ISMARA results: Hnf1b

Project

GSE58827: Dynamics of the Mouse Liver

Navigation

Downloads

Results for Hnf1b

Z-value: 2.85

Motif logo

Transcription factors associated with Hnf1b

Gene Symbol	Gene ID	Gene Info
Hnf1b Ensembl NCBI MGI UniProt	ENSMUSG00000020679.12	HNF1 homeobox B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf1b	mm39_v1_chr11_+_83741657_83741681	0.31	6.7e-02	Click!

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_89605622 Show fit	39.87	ENSMUST00000049209.13	Gc Ensembl NCBI MGI UniProt Show fit	vitamin D binding protein
chr1_-_130589321 Show fit	30.55	ENSMUST00000137276.3	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr1_-_130589349 Show fit	30.40	ENSMUST00000027657.14	C4bp Ensembl NCBI MGI UniProt Show fit	complement component 4 binding protein
chr2_-_134396268 Show fit	27.76	ENSMUST00000028704.3	Hao1 Ensembl NCBI MGI UniProt Show fit	hydroxyacid oxidase 1, liver
chr19_+_30210320 Show fit	27.19	ENSMUST00000025797.7	Mbl2 Ensembl NCBI MGI UniProt Show fit	mannose-binding lectin (protein C) 2
chr16_+_22769822 Show fit	27.07	ENSMUST00000023590.9	Hrg Ensembl NCBI MGI UniProt Show fit	histidine-rich glycoprotein
chr1_+_88139678 Show fit	26.77	ENSMUST00000073049.7	Ugt1a1 Ensembl NCBI MGI UniProt Show fit	UDP glucuronosyltransferase 1 family, polypeptide A1
chr16_+_22769844 Show fit	26.73	ENSMUST00000232422.2	Hrg Ensembl NCBI MGI UniProt Show fit	histidine-rich glycoprotein
chr11_+_101258368 Show fit	25.91	ENSMUST00000019469.3	G6pc Ensembl NCBI MGI UniProt Show fit	glucose-6-phosphatase, catalytic
chr10_-_95678786 Show fit	25.17	ENSMUST00000211096.2	Gm33543 Ensembl NCBI MGI UniProt Show fit	predicted gene, 33543

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
10.4	125.1	GO:0052696	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.5	77.7	GO:0006958	complement activation, classical pathway(GO:0006958)
17.9	53.8	GO:0097037	heme export(GO:0097037)
0.3	47.3	GO:0035725	sodium ion transmembrane transport(GO:0035725)
2.4	46.4	GO:0042359	vitamin D metabolic process(GO:0042359)
2.8	41.6	GO:0015747	urate transport(GO:0015747)
0.6	37.5	GO:0006805	xenobiotic metabolic process(GO:0006805)
6.1	30.4	GO:0009441	glycolate metabolic process(GO:0009441)
1.3	27.9	GO:0006704	glucocorticoid biosynthetic process(GO:0006704)
2.1	27.2	GO:0001867	complement activation, lectin pathway(GO:0001867)

Showing 1 to 10 of 110 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	116.0	GO:0005783	endoplasmic reticulum(GO:0005783)
0.3	76.5	GO:0072562	blood microparticle(GO:0072562)
17.9	53.8	GO:0061474	phagolysosome membrane(GO:0061474)
0.1	37.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.3	36.8	GO:0005811	lipid particle(GO:0005811)
0.1	33.6	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.0	31.5	GO:0005887	integral component of plasma membrane(GO:0005887)
1.8	26.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.2	25.8	GO:0005581	collagen trimer(GO:0005581)
0.1	24.6	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	171.6	GO:0015020	glucuronosyltransferase activity(GO:0015020)
5.5	87.9	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.4	50.1	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
10.0	39.9	GO:1902271	D3 vitamins binding(GO:1902271)
1.2	33.6	GO:0004033	aldo-keto reductase (NADP) activity(GO:0004033)
7.5	29.9	GO:0004062	aryl sulfotransferase activity(GO:0004062)
1.4	27.9	GO:0016832	aldehyde-lyase activity(GO:0016832)
6.9	27.8	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
3.4	27.2	GO:0005534	galactose binding(GO:0005534)
0.2	26.3	GO:0008170	N-methyltransferase activity(GO:0008170)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	67.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	27.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	27.4	PID FOXO PATHWAY	FoxO family signaling
0.4	20.8	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	17.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	15.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.3	14.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	13.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	10.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	6.9	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	71.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
6.1	67.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	47.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.4	37.3	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.6	35.5	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
1.9	27.9	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
3.4	27.2	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.3	23.9	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
1.1	21.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
1.0	19.9	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones

Showing 1 to 10 of 42 entries

Results for Hnf1b

Z-value: 2.85

Motif logo

Transcription factors associated with Hnf1b

Activity-expression correlation:

Activity profile of Hnf1b motif

Sorted Z-values of Hnf1b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf1b

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: