
2.6	15.6	GO:0044279	other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1	13.0	GO:0008021	synaptic vesicle(GO:0008021)
0.3	12.6	GO:0034364	high-density lipoprotein particle(GO:0034364)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	83.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.2	49.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.2	32.5	GO:0004540	ribonuclease activity(GO:0004540)
0.9	32.2	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
9.2	27.5	GO:0008431	vitamin E binding(GO:0008431)
0.6	27.2	GO:0043539	insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
6.6	26.3	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
6.1	24.5	GO:1902271	D3 vitamins binding(GO:1902271)
0.1	23.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.3	19.6	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)

Showing 1 to 10 of 48 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	28.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	27.2	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.3	26.3	PID FOXO PATHWAY	FoxO family signaling
0.4	20.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7	16.4	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	16.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	13.5	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	12.0	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.1	7.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	6.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	42.3	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
3.5	38.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
10.7	32.2	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.6	24.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
1.2	20.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	18.1	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.2	16.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.5	15.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.3	14.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.5	13.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Showing 1 to 10 of 25 entries

Results for Hnf1a

Z-value: 2.22

Motif logo

Transcription factors associated with Hnf1a

Activity-expression correlation:

Activity profile of Hnf1a motif

Sorted Z-values of Hnf1a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: