ISMARA results: Hnf4a

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GSE58827: Dynamics of the Mouse Liver

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Results for Hnf4a

Z-value: 6.19

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Transcription factors associated with Hnf4a

Gene Symbol	Gene ID	Gene Info
Hnf4a Ensembl NCBI MGI UniProt	ENSMUSG00000017950.17	hepatic nuclear factor 4, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hnf4a	mm39_v1_chr2_+_163389068_163389108	0.61	7.7e-05	Click!

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_+_39275518 Show fit	160.92	ENSMUST00000003137.15	Cyp2c29 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily c, polypeptide 29
chr4_-_62005498 Show fit	128.85	ENSMUST00000107488.4 ENSMUST00000107472.8 ENSMUST00000084531.11	Mup3 Ensembl NCBI MGI UniProt Show fit	major urinary protein 3
chr17_-_46749370 Show fit	103.46	ENSMUST00000087012.7	Slc22a7 Ensembl NCBI MGI UniProt Show fit	solute carrier family 22 (organic anion transporter), member 7
chr10_-_128796834 Show fit	99.95	ENSMUST00000026398.5	Mettl7b Ensembl NCBI MGI UniProt Show fit	methyltransferase like 7B
chr15_-_82648376 Show fit	97.82	ENSMUST00000055721.6	Cyp2d40 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily d, polypeptide 40
chr19_-_40062174 Show fit	93.25	ENSMUST00000048959.5	Cyp2c54 Ensembl NCBI MGI UniProt Show fit	cytochrome P450, family 2, subfamily c, polypeptide 54
chr2_+_172994841 Show fit	80.60	ENSMUST00000029017.6	Pck1 Ensembl NCBI MGI UniProt Show fit	phosphoenolpyruvate carboxykinase 1, cytosolic
chr2_-_25390625 Show fit	74.10	ENSMUST00000040042.11	C8g Ensembl NCBI MGI UniProt Show fit	complement component 8, gamma polypeptide
chr3_+_122688721 Show fit	69.88	ENSMUST00000023820.6	Fabp2 Ensembl NCBI MGI UniProt Show fit	fatty acid binding protein 2, intestinal
chr4_-_60697274 Show fit	69.46	ENSMUST00000117932.2	Mup12 Ensembl NCBI MGI UniProt Show fit	major urinary protein 12

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.2	469.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
9.5	274.2	GO:0035634	response to stilbenoid(GO:0035634)
5.2	222.5	GO:0019369	arachidonic acid metabolic process(GO:0019369)
28.5	142.7	GO:0071718	sodium-independent icosanoid transport(GO:0071718)
8.2	139.4	GO:0006957	complement activation, alternative pathway(GO:0006957)
6.8	102.2	GO:0015747	urate transport(GO:0015747)
32.8	98.4	GO:1903699	tarsal gland development(GO:1903699)
0.5	97.6	GO:0009636	response to toxic substance(GO:0009636)
2.3	94.5	GO:0050892	intestinal absorption(GO:0050892)
22.3	89.2	GO:0015910	peroxisomal long-chain fatty acid import(GO:0015910)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	634.9	GO:0005783	endoplasmic reticulum(GO:0005783)
0.1	282.6	GO:0005739	mitochondrion(GO:0005739)
0.9	157.4	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
1.5	139.6	GO:0009925	basal plasma membrane(GO:0009925)
0.1	135.5	GO:0005887	integral component of plasma membrane(GO:0005887)
3.8	111.5	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.4	103.2	GO:0072562	blood microparticle(GO:0072562)
3.9	90.8	GO:0042627	chylomicron(GO:0042627)
8.2	89.7	GO:0045179	apical cortex(GO:0045179)
0.5	89.7	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.3	390.3	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
4.5	199.0	GO:0008395	steroid hydroxylase activity(GO:0008395)
32.2	193.0	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
7.0	188.2	GO:0070330	aromatase activity(GO:0070330)
19.9	178.9	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.7	151.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
36.7	146.8	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
33.3	133.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
1.5	128.8	GO:0005550	pheromone binding(GO:0005550)
16.4	98.4	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)

Showing 1 to 10 of 120 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	79.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
1.8	65.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	39.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
1.0	35.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	24.5	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	16.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	15.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	12.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	12.5	PID ARF 3PATHWAY	Arf1 pathway
0.1	6.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	182.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
12.4	173.0	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
8.2	163.8	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
11.0	142.7	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
6.0	84.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
6.2	80.6	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
4.4	74.1	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
5.2	67.0	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.6	66.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.9	54.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport

Showing 1 to 10 of 50 entries

Results for Hnf4a

Z-value: 6.19

Motif logo

Transcription factors associated with Hnf4a

Activity-expression correlation:

Activity profile of Hnf4a motif

Sorted Z-values of Hnf4a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hnf4a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: